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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Paramyxoviridae Infections
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Accession:DOID:9007244 term browser browse the term
Definition:Infections with viruses of the family PARAMYXOVIRIDAE. This includes MORBILLIVIRUS INFECTIONS; RESPIROVIRUS INFECTIONS; PNEUMOVIRUS INFECTIONS; HENIPAVIRUS INFECTIONS; AVULAVIRUS INFECTIONS; and RUBULAVIRUS INFECTIONS.
Synonyms:exact_synonym: Parainfluenza;   Parainfluenza Virus Infection;   Parainfluenza Virus Infections;   Paramyxoviridae Infection
 primary_id: MESH:D018184;   RDO:0006283
For additional species annotation, visit the Alliance of Genome Resources.


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Paramyxoviridae Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL5 C-C motif chemokine ligand 5 ISO protein:increased expression:nasal mucus (human) RGD PMID:20182399 RGD:4891406 NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118 		JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:20053825 RGD:4891886 NCBI chr 6:19,312,351...19,324,439 JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:nasal mucus RGD PMID:20182399 RGD:4891406 NCBI chr 8:71,665,541...71,670,236
Ensembl chr 8:71,663,495...71,670,271 		JBrowse link
measles term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2M beta-2-microglobulin ISO protein:increased expression:plasma RGD PMID:1402029 RGD:6482707 NCBI chr 1:126,865,767...126,878,501
Ensembl chr 1:126,835,143...126,981,582 		JBrowse link
G CD46 CD46 molecule, complement regulatory protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:8402913 NCBI chr 9:135,025,439...135,078,910 JBrowse link
G MUC1 mucin 1, cell surface associated severity ISO protein:increased expression:serum RGD PMID:11802251 RGD:5131281 NCBI chr 4:94,626,317...94,631,194 JBrowse link
Metapneumovirus infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAVS mitochondrial antiviral signaling protein severity ISO RGD PMID:25953917 RGD:40903044 NCBI chr17:31,850,646...31,869,273
Ensembl chr17:31,850,155...31,869,187 		JBrowse link
G PCD1B CD1B antigen ISO protein:decreased expression:alveolar macrophage, monocyte (mouse) RGD PMID:32463330 RGD:127345107 NCBI chr 4:92,035,122...92,040,724 JBrowse link
Nasu-Hakola disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TREM2 triggering receptor expressed on myeloid cells 2 ISO ClinVar Annotator: match by term: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 ClinVar PMID:12080485 PMID:12754369 PMID:12925681 PMID:15883308 PMID:18546367 More... NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,464,034...36,471,516 		JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP ISO ClinVar Annotator: match by term: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 OMIM
ClinVar		 PMID:10888890 PMID:11109371 PMID:12370476 PMID:15883308 PMID:17125796 More... NCBI chr 6:45,309,199...45,312,562
Ensembl chr 6:45,309,197...45,312,537 		JBrowse link
Pneumovirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL21 interleukin 21 ISO mRNA:increased expression:lung (mouse) RGD PMID:22238461 RGD:6892925 NCBI chr 8:101,532,742...101,540,712
Ensembl chr 8:101,530,949...101,540,738 		JBrowse link
G IL21R interleukin 21 receptor ISO RGD PMID:22238461 RGD:6892925 NCBI chr 3:19,447,488...19,489,201
Ensembl chr 3:19,443,344...19,489,152 		JBrowse link
G PDCD1 programmed cell death 1 treatment ISO associated with reinfection RGD PMID:25339663 RGD:40822811 NCBI chr15:140,337,353...140,347,493
Ensembl chr15:140,336,210...140,347,478 		JBrowse link
respiratory syncytial virus infectious disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE2 angiotensin converting enzyme 2 severity
treatment		 ISO human protein in a mouse model RGD PMID:26813885 RGD:32716392 NCBI chr  X:12,099,849...12,152,204
Ensembl chr  X:12,099,853...12,151,275 		JBrowse link
G AICDA activation induced cytidine deaminase treatment ISO RGD PMID:27721128 RGD:127285642 NCBI chr 5:62,777,236...62,787,342
Ensembl chr 5:62,777,352...62,787,483 		JBrowse link
G CCL1 C-C motif chemokine ligand 1 ISO mRNA:increased expression:lung RGD PMID:11134301 RGD:4891417 NCBI chr12:40,728,014...40,731,411
Ensembl chr12:40,728,014...40,731,411 		JBrowse link
G CCL11 chemokine (C-C motif) ligand 11 ISO RGD PMID:10955955 RGD:4145447 NCBI chr12:40,779,906...40,782,862
Ensembl chr12:40,779,173...40,782,893 		JBrowse link
G CCL17 C-C motif chemokine ligand 17 ISO mRNA:increased expression:lung RGD PMID:17641031 RGD:4145495 NCBI chr 6:19,345,929...19,372,972
Ensembl chr 6:19,345,941...19,348,926 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO protein:altered expression:lung, T cell (mouse) RGD PMID:19124761 RGD:4891880 NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO protein:increased expression:blood, monocyte (human)
DNA:snps:5' utr:g.-2459A>G, g.-2554G>T (human)		 RGD PMID:12964123 PMID:18439876 RGD:4892079 RGD:4892113 NCBI chr13:29,382,383...29,387,902
Ensembl chr13:29,383,303...29,387,902 		JBrowse link
G CD274 CD274 molecule severity ISO protein:increased expression: lung RGD PMID:25465101 RGD:11056952 NCBI chr 1:216,646,378...216,792,731
Ensembl chr 1:216,660,047...216,792,724 		JBrowse link
G CD28 CD28 molecule ISO RGD PMID:18056387 RGD:5131621 NCBI chr15:107,128,103...107,155,431
Ensembl chr15:107,128,208...107,162,943 		JBrowse link
G CFTR CF transmembrane conductance regulator ISO DNA:mutation: : RGD PMID:20015999 RGD:4140389 NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 severity ISO RGD PMID:12941892 PMID:16424189 RGD:4892016 RGD:4892018 NCBI chr13:23,944,386...23,957,567
Ensembl chr13:23,944,369...23,957,486 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO RGD PMID:18624292 RGD:5135483 NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO protein:increased expression:nasopharynx(human) RGD PMID:29325581 RGD:150521551 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:15916706 RGD:5135444 NCBI chr 8:71,665,541...71,670,236
Ensembl chr 8:71,663,495...71,670,271 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO RGD PMID:18624292 RGD:5135483 NCBI chr  X:57,592,032...57,595,706
Ensembl chr  X:57,592,038...57,595,692 		JBrowse link
G DNASE1 deoxyribonuclease 1 ISO CTD Direct Evidence: therapeutic CTD PMID:28780505 NCBI chr 3:38,590,045...38,646,852
Ensembl chr 3:38,586,600...38,646,834 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism
protein:increased secretion:nasopharynx		 CTD
RGD		 PMID:17425601 PMID:20209309 RGD:4140425 NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205 		JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism
associated with Otitis media;protein:increased expression:serum:		 CTD
RGD		 PMID:19352211 PMID:21937650 RGD:8142352 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752 		JBrowse link
G IL10 interleukin 10 severity ISO RGD PMID:20209309 RGD:4140425 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,727...67,405,711 		JBrowse link
G IL13 interleukin 13 ISO RGD PMID:18250447 RGD:4145641 NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093 		JBrowse link
G IL17A interleukin 17A severity ISO protein:increased expression:plasma RGD PMID:19738511 RGD:4889103 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153 		JBrowse link
G IL18 interleukin 18 ISO DNA:polymorphism:intron:rs360721 (human) RGD PMID:18043444 PMID:20130064 RGD:4889550 RGD:4889584 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,966...39,873,300 		JBrowse link
G IL1RL1 interleukin 1 receptor like 1 ISO RGD PMID:11283151 RGD:5144238 NCBI chr 3:51,868,549...51,902,454
Ensembl chr 3:51,803,165...51,951,383 		JBrowse link
G IL27 interleukin 27 ameliorates ISO RGD PMID:22301139 RGD:126790525 NCBI chr 3:18,421,962...18,427,916
Ensembl chr 3:18,421,981...18,427,915 		JBrowse link
G IL2RA interleukin 2 receptor subunit alpha ISO RGD PMID:20639494 RGD:5147443 NCBI chr10:64,948,149...65,001,320
Ensembl chr10:64,948,552...65,001,173 		JBrowse link
G IL33 interleukin 33 ISO RGD PMID:26044350 PMID:28771101 RGD:11342984 RGD:39939029 NCBI chr 1:215,899,830...215,941,944
Ensembl chr 1:215,899,435...215,941,840 		JBrowse link
G IL5 interleukin 5 severity ISO RGD PMID:25410867 RGD:11354937 NCBI chr 2:134,832,143...134,846,141
Ensembl chr 2:134,832,147...134,835,212 		JBrowse link
G IL5RA interleukin 5 receptor subunit alpha ISO protein:decreased expression:blood, eosinophil RGD PMID:16734609 RGD:5128618 NCBI chr13:59,651,184...59,692,211
Ensembl chr13:59,652,755...59,690,184 		JBrowse link
G IL6 interleukin 6 severity ISO protein:increased expression:nasal mucus
associated with Otitis media;protein:increased expression:serum:		 RGD PMID:19352211 PMID:20622030 RGD:4143259 RGD:8142352 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263 		JBrowse link
G IL9 interleukin 9 susceptibility ISO DNA:SNPs: :rs2069885, rs1799962 (human) RGD PMID:19915054 PMID:20503287 RGD:5128684 RGD:5128685 NCBI chr 2:138,048,943...138,052,588
Ensembl chr 2:138,048,943...138,052,588 		JBrowse link
G IRF1 interferon regulatory factor 1 ISO protein:increased expression:dorsal root ganglion RGD PMID:20045913 RGD:5128775 NCBI chr 2:134,776,122...134,783,646
Ensembl chr 2:134,776,134...134,783,646 		JBrowse link
G MIR21 microRNA mir-21 ameliorates ISO associated with asthma; RGD PMID:27448447 RGD:41404696 NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO mRNA, protein:increased expression, increased activity:bronchoalveolar lavage fluid RGD PMID:17254480 RGD:5130726 NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,594...30,086,982 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO mRNA, protein:increased expression, increased activity:bronchoalveolar lavage fluid RGD PMID:17254480 RGD:5130726 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,175,056...48,188,264 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming ISO associated with Respiratory Hypersensitivity; protein:increased expression:lung RGD PMID:15130904 RGD:5131205 NCBI chr 2:757,897...790,321 JBrowse link
G NGF nerve growth factor ISO RGD PMID:19824047 RGD:4891065 NCBI chr 4:105,256,691...105,307,843
Ensembl chr 4:105,256,417...105,307,842 		JBrowse link
G NGFR nerve growth factor receptor ISO RGD PMID:19824047 RGD:4891065 NCBI chr12:25,699,410...25,720,355
Ensembl chr12:25,699,427...25,720,357 		JBrowse link
G PCD1B CD1B antigen ameliorates ISO RGD PMID:32463330 RGD:127345107 NCBI chr 4:92,035,122...92,040,724 JBrowse link
G PDCD1 programmed cell death 1 ISO protein:increased expression:CD4 Tcell, CD8 Tcell from lung:
protein:increased expression: CD8 Tcell from nasal wash:		 RGD PMID:25465101 RGD:11056952 NCBI chr15:140,337,353...140,347,493
Ensembl chr15:140,336,210...140,347,478 		JBrowse link
G PDE12 phosphodiesterase 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26055709 NCBI chr13:39,395,517...39,402,653
Ensembl chr13:39,395,541...39,402,650 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 ameliorates ISO RGD PMID:33303545 RGD:127229923 NCBI chr 7:74,951,145...74,955,255
Ensembl chr 7:74,951,060...74,955,192 		JBrowse link
G RSAD2 radical S-adenosyl methionine domain containing 2 treatment ISO RGD PMID:23018837 RGD:11554170 NCBI chr 3:128,880,853...128,897,809
Ensembl chr 3:128,877,186...128,897,847 		JBrowse link
G SARM1 sterile alpha and TIR motif containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478430 NCBI chr12:44,654,364...44,676,942
Ensembl chr12:44,655,811...44,676,945 		JBrowse link
G SCGB1A1 secretoglobin family 1A member 1 ISO RGD PMID:12847279 RGD:5144208 NCBI chr 2:9,297,282...9,302,204
Ensembl chr 2:9,297,283...9,302,165 		JBrowse link
G SFTPA1 surfactant protein A1 susceptibility ISO protein:decreased expression:lung
DNA:polymorphisms, haplotype: (human)		 RGD PMID:10194154 PMID:19287351 RGD:4143439 RGD:4143495 NCBI chr14:82,091,178...82,095,393
Ensembl chr14:82,091,178...82,107,675 		JBrowse link
G SFTPB surfactant protein B severity ISO protein:decreased expression:lung
DNA:SNPs:promoter, cds, intron:-32G>T (rs2077079), p.T131I (rs1130866), 5781A>C (rs2040349) (human)		 RGD PMID:10194154 PMID:17498296 RGD:4143382 RGD:4143439 NCBI chr 3:59,101,940...59,113,442
Ensembl chr 3:59,101,952...59,111,834 		JBrowse link
G SFTPC surfactant protein C ISO DNA:polymorphism: :138A>C, 186A>G (human) RGD PMID:17121584 PMID:19304906 RGD:4144065 RGD:4144116 NCBI chr14:6,440,309...6,443,104
Ensembl chr14:6,440,309...6,443,095 		JBrowse link
G SFTPD surfactant protein D susceptibility ISO protein:decreased expression:lung
DNA:polymorphisms: :p.M11T, p.A160T (human		 RGD PMID:10194154 PMID:19287351 RGD:4143439 RGD:4143495 NCBI chr14:82,051,400...82,069,258
Ensembl chr14:82,051,451...82,067,976 		JBrowse link
G SLA-8 MHC class I antigen 8 ISO RGD PMID:10706505 RGD:5144121 NCBI chr 7:23,622,352...23,625,818 JBrowse link
G TAC1 tachykinin precursor 1 ISO mRNA,protein:increased expression:lung RGD PMID:10516226 RGD:5147822 NCBI chr 9:77,197,403...77,206,529
Ensembl chr 9:77,197,535...77,206,526 		JBrowse link
G TACR1 tachykinin receptor 1 treatment ISO RGD PMID:10516226 RGD:5147822 NCBI chr 3:67,839,367...68,021,733
Ensembl chr 3:67,839,411...68,021,728 		JBrowse link
G TICAM1 toll like receptor adaptor molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478430 NCBI chr 2:74,004,566...74,021,100
Ensembl chr 2:74,004,550...74,021,094 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:19019963 RGD:4889534 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,991...75,446,850 		JBrowse link
G TLR3 toll like receptor 3 ISO RGD PMID:16424225 RGD:5129224 NCBI chr15:46,966,262...46,977,774
Ensembl chr15:46,966,040...47,058,734 		JBrowse link
G TLR4 toll like receptor 4 no_association
susceptibility		 ISO DNA:SNP:cds:p.D299G (human)
DNA:polymorphisms:cds:p.D259G, T359I (human)
DNA:SNPs:cds:p.D299G, T399I (human)		 RGD PMID:17264400 PMID:17449325 PMID:17709532 PMID:19019963 RGD:4144161 RGD:4144164 RGD:4144167 RGD:4889534 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,059,004 		JBrowse link
G TLR6 toll like receptor 6 ISO RGD PMID:19019963 RGD:4889534 NCBI chr 8:30,159,744...30,180,650
Ensembl chr 8:30,159,754...30,180,650 		JBrowse link
G TLR8 toll like receptor 8 ISO associated with Bronchiolitis; mRNA:increased expression:nasopharynx (human) RGD PMID:19386802 RGD:5129471 NCBI chr  X:9,551,284...9,616,762
Ensembl chr  X:9,549,552...9,616,759 		JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:Bronchoalveolar lavage fluid RGD PMID:15791294 RGD:4145715 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655 		JBrowse link
G TSLP thymic stromal lymphopoietin sexual_dimorphism ISO mRNA:increased expression:lung (mouse)
protein:increased expression:nasal mucus (human)		 RGD PMID:27156176 PMID:28471975 PMID:31076663 RGD:38549376 RGD:38596342 RGD:38596346 NCBI chr 2:115,832,152...115,837,572 JBrowse link
Respirovirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL28 C-C motif chemokine ligand 28 ISO mRNA:increased expression:lung (mouse) RGD PMID:17954569 RGD:4892194 NCBI chr16:27,990,024...28,010,859
Ensembl chr16:27,985,167...28,011,237 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO RGD PMID:17641009 RGD:4892127 NCBI chr13:29,382,383...29,387,902
Ensembl chr13:29,383,303...29,387,902 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO mRNA, protein:increased expression, increased activity:lung RGD PMID:16816895 RGD:5130923 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,175,056...48,188,264 		JBrowse link
G PPIA peptidylprolyl isomerase A exacerbates ISO RGD PMID:28594325 RGD:150429629 NCBI chr18:50,563,130...50,566,857 JBrowse link
subacute sclerosing panencephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ISO DNA:insertion/deletion: RGD PMID:16741935 RGD:40400901 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,639 		JBrowse link
G IL29 interleukin 29 (interferon, lambda 1) ISO protein:increased expression:blood serum (human) RGD PMID:30077763 RGD:126848745 NCBI chr17:51,484,658...51,485,233
Ensembl chr17:51,484,658...51,485,233 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14378
    disease by infectious agent 1996
      viral infectious disease 1588
        RNA Virus Infections 1321
          Mononegavirales Infections 95
            Paramyxoviridae Infections 72
              Avulavirus Infections + 0
              Henipavirus Infections + 0
              Morbillivirus Infections + 7
              Pneumovirinae infections + 62
              Respirovirus Infections + 4
              Rubulavirus Infections + 0
paths to the root