RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Dysbiosis
Accession: DOID:9007204
browse the term
Definition: Changes in quantitative and qualitative composition of MICROBIOTA. The changes may lead to altered host microbial interaction or homeostatic imbalance that can contribute to a disease state often with inflammation.
Synonyms: exact_synonym: Disbacterioses; Disbacteriosis; Disbioses; Disbiosis; Dys symbiosis; Dys-symbioses; Dysbacterioses; Dysbacteriosis; Dysbioses
primary_id: MESH:D064806
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Alpi
alkaline phosphatase, intestinal
IMP
RGD
PMID:28985873
RGD:14367878
NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877
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Bdnf
brain-derived neurotrophic factor
ISO
associated with alcohol dependence;mRNA:decreased expression:hippocampus, prefrontal cortex
RGD
PMID:30417952
RGD:596938163
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Foxp3
forkhead box P3
treatment
IEP
RGD
PMID:32227764
RGD:38549571
NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838
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Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
ISO
associated with alcohol dependence;mRNA:decreased expression:hippocampus
RGD
PMID:30417952
RGD:596938163
NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
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Gper1
G protein-coupled estrogen receptor 1
ameliorates
IMP
RGD
PMID:30354811
RGD:39939000
NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
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Gper1em1Bj
G protein-coupled estrogen receptor 1; CRISPR/Cas 9 induced mutant 1, Bj
ameliorates
IMP
RGD
PMID:30354811
RGD:39939000
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Il10
interleukin 10
treatment
IEP
RGD
PMID:32227764
RGD:38549571
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il21
interleukin 21
treatment
IEP
RGD
PMID:32227764
RGD:38549571
NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996
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Rorc
RAR-related orphan receptor C
treatment
IEP
RGD
PMID:32227764
RGD:38549571
NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
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Socs1
suppressor of cytokine signaling 1
ISO
RGD
PMID:30820436
RGD:150573685
NCBI chr10:5,389,574...5,391,265
Ensembl chr10:4,882,560...4,884,383
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Tlr4
toll-like receptor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:35390362
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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