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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Dysbiosis
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Accession:DOID:9007204 term browser browse the term
Definition:Changes in quantitative and qualitative composition of MICROBIOTA. The changes may lead to altered host microbial interaction or homeostatic imbalance that can contribute to a disease state often with inflammation.
Synonyms:exact_synonym: Disbacterioses;   Disbacteriosis;   Disbioses;   Disbiosis;   Dys symbiosis;   Dys-symbioses;   Dysbacterioses;   Dysbacteriosis;   Dysbioses
 primary_id: MESH:D064806


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Dysbiosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPI alkaline phosphatase, intestinal ISO RGD PMID:28985873 RGD:14367878 NCBI chr25:44,107,418...44,110,947 JBrowse link
G BDNF brain derived neurotrophic factor ISO associated with alcohol dependence;mRNA:decreased expression:hippocampus, prefrontal cortex RGD PMID:30417952 RGD:596938163 NCBI chr21:48,191,580...48,243,699
Ensembl chr21:48,192,670...48,204,480 		JBrowse link
G FOXP3 forkhead box P3 treatment ISO RGD PMID:32227764 RGD:38549571 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758 		JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 ISO associated with alcohol dependence;mRNA:decreased expression:hippocampus RGD PMID:30417952 RGD:596938163 NCBI chr 4:49,006,981...49,065,205
Ensembl chr 4:49,009,495...49,062,581 		JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 ameliorates ISO RGD PMID:30354811 RGD:39939000 NCBI chr 6:15,792,072...15,796,922
Ensembl chr 6:15,792,897...15,794,051 		JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:32227764 RGD:38549571 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057 		JBrowse link
G IL21 interleukin 21 treatment ISO RGD PMID:32227764 RGD:38549571 NCBI chr19:17,641,833...17,651,275
Ensembl chr19:17,641,833...17,651,266 		JBrowse link
G RORC RAR related orphan receptor C treatment ISO RGD PMID:32227764 RGD:38549571 NCBI chr17:60,821,498...60,842,485
Ensembl chr17:60,821,981...60,842,453 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 ISO RGD PMID:30820436 RGD:150573685 NCBI chr 6:31,511,003...31,511,995
Ensembl chr 6:31,509,268...31,511,557 		JBrowse link
G TLR4 toll like receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35390362 NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  disease 15757
    Pathological Conditions, Signs and Symptoms 12322
      Pathologic Processes 7822
        Dysbiosis 10
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