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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Paramyxoviridae Infections
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Accession:DOID:9007244 term browser browse the term
Definition:Infections with viruses of the family PARAMYXOVIRIDAE. This includes MORBILLIVIRUS INFECTIONS; RESPIROVIRUS INFECTIONS; PNEUMOVIRUS INFECTIONS; HENIPAVIRUS INFECTIONS; AVULAVIRUS INFECTIONS; and RUBULAVIRUS INFECTIONS.
Synonyms:exact_synonym: Parainfluenza;   Parainfluenza Virus Infection;   Parainfluenza Virus Infections;   Paramyxoviridae Infection
 primary_id: MESH:D018184;   RDO:0006283
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
 
Paramyxoviridae Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL5 C-C motif chemokine ligand 5 IEP protein:increased expression:nasal mucus (human) RGD PMID:20182399 RGD:4891406 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:20053825 RGD:4891886 NCBI chr16:57,372,490...57,385,044
Ensembl chr16:57,372,477...57,385,044
JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 IEP protein:increased expression:nasal mucus RGD PMID:20182399 RGD:4891406 NCBI chr 4:76,001,275...76,007,509
Ensembl chr 4:76,001,275...76,007,509
JBrowse link
measles term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2M beta-2-microglobulin IEP protein:increased expression:plasma RGD PMID:1402029 RGD:6482707 NCBI chr15:44,711,492...44,718,145
Ensembl chr15:44,711,487...44,718,851
JBrowse link
G CD46 CD46 molecule EXP CTD Direct Evidence: marker/mechanism CTD PMID:8402913 NCBI chr 1:207,752,038...207,795,516
Ensembl chr 1:207,752,054...207,795,513
JBrowse link
G MUC1 mucin 1, cell surface associated severity IEP protein:increased expression:serum RGD PMID:11802251 RGD:5131281 NCBI chr 1:155,185,824...155,192,915
Ensembl chr 1:155,185,824...155,192,916
JBrowse link
Metapneumovirus infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD1D CD1d molecule ISO protein:decreased expression:alveolar macrophage, monocyte (mouse) RGD PMID:32463330 RGD:127345107 NCBI chr 1:158,178,030...158,186,427
Ensembl chr 1:158,178,030...158,186,427
JBrowse link
G MAVS mitochondrial antiviral signaling protein severity ISO RGD PMID:25953917 RGD:40903044 NCBI chr20:3,846,834...3,876,118
Ensembl chr20:3,846,799...3,876,123
JBrowse link
Nasu-Hakola disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TREM2 triggering receptor expressed on myeloid cells 2 IAGP ClinVar Annotator: match by term: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
ClinVar Annotator: match by term: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1
ClinVar PMID:12080485 PMID:12754369 PMID:12925681 PMID:15883308 PMID:18546367 More... NCBI chr 6:41,158,508...41,163,116
Ensembl chr 6:41,158,506...41,163,186
JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP IAGP
EXP
ClinVar Annotator: match by term: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
ClinVar Annotator: match by term: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
OMIM
PMID:10888890 PMID:11109371 PMID:12370476 PMID:15883308 PMID:17125796 More... NCBI chr19:35,904,403...35,908,295
Ensembl chr19:35,904,401...35,908,295
JBrowse link
Pneumovirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL21 interleukin 21 ISO mRNA:increased expression:lung (mouse) RGD PMID:22238461 RGD:6892925 NCBI chr 4:122,610,108...122,621,066
Ensembl chr 4:122,610,108...122,621,066
JBrowse link
G IL21R interleukin 21 receptor ISO RGD PMID:22238461 RGD:6892925 NCBI chr16:27,402,162...27,452,043
Ensembl chr16:27,402,174...27,452,042
JBrowse link
G PDCD1 programmed cell death 1 treatment ISO associated with reinfection RGD PMID:25339663 RGD:40822811 NCBI chr 2:241,849,881...241,858,908
Ensembl chr 2:241,849,884...241,858,894
JBrowse link
respiratory syncytial virus infectious disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE2 angiotensin converting enzyme 2 severity
treatment
ISO
IDA
human protein in a mouse model RGD PMID:26813885 PMID:26813885 RGD:32716392, RGD:32716392 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236
JBrowse link
G AICDA activation induced cytidine deaminase treatment ISO RGD PMID:27721128 RGD:127285642 NCBI chr12:8,602,170...8,612,970
Ensembl chr12:8,602,170...8,612,867
JBrowse link
G CCL1 C-C motif chemokine ligand 1 ISO mRNA:increased expression:lung RGD PMID:11134301 RGD:4891417 NCBI chr17:34,360,328...34,363,233
Ensembl chr17:34,360,328...34,363,233
JBrowse link
G CCL11 C-C motif chemokine ligand 11 ISO RGD PMID:10955955 RGD:4145447 NCBI chr17:34,285,742...34,288,334
Ensembl chr17:34,285,742...34,288,334
JBrowse link
G CCL17 C-C motif chemokine ligand 17 IEP mRNA:increased expression:lung RGD PMID:17641031 RGD:4145495 NCBI chr16:57,396,076...57,416,063
Ensembl chr16:57,404,767...57,416,063
JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO protein:altered expression:lung, T cell (mouse) RGD PMID:19124761 RGD:4891880 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CCR5 C-C motif chemokine receptor 5 IEP
IAGP
protein:increased expression:blood, monocyte (human)
DNA:snps:5' utr:g.-2459A>G, g.-2554G>T (human)
RGD PMID:18439876 PMID:12964123 RGD:4892079, RGD:4892113 NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,854...46,376,206
JBrowse link
G CD1D CD1d molecule ameliorates ISO RGD PMID:32463330 RGD:127345107 NCBI chr 1:158,178,030...158,186,427
Ensembl chr 1:158,178,030...158,186,427
JBrowse link
G CD274 CD274 molecule severity ISO protein:increased expression: lung RGD PMID:25465101 PMID:25465101 RGD:11056952, RGD:11056952 NCBI chr 9:5,450,542...5,470,554
Ensembl chr 9:5,450,503...5,470,566
JBrowse link
G CD28 CD28 molecule IEP RGD PMID:18056387 RGD:5131621 NCBI chr 2:203,706,509...203,739,756
Ensembl chr 2:203,706,475...203,738,912
JBrowse link
G CFTR CF transmembrane conductance regulator ISO DNA:mutation: : RGD PMID:20015999 RGD:4140389 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 severity ISO RGD PMID:12941892 PMID:16424189 RGD:4892018, RGD:4892016 NCBI chr 3:39,263,494...39,281,735
Ensembl chr 3:39,263,495...39,281,735
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 ISO mRNA:increased expression:blood RGD PMID:20843364 RGD:5134958 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO RGD PMID:18624292 RGD:5135483 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 IEP protein:increased expression:nasopharynx(human) RGD PMID:29325581 RGD:150521551 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:15916706 RGD:5135444 NCBI chr 4:76,001,275...76,007,509
Ensembl chr 4:76,001,275...76,007,509
JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO RGD PMID:18624292 RGD:5135483 NCBI chr  X:71,615,913...71,618,515
Ensembl chr  X:71,615,916...71,618,511
JBrowse link
G DNASE1 deoxyribonuclease 1 EXP CTD Direct Evidence: therapeutic CTD PMID:28780505 NCBI chr16:3,611,737...3,665,472
Ensembl chr16:3,611,728...3,680,143
JBrowse link
G HLA-G major histocompatibility complex, class I, G IEP RGD PMID:10706505 RGD:5144121 NCBI chr 6:29,826,474...29,831,130
Ensembl chr 6:29,826,967...29,831,125
JBrowse link
G ICAM1 intercellular adhesion molecule 1 IEP
EXP
protein:increased secretion:nasopharynx
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:17425601 PMID:20209309 RGD:4140425 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IFNG interferon gamma IEP
EXP
associated with Otitis media;protein:increased expression:serum:
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:21937650 PMID:19352211 RGD:8142352 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL10 interleukin 10 severity IEP RGD PMID:20209309 RGD:4140425 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL13 interleukin 13 ISO RGD PMID:18250447 RGD:4145641 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
JBrowse link
G IL17A interleukin 17A severity IEP protein:increased expression:plasma RGD PMID:19738511 RGD:4889103 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
JBrowse link
G IL18 interleukin 18 ISO
IAGP
DNA:polymorphism:intron:rs360721 (human) RGD PMID:20130064 PMID:18043444 RGD:4889550, RGD:4889584 NCBI chr11:112,143,251...112,164,104
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G IL1RL1 interleukin 1 receptor like 1 ISO RGD PMID:11283151 RGD:5144238 NCBI chr 2:102,311,529...102,352,367
Ensembl chr 2:102,311,502...102,352,037
JBrowse link
G IL27 interleukin 27 ameliorates ISO RGD PMID:22301139 RGD:126790525 NCBI chr16:28,499,362...28,526,730
Ensembl chr16:28,499,362...28,512,051
JBrowse link
G IL2RA interleukin 2 receptor subunit alpha ISO RGD PMID:20639494 RGD:5147443 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370
JBrowse link
G IL33 interleukin 33 ISO RGD PMID:28771101 PMID:26044350 RGD:39939029, RGD:11342984 NCBI chr 9:6,214,591...6,257,983
Ensembl chr 9:6,215,786...6,257,983
JBrowse link
G IL5 interleukin 5 severity ISO RGD PMID:25410867 RGD:11354937 NCBI chr 5:132,539,194...132,556,864
Ensembl chr 5:132,541,445...132,556,838
JBrowse link
G IL5RA interleukin 5 receptor subunit alpha IEP protein:decreased expression:blood, eosinophil RGD PMID:16734609 RGD:5128618 NCBI chr 3:3,066,324...3,110,414
Ensembl chr 3:3,066,324...3,126,613
JBrowse link
G IL6 interleukin 6 severity IEP protein:increased expression:nasal mucus
associated with Otitis media;protein:increased expression:serum:
RGD PMID:20622030 PMID:19352211 RGD:4143259, RGD:8142352 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IL9 interleukin 9 susceptibility ISO
IAGP
DNA:SNPs: :rs2069885, rs1799962 (human) RGD PMID:19915054 PMID:20503287 RGD:5128685, RGD:5128684 NCBI chr 5:135,892,246...135,895,841
Ensembl chr 5:135,892,246...135,895,841
JBrowse link
G IRF1 interferon regulatory factor 1 ISO protein:increased expression:dorsal root ganglion RGD PMID:20045913 RGD:5128775 NCBI chr 5:132,481,609...132,490,789
Ensembl chr 5:132,440,440...132,508,719
JBrowse link
G MIR21 microRNA 21 ameliorates ISO associated with asthma; RGD PMID:27448447 RGD:41404696 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337
JBrowse link
G MMP2 matrix metallopeptidase 2 ISO mRNA, protein:increased expression, increased activity:bronchoalveolar lavage fluid RGD PMID:17254480 RGD:5130726 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 ISO mRNA, protein:increased expression, increased activity:bronchoalveolar lavage fluid RGD PMID:17254480 RGD:5130726 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming ISO associated with Respiratory Hypersensitivity; protein:increased expression:lung RGD PMID:15130904 RGD:5131205 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138
JBrowse link
G NGF nerve growth factor ISO RGD PMID:19824047 RGD:4891065 NCBI chr 1:115,285,915...115,338,253
Ensembl chr 1:115,285,904...115,338,770
JBrowse link
G NGFR nerve growth factor receptor ISO RGD PMID:19824047 RGD:4891065 NCBI chr17:49,495,293...49,515,008
Ensembl chr17:49,495,293...49,515,008
JBrowse link
G PDCD1 programmed cell death 1 ISO
IEP
protein:increased expression:CD4 Tcell, CD8 Tcell from lung:
protein:increased expression: CD8 Tcell from nasal wash:
RGD PMID:25465101 PMID:25465101 RGD:11056952, RGD:11056952 NCBI chr 2:241,849,881...241,858,908
Ensembl chr 2:241,849,884...241,858,894
JBrowse link
G PDE12 phosphodiesterase 12 EXP CTD Direct Evidence: marker/mechanism CTD PMID:26055709 NCBI chr 3:57,556,274...57,656,495
Ensembl chr 3:57,556,274...57,566,848
JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 ameliorates ISO RGD PMID:33303545 RGD:127229923 NCBI chr14:24,336,025...24,339,991
Ensembl chr14:24,336,025...24,340,022
JBrowse link
G RSAD2 radical S-adenosyl methionine domain containing 2 treatment IDA
ISO
RGD PMID:23018837 PMID:23018837 RGD:11554170, RGD:11554170 NCBI chr 2:6,865,733...6,898,239
Ensembl chr 2:6,865,557...6,898,239
JBrowse link
G SARM1 sterile alpha and TIR motif containing 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24478430 NCBI chr17:28,371,694...28,404,049
Ensembl chr17:28,364,356...28,404,049
JBrowse link
G SCGB1A1 secretoglobin family 1A member 1 ISO RGD PMID:12847279 RGD:5144208 NCBI chr11:62,419,033...62,423,195
Ensembl chr11:62,405,103...62,423,195
JBrowse link
G SFTPA1 surfactant protein A1 susceptibility IEP
IAGP
protein:decreased expression:lung
DNA:polymorphisms, haplotype: (human)
RGD PMID:10194154 PMID:19287351 RGD:4143439, RGD:4143495 NCBI chr10:79,610,939...79,615,455
Ensembl chr10:79,610,939...79,615,455
JBrowse link
G SFTPB surfactant protein B severity IEP
IAGP
protein:decreased expression:lung
DNA:SNPs:promoter, cds, intron:-32G>T (rs2077079), p.T131I (rs1130866), 5781A>C (rs2040349) (human)
RGD PMID:10194154 PMID:17498296 RGD:4143439, RGD:4143382 NCBI chr 2:85,657,307...85,668,741
Ensembl chr 2:85,657,314...85,668,741
JBrowse link
G SFTPC surfactant protein C IAGP
ISO
DNA:polymorphism: :138A>C, 186A>G (human) RGD PMID:17121584 PMID:19304906 RGD:4144116, RGD:4144065 NCBI chr 8:22,157,383...22,164,479
Ensembl chr 8:22,156,913...22,164,479
JBrowse link
G SFTPD surfactant protein D susceptibility IEP
IAGP
protein:decreased expression:lung
DNA:polymorphisms: :p.M11T, p.A160T (human
RGD PMID:10194154 PMID:19287351 RGD:4143439, RGD:4143495 NCBI chr10:79,937,740...79,982,236
Ensembl chr10:79,937,467...79,982,614
JBrowse link
G TAC1 tachykinin precursor 1 ISO mRNA,protein:increased expression:lung RGD PMID:10516226 RGD:5147822 NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472
JBrowse link
G TACR1 tachykinin receptor 1 treatment ISO RGD PMID:10516226 RGD:5147822 NCBI chr 2:75,046,463...75,199,520
Ensembl chr 2:75,046,463...75,199,520
JBrowse link
G TICAM1 toll like receptor adaptor molecule 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24478430 NCBI chr19:4,815,932...4,831,712
Ensembl chr19:4,815,932...4,831,712
JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:19019963 RGD:4889534 NCBI chr 4:153,684,080...153,710,643
Ensembl chr 4:153,684,070...153,706,260
JBrowse link
G TLR3 toll like receptor 3 ISO RGD PMID:16424225 RGD:5129224 NCBI chr 4:186,069,156...186,088,073
Ensembl chr 4:186,069,155...186,088,073
JBrowse link
G TLR4 toll like receptor 4 no_association
susceptibility
ISO
IAGP
DNA:SNP:cds:p.D299G (human)
DNA:polymorphisms:cds:p.D259G, T359I (human)
DNA:SNPs:cds:p.D299G, T399I (human)
RGD PMID:19019963 PMID:17449325 PMID:17264400 PMID:17709532 RGD:4889534, RGD:4144164, RGD:4144167, RGD:4144161 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TLR6 toll like receptor 6 ISO RGD PMID:19019963 RGD:4889534 NCBI chr 4:38,822,897...38,857,755
Ensembl chr 4:38,823,715...38,856,817
JBrowse link
G TLR7 toll like receptor 7 IEP associated with Bronchiolitis; mRNA:increased expression:nasopharynx (human) RGD PMID:19386802 RGD:5129471 NCBI chr  X:12,867,072...12,890,361
Ensembl chr  X:12,867,072...12,890,361
JBrowse link
G TLR8 toll like receptor 8 IEP associated with Bronchiolitis; mRNA:increased expression:nasopharynx (human) RGD PMID:19386802 RGD:5129471 NCBI chr  X:12,906,620...12,923,169
Ensembl chr  X:12,906,620...12,923,169
JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:Bronchoalveolar lavage fluid RGD PMID:15791294 RGD:4145715 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TSLP thymic stromal lymphopoietin sexual_dimorphism ISO
IEP
mRNA:increased expression:lung (mouse)
protein:increased expression:nasal mucus (human)
RGD PMID:27156176 PMID:31076663 PMID:28471975 RGD:38549376, RGD:38596346, RGD:38596342 NCBI chr 5:111,070,062...111,078,026
Ensembl chr 5:111,070,062...111,078,026
JBrowse link
Respirovirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL28 C-C motif chemokine ligand 28 ISO mRNA:increased expression:lung (mouse) RGD PMID:17954569 RGD:4892194 NCBI chr 5:43,356,972...43,412,391
Ensembl chr 5:43,376,645...43,412,391
JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO RGD PMID:17641009 RGD:4892127 NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,854...46,376,206
JBrowse link
G MMP9 matrix metallopeptidase 9 ISO mRNA, protein:increased expression, increased activity:lung RGD PMID:16816895 RGD:5130923 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G PPIA peptidylprolyl isomerase A exacerbates ISO RGD PMID:28594325 RGD:150429629 NCBI chr 7:44,795,960...44,803,117
Ensembl chr 7:44,796,680...44,824,564
JBrowse link
subacute sclerosing panencephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme IAGP DNA:insertion/deletion: RGD PMID:16741935 RGD:40400901 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
JBrowse link
G IFNL1 interferon lambda 1 IEP protein:increased expression:blood serum (human) RGD PMID:30077763 RGD:126848745 NCBI chr19:39,296,407...39,298,673
Ensembl chr19:39,296,407...39,298,673
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 20297
    disease by infectious agent 2244
      viral infectious disease 1922
        RNA Virus Infections 1702
          Mononegavirales Infections 98
            Paramyxoviridae Infections 74
              Avulavirus Infections + 0
              Henipavirus Infections + 0
              Morbillivirus Infections + 7
              Pneumovirinae infections + 64
              Respirovirus Infections + 4
              Rubulavirus Infections + 0
paths to the root