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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Chemical and Drug Induced Liver Injury
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Accession:DOID:9007383 term browser browse the term
Definition:A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
Synonyms:exact_synonym: Chemically Induced Liver Toxicity;   Drug Induced Acute Liver Injury;   Drug Induced Liver Disease;   Drug Induced Liver Injury;   Drug-Induced Liver Diseases;   Drug-Induced Liver Injuries;   Toxic Hepatitis;   chemically-induced liver toxicities;   hepatotoxicity;   toxic hepatitides
 narrow_synonym: Drug-induced liver injury due to flucloxacillin
 primary_id: MESH:D056486
 alt_id: RDO:0007742
 xref: EFO:0004228;   EFO:0011052;   NCI:C84427

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Chemical and Drug Induced Liver Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AASS aminoadipate-semialdehyde synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr21:90,891,781...90,959,351
Ensembl chr21:90,892,023...90,959,343 		JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 severity
susceptibility		 ISO DNA:SNP::2677G>T/A(rs2032582)(human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:20623750 PMID:26134275 PMID:27296832 RGD:11041130 RGD:14700895 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 severity ISO DNA:SNP: :rs2287616(human) RGD PMID:27293027 RGD:14402413 NCBI chr10:54,458,283...54,575,943
Ensembl chr10:54,459,377...54,575,059 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:18466103 NCBI chr 5:14,972,589...15,164,594
Ensembl chr 5:14,972,646...15,164,567 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:polymorphism:promoter:-24C>T(human)		 CTD
RGD		 PMID:17241877 PMID:18381794 PMID:18466103 PMID:25196354 RGD:14700812 RGD:14700814 NCBI chr 9:92,826,423...92,902,389
Ensembl chr 9:92,841,818...92,902,265 		JBrowse link
G ABI1 abl interactor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 9:26,377,822...26,495,665
Ensembl chr 9:26,379,516...26,495,676 		JBrowse link
G ACOX3 acyl-CoA oxidase 3, pristanoyl ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr27:44,313,297...44,366,702 JBrowse link
G ACSL1 acyl-CoA synthetase long chain family member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 7:130,712,633...130,783,360
Ensembl chr 7:130,712,308...130,763,756 		JBrowse link
G ACTB actin beta ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver		 CTD
RGD		 PMID:22563491 PMID:25231249 RGD:9587759 NCBI chr28:16,195,676...16,197,161
Ensembl chr12:52,426,752...52,427,879 		JBrowse link
G ACTN4 actinin alpha 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 6:33,290,639...33,373,059
Ensembl chr 6:33,290,622...33,374,693 		JBrowse link
G ACTR3 actin related protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr10:16,296,350...16,369,561
Ensembl chr10:16,297,502...16,369,220 		JBrowse link
G ADA adenosine deaminase ISO protein:increased expression:liver RGD PMID:21161045 RGD:5128859 NCBI chr 2:19,167,209...19,200,233 JBrowse link
G ADAM8 ADAM metallopeptidase domain 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24646716 NCBI chr26:53,114,184...53,129,650
Ensembl chr26:53,114,924...53,126,900 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO CTD Direct Evidence: therapeutic CTD PMID:20709802 NCBI chr15:81,128,427...81,142,779
Ensembl chr15:81,129,795...81,147,391 		JBrowse link
G ADIPOR2 adiponectin receptor 2 severity ISO associated with obesity, LPS;mRNA:decreased expression:liver (rat) RGD PMID:23838384 RGD:8695926 NCBI chr11:1,802,694...1,836,703
Ensembl chr11:1,738,026...1,837,060 		JBrowse link
G ADORA2B adenosine A2b receptor ISO CTD Direct Evidence: therapeutic CTD PMID:35292334 NCBI chr16:15,682,669...15,712,079
Ensembl chr16:15,683,077...15,711,858 		JBrowse link
G AGT angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:29499335 NCBI chr25:67,964,840...67,977,006
Ensembl chr25:67,962,401...67,973,324 		JBrowse link
G AHR aryl hydrocarbon receptor ISO CTD Direct Evidence: marker/mechanism|therapeutic
mRNA:decreased expression:liver (rat)		 CTD
RGD		 PMID:21890736 PMID:28959666 PMID:34848246 RGD:401794432 NCBI chr21:40,778,198...40,826,491
Ensembl chr21:40,778,218...40,826,478 		JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25743375 NCBI chr  X:105,383,408...105,419,146
Ensembl chr  X:105,382,693...105,419,095 		JBrowse link
G AK4 adenylate kinase 4 ISO protein:increased expression:liver (rat) RGD PMID:16538043 RGD:2301096 NCBI chr20:67,840,572...67,924,691 JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:29763686 PMID:32805337 RGD:27226688 NCBI chr20:87,228,348...87,245,511
Ensembl chr20:87,228,189...87,245,466 		JBrowse link
G ALB albumin treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:18779383 PMID:22310181 PMID:27567545 RGD:14694844 NCBI chr 7:21,872,036...21,890,095
Ensembl chr 7:21,876,132...21,891,407 		JBrowse link
G ALDH1L2 aldehyde dehydrogenase 1 family member L2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr11:100,242,649...100,311,164
Ensembl chr11:100,247,262...100,298,621 		JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member severity
susceptibility		 ISO DNA:deletion:exon 3 (mouse)
protein:increased expression:liver		 RGD PMID:21138988 PMID:24492981 PMID:30121625 RGD:14975148 RGD:15036810 RGD:7241599 NCBI chr11:107,019,015...107,060,784
Ensembl chr11:107,019,111...107,060,374 		JBrowse link
G ALDH9A1 aldehyde dehydrogenase 9 family member A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr25:63,184,220...63,223,865 JBrowse link
G ALDOB aldolase, fructose-bisphosphate B ISO CTD Direct Evidence: marker/mechanism CTD PMID:16115720 NCBI chr12:37,993,367...38,021,693
Ensembl chr12:38,007,265...38,021,258 		JBrowse link
G AMBP alpha-1-microglobulin/bikunin precursor ISO CTD Direct Evidence: marker/mechanism CTD PMID:18779383 NCBI chr12:25,508,516...25,526,821
Ensembl chr12:25,508,682...25,527,016 		JBrowse link
G ANXA2 annexin A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr26:23,100,000...23,147,687
Ensembl chr26:23,099,992...23,145,457 		JBrowse link
G ANXA6 annexin A6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr23:53,657,377...53,714,828
Ensembl chr23:53,657,718...53,714,850 		JBrowse link
G APOA1 apolipoprotein A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chr 1:108,201,967...108,203,902
Ensembl chr 1:108,201,439...108,203,609 		JBrowse link
G APOE apolipoprotein E ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chr 6:38,377,154...38,381,219
Ensembl chr 6:38,376,887...38,381,438 		JBrowse link
G APOH apolipoprotein H ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:plasma:		 CTD
RGD		 PMID:16099942 PMID:23288050 RGD:10054107 NCBI chr16:55,209,142...55,231,176 JBrowse link
G ARG1 arginase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22872058 NCBI chr13:41,971,955...41,983,372
Ensembl chr13:41,971,802...41,983,049 		JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator ISO CTD Direct Evidence: marker/mechanism CTD PMID:20935161
G ATG5 autophagy related 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22491424 NCBI chr13:67,482,538...67,619,201
Ensembl chr13:67,482,595...67,617,902 		JBrowse link
G ATOH8 atonal bHLH transcription factor 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr14:21,368,197...21,402,650 JBrowse link
G ATP6V1D ATPase H+ transporting V1 subunit D ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr24:44,578,057...44,598,918
Ensembl chr24:44,578,807...44,598,394 		JBrowse link
G BAD BCL2 associated agonist of cell death treatment ISO RGD PMID:25447754 RGD:10053709 NCBI chr 1:9,949,717...9,964,433
Ensembl chr 1:9,949,762...9,964,432 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:17906064 NCBI chr 6:42,186,028...42,193,105 JBrowse link
G BDH1 3-hydroxybutyrate dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr15:89,678,844...89,741,848
Ensembl chr15:89,707,046...89,742,434 		JBrowse link
G BDKRB2 bradykinin receptor B2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30685357 NCBI chr24:74,084,907...74,125,604
Ensembl chr24:74,118,210...74,122,909 		JBrowse link
G BLVRB biliverdin reductase B ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 6:34,902,632...34,925,105
Ensembl chr 6:34,902,598...34,925,100 		JBrowse link
G BMAL1 basic helix-loop-helix ARNT like 1 ISO CTD Direct Evidence: therapeutic CTD PMID:36602574 NCBI chr 1:51,430,670...51,540,344
Ensembl chr 1:51,431,180...51,462,674 		JBrowse link
G BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr25:9,489,479...9,518,936
Ensembl chr25:9,490,763...9,519,721 		JBrowse link
G BRD4 bromodomain containing 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 6:13,836,332...13,883,459
Ensembl chr 6:13,836,324...13,873,877 		JBrowse link
G BTD biotinidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15469856 NCBI chr15:60,433,035...60,470,600
Ensembl chr15:60,459,913...60,470,615 		JBrowse link
G C3 complement C3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chr 6:6,250,422...6,289,264 JBrowse link
G CA3 carbonic anhydrase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 PMID:25231249 NCBI chr 8:80,805,296...80,816,127
Ensembl chr 8:80,805,134...80,816,190 		JBrowse link
G CABP1 calcium binding protein 1 ISO protein:increased expression:liver RGD PMID:21138988 RGD:7241599 NCBI chr11:115,934,747...116,021,645 JBrowse link
G CADPS2 calcium dependent secretion activator 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chr21:91,117,749...91,669,284 JBrowse link
G CANX calnexin ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr23:81,422,701...81,454,683
Ensembl chr23:81,422,693...81,482,332 		JBrowse link
G CAP1 cyclase associated actin cytoskeleton regulatory protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr20:92,833,112...92,865,258
Ensembl chr20:92,829,735...92,864,697 		JBrowse link
G CASP8 caspase 8 treatment ISO RGD PMID:25447754 RGD:10053709 NCBI chr10:86,888,654...86,944,159
Ensembl chr10:86,916,527...86,943,829 		JBrowse link
G CAST calpastatin ISO RGD PMID:16871587 RGD:5683869 NCBI chr 4:90,496,867...90,607,019
Ensembl chr 4:90,497,754...90,605,481 		JBrowse link
G CAT catalase ISO protein:decreased expression:liver
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:20623750 PMID:21138988 PMID:25231249 RGD:7241599 NCBI chr 1:30,792,533...30,828,920
Ensembl chr 1:30,792,399...30,829,592 		JBrowse link
G CCDC80 coiled-coil domain containing 80 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513
G CCL2 C-C motif chemokine ligand 2 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:20623750 PMID:21813474 PMID:30663942 RGD:14995458 RGD:14995466 NCBI chr16:27,763,354...27,765,437
Ensembl chr16:27,763,555...27,765,416 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 NCBI chr22:7,795,192...7,801,242
Ensembl chr22:7,798,646...7,799,728 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 susceptibility ISO acetaminophen RGD PMID:24770590 RGD:14401733 NCBI chr22:7,803,794...7,818,112 JBrowse link
G CCT3 chaperonin containing TCP1 subunit 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr20:7,518,729...7,545,296
Ensembl chr20:7,518,846...7,545,677 		JBrowse link
G CCT5 chaperonin containing TCP1 subunit 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 4:9,787,093...9,802,892
Ensembl chr 4:9,787,101...9,805,852 		JBrowse link
G CDC25B cell division cycle 25B ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 2:34,482,709...34,493,737
Ensembl chr 2:34,483,771...34,494,071 		JBrowse link
G CDS1 CDP-diacylglycerol synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 7:32,947,644...33,014,807
Ensembl chr 7:32,948,053...33,014,944 		JBrowse link
G CELA1 chymotrypsin like elastase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr11:47,526,354...47,545,390
Ensembl chr11:47,526,365...47,544,726 		JBrowse link
G CFAP20 cilia and flagella associated protein 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 5:44,047,860...44,063,605
Ensembl chr 5:44,047,464...44,063,738 		JBrowse link
G CFH complement factor H ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr25:32,557,697...32,744,763 JBrowse link
G CHRM3 cholinergic receptor muscarinic 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20197374 NCBI chr25:76,772,212...77,009,433
Ensembl chr25:77,001,477...77,003,249 		JBrowse link
G CKB creatine kinase B ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr24:81,462,164...81,463,873 JBrowse link
G CLU clusterin ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 NCBI chr 8:25,704,441...25,721,789
Ensembl chr 8:25,703,257...25,721,789 		JBrowse link
G COL14A1 collagen type XIV alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 8:114,701,662...114,946,216
Ensembl chr 8:114,701,664...114,887,483 		JBrowse link
G COL3A1 collagen type III alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:16679477 NCBI chr10:74,455,133...74,493,392 JBrowse link
G COMT catechol-O-methyltransferase ISO protein:decreased expression:liver RGD PMID:21138988 RGD:7241599 NCBI chr19:5,775,829...5,803,260
Ensembl chr19:5,773,225...5,785,422 		JBrowse link
G COQ9 coenzyme Q9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 5:43,378,467...43,393,037
Ensembl chr 5:43,378,539...43,392,384 		JBrowse link
G CPB2 carboxypeptidase B2 ISO mRNA,protein:increased expression,increased activity:liver,plasma RGD PMID:19386599 RGD:7243112 NCBI chr 3:24,108,854...24,161,669
Ensembl chr 3:24,109,416...24,161,408 		JBrowse link
G CPS1 carbamoyl-phosphate synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr10:96,267,890...96,392,393
Ensembl chr10:96,267,889...96,392,206 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A ISO mRNA:decreased expression:liver (rat) RGD PMID:28959666 RGD:401794432 NCBI chr 1:5,704,275...5,784,077
Ensembl chr 1:5,730,853...5,784,337 		JBrowse link
G CRP C-reactive protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr20:4,232,262...4,235,826
Ensembl chr20:4,232,913...4,235,377 		JBrowse link
G CSF3 colony stimulating factor 3 ISO CTD Direct Evidence: therapeutic CTD PMID:20005281 NCBI chr16:66,162,814...66,166,192
Ensembl chr16:66,163,681...66,165,172 		JBrowse link
G CTNNB1 catenin beta 1 ISO CTD Direct Evidence: therapeutic CTD PMID:19679878 NCBI chr22:2,679,488...2,725,034
Ensembl chr22:2,684,022...2,723,949 		JBrowse link
G CTSE cathepsin E ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr25:23,318,421...23,333,885
Ensembl chr25:23,319,248...23,332,980 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16118408 NCBI chr 7:22,327,041...22,329,405
Ensembl chr 7:22,569,355...22,569,900
Ensembl chr 7:22,569,355...22,569,900 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO CTD Direct Evidence: therapeutic CTD PMID:11739529 NCBI chr 7:24,526,657...24,529,193
Ensembl chr 7:24,526,680...24,529,130 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33814510 NCBI chr26:8,753,236...8,759,378
Ensembl chr26:8,753,327...8,759,384 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28762043 NCBI chr26:8,727,996...8,733,254 JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33814510 NCBI chr14:69,318,713...69,327,277
Ensembl chr14:69,319,495...69,324,157 		JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 ISO mRNA, protein:decreased expression:kidney (mouse) RGD PMID:26476181 RGD:25671412 NCBI chr11:53,675,704...53,681,372
Ensembl chr11:53,675,226...53,680,443 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28762043 PMID:33814510 NCBI chr 6:35,392,699...35,418,171
Ensembl chr 6:35,393,342...35,418,106 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12963435 PMID:28762043 NCBI chr 9:87,981,300...88,025,007 JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14971821 PMID:21741958 PMID:25226513 PMID:28762043 PMID:33814510 NCBI chr 9:88,082,124...88,125,390 JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 ISO DNA:hypermethylation:promoter RGD PMID:27490558 RGD:14700879 NCBI chr19:24,667,207...24,672,580
Ensembl chr19:24,667,282...24,671,513 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 treatment ISO associated with Endotoxemia
DNA:hypermethylation:promoter
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:12668988 PMID:16770646 PMID:21741958 PMID:25681370 PMID:27324775 More... RGD:14700872 RGD:14700873 RGD:14700878 RGD:14700879 RGD:14700901 NCBI chr26:53,390,054...53,403,309
Ensembl chr26:53,390,089...53,404,211 		JBrowse link
G CYP8B1 cytochrome P450 family 8 subfamily B member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25448281 NCBI chr22:4,323,840...4,326,459
Ensembl chr22:4,324,396...4,325,901 		JBrowse link
G DBT dihydrolipoamide branched chain transacylase E2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr20:33,088,452...33,157,693
Ensembl chr20:33,088,496...33,140,403 		JBrowse link
G DDB1 damage specific DNA binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 1:12,508,712...12,543,127
Ensembl chr 1:12,508,443...12,544,913 		JBrowse link
G DGAT2 diacylglycerol O-acyltransferase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17984051 NCBI chr 1:66,985,413...67,018,058
Ensembl chr 1:66,985,466...67,021,182 		JBrowse link
G DHFR dihydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19648163 NCBI chr 4:74,787,292...74,811,196
Ensembl chr 4:74,787,629...74,810,960 		JBrowse link
G DHRS7 dehydrogenase/reductase 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr24:37,368,792...37,389,433
Ensembl chr24:37,368,982...37,389,403 		JBrowse link
G DLAT dihydrolipoamide S-acetyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 1:103,379,165...103,419,585
Ensembl chr 1:103,380,426...103,420,386 		JBrowse link
G DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chr21:77,477,177...77,482,190
Ensembl chr21:77,479,112...77,482,571 		JBrowse link
G DNAJC12 DnaJ heat shock protein family (Hsp40) member C12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chr 9:63,545,032...63,588,391
Ensembl chr 9:63,545,045...63,588,401 		JBrowse link
G DSC2 desmocollin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr18:49,596,870...49,637,587
Ensembl chr18:49,599,940...49,639,526 		JBrowse link
G E2F1 E2F transcription factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30515189 NCBI chr 2:37,968,541...37,980,461
Ensembl chr 2:37,968,556...37,980,326 		JBrowse link
G ECHDC1 ethylmalonyl-CoA decarboxylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr13:46,386,543...46,440,730
Ensembl chr13:46,398,058...46,439,533 		JBrowse link
G ECHS1 enoyl-CoA hydratase, short chain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr26:53,212,299...53,222,805 JBrowse link
G EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr22:41,253,861...41,286,185
Ensembl chr22:41,253,989...41,282,140 		JBrowse link
G EIF2AK1 eukaryotic translation initiation factor 2 alpha kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25411909 NCBI chr28:15,225,768...15,269,692
Ensembl chr28:15,233,909...15,269,594 		JBrowse link
G EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 9:60,867,810...60,894,899
Ensembl chr 9:60,874,602...60,894,919 		JBrowse link
G ENDOG endonuclease G ISO protein:decreased expression:mitochondrion: RGD PMID:22509279 RGD:9685364 NCBI chr12:9,322,828...9,326,833
Ensembl chr12:9,322,892...9,326,549 		JBrowse link
G ENG endoglin ISO protein:increased expression:liver (rat) RGD PMID:21146604 RGD:7257529 NCBI chr12:10,274,705...10,315,715
Ensembl chr12:10,275,064...10,315,040 		JBrowse link
G ENO1 enolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 PMID:25231249 NCBI chr20:122,884,846...122,902,669
Ensembl chr20:122,884,727...122,903,372 		JBrowse link
G ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 ISO protein:increased activity:serum: RGD PMID:17850827 RGD:9685426 NCBI chr 8:114,113,780...114,232,656
Ensembl chr 8:114,113,778...114,195,956 		JBrowse link
G EPHX1 epoxide hydrolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr25:3,924,396...3,960,264
Ensembl chr25:3,924,606...3,945,535 		JBrowse link
G ERLEC1 endoplasmic reticulum lectin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chr14:53,150,627...53,188,821
Ensembl chr14:53,154,556...53,188,538 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30538632 NCBI chr16:57,145,080...57,233,757
Ensembl chr16:57,145,191...57,236,230 		JBrowse link
G F13A1 coagulation factor XIII A chain ISO RGD PMID:22019897 RGD:11041813 NCBI chr17:65,885,498...66,040,026
Ensembl chr17:65,885,658...66,040,040 		JBrowse link
G F2RL3 F2R like thrombin or trypsin receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20974703 NCBI chr 6:15,397,552...15,400,708 JBrowse link
G F3 coagulation factor III, tissue factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:22407844 NCBI chr20:38,726,690...38,738,457
Ensembl chr20:38,726,798...38,739,408 		JBrowse link
G FADD Fas associated via death domain treatment ISO RGD PMID:25447754 PMID:26062544 RGD:10053709 RGD:11341803 NCBI chr 1:4,358,314...4,361,863 JBrowse link
G FADS1 fatty acid desaturase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 1:12,037,173...12,051,907
Ensembl chr 1:12,037,513...12,055,159 		JBrowse link
G FADS2 fatty acid desaturase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 1:11,934,352...11,978,355
Ensembl chr 1:11,934,270...11,974,030 		JBrowse link
G FASN fatty acid synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr16:73,988,410...74,008,374
Ensembl chr16:73,982,899...74,006,551 		JBrowse link
G FCMR Fc mu receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr25:22,435,252...22,453,582
Ensembl chr25:22,435,339...22,447,732 		JBrowse link
G FGA fibrinogen alpha chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:20974703 NCBI chr 7:101,127,554...101,134,881
Ensembl chr 7:101,125,791...101,134,405 		JBrowse link
G FGF21 fibroblast growth factor 21 severity ISO mRNA:increased expression:liver (rat) RGD PMID:29883717 RGD:15045603 NCBI chr 6:42,006,125...42,008,749
Ensembl chr 6:42,006,064...42,008,736 		JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:21135413 NCBI chr 3:7,412,506...7,608,122
Ensembl chr 3:7,412,172...7,607,967 		JBrowse link
G FMO3 flavin containing dimethylaniline monoxygenase 3 ISO CTD Direct Evidence: therapeutic CTD PMID:24973094 NCBI chr25:57,971,737...57,995,850
Ensembl chr25:57,969,234...57,995,613 		JBrowse link
G FTL ferritin light chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 6:42,196,682...42,198,575
Ensembl chr 6:42,196,538...42,199,614 		JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 ISO mRNA:decreased expression:liver (mouse) RGD PMID:28189721 RGD:14695531 NCBI chr16:63,380,921...63,392,122
Ensembl chr16:63,381,382...63,391,540 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase treatment ISO RGD PMID:21864513 RGD:10449168 NCBI chr  X:128,768,028...128,788,366
Ensembl chr  X:128,770,268...128,786,961 		JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 NCBI chr20:65,422,668...65,425,845
Ensembl chr20:65,422,451...65,425,840 		JBrowse link
G GANAB glucosidase II alpha subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 1:11,257,867...11,279,534
Ensembl chr 1:11,257,935...11,281,111 		JBrowse link
G GC GC vitamin D binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chr 7:20,254,604...20,298,384
Ensembl chr 7:20,253,879...20,298,265 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:17573345 PMID:19481141 RGD:10402383 NCBI chr17:19,012,994...19,060,617
Ensembl chr17:19,013,026...19,060,659 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr20:39,339,948...39,359,980
Ensembl chr20:39,339,908...39,359,430 		JBrowse link
G GDA guanine deaminase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr12:83,195,746...83,305,181
Ensembl chr12:83,195,994...83,306,792 		JBrowse link
G GDI1 GDP dissociation inhibitor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249
G GFER growth factor, augmenter of liver regeneration treatment ISO RGD PMID:15968720 PMID:22033404 RGD:9685722 RGD:9685727 NCBI chr 5:1,880,025...1,886,829
Ensembl chr 5:1,879,968...1,883,696 		JBrowse link
G GGH gamma-glutamyl hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21219404 NCBI chr 8:58,908,524...58,932,885
Ensembl chr 8:58,908,417...58,932,685 		JBrowse link
G GLUD1 glutamate dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33483742 NCBI chr 9:44,653,044...44,690,142
Ensembl chr 9:44,653,289...44,688,954 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 9:92,463,017...92,489,227
Ensembl chr 9:92,462,782...92,488,310 		JBrowse link
G GPD1 glycerol-3-phosphate dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr11:46,329,479...46,339,227
Ensembl chr11:46,331,569...46,337,439 		JBrowse link
G GPT glutamic--pyruvic transaminase treatment ISO CTD Direct Evidence: marker/mechanism
protein:increased expression, activity:serum:		 RGD
CTD		 PMID:145039 PMID:19085960 PMID:19481104 PMID:21772750 PMID:27293452 More... RGD:14975162 RGD:14975166 RGD:14975168 RGD:14975249 NCBI chr 8:138,716,802...138,721,421
Ensembl chr 8:138,718,767...138,721,251 		JBrowse link
G GPT2 glutamic--pyruvic transaminase 2 ISO protein:increased expression, activity:serum: RGD PMID:19085960 RGD:14975249 NCBI chr 5:32,743,850...32,791,299
Ensembl chr 5:32,744,065...32,791,479 		JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr27:45,691,936...45,765,334 JBrowse link
G GSN gelsolin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chr12:18,253,079...18,317,285
Ensembl chr12:18,253,324...18,285,938 		JBrowse link
G GSR glutathione-disulfide reductase treatment ISO mRNA, protein:increased expression:liver
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:23554813 PMID:24154663 PMID:25226513 PMID:28069987 RGD:10401878 RGD:7257532 NCBI chr 8:28,778,713...28,851,907 JBrowse link
G GSTA4 glutathione S-transferase alpha 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr17:19,575,835...19,591,713
Ensembl chr17:19,575,876...19,591,919 		JBrowse link
G GSTM3 glutathione S-transferase mu 3 ISO CTD Direct Evidence: therapeutic CTD PMID:25743375 NCBI chr20:23,797,794...23,802,910
Ensembl chr20:23,799,177...23,802,921 		JBrowse link
G GSTO1 glutathione S-transferase omega 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 9:97,305,094...97,317,892 JBrowse link
G GSTP1 glutathione S-transferase pi 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 PMID:25226513 NCBI chr 1:6,676,897...6,679,936 JBrowse link
G H2AFX histone H2AX treatment ISO RGD PMID:23265463 RGD:8693741 NCBI chr 1:110,466,692...110,468,776
Ensembl chr 1:110,467,775...110,468,206 		JBrowse link
G HACL1 2-hydroxyacyl-CoA lyase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chr15:60,360,380...60,433,528
Ensembl chr15:60,322,722...60,433,647 		JBrowse link
G HADHA hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr14:81,411,620...81,468,415
Ensembl chr14:81,411,648...81,472,257 		JBrowse link
G HAMP hepcidin antimicrobial peptide ISO mRNA:increased expression:hepatocyte RGD PMID:24373749 RGD:11041724 NCBI chr 6:30,214,820...30,218,100
Ensembl chr 6:30,215,563...30,217,996 		JBrowse link
G HAO2 hydroxyacid oxidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr20:14,376,096...14,408,753
Ensembl chr20:14,374,543...14,407,992 		JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 NCBI chr23:59,422,769...59,454,183
Ensembl chr23:59,423,334...59,453,531 		JBrowse link
G HMGB1 high mobility group box 1 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:19783637 PMID:29091898 RGD:15090820 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO CTD Direct Evidence: marker/mechanism|therapeutic RGD
CTD		 PMID:18227147 PMID:22688006 PMID:22886620 PMID:29091898 RGD:10762620 RGD:15090820 NCBI chr19:18,144,466...18,157,944
Ensembl chr19:18,144,545...18,157,971 		JBrowse link
G HPD 4-hydroxyphenylpyruvate dioxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 PMID:22872058 NCBI chr11:117,203,844...117,246,249
Ensembl chr11:117,203,307...117,224,038 		JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr  X:109,629,674...109,671,409 JBrowse link
G HPX hemopexin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chr 1:58,385,860...58,396,269
Ensembl chr 1:58,386,190...58,396,298 		JBrowse link
G HRH2 histamine receptor H2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22926047 NCBI chr23:77,808,108...77,858,936
Ensembl chr23:77,807,998...77,841,467 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr12:12,920,705...12,925,888
Ensembl chr12:12,920,710...12,927,431 		JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 ISO protein:altered localization:liver (rat) RGD PMID:12376827 RGD:10059389 NCBI chr 1:114,447,348...114,452,693
Ensembl chr 1:114,446,544...114,451,562 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 treatment ISO RGD PMID:29091898 RGD:15090820 NCBI chr 6:9,320,991...9,338,125
Ensembl chr 6:9,322,550...9,338,263 		JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32289347 NCBI chr 8:37,951,810...38,027,689
Ensembl chr 8:37,959,078...38,027,632 		JBrowse link
G IFNA2 interferon alpha 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:1670585 NCBI chr12:58,468,018...58,469,825 JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:12153990 PMID:21245496 PMID:30013034 RGD:14975100 NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473 		JBrowse link
G IGF1 insulin like growth factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23639586 PMID:25226513 NCBI chr11:97,624,498...97,708,730
Ensembl chr11:97,631,189...97,707,308 		JBrowse link
G IL11 interleukin 11 ISO CTD Direct Evidence: therapeutic CTD PMID:11421492 NCBI chr 6:47,967,245...47,972,557
Ensembl chr 6:47,967,680...47,971,316 		JBrowse link
G IL12B interleukin 12B ISO CTD Direct Evidence: therapeutic CTD PMID:36520315 NCBI chr23:61,714,293...61,731,835 JBrowse link
G IL17A interleukin 17A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19633216 PMID:24949944 NCBI chr17:20,314,082...20,319,917
Ensembl chr17:20,315,773...20,318,785 		JBrowse link
G IL18 interleukin 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19164858 NCBI chr 1:103,485,868...103,511,632
Ensembl chr 1:103,482,083...103,510,150 		JBrowse link
G IL1A interleukin 1 alpha ISO CTD Direct Evidence: therapeutic CTD PMID:8218930 NCBI chr14:15,789,710...15,801,938
Ensembl chr14:15,789,013...15,796,611 		JBrowse link
G IL1B interleukin 1 beta treatment ISO CTD Direct Evidence: marker/mechanism|therapeutic RGD
CTD		 PMID:19164858 PMID:23102243 PMID:28138970 PMID:29091898 PMID:29278859 More... RGD:13793380 RGD:14975281 RGD:15036799 RGD:15090820 RGD:7204421 NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729 		JBrowse link
G IL1R2 interleukin 1 receptor type 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17984051 NCBI chr14:5,672,434...5,708,270
Ensembl chr14:5,673,163...5,708,372 		JBrowse link
G IL22 interleukin 22 ISO CTD Direct Evidence: therapeutic CTD PMID:15122762 PMID:16212920 PMID:23375450 NCBI chr11:63,881,743...63,887,695
Ensembl chr11:63,882,093...63,886,761 		JBrowse link
G IL4 interleukin 4 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:21094227 PMID:21735453 PMID:22107450 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258 		JBrowse link
G IL6 interleukin 6 treatment ISO CTD Direct Evidence: therapeutic RGD
CTD		 PMID:7532385 PMID:15763341 PMID:29091898 RGD:15090820 NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237 		JBrowse link
G IMMT inner membrane mitochondrial protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr14:20,949,586...21,013,535
Ensembl chr14:20,971,622...21,013,197 		JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr  X:128,433,462...128,443,126
Ensembl chr  X:128,433,465...128,443,043 		JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr22:40,574,569...40,925,857
Ensembl chr22:40,574,374...40,926,842 		JBrowse link
G JUND JunD proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:30515189 NCBI chr 6:16,754,553...16,756,458
Ensembl chr 6:16,755,247...16,756,290 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 ISO RGD PMID:18417483 RGD:6893370 NCBI chr 6:9,515,789...9,526,699
Ensembl chr 6:9,515,416...9,522,797 		JBrowse link
G KITLG KIT ligand ISO CTD Direct Evidence: therapeutic CTD PMID:12594235 NCBI chr11:83,856,149...83,943,095
Ensembl chr11:83,856,157...83,943,083 		JBrowse link
G KNG1 kininogen 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20362651 PMID:30685357 NCBI chr15:81,002,287...81,027,893 JBrowse link
G KRT18 keratin 18 ISO mRNA, protein:increased expression:liver (mouse)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:17340120 PMID:19783637 PMID:33483742 RGD:18337498 NCBI chr11:49,073,733...49,081,706 JBrowse link
G KRT8 keratin 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr11:49,027,879...49,051,753 JBrowse link
G LAP3 leucine aminopeptidase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr27:32,616,277...32,647,839
Ensembl chr27:32,616,273...32,647,706 		JBrowse link
G LBP lipopolysaccharide binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 2:25,375,364...25,407,181
Ensembl chr 2:25,374,755...25,406,839 		JBrowse link
G LCAT lecithin-cholesterol acyltransferase ISO mRNA:decreased expression:liver (rat) RGD PMID:28959666 RGD:401794432 NCBI chr 5:59,495,936...59,500,530
Ensembl chr 5:59,497,115...59,500,448 		JBrowse link
G LCN2 lipocalin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20362651 PMID:20623750 NCBI chr12:9,976,278...9,981,087
Ensembl chr12:9,976,614...9,980,870 		JBrowse link
G LDLR low density lipoprotein receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:36108984 NCBI chr 6:10,062,204...10,091,780
Ensembl chr 6:10,062,790...10,091,377 		JBrowse link
G LGALS3 galectin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22461450 NCBI chr24:32,311,343...32,328,335
Ensembl chr24:32,311,271...32,328,339 		JBrowse link
G LIPC lipase C, hepatic type ISO mRNA:decreased expression:liver (rat) RGD PMID:28959666 RGD:401794432 NCBI chr26:24,946,843...25,109,338
Ensembl chr26:24,946,673...25,087,921 		JBrowse link
G LOC103223058 glutathione hydrolase light chain 2 ISO RGD PMID:10934156 RGD:14701049 NCBI chr19:7,353,922...7,406,392 JBrowse link
G LOC103223491 peroxisome proliferator-activated receptor alpha ISO LPS-induced acute liver damage RGD PMID:21262334 RGD:5509941 NCBI chr19:28,614,892...28,709,272
Ensembl chr19:28,615,413...28,708,763 		JBrowse link
G LOC103224275 glutathione S-transferase Mu 1 no_association ISO protein:increased expression:liver
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:17465707 PMID:18666253 PMID:21138988 PMID:24465778 PMID:24903797 More... RGD:14700937 RGD:14700941 RGD:14700959 RGD:14700970 RGD:7241599 NCBI chr20:23,854,969...23,861,634 JBrowse link
G LOC103230356 uncharacterized LOC103230356 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29515023 NCBI chr25:29,230,358...29,380,617
Ensembl chr25:29,233,558...29,379,922 		JBrowse link
G LOC103231165 isocitrate dehydrogenase (NADP(+)) 2 severity ISO RGD PMID:31121248 RGD:14985250 NCBI chr29:8,633,429...8,650,744
Ensembl chr29:8,633,715...8,650,657 		JBrowse link
G LOC103233689 thromboxane A2 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:22206755 NCBI chr 6:3,354,358...3,365,779
Ensembl chr 6:3,355,314...3,359,761 		JBrowse link
G LOC103238261 tubulin alpha-1A chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr11:45,419,046...45,423,574
Ensembl chr11:45,418,748...45,423,685 		JBrowse link
G LOC103242911 nucleoside diphosphate kinase B ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr16:42,176,690...42,182,041
Ensembl chr16:42,176,524...42,182,019 		JBrowse link
G LOC103246766 cytochrome P450 3A8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28762043 NCBI chr28:13,297,566...13,330,023 JBrowse link
G LOC103247947 olfactory receptor 51E2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 1:62,172,573...62,180,085
Ensembl chr 1:62,177,553...62,178,515 		JBrowse link
G LPL lipoprotein lipase treatment ISO RGD PMID:27071702 RGD:13794380 NCBI chr 8:18,009,049...18,038,315
Ensembl chr 8:18,009,093...18,038,598 		JBrowse link
G LRAT lecithin retinol acyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 7:101,297,114...101,304,675
Ensembl chr 7:101,297,691...101,302,520 		JBrowse link
G LTB4R leukotriene B4 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:28487374 NCBI chr24:1,294,453...1,301,113
Ensembl chr24:1,298,729...1,299,790 		JBrowse link
G LTF lactotransferrin ISO CTD Direct Evidence: therapeutic CTD PMID:16141546 NCBI chr22:7,867,332...7,896,403
Ensembl chr22:7,867,286...7,894,521 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 5:72,762,428...72,774,204
Ensembl chr 5:72,763,050...72,772,770 		JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18700144 NCBI chr13:36,614,489...36,858,524
Ensembl chr13:36,615,633...36,858,601 		JBrowse link
G MAT1A methionine adenosyltransferase 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 9:51,540,162...51,558,076
Ensembl chr 9:51,540,162...51,558,576 		JBrowse link
G MCCC1 methylcrotonyl-CoA carboxylase subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr15:6,318,788...6,400,539
Ensembl chr15:6,318,791...6,401,849 		JBrowse link
G MDH1 malate dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chr14:43,406,502...43,425,525
Ensembl chr14:43,406,499...43,425,095 		JBrowse link
G ME1 malic enzyme 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr13:7,889,211...8,112,793
Ensembl chr13:7,887,984...8,112,533 		JBrowse link
G MED1 mediator complex subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16109766 NCBI chr16:66,719,393...66,764,902
Ensembl chr16:66,719,423...66,762,896 		JBrowse link
G MHC-DQA1 major histocompatibility complex, class II, DQ alpha 1 susceptibility ISO associated with tuberculosis;DNA:polymorphism: :HLA-DQA1*0102(human) RGD PMID:12359646 PMID:20639878 RGD:14398844 RGD:14401573 NCBI chr17:39,422,445...39,428,777
Ensembl chr17:39,420,134...39,428,871 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15763341 NCBI chr 5:41,264,382...41,291,657
Ensembl chr 5:41,264,354...41,291,004 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22507835 NCBI chr 2:17,867,267...17,874,757
Ensembl chr 2:17,867,177...17,874,712 		JBrowse link
G MST1 macrophage stimulating 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr22:11,078,662...11,083,885
Ensembl chr22:11,074,114...11,083,368 		JBrowse link
G MST1R macrophage stimulating 1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:22575169 NCBI chr22:11,293,637...11,310,239
Ensembl chr22:11,293,263...11,309,980 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase treatment ISO associated with precursor lymphoblastic lymphoma/leukemia; DNA:SNP: :677C>T(human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:18551038 PMID:19648163 PMID:30545275 RGD:14696733 NCBI chr20:119,987,667...120,003,611
Ensembl chr20:119,990,133...120,002,950 		JBrowse link
G MTPN myotrophin ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr21:104,605,924...104,657,664
Ensembl chr21:104,605,592...104,657,866 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor ameliorates ISO RGD PMID:17615358 RGD:150521532 NCBI chr15:1,276,804...1,281,811
Ensembl chr15:1,276,798...1,281,166 		JBrowse link
G NAT2 N-acetyltransferase 2 treatment ISO CTD Direct Evidence: marker/mechanism
associated with Tuberculosis;DNA:haplotype: :		 CTD
RGD		 PMID:11915035 PMID:16799928 PMID:17950035 PMID:18023090 PMID:25693865 RGD:8552665 NCBI chr 8:16,451,144...16,494,961
Ensembl chr 8:16,493,749...16,494,621 		JBrowse link
G NDUFS3 NADH:ubiquinone oxidoreductase core subunit S3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 1:17,735,040...17,740,508
Ensembl chr 1:17,733,645...17,745,677 		JBrowse link
G NFATC4 nuclear factor of activated T cells 4 ISO CTD Direct Evidence: therapeutic CTD PMID:34192554 NCBI chr24:1,352,173...1,362,150
Ensembl chr24:1,352,291...1,362,680 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 treatment ISO CTD Direct Evidence: therapeutic
induced by methotrexate (CHEBI:44185), treated by ferulic acid (CHEBI:17620)		 CTD
RGD		 PMID:18417483 PMID:22491424 PMID:22627062 PMID:24813929 PMID:26958860 More... RGD:15090820 RGD:21201280 RGD:21201283 RGD:21201305 RGD:21201308 RGD:6893370 NCBI chr10:62,789,647...62,825,651
Ensembl chr10:62,790,124...62,825,339 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 susceptibility
treatment		 ISO associated with tuberculosis ;DNA:SNPs,haplotypes: 3'utr,5'utr: (rs78872571,rs4647992) (human) RGD PMID:29091898 PMID:31490979 RGD:15090820 RGD:40902984 NCBI chr 7:50,589,494...50,711,472
Ensembl chr 7:50,589,856...50,711,498 		JBrowse link
G NFXL1 nuclear transcription factor, X-box binding like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chr27:2,333,158...2,401,008
Ensembl chr27:2,333,809...2,400,084 		JBrowse link
G NOTCH1 notch receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:30394310 NCBI chr12:1,656,815...1,707,566
Ensembl chr12:1,656,918...1,709,585 		JBrowse link
G NOX4 NADPH oxidase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 1:80,470,418...80,642,513
Ensembl chr 1:80,470,826...80,642,722 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 treatment ISO RGD PMID:28472605 PMID:28522909 PMID:29091898 RGD:13439737 RGD:13439739 RGD:15090820 NCBI chr 5:57,676,547...57,695,434
Ensembl chr 5:57,675,981...57,716,599 		JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 ISO CTD Direct Evidence: therapeutic CTD PMID:29943110 NCBI chr20:105,850,328...105,853,076
Ensembl chr20:105,850,598...105,853,060 		JBrowse link
G NR1D1 nuclear receptor subfamily 1 group D member 1 treatment ISO RGD PMID:24497272 RGD:10448995 NCBI chr16:66,078,990...66,086,927
Ensembl chr16:66,079,089...66,090,685 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 ISO CTD Direct Evidence: therapeutic CTD PMID:17256725 NCBI chr 1:18,041,495...18,061,196
Ensembl chr 1:18,041,830...18,051,501 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 severity
treatment		 ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:liver (rat)
mRNA:decreased expression:liver (rat)		 CTD
RGD		 PMID:12875239 PMID:20573685 PMID:22711662 PMID:28827769 PMID:29091898 More... RGD:14701035 RGD:14701036 RGD:15042870 RGD:15045609 RGD:15090820 NCBI chr11:95,792,428...95,877,989
Ensembl chr11:95,792,996...95,878,293 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 susceptibility ISO associated with tuberculosis ;DNA:SNP,haplotypes:promoter: (rs3814055) (human)
CTD Direct Evidence: marker/mechanism|therapeutic		 RGD
CTD		 PMID:19797606 PMID:28058446 PMID:31490979 RGD:40902984 NCBI chr22:61,005,404...61,043,016
Ensembl chr22:61,006,667...61,040,832 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:14742670 PMID:25656644 PMID:28058446 NCBI chr20:2,724,843...2,752,999
Ensembl chr20:2,744,908...2,756,658 		JBrowse link
G NR2F2 nuclear receptor subfamily 2 group F member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr29:14,889,526...14,901,848
Ensembl chr29:14,891,737...14,903,813 		JBrowse link
G NREP neuronal regeneration related protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr23:15,065,565...15,314,999
Ensembl chr23:15,064,445...15,093,992 		JBrowse link
G NTN1 netrin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:35292334 NCBI chr16:8,359,682...8,603,231
Ensembl chr16:8,379,129...8,603,223 		JBrowse link
G NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit ISO CTD Direct Evidence: therapeutic CTD PMID:33812996 NCBI chr13:56,115,581...56,147,918
Ensembl chr13:56,113,428...56,147,982 		JBrowse link
G OCIAD1 OCIA domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr27:1,394,512...1,424,286
Ensembl chr27:1,391,852...1,424,270 		JBrowse link
G OGDH oxoglutarate dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr21:13,975,825...14,070,216
Ensembl chr21:13,973,845...14,070,731 		JBrowse link
G P4HB prolyl 4-hydroxylase subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr16:73,718,743...73,733,488
Ensembl chr16:73,718,656...73,733,892 		JBrowse link
G PAH phenylalanine hydroxylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr11:98,065,869...98,140,011
Ensembl chr11:98,063,199...98,139,285 		JBrowse link
G PAN2 poly(A) specific ribonuclease subunit PAN2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chr11:52,273,867...52,290,514
Ensembl chr11:52,274,540...52,289,410 		JBrowse link
G PANX1 pannexin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29246445 NCBI chr 1:85,356,507...85,413,146
Ensembl chr 1:85,356,610...85,409,275 		JBrowse link
G PARK7 Parkinsonism associated deglycase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr20:123,776,084...123,808,031
Ensembl chr20:123,776,297...123,798,434 		JBrowse link
G PC pyruvate carboxylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 1:7,310,738...7,418,357
Ensembl chr 1:7,357,246...7,417,998 		JBrowse link
G PCOLCE procollagen C-endopeptidase enhancer ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr28:12,604,552...12,610,814
Ensembl chr28:12,604,526...12,610,814 		JBrowse link
G PCYT1A phosphate cytidylyltransferase 1A, choline ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr15:90,905,691...90,944,485 JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:21182459 PMID:31809757 NCBI chr21:53,445,607...53,458,729
Ensembl chr21:53,445,457...53,460,776 		JBrowse link
G PDLIM5 PDZ and LIM domain 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 7:42,702,175...42,912,859
Ensembl chr 7:42,819,454...42,908,137 		JBrowse link
G PEX11A peroxisomal biogenesis factor 11 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr29:8,220,082...8,229,448
Ensembl chr29:8,221,920...8,229,243 		JBrowse link
G PGM1 phosphoglucomutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr20:69,391,487...69,495,156
Ensembl chr20:69,428,996...69,466,191 		JBrowse link
G PLAT plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism CTD PMID:22507835 NCBI chr 8:40,164,391...40,196,627
Ensembl chr 8:40,163,891...40,196,555 		JBrowse link
G PLG plasminogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:22507835 NCBI chr13:88,266,054...88,321,596
Ensembl chr13:88,268,198...88,322,644 		JBrowse link
G PLS3 plastin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249
G PNP purine nucleoside phosphorylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chr29:20,992,892...21,001,400
Ensembl chr29:20,993,280...21,001,606 		JBrowse link
G PNRC1 proline rich nuclear receptor coactivator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr13:13,846,691...13,850,785
Ensembl chr13:13,846,864...13,850,141 		JBrowse link
G POLG DNA polymerase gamma, catalytic subunit susceptibility
no_association		 ISO DNA:missense mutation:cds:p.W748S, p.E1143G (2243G>C, 3428A>G) (human)
DNA:missense mutations:cds:p.Q1236H, p.E1143G (33708G>T, 3428A>G) (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:18208989 PMID:20138553 PMID:25065347 PMID:30255931 RGD:15039297 RGD:15039302 NCBI chr29:7,864,319...7,881,577
Ensembl chr29:7,863,277...7,882,068 		JBrowse link
G POLR2G RNA polymerase II subunit G ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 1:11,140,897...11,150,879
Ensembl chr 1:11,140,867...11,150,882 		JBrowse link
G PON1 paraoxonase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chr21:53,713,434...53,739,658
Ensembl chr21:53,714,012...53,739,875 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:24385052
G PPARG peroxisome proliferator activated receptor gamma ISO mRNA, protein:decreased expression:liver RGD PMID:26599535 RGD:11554658 NCBI chr22:48,262,743...48,407,415
Ensembl chr22:48,275,600...48,407,418 		JBrowse link
G PPTC7 protein phosphatase targeting COQ7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr11:105,774,912...105,823,882
Ensembl chr11:105,778,596...105,823,836 		JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 treatment ISO RGD PMID:29091898 RGD:15090820 NCBI chr 4:39,516,307...39,553,627 JBrowse link
G PRKCD protein kinase C delta ISO CTD Direct Evidence: therapeutic CTD PMID:30393195 NCBI chr22:14,561,401...14,592,877
Ensembl chr22:14,565,282...14,592,873 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:21224054 NCBI chr 8:43,915,226...44,119,547
Ensembl chr 8:43,914,636...44,119,541 		JBrowse link
G PTF1A pancreas associated transcription factor 1a ISO CTD Direct Evidence: therapeutic CTD PMID:21182459 NCBI chr 9:22,944,122...22,965,905
Ensembl chr 9:22,964,164...22,965,565 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 treatment ISO CTD Direct Evidence: therapeutic RGD
CTD		 PMID:11743745 PMID:29091898 RGD:15090820 NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429 		JBrowse link
G PUM1 pumilio RNA binding family member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr20:101,773,819...101,910,433
Ensembl chr20:101,773,960...101,910,519 		JBrowse link
G PYGL glycogen phosphorylase L ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum (rat)		 CTD
RGD		 PMID:25231249 PMID:25336395 RGD:21079733 NCBI chr24:27,987,676...28,030,919
Ensembl chr24:27,987,649...28,030,869 		JBrowse link
G PZP PZP alpha-2-macroglobulin like ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chr11:8,963,883...9,023,148
Ensembl chr11:8,963,461...9,014,957 		JBrowse link
G RASA1 RAS p21 protein activator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr 4:81,249,851...81,371,486
Ensembl chr 4:81,249,805...81,370,453 		JBrowse link
G RBP1 retinol binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chr15:51,011,664...51,033,963 JBrowse link
G RDH13 retinol dehydrogenase 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27865848 NCBI chr 6:47,634,909...47,652,829
Ensembl chr 6:47,636,094...47,652,772 		JBrowse link
G REEP5 receptor accessory protein 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chr23:16,165,233...16,210,082
Ensembl chr23:16,167,557...16,210,050 		JBrowse link
G RGN regucalcin ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr  X:44,282,825...44,299,027
Ensembl chr  X:44,285,601...44,299,258 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 ISO CTD Direct Evidence: therapeutic
protein:increased expression:liver (mouse)		 CTD
RGD		 PMID:26769846 PMID:28205631 RGD:127229945 NCBI chr24:1,318,265...1,322,610
Ensembl chr24:1,318,216...1,322,462 		JBrowse link
G S100A11 S100 calcium binding protein A11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr20:11,613,171...11,617,711 JBrowse link
G SCARB1 scavenger receptor class B member 1 ISO mRNA:increased expression:liver (rat) RGD PMID:28959666 RGD:401794432 NCBI chr11:120,134,485...120,223,512
Ensembl chr11:120,134,874...120,216,904 		JBrowse link
G SELENBP1 selenium binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 NCBI chr20:12,321,445...12,330,495
Ensembl chr20:12,321,292...12,330,746 		JBrowse link
G SEMA3A semaphorin 3A ISO CTD Direct Evidence: therapeutic CTD PMID:33290778 NCBI chr21:64,723,860...64,942,705
Ensembl chr21:64,784,039...64,939,682 		JBrowse link
G SEMA4A semaphorin 4A ISO CTD Direct Evidence: marker/mechanism CTD PMID:33290778 NCBI chr20:7,684,107...7,716,866
Ensembl chr20:7,683,994...7,708,741 		JBrowse link
G SENP2 SUMO specific peptidase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:29535048 NCBI chr15:3,805,916...3,853,529 JBrowse link
G SERPINA1 serpin family A member 1 susceptibility ISO protein:decreased expression:plasma
DNA:missense mutation:cds:p.E264V(human)		 RGD PMID:11140575 PMID:20170533 RGD:14695048 RGD:1643168 NCBI chr24:72,158,521...72,171,139
Ensembl chr24:72,156,784...72,163,500 		JBrowse link
G SERPINA6 serpin family A member 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr24:72,079,084...72,098,549
Ensembl chr24:72,077,274...72,098,154 		JBrowse link
G SERPINE1 serpin family E member 1 treatment ISO associated with precursor lymphoblastic lymphoma/leukemia;DNA:SNPs: :DNA:SNPs: :677C>T, 1298A>C(human) RGD PMID:23183238 RGD:14696750 NCBI chr28:12,047,520...12,060,662
Ensembl chr28:12,047,529...12,060,202 		JBrowse link
G SERPING1 serpin family G member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 1:15,617,122...15,634,540
Ensembl chr 1:15,616,674...15,633,855 		JBrowse link
G SESN2 sestrin 2 ISO CTD Direct Evidence: therapeutic CTD PMID:28209544 NCBI chr20:104,521,131...104,544,161
Ensembl chr20:104,521,132...104,544,001 		JBrowse link
G SGF29 SAGA complex associated factor 29 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 5:26,399,760...26,439,616
Ensembl chr 5:26,399,677...26,439,530 		JBrowse link
G SHC1 SHC adaptor protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 PMID:32659284 NCBI chr20:8,854,189...8,866,406
Ensembl chr20:8,858,458...8,866,610 		JBrowse link
G SLC10A1 solute carrier family 10 member 1 ISO mRNA:decreased expression:liver (rat) RGD PMID:28827769 RGD:15045609 NCBI chr24:47,018,237...47,034,360
Ensembl chr24:47,017,414...47,033,940 		JBrowse link
G SLC10A7 solute carrier family 10 member 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chr 7:92,798,344...93,052,737 JBrowse link
G SLC13A4 solute carrier family 13 member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr21:104,359,577...104,407,905
Ensembl chr21:104,363,792...104,405,562 		JBrowse link
G SLC22A8 solute carrier family 22 member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 1:10,885,895...10,909,739
Ensembl chr 1:10,886,690...10,910,546 		JBrowse link
G SLC25A29 solute carrier family 25 member 29 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr24:78,251,571...78,266,550
Ensembl chr24:78,250,796...78,266,490 		JBrowse link
G SLC7A5 solute carrier family 7 member 5 treatment ISO RGD PMID:9200186 RGD:151357001 NCBI chr 5:73,229,953...73,269,801
Ensembl chr 5:73,229,951...73,269,754 		JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32259555 NCBI chr11:20,992,353...21,091,761
Ensembl chr11:21,001,655...21,093,278 		JBrowse link
G SLPI secretory leukocyte peptidase inhibitor ISO CTD Direct Evidence: marker/mechanism CTD PMID:17984051 NCBI chr 2:18,579,549...18,581,897
Ensembl chr 2:18,579,515...18,582,076 		JBrowse link
G SNX18 sorting nexin 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17984051 NCBI chr 4:50,782,842...50,810,220
Ensembl chr 4:50,782,929...50,811,253 		JBrowse link
G SOD1 superoxide dismutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 PMID:27349771 NCBI chr 2:60,461,219...60,472,999 JBrowse link
G SOD2 superoxide dismutase 2 susceptibility
severity
treatment		 ISO DNA:SNP:cds:p.Val16Ala(human)
associated with acute lymphoblastic leukemia;DNA:SNP: :(rs4880)(human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:19332662 PMID:19647030 PMID:20578157 PMID:25226513 PMID:27019981 RGD:11060605 RGD:26923957 RGD:26923959 RGD:26923961 NCBI chr13:87,284,537...87,297,998
Ensembl chr13:87,280,686...87,297,974 		JBrowse link
G SOD3 superoxide dismutase 3 ISO CTD Direct Evidence: therapeutic CTD PMID:11529661 NCBI chr27:25,554,474...25,559,873
Ensembl chr27:25,555,082...25,555,804 		JBrowse link
G SORD sorbitol dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12763371 NCBI chr26:38,129,236...38,173,867
Ensembl chr26:38,126,911...38,155,381 		JBrowse link
G SORL1 sortilin related receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chr 1:112,877,052...113,062,167
Ensembl chr 1:112,877,151...113,058,050 		JBrowse link
G SPP1 secreted phosphoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 NCBI chr 7:36,337,165...36,344,927
Ensembl chr 7:36,338,386...36,344,407 		JBrowse link
G SRP72 signal recognition particle 72 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chr 7:12,127,817...12,162,992
Ensembl chr 7:12,126,607...12,162,951 		JBrowse link
G STAT4 signal transducer and activator of transcription 4 severity ISO protein:increased phosphorylation:liver, inflammatory cell (mouse)
mRNA:increased expression:liver, macrophage (mouse)		 RGD PMID:23876342 PMID:24731448 RGD:25671417 RGD:25671422 NCBI chr10:76,553,626...76,708,540
Ensembl chr10:76,553,606...76,674,928 		JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:36520315 NCBI chr23:42,153,576...42,160,903
Ensembl chr23:42,153,026...42,160,907 		JBrowse link
G SULT1C3 sulfotransferase family 1C member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr14:11,621,851...11,638,719
Ensembl chr14:11,622,043...11,636,652 		JBrowse link
G SULT1E1 sulfotransferase family 1E member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 7:18,313,510...18,330,768
Ensembl chr 7:18,313,238...18,330,741 		JBrowse link
G SULT2B1 sulfotransferase family 2B member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27052460 NCBI chr 6:41,809,654...41,852,685
Ensembl chr 6:41,810,049...41,852,681 		JBrowse link
G SUOX sulfite oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr11:51,935,809...51,943,090
Ensembl chr11:51,939,809...51,942,603 		JBrowse link
G TAGLN2 transgelin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr20:4,024,948...4,032,361
Ensembl chr20:4,024,775...4,032,526 		JBrowse link
G TALDO1 transaldolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19436114 NCBI chr 1:553,475...569,935
Ensembl chr 1:553,458...573,546 		JBrowse link
G TCTN1 tectonic family member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17984051 NCBI chr11:105,855,138...105,898,764
Ensembl chr11:105,855,288...105,891,093 		JBrowse link
G TF transferrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chr15:56,586,311...56,618,304
Ensembl chr15:56,586,104...56,618,149 		JBrowse link
G TGFB1 transforming growth factor beta 1 treatment ISO RGD PMID:27516150 RGD:14995464 NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28560358 NCBI chr12:40,272,507...40,321,740
Ensembl chr12:40,276,916...40,297,372 		JBrowse link
G THBS1 thrombospondin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35357534 NCBI chr26:43,410,693...43,427,816
Ensembl chr26:43,410,580...43,427,812 		JBrowse link
G THPO thrombopoietin ISO CTD Direct Evidence: therapeutic CTD PMID:33122006 NCBI chr15:5,040,684...5,048,387 JBrowse link
G TLR4 toll like receptor 4 disease_progression ISO RGD PMID:17504260 RGD:14697733 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
G TLR5 toll like receptor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30508503 NCBI chr25:6,418,895...6,440,433
Ensembl chr25:6,437,638...6,440,211 		JBrowse link
G TMED7 transmembrane p24 trafficking protein 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chr23:18,864,021...18,875,089
Ensembl chr23:18,866,758...18,874,975 		JBrowse link
G TMEM117 transmembrane protein 117 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chr11:40,049,469...40,590,373 JBrowse link
G TMEM164 transmembrane protein 164 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr  X:97,833,179...98,007,700
Ensembl chr  X:97,833,496...98,003,343 		JBrowse link
G TMEM38B transmembrane protein 38B ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr12:33,759,311...33,840,357
Ensembl chr12:33,759,157...33,840,009 		JBrowse link
G TNF tumor necrosis factor treatment
severity		 ISO protein:increased expression:serum (rat)
CTD Direct Evidence: marker/mechanism|therapeutic		 RGD
CTD		 PMID:7532385 PMID:9309314 PMID:9696492 PMID:10801287 PMID:10801288 More... RGD:10450531 RGD:14696804 RGD:14975281 RGD:14995429 RGD:14995432 RGD:14995435 RGD:14995437 RGD:14995485 RGD:15036799 RGD:15090820
G TRPM2 transient receptor potential cation channel subfamily M member 2 ISO RGD PMID:24569808 RGD:9999438 NCBI chr 2:88,082,391...88,170,340
Ensembl chr 2:88,087,448...88,170,344 		JBrowse link
G TTR transthyretin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chr18:49,124,302...49,131,495
Ensembl chr18:49,124,121...49,131,399 		JBrowse link
G TUBB4B tubulin beta 4B class IVb ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr12:945,643...948,087
Ensembl chr12:945,459...948,065 		JBrowse link
G UBA5 ubiquitin like modifier activating enzyme 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chr15:57,596,490...57,613,103
Ensembl chr15:57,592,728...57,612,928 		JBrowse link
G UNC93B1 unc-93 homolog B1, TLR signaling regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 1:6,537,198...6,549,457
Ensembl chr 1:6,537,273...6,549,450 		JBrowse link
G USP5 ubiquitin specific peptidase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr11:6,885,401...6,899,983
Ensembl chr11:6,885,311...6,898,442 		JBrowse link
G VEGFA vascular endothelial growth factor A treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17784864 PMID:25231249 RGD:15003197 NCBI chr17:28,377,959...28,394,508 JBrowse link
G VIM vimentin ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 9:17,183,466...17,191,771
Ensembl chr 9:17,183,388...17,191,829 		JBrowse link
G VWF von Willebrand factor ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:liver:		 CTD
RGD		 PMID:7531171 PMID:28527913 RGD:11079232 NCBI chr11:5,994,499...6,176,949
Ensembl chr11:5,994,039...6,162,260 		JBrowse link
G WASL WASP like actin nucleation promoting factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr21:92,480,392...92,546,725
Ensembl chr21:92,482,918...92,546,481 		JBrowse link
G XRCC1 X-ray repair cross complementing 1 susceptibility ISO DNA:haploinsufficiency: : (mouse) RGD PMID:21737425 RGD:15036796 NCBI chr 6:37,062,149...37,095,138
Ensembl chr 6:37,060,439...37,095,094 		JBrowse link
G XYLB xylulokinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chr15:1,003,809...1,070,385
Ensembl chr15:1,005,340...1,069,275 		JBrowse link
G ZDHHC23 zinc finger DHHC-type palmitoyltransferase 23 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr22:66,905,388...66,917,104
Ensembl chr22:66,901,395...66,915,702 		JBrowse link
drug-induced hepatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 no_association
susceptibility		 ISO DNA:SNPs:multiple:
DNA:polymorphisms,haplotype:promoter:g.-1774delG,g.-1549G>A(human)		 RGD PMID:17502832 PMID:22178260 RGD:14700816 RGD:14700817 NCBI chr 9:92,826,423...92,902,389
Ensembl chr 9:92,841,818...92,902,265 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO DNA:hypermethylation:promoter RGD PMID:23619520 RGD:14700910 NCBI chr26:53,390,054...53,403,309
Ensembl chr26:53,390,089...53,404,211 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:16140414 RGD:2316848 NCBI chr 4:69,664,784...69,690,343
Ensembl chr 4:69,665,417...69,688,686 		JBrowse link
G LPAR1 lysophosphatidic acid receptor 1 ISO protein:increased expression:liver (mouse) RGD PMID:12201952 RGD:10054288 NCBI chr12:28,502,717...28,669,581
Ensembl chr12:28,503,354...28,669,795 		JBrowse link
Halothane Hepatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPT glutamic--pyruvic transaminase treatment ISO RGD PMID:28921207 RGD:14975164 NCBI chr 8:138,716,802...138,721,421
Ensembl chr 8:138,718,767...138,721,251 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17472
    Chemically-Induced Disorders 1160
      Poisoning 628
        Chemical and Drug Induced Liver Injury 347
          Halothane Hepatitis 1
          drug-induced hepatitis 4
Path 2
Term Annotations click to browse term
  disease 17472
    disease of anatomical entity 14859
      gastrointestinal system disease 6327
        hepatobiliary disease 2755
          liver disease 2651
            Liver Injury 427
              Chemical and Drug Induced Liver Injury 347
                Halothane Hepatitis 1
                drug-induced hepatitis 4
paths to the root