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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Cachexia
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Accession:DOID:9007346 term browser browse the term
Definition:General ill health, malnutrition, and weight loss, usually associated with chronic disease.
Synonyms:primary_id: MESH:D002100


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Cachexia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 IEP associated with hepatocellular carcinoma RGD PMID:23200745 RGD:13782066 NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 IEP associated with hepatocellular carcinoma RGD PMID:23200745 RGD:13782066 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc-binding ISO associated with gastrointestinal system cancer;mRNA,protein:increased expression:subcutaneous adipose tissue: RGD PMID:21245862 RGD:153350145 NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091 		JBrowse link
G Bard1 BRCA1 associated RING domain 1 IEP associated with Carcinoma, Hepatocellular;protein:increased expression:skeletal muscle RGD PMID:16685375 RGD:2315732 NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265 		JBrowse link
G Cd27 CD27 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:17878525 NCBI chr 4:158,030,700...158,035,862
Ensembl chr 4:158,030,703...158,035,592 		JBrowse link
G Cdh6 cadherin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17878525 NCBI chr 2:62,079,139...62,225,298
Ensembl chr 2:62,079,137...62,225,228 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta treatment ISO RGD PMID:27122162 RGD:40903021 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Coq7 coenzyme Q7, hydroxylase susceptibility ISO RGD PMID:23166727 RGD:10402105 NCBI chr 1:172,836,359...172,851,173
Ensembl chr 1:172,835,188...172,851,158 		JBrowse link
G Ddx42 DEAD-box helicase 42 IEP
ISO		 associated with Diabetes Mellitus, Experimental;mRNA:increased expression:gastrocnemius muscle (rat)
associated with Malnutrition;mRNA:increased expression:gastrocnemius muscle (mouse)		 RGD PMID:14718385 PMID:14718385 RGD:1641826, RGD:1641826 NCBI chr10:91,148,926...91,180,940
Ensembl chr10:91,148,254...91,180,939 		JBrowse link
G Gdf15 growth differentiation factor 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30782979 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:17347304 PMID:12576449 RGD:7242556 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30782979 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il1b interleukin 1 beta IDA associated with Inflammation RGD PMID:15005009 RGD:1626680 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist IDA associated with Inflammation RGD PMID:15005009 RGD:1626680 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il6 interleukin 6 IEP
ISO		 associated with Leukemia, T-Cell;protein:increased activity:plasma (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17878525 PMID:9110147 RGD:11062106 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 treatment ISO associated with colon adenocarcinoma RGD PMID:28489606 RGD:127285673 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Lpin1 lipin 1 IEP associated with Carcinoma, Hepatocellular;mRNA:increased expression:skeletal muscle RGD PMID:14718385 RGD:1641826 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097 		JBrowse link
G Lta lymphotoxin alpha susceptibility ISO associated with Breast Neoplasms;DNA:polymorphism:intron:252G>A (human) RGD PMID:18953879 RGD:8548798 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 treatment IMP associated with Pulmonary Arterial Hypertension RGD PMID:30554141 RGD:155791671 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mc4r melanocortin 4 receptor ISO associated with Myocardial Infarction RGD PMID:20371568 RGD:6484229 NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719 		JBrowse link
G Mstn myostatin IEP associated with Carcinoma, Hepatocellular;mRNA:increased expression:skeletal muscle RGD PMID:18578694 RGD:2303552 NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor ameliorates ISO associated with Carcinoma, Lewis Lung RGD PMID:31138662 RGD:150530282 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Parl presenilin associated, rhomboid-like ISO RGD PMID:16839884 RGD:12902627 NCBI chr11:80,594,059...80,620,506
Ensembl chr11:80,593,192...80,620,506 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO associated with Pulmonary Disease, Chronic Obstructive (COPD, MeSH:D029424); RNA:decreased expression:skeletal muscle (human) RGD PMID:17459894 RGD:5683621 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17878525 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pthlh parathyroid hormone-like hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:17878525 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 IEP associated with hepatocellular carcinoma RGD PMID:23200745 RGD:13782066 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733 		JBrowse link
G Tfam transcription factor A, mitochondrial ISO associated with Pulmonary Disease, Chronic Obstructive (COPD, MeSH:D029424); RNA, protein:decreased expression:skeletal muscle (human) RGD PMID:17459894 RGD:5683621 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO RGD PMID:2054795 RGD:7394820 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor ISO
IEP		 CTD Direct Evidence: marker/mechanism
associated with hepatocellular carcinoma;mRNA:altered expression:skeletal muscle tissue, adipose tissue (rat)		 CTD
RGD		 PMID:17878525 PMID:16077938 RGD:1624190 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IEP
ISO		 associated with Carcinoma, Hepatocellular;protein, mRNA:increased expression:skeletal muscle, adipose tissue
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:18801959 PMID:16077938 RGD:1624190 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Zfp36 zinc finger protein 36 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12756304 PMID:15944294 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    Pathological Conditions, Signs and Symptoms 13331
      Signs and Symptoms 10807
        Body Weight 1063
          Body Weight Changes 248
            Weight Loss 78
              Emaciation 34
                Cachexia 32
                  FACES Syndrome 0
                  Groll Hirschowitz Syndrome 0
paths to the root