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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Viral Hemorrhagic Fevers
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Accession:DOID:9007401 term browser browse the term
Definition:A group of viral diseases of diverse etiology but having many similar clinical characteristics; increased capillary permeability, leukopenia, and thrombocytopenia are common to all. Hemorrhagic fevers are characterized by sudden onset, fever, headache, generalized myalgia, backache, conjunctivitis, and severe prostration, followed by various hemorrhagic symptoms. Hemorrhagic fever with kidney involvement is HEMORRHAGIC FEVER WITH RENAL SYNDROME.
Synonyms:exact_synonym: Viral Hemorrhagic Fever
 primary_id: MESH:D006482
 alt_id: RDO:0005324
For additional species annotation, visit the Alliance of Genome Resources.


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dengue disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd209d CD209d antigen severity ISO DNA:SNP:promoter: -336G>A (human) RGD PMID:16274635 RGD:39939064 NCBI chr 8:3,871,824...3,878,548
Ensembl chr 8:3,871,824...3,878,555
JBrowse link
G Cxcr2 chemokine (C-X-C motif) receptor 2 treatment IMP RGD PMID:30098206 RGD:39938828 NCBI chr 1:74,153,994...74,161,246
Ensembl chr 1:74,153,989...74,161,246
JBrowse link
G F2 coagulation factor II ISO RGD PMID:22138554 RGD:40818430 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III severity ISO DNA:polymorphism:cds:p.H131R(human) RGD PMID:26240159 RGD:13463456 NCBI chr 1:171,051,169...171,065,915
Ensembl chr 1:171,051,174...171,064,935
JBrowse link
G Gc vitamin D binding protein ISO protein:increased expression:plasma RGD PMID:19845402 RGD:5509870 NCBI chr 5:89,417,511...89,457,898
Ensembl chr 5:89,417,522...89,457,898
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 treatment ISO RGD PMID:31821895 RGD:39939074 NCBI chr 8:24,584,133...24,596,952
Ensembl chr 8:24,584,136...24,597,009
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 treatment IMP RGD PMID:30098206 RGD:39938828 NCBI chr 1:40,404,864...40,465,418
Ensembl chr 1:40,429,570...40,465,415
JBrowse link
G Il33 interleukin 33 severity IDA RGD PMID:30098206 RGD:39938828 NCBI chr19:29,925,113...29,960,718
Ensembl chr19:29,925,114...29,960,718
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEP protein:increased phosphorylation:liver (mouse) RGD PMID:28188818 RGD:150340680 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mir146 microRNA 146 ISO RNA:decreased expression:serum: RGD PMID:26941580 RGD:41404658 NCBI chr11:43,374,397...43,374,461
Ensembl chr11:43,374,397...43,374,461
JBrowse link
G Mir21a microRNA 21a ISO RNA:increased expression:serum: RGD PMID:26941580 RGD:41404658 NCBI chr11:86,584,067...86,584,158
Ensembl chr11:86,584,067...86,584,158
JBrowse link
G Stat2 signal transducer and activator of transcription 2 susceptibility IMP RGD PMID:21075352 PMID:21379341 RGD:41789625, RGD:41789629 NCBI chr10:128,270,498...128,292,853
Ensembl chr10:128,270,559...128,292,849
JBrowse link
dengue hemorrhagic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 antigen disease_progression ISO protein:increased expression:cd14-positive monocyte (human) RGD PMID:24945350 RGD:127345113 NCBI chr 3:86,995,834...87,012,358
Ensembl chr 3:86,995,834...86,999,441
JBrowse link
G Clec5a C-type lectin domain family 5, member a ISO CTD Direct Evidence: therapeutic CTD PMID:18496526 NCBI chr 6:40,574,898...40,585,805
Ensembl chr 6:40,574,894...40,585,821
JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III susceptibility ISO DNA:polymorphism:cds:p.H131R(human) RGD PMID:22817980 RGD:11040906 NCBI chr 1:171,051,169...171,065,915
Ensembl chr 1:171,051,174...171,064,935
JBrowse link
G Il21 interleukin 21 severity ISO protein:increased expression:blood serum (human) RGD PMID:24858204 RGD:127285368 NCBI chr 3:37,222,759...37,232,636
Ensembl chr 3:37,222,759...37,232,636
JBrowse link
G Mill2 MHC I like leukocyte 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22001756 NCBI chr 7:18,839,958...18,869,696
Ensembl chr 7:18,839,966...18,865,402
JBrowse link
G Osbp oxysterol binding protein ISO mRNA:increased expression:peripheral blood mononuclear cell RGD PMID:28241052 RGD:41404654 NCBI chr19:11,965,844...11,994,114
Ensembl chr19:11,965,941...11,994,112
JBrowse link
G Plce1 phospholipase C, epsilon 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22001756 NCBI chr19:38,481,034...38,785,105
Ensembl chr19:38,481,109...38,785,030
JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 severity ISO DNA;polymorphism:5'utr: (rs25531) (human) RGD PMID:30452889 RGD:38676265 NCBI chr11:76,998,597...77,032,343
Ensembl chr11:76,998,603...77,032,340
JBrowse link
G Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) susceptibility ISO DNA:SNPs: : RGD PMID:18071882 RGD:6482261 NCBI chr17:34,204,479...34,216,321
Ensembl chr17:34,203,527...34,216,321
JBrowse link
Ebola hemorrhagic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd163 CD163 antigen exacerbates ISO protein:increased expression:blood plasma (human) RGD PMID:30666927 RGD:149735528 NCBI chr 6:124,304,636...124,330,529
Ensembl chr 6:124,304,656...124,330,527
JBrowse link
G Il3 interleukin 3 ISO protein: reduced expression: plasma RGD PMID:20957152 RGD:5686879 NCBI chr11:54,265,085...54,267,279
Ensembl chr11:54,265,303...54,267,277
JBrowse link
Hantavirus hemorrhagic fever with renal syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin severity ISO RGD PMID:14555823 RGD:11035280 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Apoc3 apolipoprotein C-III disease_progression ISO RGD PMID:20797315 RGD:7207210 NCBI chr 9:46,233,050...46,235,636
Ensembl chr 9:46,232,933...46,235,636
JBrowse link
G Cd163 CD163 antigen exacerbates ISO protein:increased expression:blood plasma (human)
protein:increased expression:CD14-positive, CD16-positive monocyte, blood plasma (human)
protein:increased expression:CD14-positive monocyte (human)
RGD PMID:25789628 PMID:25392926 PMID:29857122 RGD:127285679, RGD:127345131, RGD:127285683 NCBI chr 6:124,304,636...124,330,529
Ensembl chr 6:124,304,656...124,330,527
JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta susceptibility ISO DNA:polymorphism:cds:HLA-DRB1*0401-0411, HLA-DRB1*1001, HLA-DRB1*1101-1105, HLA-DRB1*1201-1202 and HLA-DRB1*1305 (human) RGD PMID:25169964 RGD:40818303 NCBI chr17:34,305,867...34,316,674
Ensembl chr17:34,305,867...34,316,674
JBrowse link
G Ifng interferon gamma severity ISO protein:increased expression:serum RGD PMID:22613426 RGD:6893374 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 severity ISO RGD PMID:25658420 RGD:40400702 NCBI chr 1:40,404,864...40,465,418
Ensembl chr 1:40,429,570...40,465,415
JBrowse link
G Il2ra interleukin 2 receptor, alpha chain ISO protein:increased expression:T cell RGD PMID:21436245 RGD:5147436 NCBI chr 2:11,642,792...11,693,194
Ensembl chr 2:11,642,807...11,693,193
JBrowse link
G Il33 interleukin 33 severity ISO RGD PMID:25658420 RGD:40400702 NCBI chr19:29,925,113...29,960,718
Ensembl chr19:29,925,114...29,960,718
JBrowse link
G Itgb3 integrin beta 3 severity ISO protein:increased expression:platelet RGD PMID:18419255 RGD:6907404 NCBI chr11:104,608,000...104,670,476
Ensembl chr11:104,608,000...104,670,476
JBrowse link
Korean hemorrhagic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 ISO mRNA:increased expression:lung RGD PMID:17878294 RGD:2325989 NCBI chr  X:7,579,676...7,595,243
Ensembl chr  X:7,573,644...7,595,245
JBrowse link
G Il2ra interleukin 2 receptor, alpha chain treatment ISO RGD PMID:17878294 RGD:2325989 NCBI chr 2:11,642,792...11,693,194
Ensembl chr 2:11,642,807...11,693,193
JBrowse link
Lassa fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dag1 dystroglycan 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17287727 NCBI chr 9:108,204,861...108,263,977
Ensembl chr 9:108,204,634...108,263,958
JBrowse link
yellow fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stat2 signal transducer and activator of transcription 2 susceptibility IMP RGD PMID:31043530 RGD:41789622 NCBI chr10:128,270,498...128,292,853
Ensembl chr10:128,270,559...128,292,849
JBrowse link

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  disease 14517
    disease by infectious agent 1899
      viral infectious disease 1588
        RNA Virus Infections 1384
          Viral Hemorrhagic Fevers 30
            Bolivian hemorrhagic fever 0
            Crimean-Congo hemorrhagic fever 0
            Ebola hemorrhagic fever 2
            Hantavirus hemorrhagic fever with renal syndrome + 10
            Kyasanur forest disease + 0
            Lassa fever 1
            Marburg hemorrhagic fever 0
            Omsk hemorrhagic fever 0
            Rift Valley fever 0
            dengue disease + 20
            yellow fever 1
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