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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Stroke
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Accession:DOID:9007096 term browser browse the term
Definition:A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Synonyms:exact_synonym: Acute Cerebrovascular Accident;   Acute Cerebrovascular Accidents;   Acute Stroke;   Acute Strokes;   Apoplexy;   Brain Vascular Accident;   Brain Vascular Accidents;   CVA;   Cerebral Stroke;   Cerebral Strokes;   Cerebrovascular Accidents;   Cerebrovascular Apoplexy;   Cerebrovascular Stroke;   Cerebrovascular Strokes;   STRK1;   cerebrovascular accident;   strokes
 narrow_synonym: post-operative stroke;   small vessel stroke
 related_synonym: stroke, susceptibility to, 1
 primary_id: MESH:D020521
 alt_id: MIM:606799
 xref: EFO:0000712;   EFO:0009956;   EFO:1001504


show annotations for term's descendants           Sort by:
Stroke term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:17673715 RGD:2301906 NCBI chr11:17,447,564...17,531,513
Ensembl chr11:17,133,063...17,216,870 		JBrowse link
G ABO ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr 9:104,354,115...104,399,057
Ensembl chr 9:132,989,574...133,010,324 		JBrowse link
G ACAN aggrecan treatment ISO RGD PMID:24664200 RGD:11570545 NCBI chr15:67,492,494...67,563,265
Ensembl chr15:86,733,853...86,771,420 		JBrowse link
G ACE angiotensin I converting enzyme treatment ISO ClinVar Annotator: match by term: CEREBROVASCULAR ACCIDENT RGD
ClinVar		 PMID:1313972 PMID:1319114 PMID:1328889 PMID:1386652 PMID:1976655 More... RGD:40400712 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853 		JBrowse link
G ACHE acetylcholinesterase (Yt blood group) disease_progression ISO protein:decreased expression:serum RGD PMID:20464061 RGD:5688131 NCBI chr 7:92,915,065...92,922,079
Ensembl chr 7:106,311,944...106,318,184 		JBrowse link
G ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif 12 susceptibility ISO DNA:SNP::rs1364044(human) RGD PMID:22990015 RGD:9681739 NCBI chr 5:76,442,053...76,818,726
Ensembl chr 5:81,827,560...82,199,840 		JBrowse link
G ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif 2 susceptibility ISO DNA:SNP::rs469568(human) RGD PMID:22990015 RGD:9681739 NCBI chr 5:174,264,811...174,502,817
Ensembl chr 5:181,557,928...181,786,175 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO protein:increased expression:plasma,brain
protein:decreased expression:serum 		RGD PMID:19699724 PMID:20047566 RGD:5686837 RGD:5686856 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885 		JBrowse link
G ADM adrenomedullin ISO protein:increased expression:plasma: RGD PMID:21695352 RGD:5508764 NCBI chr11:10,437,712...10,440,053
Ensembl chr11:10,165,418...10,167,842 		JBrowse link
G AGER advanced glycosylation end-product specific receptor treatment
susceptibility 		ISO associated with Diabetes Mellitus, Experimental
DNA:polymorphism:promoter:-374T>A (human) 		RGD PMID:16728681 PMID:21683770 RGD:1625333 RGD:7245961 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641 		JBrowse link
G AGT angiotensinogen susceptibility ISO associated with hypertension;DNA:polymorphism: :p.M235T
associated with sickle cell anemia;DNA:repeat:exon: 		RGD PMID:11754397 PMID:17299437 RGD:11039048 RGD:1601132 NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:19246705 RGD:6903905 NCBI chr  X:105,252,903...105,257,171
Ensembl chr  X:115,671,594...115,672,685 		JBrowse link
G AGXT2 alanine--glyoxylate aminotransferase 2 ISO DNA:SNP:cds:rs40200 (human) RGD PMID:25245031 RGD:329970278 NCBI chr 5:75,322,351...75,373,261
Ensembl chr 5:80,601,554...80,652,575 		JBrowse link
G AHSG alpha 2-HS glycoprotein ISO protein:increased expression:plasma RGD PMID:19029462 RGD:2313810 NCBI chr 3:183,644,223...183,652,620
Ensembl chr 3:192,110,770...192,119,915 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 disease_progression ISO RGD PMID:19440551 RGD:5509077 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756 		JBrowse link
G ALB albumin disease_progression ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD		 PMID:8291969 PMID:14514741 PMID:16174931 PMID:16809570 PMID:17270091 RGD:11036080 NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418 		JBrowse link
G ALDOC aldolase, fructose-bisphosphate C ISO protein:increased expression:cerebrospinal fluid RGD PMID:17053973 RGD:2301133 NCBI chr17:28,198,895...28,202,950
Ensembl chr17:28,700,976...28,706,507 		JBrowse link
G ALOX5AP arachidonate 5-lipoxygenase activating protein ISO mRNA:increased expression:leukocyte (rat)
DNA:polymorphism: :2354T>A (human) 		RGD PMID:17922411 PMID:19373490 RGD:2313886 RGD:2313907 NCBI chr13:12,012,399...12,041,557
Ensembl chr13:30,425,510...30,476,607 		JBrowse link
G ANGPT1 angiopoietin 1 ISO RGD PMID:11822892 PMID:17356562 RGD:1626162 RGD:704373 NCBI chr 8:103,893,234...104,137,661
Ensembl chr 8:106,042,041...106,286,783 		JBrowse link
G ANGPT2 angiopoietin 2 ISO mRNA:increased expression:brain (rat) RGD PMID:15637314 RGD:1626166 NCBI chr 8:718,367...782,534
Ensembl chr 8:6,506,014...6,566,915 		JBrowse link
G ANK2 ankyrin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr 4:105,315,776...105,882,506
Ensembl chr 4:115,967,106...116,443,905 		JBrowse link
G APOA1 apolipoprotein A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19433014 NCBI chr11:111,673,539...111,675,428
Ensembl chr11:115,606,136...115,608,122 		JBrowse link
G APOD apolipoprotein D ISO RGD PMID:17851453 RGD:2311182 NCBI chr 3:192,852,887...192,868,233
Ensembl chr 3:203,152,476...203,168,060 		JBrowse link
G APOH apolipoprotein H ISO RGD PMID:14595478 RGD:2313986 NCBI chr17:60,154,389...60,171,762
Ensembl chr17:65,365,250...65,382,483 		JBrowse link
G ASCL1 achaete-scute family bHLH transcription factor 1 ISO RGD PMID:16730914 RGD:2314146 NCBI chr12:100,536,895...100,539,737
Ensembl chr12:103,932,302...103,932,999 		JBrowse link
G AVP arginine vasopressin ISO protein:decreased expression:plasma RGD PMID:15897635 RGD:1601304 NCBI chr20:3,169,094...3,172,900 JBrowse link
G BCHE butyrylcholinesterase ISO protein:increased expression:serum RGD PMID:20464061 RGD:5688131 NCBI chr 3:162,794,184...162,858,574
Ensembl chr 3:170,845,494...170,911,481 		JBrowse link
G BCL2L1 BCL2 like 1 ISO protein:altered localization:cerebral cortex (mouse) RGD PMID:17301160 RGD:11353792 NCBI chr20:27,955,688...28,015,950
Ensembl chr20:29,088,055...29,146,585 		JBrowse link
G BDNF brain derived neurotrophic factor treatment ISO associated with middle cerebral artery infarction RGD PMID:34284448 RGD:597015748 NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239 		JBrowse link
G BMP4 bone morphogenetic protein 4 ISO protein:increased expression:brain, astrocyte RGD PMID:16730912 RGD:2289004 NCBI chr14:34,542,132...34,549,286
Ensembl chr14:52,821,872...52,828,752 		JBrowse link
G C1H1orf167 chromosome 1 C1orf167 homolog ISO DNA:SNP: :rs56001051(human) RGD PMID:31175347 RGD:14696712 NCBI chr 1:10,524,980...10,551,759
Ensembl chr 1:11,741,083...11,769,155 		JBrowse link
G CASP2 caspase 2 ISO RGD PMID:12067235 RGD:4107080 NCBI chr 7:135,283,072...135,307,855
Ensembl chr 7:147,773,749...147,792,958 		JBrowse link
G CASP3 caspase 3 ISO protein:increased activation:cerebral cortex RGD PMID:18463494 RGD:2293316 NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185 		JBrowse link
G CAST calpastatin ISO RGD PMID:20116408 RGD:5509801 NCBI chr 5:91,972,572...92,084,657
Ensembl chr 5:97,527,071...97,636,650 		JBrowse link
G CASZ1 castor zinc finger 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr 1:9,396,936...9,557,100
Ensembl chr 1:10,622,519...10,677,091 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO protein:increased expression:brain, neuron
DNA:snp:promoter:g.-2518A>G (human) 		RGD PMID:15308783 PMID:18473828 RGD:1581163 RGD:2307024 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G CD40 CD40 molecule ISO associated with Hypertension RGD PMID:20456428 RGD:5490543 NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994 		JBrowse link
G CD44 CD44 molecule (IN blood group) ISO RGD PMID:16837837 RGD:2289371 NCBI chr11:35,110,732...35,258,238
Ensembl chr11:34,985,634...35,079,009 		JBrowse link
G CD63 CD63 molecule ISO protein:increased expression:platelet RGD PMID:19233449 RGD:2314182 NCBI chr12:33,181,896...33,186,123
Ensembl chr12:33,906,314...33,910,595 		JBrowse link
G CDK6 cyclin dependent kinase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr 7:84,603,419...84,835,082 JBrowse link
G CFH complement factor H ISO protein:decreased expression:plasma: RGD PMID:21695352 RGD:5508764 NCBI chr 1:172,155,882...172,251,632
Ensembl chr 1:176,455,247...176,525,521 		JBrowse link
G COL4A1 collagen type IV alpha 1 chain ISO RGD PMID:16374828 RGD:1581205 NCBI chr13:91,282,617...91,440,187
Ensembl chr13:110,407,009...110,562,529 		JBrowse link
G CSF3 colony stimulating factor 3 ISO RGD PMID:17656664 RGD:5134350 NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729 		JBrowse link
G CSPG4 chondroitin sulfate proteoglycan 4 ISO RGD PMID:21951366 RGD:5686849 NCBI chr15:54,583,010...54,621,240
Ensembl chr15:74,177,909...74,200,498 		JBrowse link
G CTNNB1 catenin beta 1 ISO protein:increased phosphorylation, decreased expression:brain RGD PMID:18241848 RGD:2289837 NCBI chr 3:41,104,940...41,145,934
Ensembl chr 3:41,373,726...41,414,030 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr  X:60,880,759...60,883,355
Ensembl chr  X:70,933,160...70,935,756 		JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 ISO associated with Hypertension;DNA:polymorphism RGD PMID:15894891 RGD:2307308 NCBI chr 8:139,622,632...139,630,014
Ensembl chr 8:142,666,534...142,672,575 		JBrowse link
G EDN1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20083630 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545 		JBrowse link
G EDNRA endothelin receptor type A ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:17597600 PMID:29531354 RGD:4892584 NCBI chr 4:139,815,336...139,879,600
Ensembl chr 4:151,476,356...151,536,497 		JBrowse link
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 susceptibility ISO associated with Anemia, Sickle Cell;DNA:missense mutation:cds:p.K173Q (human) RGD PMID:23422753 RGD:13204735 NCBI chr 6:129,591,858...129,673,000
Ensembl chr 6:133,698,640...133,783,644 		JBrowse link
G EPHX2 epoxide hydrolase 2 susceptibility ISO DNA:missense mutation:cds:p.K55R (human)
DNA:SNPs, haplotype:promoter:-255T>C, -111G>A, 25C>T (rat)
DNA:SNP:intron:IVS16 (rs2291635) (human) 		RGD PMID:18086949 PMID:18323494 PMID:20065888 RGD:5688362 RGD:5688363 RGD:5688727 NCBI chr 8:26,761,090...26,818,436
Ensembl chr 8:23,964,094...24,017,749 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 ISO protein:increased expression:brain RGD PMID:15694257 RGD:2289956 NCBI chr2B:98,625,630...99,795,371
Ensembl chr2B:217,069,644...218,272,006 		JBrowse link
G ESR2 estrogen receptor 2 treatment ISO RGD PMID:24406718 RGD:10045677 NCBI chr14:44,807,875...44,919,780
Ensembl chr14:63,064,402...63,131,303 		JBrowse link
G F12 coagulation factor XII susceptibility ISO DNA:polymorphism::46C>T(human) RGD PMID:15232129 RGD:11041862 NCBI chr 5:172,703,724...172,711,618
Ensembl chr 5:179,766,243...179,773,485 		JBrowse link
G F13A1 coagulation factor XIII A chain ISO RGD PMID:11692020 RGD:1581026 NCBI chr 6:5,978,505...6,156,705
Ensembl chr 6:6,157,926...6,513,961 		JBrowse link
G F2 coagulation factor II, thrombin ISO ClinVar Annotator: match by term: CEREBROVASCULAR ACCIDENT ClinVar PMID:2222810 PMID:2429850 PMID:2825773 PMID:6305407 PMID:6405779 More... NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157 		JBrowse link
G F5 coagulation factor V ISO ClinVar Annotator: match by term: CEREBROVASCULAR ACCIDENT ClinVar PMID:7586244 PMID:7803250 PMID:7877648 PMID:7910348 PMID:7911872 More... NCBI chr 1:144,996,757...145,070,046
Ensembl chr 1:148,718,897...148,790,915 		JBrowse link
G F8 coagulation factor VIII ISO RGD PMID:15202164 RGD:1582360 NCBI chr  X:144,316,192...144,505,773
Ensembl chr  X:154,156,873...154,341,317 		JBrowse link
G FABP2 fatty acid binding protein 2 ISO DNA:missense mutation:cds:p.A54T (human) RGD PMID:10946885 RGD:1300312 NCBI chr 4:111,505,269...111,510,197
Ensembl chr 4:122,055,544...122,060,461 		JBrowse link
G FBN1 fibrillin 1 ISO ClinVar Annotator: match by term: CEREBROVASCULAR ACCIDENT ClinVar PMID:7611299 PMID:8894692 PMID:9401003 PMID:9536098 PMID:10533071 More... NCBI chr15:27,358,780...27,593,539
Ensembl chr15:45,682,450...45,918,111 		JBrowse link
G FGA fibrinogen alpha chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr 4:146,949,680...146,957,291 JBrowse link
G FGB fibrinogen beta chain susceptibility ISO DNA:SNP:promoter:1038G>A (rs1800791) (human)
DNA:polymorphism: :-455G>A(human) 		RGD PMID:18278190 PMID:24107890 RGD:10450767 RGD:5688760 NCBI chr 4:146,929,561...146,937,665
Ensembl chr 4:158,747,659...158,755,766 		JBrowse link
G FGG fibrinogen gamma chain susceptibility ISO DNA:SNP:promoter:902A>G (rs1800792) (human) RGD PMID:18278190 RGD:5688760 NCBI chr 4:146,970,671...146,979,348
Ensembl chr 4:158,788,966...158,797,237 		JBrowse link
G FOXF2 forkhead box F2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr 6:1,209,899...1,215,970 JBrowse link
G GAS6 growth arrest specific 6 ISO RGD PMID:15108283 RGD:1579883 Ensembl chr13:113,968,843...114,009,562 JBrowse link
G GFAP glial fibrillary acidic protein severity ISO protein:increased expression:cerebrospinal fluid RGD PMID:19959621 RGD:5508793 NCBI chr17:12,407,211...12,417,072
Ensembl chr17:12,579,754...12,591,961 		JBrowse link
G GFRA1 GDNF family receptor alpha 1 ISO mRNA:increased expression:brain RGD PMID:11476594 RGD:6218974 NCBI chr10:112,645,574...112,862,413
Ensembl chr10:116,079,063...116,295,164 		JBrowse link
G GPX3 glutathione peroxidase 3 ISO protein:decreased expression:plasma RGD PMID:10446087 RGD:401827831 NCBI chr 5:146,447,939...146,456,476 JBrowse link
G GRN granulin precursor ISO ClinVar Annotator: match by term: CEREBROVASCULAR ACCIDENT ClinVar PMID:18723524 PMID:25741868 PMID:28492532 NCBI chr17:13,046,329...13,054,236
Ensembl chr17:13,211,784...13,219,609 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 susceptibility ISO associated with sickle cell anemia; RGD PMID:23590899 RGD:10450838 Ensembl chr 1:127,979,238...128,010,411 JBrowse link
G HDAC1 histone deacetylase 1 ISO RGD PMID:24657831 RGD:9590303 NCBI chr 1:31,578,373...31,619,970
Ensembl chr 1:32,585,791...32,626,410 		JBrowse link
G HDAC2 histone deacetylase 2 ISO mRNA:decreased expression:lymphocyte RGD PMID:24657831 PMID:31465536 RGD:156430320 RGD:9590303 NCBI chr 6:111,731,139...111,761,826
Ensembl chr 6:115,802,367...115,833,004 		JBrowse link
G HDAC4 histone deacetylase 4 ISO RGD PMID:24657831 RGD:9590303 NCBI chr2B:126,287,745...126,649,815
Ensembl chr2B:245,123,061...245,427,054 		JBrowse link
G HDAC9 histone deacetylase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22306652 NCBI chr 7:18,740,580...19,653,615
Ensembl chr 7:18,138,761...18,970,717 		JBrowse link
G HGF hepatocyte growth factor treatment ISO RGD PMID:16421510 RGD:8548626 NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:16316970 RGD:5508472 NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785 		JBrowse link
G HMOX1 heme oxygenase 1 ISO RGD PMID:14753445 RGD:1598410 NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063 		JBrowse link
G HTR4 5-hydroxytryptamine receptor 4 ISO CTD Direct Evidence: therapeutic CTD PMID:7886817 NCBI chr 5:143,918,925...144,208,779
Ensembl chr 5:149,889,969...150,108,357 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:10066862 PMID:20083630 RGD:11522710 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605 		JBrowse link
G IFNG interferon gamma ISO mRNA:decreased expression:lymphocyte RGD PMID:31465536 RGD:156430320 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IGF1 insulin like growth factor 1 severity ISO RGD PMID:15567334 PMID:16882751 RGD:1598413 RGD:1598423 NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177 		JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO DNA: SNP: : rs2229765 RGD PMID:18477064 RGD:5686435 NCBI chr15:77,332,926...77,648,474
Ensembl chr15:96,535,164...96,832,974 		JBrowse link
G IL10 interleukin 10 treatment
severity
no_association 		ISO mRNA:increased expression:brain RGD PMID:15894335 PMID:16323614 PMID:23786953 PMID:23981596 RGD:1598623 RGD:1598629 RGD:7364869 RGD:7365015 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL18 interleukin 18 ISO mRNA:increased expression:brain RGD PMID:21171972 RGD:4891154 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371 		JBrowse link
G IL1B interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:10950380 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO CTD Direct Evidence: marker/mechanism
rat model treated with human protein 		CTD
RGD		 PMID:12374626 PMID:22781338 RGD:6909180 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839 		JBrowse link
G IL4 interleukin 4 ISO mRNA:increased expression:lymphocyte RGD PMID:31465536 RGD:156430320 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G IL4R interleukin 4 receptor disease_progression
susceptibility 		ISO associated with Anemia, Sickle Cell;DNA:polymorphism:cds:p.S503P(rs1805015)(human) RGD PMID:14615367 PMID:24386991 RGD:11529997 RGD:11530005 Ensembl chr16:27,642,702...27,737,445 JBrowse link
G IL6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:14512079 PMID:18319729 RGD:1580486 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G IRF1 interferon regulatory factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr 5:127,903,887...127,913,843
Ensembl chr 5:134,067,441...134,075,035 		JBrowse link
G ITGA2 integrin subunit alpha 2 susceptibility
no_association 		ISO DNA:SNP::807C>T(human) RGD PMID:12871362 PMID:25207168 RGD:13592606 RGD:1582299 NCBI chr 5:60,935,452...61,040,726
Ensembl chr 5:62,555,370...62,659,720 		JBrowse link
G ITGA2B integrin subunit alpha 2b ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:9445356 PMID:15678115 RGD:2316358 NCBI chr17:13,009,514...13,027,289
Ensembl chr17:13,176,843...13,193,269 		JBrowse link
G ITGAM integrin subunit alpha M treatment ISO RGD PMID:12805500 RGD:329901938 NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406 		JBrowse link
G ITGAV integrin subunit alpha V ISO CTD Direct Evidence: marker/mechanism CTD PMID:9445356 NCBI chr2B:73,880,962...73,972,486
Ensembl chr2B:191,680,655...191,773,028 		JBrowse link
G ITGB3 integrin subunit beta 3 ISO associated with hypertension; DNA:polymorphism:exon
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:9445356 PMID:15678115 PMID:20846430 RGD:2316358 RGD:5128476 NCBI chr17:10,134,450...10,194,596
Ensembl chr17:10,353,111...10,392,382 		JBrowse link
G JAK2 Janus kinase 2 ISO RGD PMID:18079966 RGD:6483032 NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626 		JBrowse link
G KCNK3 potassium two pore domain channel subfamily K member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr2A:26,688,938...26,729,860
Ensembl chr2A:26,780,475...26,819,123 		JBrowse link
G KDR kinase insert domain receptor ISO RGD PMID:20101028 RGD:5684395 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109 		JBrowse link
G KIF6 kinesin family member 6 ISO DNA:SNP: :p.W719R (rs20455) (human) RGD PMID:19752551 RGD:2317144 NCBI chr 6:38,917,083...39,306,190
Ensembl chr 6:40,234,426...40,616,738 		JBrowse link
G KL klotho ISO RGD PMID:15677572 RGD:1581727 NCBI chr13:14,272,463...14,321,122
Ensembl chr13:32,702,336...32,751,458 		JBrowse link
G KNG1 kininogen 1 susceptibility ISO DNA:SNP: :rs710446(human) RGD PMID:26159646 RGD:10411883 NCBI chr 3:183,751,598...183,778,655
Ensembl chr 3:192,219,462...192,245,149 		JBrowse link
G LCN2 lipocalin 2 ISO protein:increased expression:brain, neuron RGD PMID:24916903 RGD:126790489 NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798 		JBrowse link
G LDLR low density lipoprotein receptor susceptibility ISO DNA:SNPs:introns: (rs2738446, rs2738450) (human) RGD PMID:19589204 RGD:5490232 NCBI chr19:10,640,225...10,683,728
Ensembl chr19:11,357,311...11,396,791 		JBrowse link
G LIF LIF interleukin 6 family cytokine ISO RGD PMID:18042242 RGD:2326063 NCBI chr22:11,276,576...11,282,972
Ensembl chr22:29,078,862...29,095,608 		JBrowse link
G LOC100972994 HLA class II histocompatibility antigen, DQ beta 1 chain susceptibility ISO DNA:polymorphism:cds:HLA-DQB1*0402 (human) RGD PMID:12373032 RGD:5147804 NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272 		JBrowse link
G LOC100976904 growth-regulated alpha protein ISO mRNA:increased expression:brain RGD PMID:21124781 RGD:5134994 NCBI chr 4:50,325,248...50,327,165
Ensembl chr 4:56,153,899...56,159,474 		JBrowse link
G LOC100991644 low affinity immunoglobulin gamma Fc region receptor II-a susceptibility ISO DNA:SNPs:enhancers: (rs7512140, rs7535475) (human)
DNA:SNPs:enhancers:multiple 		RGD PMID:19357503 PMID:20034444 RGD:5147920 RGD:5147924 NCBI chr 1:136,892,311...136,906,450 JBrowse link
G LPA lipoprotein(a) ISO DNA:SNP:CDS:rs3798220, g.160961137T>C, p.Ile1891Met
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:10484779 PMID:18775538 RGD:5509091 NCBI chr 6:158,434,394...158,628,028 JBrowse link
G LRCH1 leucine rich repeats and calponin homology domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr13:27,697,684...27,897,762
Ensembl chr13:46,416,017...46,613,065 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 treatment ISO RGD PMID:33434616 RGD:155791452 NCBI chr 6:88,398,329...88,470,926
Ensembl chr 6:91,664,263...91,737,468 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 ISO RGD PMID:10773432 RGD:1582317 NCBI chr10:45,806,748...45,936,362 JBrowse link
G MIF macrophage migration inhibitory factor ISO mRNA,protein:increased expression:brain
mRNA,protein:increased expression:leukocytes, mononuclear, plasma 		RGD PMID:19131653 RGD:4890976 NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009 		JBrowse link
G MMP1 matrix metallopeptidase 1 ISO RGD PMID:11720009 RGD:1582542 NCBI chr11:97,730,545...97,739,190
Ensembl chr11:101,221,393...101,230,104 		JBrowse link
G MMP12 matrix metallopeptidase 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr11:97,809,644...97,822,063
Ensembl chr11:101,294,475...101,306,762 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO protein:increased expression: : RGD PMID:16599837 PMID:19840223 RGD:1582617 RGD:2325713 NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279 		JBrowse link
G MMP3 matrix metallopeptidase 3 treatment ISO RGD PMID:24194350 RGD:8694111 NCBI chr11:97,776,729...97,784,549
Ensembl chr11:101,267,566...101,275,354 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO protein:increased expression, increased activity:brain, plasma RGD PMID:16051896 PMID:16690896 PMID:19556529 RGD:1582615 RGD:1582635 RGD:2325825 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase no_association ISO associated with Anemia, Sickle Cell;DNA:missense mutation:cds:677C>T (human)
DNA:transition:cds:g.677C>T (human)
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:9840906 PMID:15534175 PMID:15652605 PMID:16681562 PMID:19646848 RGD:10449417 RGD:6893467 NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419 		JBrowse link
G MYH15 myosin heavy chain 15 ISO DNA:snp:exon:EX28T>C rs3900940 (human) RGD PMID:19752551 RGD:2317144 NCBI chr 3:105,498,196...105,635,979
Ensembl chr 3:112,432,417...112,586,559 		JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 ISO RGD PMID:22417925 RGD:6893327 NCBI chr 5:137,467,161...137,511,569
Ensembl chr 5:143,600,789...143,622,913 		JBrowse link
G NDUFC2 NADH:ubiquinone oxidoreductase subunit C2 susceptibility ISO DNA:SNPs,haplotype::rs641836, rs11237379 (human)
incidence 40% in heterozygous SHR-Ndufc2 rats vs 0% in parental SHR rats after 3 months of stroke-permissive diet 		RGD PMID:26888427 RGD:11040458 NCBI chr11:73,128,457...73,140,344
Ensembl chr11:76,720,094...76,763,098 		JBrowse link
G NEDD4L NEDD4 like E3 ubiquitin protein ligase ISO RGD PMID:22417925 RGD:6893327 NCBI chr18:51,428,077...51,792,995
Ensembl chr18:54,867,149...55,123,423 		JBrowse link
G NEFL neurofilament light chain ISO RGD PMID:29967576 RGD:27226878 NCBI chr 8:24,218,510...24,224,627
Ensembl chr 8:21,134,533...21,140,694 		JBrowse link
G NGF nerve growth factor ISO RGD PMID:19061539 RGD:2303801 NCBI chr 1:87,223,597...87,276,759 JBrowse link
G NKX2-5 NK2 homeobox 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr 5:168,584,197...168,589,406
Ensembl chr 5:175,492,288...175,495,514 		JBrowse link
G NOS1 nitric oxide synthase 1 ISO RGD PMID:19408167 RGD:5132594 NCBI chr12:114,784,232...114,938,385
Ensembl chr12:118,163,655...118,314,005 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO mRNA:increased expression:brain
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:20083630 PMID:21171972 RGD:4891154 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093 		JBrowse link
G NOS3 nitric oxide synthase 3 susceptibility
treatment 		ISO associated with Anemia, Sickle Cell;DNA:repeats:intron: RGD PMID:18234158 PMID:25263931 PMID:29152647 RGD:11533931 RGD:13504814 RGD:2292103 NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233 		JBrowse link
G NOSTRIN nitric oxide synthase trafficking ISO RGD PMID:11489260 RGD:631971 NCBI chr2B:56,064,199...56,126,759
Ensembl chr2B:173,516,771...173,592,692 		JBrowse link
G NOTCH3 notch receptor 3 ISO ClinVar Annotator: match by term: Stroke ClinVar PMID:8878478 PMID:9388399 PMID:12754354 PMID:15229130 PMID:15857853 More... NCBI chr19:14,692,571...14,733,758
Ensembl chr19:15,678,674...15,715,080 		JBrowse link
G NPPA natriuretic peptide A susceptibility ISO DNA:missense:exon:rs5063(human)
DNA:SNP, missense mutation:intron 2, CDS:1837G>A, 664G>A (p.V7M) (human)
DNA:polymorphism:TC2238 		RGD PMID:10525492 PMID:15017020 PMID:25452597 RGD:14696737 RGD:149735577 RGD:1580137 NCBI chr 1:10,608,025...10,610,287
Ensembl chr 1:11,825,072...11,827,373 		JBrowse link
G NPY1R neuropeptide Y receptor Y1 ISO RGD PMID:10891620 RGD:1642319 NCBI chr 4:155,583,870...155,604,336
Ensembl chr 4:167,372,310...167,381,597 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO RGD PMID:20858282 RGD:4892205 NCBI chr 5:138,634,278...139,089,171
Ensembl chr 5:144,741,452...144,865,269 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 treatment ISO associated with middle cerebral artery infarction RGD PMID:34284448 RGD:597015748 NCBI chr 9:39,663,986...40,208,770
Ensembl chr 9:84,021,837...84,372,678 		JBrowse link
G PAK1 p21 (RAC1) activated kinase 1 ISO mRNA, protein:increased expression:brain RGD PMID:17997827 RGD:2299171 NCBI chr11:72,372,577...72,524,817
Ensembl chr11:76,015,998...76,104,197 		JBrowse link
G PAOX polyamine oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16269634 Ensembl chr10:134,294,760...134,307,179 JBrowse link
G PDE3A phosphodiesterase 3A ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr12:20,380,213...20,690,540
Ensembl chr12:20,763,999...21,064,391 		JBrowse link
G PDE4D phosphodiesterase 4D ISO mRNA:increased expression:blood, leukocyte RGD PMID:14517540 PMID:16675738 PMID:16825591 PMID:16914755 PMID:17922411 RGD:1581003 RGD:1581004 RGD:1581005 RGD:1581007 RGD:2313907 NCBI chr 5:53,510,287...55,039,181
Ensembl chr 5:55,749,214...56,670,111 		JBrowse link
G PDE5A phosphodiesterase 5A ISO RGD PMID:19729580 RGD:2314459 NCBI chr 4:111,682,772...111,817,234
Ensembl chr 4:122,832,175...122,966,636 		JBrowse link
G PDGFRA platelet derived growth factor receptor alpha ISO mRNA, protein:increased expression:cerebral cortex RGD PMID:15342968 RGD:2292165 NCBI chr 4:69,639,081...69,709,870
Ensembl chr 4:76,199,382...76,271,097 		JBrowse link
G PGF placental growth factor ISO protein:increased expression:brain, astrocyte RGD PMID:11939589 RGD:6483603 NCBI chr14:55,494,152...55,508,066
Ensembl chr14:74,338,976...74,352,964 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO ClinVar Annotator: match by term: Stroke ClinVar PMID:15520168 PMID:22658544 PMID:22729222 PMID:23100325 PMID:23946963 More... NCBI chr 3:176,182,765...176,272,024
Ensembl chr 3:184,355,785...184,441,977 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO RGD PMID:21546487 RGD:6482678 NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614 		JBrowse link
G PITX2 paired like homeodomain 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr 4:103,112,624...103,137,356 JBrowse link
G PLA2G7 phospholipase A2 group VII ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:serum 		CTD
RGD		 PMID:19644070 PMID:21356620 RGD:6482786 NCBI chr 6:46,264,262...46,318,487
Ensembl chr 6:47,558,861...47,590,212 		JBrowse link
G PLAT plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD		 PMID:1598096 PMID:2124386 PMID:2514002 PMID:7477192 PMID:8427107 More... RGD:2311666 RGD:9698433 NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779 		JBrowse link
G PLAU plasminogen activator, urokinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12742636 NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136 		JBrowse link
G PON2 paraoxonase 2 ISO large vessel disease (LVD) stroke;DNA:missense mutation:cds:p.C311S (human)
associated with type 2 diabetes mellitus;DNA:missense mutation:cds:p.S311C (human) 		RGD PMID:12778447 PMID:17406108 RGD:1642614 RGD:2313491 NCBI chr 7:87,362,447...87,392,795
Ensembl chr 7:100,950,074...100,980,433 		JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A treatment ISO RGD PMID:24573692 RGD:9999417 NCBI chr19:45,872,596...45,876,376
Ensembl chr19:54,880,141...54,883,003 		JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 ISO CTD Direct Evidence: therapeutic CTD PMID:20847317 NCBI chr 1:55,928,577...55,998,628
Ensembl chr 1:57,664,237...57,702,227 		JBrowse link
G PRKAG2 protein kinase AMP-activated non-catalytic subunit gamma 2 ISO ClinVar Annotator: match by term: Stroke ClinVar PMID:25741868 PMID:28492532 PMID:37198425 NCBI chr 7:143,143,556...143,463,492
Ensembl chr 7:155,293,748...155,610,078 		JBrowse link
G PRKCD protein kinase C delta ISO RGD PMID:17350602 RGD:1642524 NCBI chr 3:53,104,137...53,135,588
Ensembl chr 3:54,330,328...54,357,910 		JBrowse link
G PROZ protein Z, vitamin K dependent plasma glycoprotein ISO RGD PMID:15879328 RGD:1580691 NCBI chr13:94,294,846...94,314,458
Ensembl chr13:113,364,280...113,383,010 		JBrowse link
G PRPF8 pre-mRNA processing factor 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr17:1,635,991...1,669,703
Ensembl chr17:1,532,579...1,565,254 		JBrowse link
G PTGER4 prostaglandin E receptor 4 ISO RGD PMID:21965326 RGD:6483526 NCBI chr 5:69,686,906...69,700,739
Ensembl chr 5:74,731,470...74,745,148 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:15138244 PMID:20083630 RGD:1581289 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519 		JBrowse link
G PTH parathyroid hormone ISO protein:increased expression:serum (human) RGD PMID:23460043 RGD:7242420 NCBI chr11:13,653,777...13,657,901
Ensembl chr11:13,347,838...13,351,802 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 ISO protein:increased expression:cerebral cortex (mouse) RGD PMID:32788467 RGD:401976392 NCBI chr20:46,854,918...46,929,509
Ensembl chr20:47,983,098...48,057,421 		JBrowse link
G RETN resistin ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNP:promoter:-420G>C (rs1862513) (human) RGD PMID:19269054 RGD:2313497 NCBI chr19:6,958,536...6,960,032
Ensembl chr19:7,812,942...7,814,909 		JBrowse link
G RGS7 regulator of G protein signaling 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr 1:216,329,373...216,919,898
Ensembl chr 1:221,313,924...221,899,627 		JBrowse link
G RNLS renalase, FAD dependent amine oxidase ISO DNA:SNP: : rs10887800 (human) RGD PMID:21964580 RGD:7327172 NCBI chr10:84,996,999...85,304,240
Ensembl chr10:88,503,683...88,808,990 		JBrowse link
G S100B S100 calcium binding protein B severity ISO protein:increased expression:serum RGD PMID:17706250 PMID:19959621 RGD:5508793 RGD:5508838 NCBI chr21:33,063,845...33,070,073
Ensembl chr21:46,197,750...46,203,953 		JBrowse link
G SCNN1A sodium channel epithelial 1 subunit alpha ISO RGD PMID:15734793 RGD:5509790 NCBI chr12:6,475,723...6,506,443 JBrowse link
G SELL selectin L susceptibility ISO DNA:missense mutation:cds:p.P213S (human) RGD PMID:21465128 RGD:5685695 NCBI chr 1:145,173,700...145,194,927
Ensembl chr 1:148,895,373...148,916,393 		JBrowse link
G SELP selectin P ISO RGD PMID:20122276 RGD:6478688 NCBI chr 1:145,071,094...145,112,851
Ensembl chr 1:148,793,677...148,834,701 		JBrowse link
G SERPINE1 serpin family E member 1 ISO protein:increased expression:plasma RGD PMID:11450024 RGD:4144847 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450 		JBrowse link
G SH2B3 SH2B adaptor protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr12:108,977,344...109,024,029 JBrowse link
G SH3PXD2A SH3 and PX domains 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr10:100,193,961...100,455,200
Ensembl chr10:103,663,163...103,861,437 		JBrowse link
G SMOX spermine oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16269634 NCBI chr20:4,167,417...4,206,956
Ensembl chr20:3,965,616...4,004,468 		JBrowse link
G SOD1 superoxide dismutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10698074 NCBI chr21:18,029,831...18,037,526 JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:19741150 RGD:2315083 NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634 		JBrowse link
G TBX3 T-box transcription factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr12:112,240,050...112,254,299
Ensembl chr12:115,620,002...115,631,316 		JBrowse link
G TGFA transforming growth factor alpha ISO RGD PMID:19248822 RGD:2317476 NCBI chr2A:70,510,727...70,617,628
Ensembl chr2A:71,625,196...71,731,461 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973 		JBrowse link
G THBD thrombomodulin ISO RGD PMID:20581778 PMID:21645225 RGD:5684982 RGD:5684986 NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 ISO mRNA:increased expression:cerebral cortex RGD PMID:9472898 RGD:2290356 NCBI chr  X:40,018,190...40,022,636
Ensembl chr  X:47,914,906...47,919,419 		JBrowse link
G TLR4 toll like receptor 4 ISO associated with atherosclerosis;protein:increased expression:endothelial cell: RGD PMID:20001205 RGD:7794781 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TNF tumor necrosis factor susceptibility ISO mRNA:increased expression:brain
CTD Direct Evidence: marker/mechanism
associated with Anemia, Sickle Cell;DNA:polymorphism:promoter:-308G>A(rs1800629)(human) 		RGD
CTD		 PMID:10950380 PMID:14615367 PMID:21171972 RGD:11529997 RGD:4891154 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b ISO protein:increased expression:serum RGD PMID:17258300 RGD:1620776 NCBI chr 8:115,614,778...115,643,387
Ensembl chr 8:118,134,305...118,162,422 		JBrowse link
G TNNI3 troponin I3, cardiac type ISO RGD PMID:15604421 RGD:1580421 NCBI chr19:52,193,061...52,198,782
Ensembl chr19:60,887,630...60,894,219 		JBrowse link
G TSPAN2 tetraspanin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr 1:87,472,017...87,511,719
Ensembl chr 1:122,520,308...122,561,850 		JBrowse link
G UCP2 uncoupling protein 2 ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:12858170 RGD:7204436 NCBI chr11:69,047,397...69,056,056
Ensembl chr11:72,354,529...72,363,185 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 susceptibility ISO associated with sickle cell anemia;DNA:missense mutation:exon 6:1238G>C (human) RGD PMID:12393616 RGD:737738 NCBI chr 1:103,377,815...103,395,118
Ensembl chr 1:102,091,336...102,107,732 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO protein:increased expression:brain: RGD PMID:11585245 RGD:7421577 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353 		JBrowse link
G VKORC1 vitamin K epoxide reductase complex subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16549638 NCBI chr16:23,871,756...23,876,599
Ensembl chr16:31,459,560...31,464,897 		JBrowse link
G WNT2B Wnt family member 2B ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr 1:115,119,360...115,177,942
Ensembl chr 1:125,173,906...125,230,675 		JBrowse link
G ZCCHC14 zinc finger CCHC-type containing 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr16:68,078,237...68,165,406
Ensembl chr16:87,401,184...87,486,124 		JBrowse link
G ZFHX3 zinc finger homeobox 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29531354 NCBI chr16:51,936,471...52,209,695
Ensembl chr16:72,635,666...72,808,360 		JBrowse link
brain infarction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO RGD PMID:19362080 RGD:5686830 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885 		JBrowse link
G ADK adenosine kinase ISO RGD PMID:9731623 PMID:16685255 RGD:6482657 RGD:6482667 NCBI chr10:70,672,967...71,236,950
Ensembl chr10:73,342,900...73,902,490 		JBrowse link
G ADM adrenomedullin treatment ISO RGD PMID:21695352 RGD:5508764 NCBI chr11:10,437,712...10,440,053
Ensembl chr11:10,165,418...10,167,842 		JBrowse link
G ADNP activity dependent neuroprotector homeobox ISO RGD PMID:11935065 RGD:1358226 NCBI chr20:47,233,696...47,276,075
Ensembl chr20:48,361,043...48,400,387 		JBrowse link
G AIF1 allograft inflammatory factor 1 ISO protein:increased expression:brain subventricular zone (rat)
protein:increased expression:brain white matter (human) 		RGD PMID:10683518 PMID:19053043 RGD:2313025 RGD:2313026 NCBI chr 6:31,276,215...31,278,051
Ensembl chr 6:32,166,301...32,168,125 		JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member susceptibility ISO RGD PMID:17388993 RGD:1601161 NCBI chr12:109,343,020...109,385,060
Ensembl chr12:112,734,243...112,776,471 		JBrowse link
G ALOX5AP arachidonate 5-lipoxygenase activating protein ISO associated with Metabolic Syndrome X; DNA:polymorphism:g.162A>C rs4769055 (human) RGD PMID:18506375 RGD:2311309 NCBI chr13:12,012,399...12,041,557
Ensembl chr13:30,425,510...30,476,607 		JBrowse link
G ARRB2 arrestin beta 2 ISO protein:increased expression:spleen RGD PMID:29636059 RGD:401938621 NCBI chr17:4,766,616...4,777,253
Ensembl chr17:4,757,048...4,767,517 		JBrowse link
G ATP2B2 ATPase plasma membrane Ca2+ transporting 2 ISO mRNA:decreased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr 3:10,260,556...10,643,346
Ensembl chr 3:10,611,619...10,738,006 		JBrowse link
G BECN1 beclin 1 ISO protein:increased expression:brain RGD PMID:22227058 RGD:6483057 NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286 		JBrowse link
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 ISO mRNA:decreased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr 7:73,917,439...74,410,627
Ensembl chr 7:87,579,004...88,068,482 		JBrowse link
G CALCRL calcitonin receptor like receptor ISO mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr2B:74,622,892...74,728,067
Ensembl chr2B:192,422,283...192,463,064 		JBrowse link
G CD8A CD8 subunit alpha ISO mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr2A:86,832,559...86,855,772
Ensembl chr2A:88,377,722...88,382,635 		JBrowse link
G CFH complement factor H treatment ISO RGD PMID:21695352 RGD:5508764 NCBI chr 1:172,155,882...172,251,632
Ensembl chr 1:176,455,247...176,525,521 		JBrowse link
G CORT cortistatin ISO mRNA:decreased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr 1:9,210,186...9,212,201 JBrowse link
G CTSB cathepsin B ISO protein:increased expression:cerebral cortical segment, cytoplasm (rat) RGD PMID:19941836 RGD:2315502 NCBI chr 8:7,333,498...7,359,264 JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO protein:increased expression:brain (rat) RGD PMID:19895873 RGD:2325193 NCBI chr 4:48,182,355...48,184,733
Ensembl chr 4:54,020,204...54,022,606 		JBrowse link
G CYBB cytochrome b-245 beta chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:19417757 NCBI chr  X:30,230,394...30,267,379
Ensembl chr  X:37,939,704...37,973,183 		JBrowse link
G CYP2R1 cytochrome P450 family 2 subfamily R member 1 ISO DNA:variants:CDS:multiple (human) RGD PMID:36762557 RGD:401901151 NCBI chr11:14,960,651...14,989,083
Ensembl chr11:14,656,939...14,671,584 		JBrowse link
G DCX doublecortin ISO protein:altered expression:brain (rat) RGD PMID:12161747 RGD:155630606 NCBI chr  X:100,411,871...100,529,833
Ensembl chr  X:110,875,032...110,988,582 		JBrowse link
G ECE1 endothelin converting enzyme 1 ISO RGD PMID:15485550 RGD:1580908 NCBI chr 1:20,166,019...20,290,803
Ensembl chr 1:21,206,199...21,278,909 		JBrowse link
G FGF2 fibroblast growth factor 2 ISO CTD Direct Evidence: therapeutic CTD PMID:17524524 NCBI chr 4:115,005,136...115,076,369
Ensembl chr 4:126,149,813...126,214,942 		JBrowse link
G GPNMB glycoprotein nmb ISO mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr 7:23,931,220...23,959,687
Ensembl chr 7:23,539,928...23,568,624 		JBrowse link
G GPR17 G protein-coupled receptor 17 ISO CTD Direct Evidence: therapeutic CTD PMID:18974869 NCBI chr2B:32,623,444...32,630,256
Ensembl chr2B:128,316,464...128,321,519 		JBrowse link
G GZMB granzyme B ISO protein:increased expression:brain (rat) RGD PMID:19895873 RGD:2325193 NCBI chr14:5,399,888...5,403,200
Ensembl chr14:23,523,619...23,526,931 		JBrowse link
G HGF hepatocyte growth factor treatment ISO RGD PMID:16421510 RGD:8548626 NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha exacerbates ISO RGD PMID:30052311 RGD:155663378 NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885 		JBrowse link
G HMGB1 high mobility group box 1 ISO RGD PMID:19944723 RGD:2316741 NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527 		JBrowse link
G HNMT histamine N-methyltransferase severity ISO RGD PMID:16330002 PMID:21131122 RGD:5509772 RGD:5509773 NCBI chr2B:21,840,342...21,892,744
Ensembl chr2B:142,036,321...142,088,315 		JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B ISO mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr2B:118,362,719...118,381,253
Ensembl chr2B:237,153,709...237,170,591 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:serum RGD PMID:18692933 RGD:2313474 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605 		JBrowse link
G IGF2 insulin like growth factor 2 ISO mRNA, protein:increased expression:brain RGD PMID:7770004 RGD:5509999 NCBI chr11:2,170,190...2,199,442
Ensembl chr11:2,202,743...2,228,890 		JBrowse link
G IL15 interleukin 15 ISO associated with Hypertension;protein:increased expression:serum RGD PMID:16109314 RGD:1626610 NCBI chr 4:133,693,995...134,115,470
Ensembl chr 4:145,402,111...145,416,622 		JBrowse link
G IL1B interleukin 1 beta ISO protein:increased expression:cerebral cortex (rat) RGD PMID:17678971 RGD:1626644 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL2 interleukin 2 ISO protein:increased expression:brain (rat) RGD PMID:19895873 RGD:2325193 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
G KCNK6 potassium two pore domain channel subfamily K member 6 ISO mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr19:35,409,752...35,422,490
Ensembl chr19:43,985,074...43,995,374 		JBrowse link
G MDK midkine ISO RGD PMID:15450683 RGD:1582478 NCBI chr11:46,339,365...46,342,388
Ensembl chr11:46,891,540...46,893,254 		JBrowse link
G MEIS2 Meis homeobox 2 ISO protein:altered expression:brain (rat) RGD PMID:12161747 RGD:155630606 NCBI chr15:15,814,739...16,025,512
Ensembl chr15:34,072,665...34,282,477 		JBrowse link
G MGP matrix Gla protein ISO mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr12:14,887,806...14,891,796
Ensembl chr12:15,284,883...15,288,523 		JBrowse link
G MMP14 matrix metallopeptidase 14 ISO mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr14:3,654,125...3,665,158
Ensembl chr14:21,753,305...21,764,058 		JBrowse link
G MMP8 matrix metallopeptidase 8 ISO mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr11:97,650,408...97,663,731
Ensembl chr11:101,143,268...101,156,736 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO RGD PMID:16599837 RGD:1582617 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129 		JBrowse link
G MSI1 musashi RNA binding protein 1 ISO RGD PMID:15250238 RGD:1582664 NCBI chr12:117,915,879...117,943,772
Ensembl chr12:121,289,281...121,316,276 		JBrowse link
G NES nestin ISO associated with Hypertension RGD PMID:16321245 RGD:1642069 NCBI chr 1:132,012,273...132,020,907
Ensembl chr 1:135,835,456...135,844,094 		JBrowse link
G PARG poly(ADP-ribose) glycohydrolase ISO associated with Reperfusion Injury RGD PMID:12834903 RGD:2316742 NCBI chr10:44,290,391...44,420,184 JBrowse link
G PBX1 PBX homeobox 1 ISO protein:altered expression:brain (rat) RGD PMID:12161747 RGD:155630606 NCBI chr 1:139,985,392...140,311,845
Ensembl chr 1:143,778,701...144,104,797 		JBrowse link
G PLAT plasminogen activator, tissue type ISO CTD Direct Evidence: therapeutic CTD PMID:16190367 NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779 		JBrowse link
G PPP1R1B protein phosphatase 1 regulatory inhibitor subunit 1B ISO protein:altered expression:brain (rat) RGD PMID:12161747 RGD:155630606 NCBI chr17:17,652,216...17,662,085
Ensembl chr17:17,868,965...17,878,120 		JBrowse link
G PRCP prolylcarboxypeptidase ISO mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr11:77,890,115...77,967,056
Ensembl chr11:81,502,658...81,578,361 		JBrowse link
G RBFOX3 RNA binding fox-1 homolog 3 ISO protein:altered expression:brain (rat) RGD PMID:12161747 RGD:155630606 NCBI chr17:73,163,818...73,690,675
Ensembl chr17:78,711,056...78,732,131 		JBrowse link
G SCN7A sodium voltage-gated channel alpha subunit 7 ISO mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr2B:53,676,298...53,768,289
Ensembl chr2B:171,151,969...171,243,717 		JBrowse link
G SIRT1 sirtuin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22878646 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069 		JBrowse link
G TBXAS1 thromboxane A synthase 1 ISO RGD PMID:14650360 RGD:1601455 NCBI chr 7:131,772,947...131,958,647
Ensembl chr 7:144,255,211...144,439,523 		JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:brain (rat) RGD PMID:19895873 RGD:2325193 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TPCN2 two pore segment channel 2 ISO mRNA:increased expression:brain (rat) RGD PMID:23251410 RGD:329845556 NCBI chr11:64,139,512...64,227,913
Ensembl chr11:67,438,635...67,478,106 		JBrowse link
Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARMS2 age-related maculopathy susceptibility 2 ISO ClinVar Annotator: match by term: CARASIL syndrome ClinVar PMID:18316707 PMID:20437615 PMID:25741868 PMID:26467025 PMID:28492532 NCBI chr10:119,022,726...119,026,201
Ensembl chr10:122,434,856...122,437,551 		JBrowse link
G HTRA1 HtrA serine peptidase 1 ISO ClinVar Annotator: match by term: CARASIL syndrome | ClinVar Annotator: match by term: Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy | ClinVar Annotator: match by term: Cerebrovascular disease with thin skin, alopecia, and disc disease | ClinVar Annotator: match by term: HTRA1-related cerebral small vessel disease OMIM
ClinVar		 PMID:11889251 PMID:18316707 PMID:19387015 PMID:20437615 PMID:21115960 More... NCBI chr10:119,030,409...119,083,682
Ensembl chr10:122,441,098...122,494,733 		JBrowse link
G MECP2 methyl-CpG binding protein 2 ISO ClinVar Annotator: match by term: CARASIL ClinVar PMID:9536098 PMID:15737703 PMID:17576681 PMID:20142466 PMID:24500651 More... NCBI chr  X:143,571,864...143,647,192
Ensembl chr  X:153,465,204...153,527,854 		JBrowse link
G PURA purine rich element binding protein A ISO ClinVar Annotator: match by term: Cerebrovascular disease with thin skin, alopecia, and disc disease ClinVar PMID:24500651 PMID:27148565 NCBI chr 5:135,541,865...135,610,526
Ensembl chr 5:141,659,224...141,727,870
Ensembl chr 5:141,659,224...141,727,870 		JBrowse link
cerebral infarction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme ISO ClinVar Annotator: match by term: Ischemic stroke, susceptibility to ClinVar PMID:1313972 PMID:1319114 PMID:1328889 PMID:1386652 PMID:1976655 More... NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853 		JBrowse link
G ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:15534263 NCBI chr 4:91,726,870...91,741,824
Ensembl chr 4:102,388,575...102,435,079 		JBrowse link
G ADORA1 adenosine A1 receptor ISO RGD PMID:17067559 RGD:1625229 NCBI chr 1:178,728,751...178,769,066
Ensembl chr 1:183,023,466...183,063,760 		JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO protein:increased expression:plasma RGD PMID:23288172 RGD:8696004 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641 		JBrowse link
G AGXT2 alanine--glyoxylate aminotransferase 2 onset ISO DNA:missense mutation:cds:V498L (rs16899974) (human) RGD PMID:26984639 RGD:329961314 NCBI chr 5:75,322,351...75,373,261
Ensembl chr 5:80,601,554...80,652,575 		JBrowse link
G AHSP alpha hemoglobin stabilizing protein ISO mRNA:increased expression:venous blood (human) RGD PMID:29284304 RGD:329961296 NCBI chr16:23,436,746...23,438,184
Ensembl chr16:31,897,868...31,899,143 		JBrowse link
G ALOX5AP arachidonate 5-lipoxygenase activating protein susceptibility ISO OMIM NCBI chr13:12,012,399...12,041,557
Ensembl chr13:30,425,510...30,476,607 		JBrowse link
G ANG angiogenin severity ISO protein:increased expression:serum RGD PMID:17823536 RGD:6892714 NCBI chr14:1,548,693...1,558,528
Ensembl chr14:19,614,950...19,615,393 		JBrowse link
G ANXA1 annexin A1 treatment ISO associated with Ischemic Attack, Transient RGD PMID:22617647 RGD:7483559 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779 		JBrowse link
G APOA5 apolipoprotein A5 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :-1131T>C (human) RGD PMID:19107359 RGD:2313314 NCBI chr11:111,625,403...111,627,932
Ensembl chr11:115,559,231...115,562,286 		JBrowse link
G APOB apolipoprotein B ISO protein:increased expression:serum RGD PMID:2352345 RGD:2313973 NCBI chr2A:20,986,464...21,029,004
Ensembl chr2A:21,100,356...21,145,129 		JBrowse link
G APOE apolipoprotein E susceptibility ISO DNA:polymorphism: :3932T>C (human) RGD PMID:17016617 RGD:1601237 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490 		JBrowse link
G BHMT betaine--homocysteine S-methyltransferase susceptibility ISO DNA:SNPs,haplotypes:multiple RGD PMID:20458436 RGD:401794454 NCBI chr 5:36,181,183...36,201,833
Ensembl chr 5:36,670,854...36,728,993 		JBrowse link
G BRINP3 BMP/retinoic acid inducible neural specific 3 ISO associated with diabetes mellitus;mRNA:protein:increased expression:blood mononuclear cell: RGD PMID:26717922 RGD:14398486 NCBI chr 1:165,586,510...165,972,173
Ensembl chr 1:169,873,541...170,258,015 		JBrowse link
G CARTPT CART prepropeptide ameliorates ISO RGD PMID:16971488 RGD:407986645 NCBI chr 5:43,591,683...43,593,586
Ensembl chr 5:44,236,114...44,238,229 		JBrowse link
G CBS cystathionine beta-synthase susceptibility ISO DNA:SNPs,haplotypes:multiple RGD PMID:20458436 RGD:401794454 NCBI chr21:29,361,519...29,385,610
Ensembl chr21:42,670,530...42,690,932 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 treatment ISO RGD PMID:29111308 RGD:155260331 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO RGD PMID:23602964 RGD:8552262 NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379 		JBrowse link
G CD36 CD36 molecule (CD36 blood group) ISO associated with Hyperlipidemias RGD PMID:22718544 RGD:6893487 NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865 		JBrowse link
G EPHX2 epoxide hydrolase 2 ISO RGD PMID:16306811 RGD:1580986 NCBI chr 8:26,761,090...26,818,436
Ensembl chr 8:23,964,094...24,017,749 		JBrowse link
G F2 coagulation factor II, thrombin susceptibility ISO ClinVar Annotator: match by term: Ischemic stroke | ClinVar Annotator: match by term: Ischemic stroke, susceptibility to ClinVar
OMIM		 PMID:2222810 PMID:2429850 PMID:2825773 PMID:6305407 PMID:6405779 More... NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157 		JBrowse link
G F5 coagulation factor V ISO ClinVar Annotator: match by term: Ischemic stroke | ClinVar Annotator: match by term: Ischemic stroke, susceptibility to ClinVar
OMIM		 PMID:7586244 PMID:7803250 PMID:7877648 PMID:7910348 PMID:7911872 More... NCBI chr 1:144,996,757...145,070,046
Ensembl chr 1:148,718,897...148,790,915 		JBrowse link
G F7 coagulation factor VII treatment ISO human protein in a mouse model
protein:increased expression, increased activity:plasma (human) 		RGD PMID:14733777 PMID:21998055 RGD:11049518 RGD:11049520 NCBI chr13:94,246,694...94,261,133
Ensembl chr13:113,315,868...113,329,995 		JBrowse link
G FBN1 fibrillin 1 ISO ClinVar Annotator: match by term: Ischemic stroke ClinVar PMID:7611299 PMID:8894692 PMID:9401003 PMID:9536098 PMID:10533071 More... NCBI chr15:27,358,780...27,593,539
Ensembl chr15:45,682,450...45,918,111 		JBrowse link
G GCH1 GTP cyclohydrolase 1 exacerbates
treatment 		ISO DNA:SNP:3' UTR:+243C>T (human)
DNA:SNP, haplotype:rs841 (human) 		RGD PMID:16282548 PMID:21181356 PMID:21963893 RGD:329961322 RGD:329961572 RGD:329961574 NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393 		JBrowse link
G GP6 glycoprotein VI platelet ameliorates ISO RGD PMID:34237320 RGD:401794450 NCBI chr19:52,051,138...52,071,673
Ensembl chr19:60,746,578...60,770,643 		JBrowse link
G GPX3 glutathione peroxidase 3 susceptibility ISO DNA, protein:SNP,decreased expression:promoter,plasma:-861A>T (human)
DNA:SNPs, haplotype:promoter:-942 A>C, -927 T>C, -861 A>T, -302 A>T, -284 T>A, -568 T>C, -518 T>C, -65 T>C (human)
DNA:SNPs, haplotypes:promoter:rs8177412, rs870407, rs870406 (human) 		RGD PMID:17122425 PMID:20946167 PMID:25126700 RGD:401827128 RGD:401827163 RGD:401827165 NCBI chr 5:146,447,939...146,456,476 JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 severity ISO RGD PMID:23723305 RGD:13792693 NCBI chr 9:108,198,350...108,228,887
Ensembl chr 9:137,168,722...137,197,382 		JBrowse link
G GRN granulin precursor ISO ClinVar Annotator: match by term: Ischemic stroke ClinVar PMID:18723524 PMID:25741868 PMID:28492532 NCBI chr17:13,046,329...13,054,236
Ensembl chr17:13,211,784...13,219,609 		JBrowse link
G GSN gelsolin severity ISO protein:decreased expression:blood plasma (human) RGD PMID:21481565 RGD:329337334 NCBI chr 9:92,413,819...92,460,483
Ensembl chr 9:120,741,148...120,805,831 		JBrowse link
G HBA1 hemoglobin subunit alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:1634355 Ensembl chr16:164,618...165,476 JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha severity ISO protein:increased expression:blood serum (human) RGD PMID:34708885 RGD:155260326 NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885 		JBrowse link
G HMGB1 high mobility group box 1 ISO protein:increased expression:plasma RGD PMID:23288172 RGD:8696004 NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527 		JBrowse link
G HMOX1 heme oxygenase 1 ISO RGD PMID:23311871 RGD:10755574 NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063 		JBrowse link
G HNF1A HNF1 homeobox A susceptibility ISO DNA:SNPs,haplotypes:multiple RGD PMID:28035729 RGD:329901837 NCBI chr12:118,562,308...118,584,596
Ensembl chr12:121,932,671...121,955,911 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO mRNA, protein:increased expression:cerebral cortex RGD PMID:20083630 RGD:8547724 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605 		JBrowse link
G IFNB1 interferon beta 1 susceptibility
no_association 		ISO DNA:SNP,haplotype: rs9333358(human) RGD PMID:16514094 PMID:31810024 RGD:401851921 RGD:401854228 NCBI chr 9:20,884,742...20,886,317 JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:29111308 RGD:155260331 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL18 interleukin 18 treatment ISO RGD PMID:20584315 RGD:8655991 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371 		JBrowse link
G IL1B interleukin 1 beta treatment ISO RGD PMID:29111308 RGD:155260331 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL6 interleukin 6 treatment ISO RGD PMID:29111308 RGD:155260331 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G IRF8 interferon regulatory factor 8 exacerbates ISO RGD PMID:24528256 RGD:329902074 NCBI chr16:66,568,370...66,591,949
Ensembl chr16:85,905,334...85,929,073 		JBrowse link
G ITGA9 integrin subunit alpha 9 susceptibility ISO DNA:SNPs,haplotype:rs189897,rs2212020(human) RGD PMID:21764681 RGD:13602007 NCBI chr 3:37,349,120...37,722,572
Ensembl chr 3:37,651,395...38,006,363 		JBrowse link
G ITGAM integrin subunit alpha M ISO protein:increased expression:neutrophil (human) RGD PMID:31355307 RGD:329901831 NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406 		JBrowse link
G KALRN kalirin RhoGEF kinase susceptibility
sexual_dimorphism 		ISO DNA:SNP:intron: (rs6438833) (human)
DNA:SNPs::multiple (human)
DNA:SNPs, haplotypes:intron,cds: (rs7620580, rs1708303) (human) 		RGD PMID:20107840 PMID:25917671 PMID:28706949 RGD:11085239 RGD:329955374 RGD:329956420 NCBI chr 3:121,138,136...121,828,723
Ensembl chr 3:128,225,413...128,720,441 		JBrowse link
G KCNN4 potassium calcium-activated channel subfamily N member 4 ameliorates ISO RGD PMID:29037241 RGD:329969881 NCBI chr19:40,715,621...40,735,025
Ensembl chr19:49,321,403...49,335,900 		JBrowse link
G LIPG lipase G, endothelial type susceptibility ISO DNA:polymorphism: :584C>T (human) RGD PMID:17016617 RGD:1601237 NCBI chr18:42,942,132...42,972,112
Ensembl chr18:46,292,154...46,320,652 		JBrowse link
G LOC100979269 alpha-2-macroglobulin disease_progression ISO RGD PMID:28266892 RGD:13702087 NCBI chr12:9,154,457...9,202,833
Ensembl chr12:9,385,359...9,433,979 		JBrowse link
G LOC100982859 class I histocompatibility antigen, Gogo-B*0101 alpha chain susceptibility ISO DNA:polymorphism::HLA-B37:01 (human) RGD PMID:24767290 RGD:401827096 NCBI chr 6:31,106,562...31,109,933
Ensembl chr 6:31,997,381...32,000,067 		JBrowse link
G LPA lipoprotein(a) ISO protein:increased expression, alternative form:serum:increased levels overall and increased frequency of low molecular weight isoforms
protein:increased expression:serum 		RGD PMID:1440702 PMID:12894903 RGD:5509894 RGD:5509897 NCBI chr 6:158,434,394...158,628,028 JBrowse link
G LTA lymphotoxin alpha ISO RGD PMID:14593215 RGD:1580416 NCBI chr 6:31,233,411...31,235,409
Ensembl chr 6:32,123,353...32,125,375 		JBrowse link
G MAP2 microtubule associated protein 2 ISO RGD PMID:22444278 RGD:6483079 NCBI chr2B:96,681,268...96,991,650
Ensembl chr2B:215,314,857...215,391,728 		JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 treatment ISO RGD PMID:23968852 RGD:10412642 NCBI chr 6:134,316,841...134,582,843
Ensembl chr 6:138,406,398...138,641,727 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16846501 NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16846501 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO DNA:transition:cds:g.677C>T (human) RGD PMID:10929044 RGD:1580590 NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase susceptibility ISO DNA:SNPs,haplotypes:multiple RGD PMID:20458436 RGD:401794454 NCBI chr 1:212,353,195...212,463,304
Ensembl chr 1:217,358,050...217,460,946 		JBrowse link
G MYRF myelin regulatory factor ISO DNA:SNP:exon:rs174535(human) RGD PMID:36193932 RGD:213230151 NCBI chr11:57,052,219...57,088,105
Ensembl chr11:60,412,780...60,448,579 		JBrowse link
G NOS3 nitric oxide synthase 3 ISO ClinVar Annotator: match by term: Ischemic stroke ClinVar PMID:9737779 PMID:9894802 PMID:10475066 PMID:10510054 PMID:10514107 More... NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233 		JBrowse link
G NOTCH3 notch receptor 3 ISO ClinVar Annotator: match by term: Ischemic stroke ClinVar PMID:9388399 PMID:10371548 PMID:10802804 PMID:10854111 PMID:11102981 More... NCBI chr19:14,692,571...14,733,758
Ensembl chr19:15,678,674...15,715,080 		JBrowse link
G NPY neuropeptide Y ISO protein:increased expression:cerebral cortex
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:11821007 PMID:17123484 RGD:10448931 NCBI chr 7:24,963,056...24,970,803
Ensembl chr 7:24,568,041...24,574,657 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 susceptibility ISO DNA:SNPs, haplotype:promoter:c.-115G>A, c.-840C>A (rs12221497, rs61896015) (human) RGD PMID:21903943 RGD:401842365 NCBI chr11:47,195,122...47,215,277
Ensembl chr11:47,748,353...47,768,672 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISO DNA:SNPs:peripheral blood, leukocyte, 3' utr RGD PMID:33209049 RGD:408418730 NCBI chr 9:39,663,986...40,208,770
Ensembl chr 9:84,021,837...84,372,678 		JBrowse link
G PARK7 Parkinsonism associated deglycase treatment ISO RGD PMID:18003894 RGD:13462069 NCBI chr 1:6,722,260...6,745,915
Ensembl chr 1:7,969,280...7,993,271 		JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 ISO associated with Metabolic Syndrome; DNA:duplication:5' utr:-108 3G>4G (human) RGD PMID:18506375 RGD:2311309 NCBI chr13:9,199,572...9,206,202 JBrowse link
G PHACTR1 phosphatase and actin regulator 1 ISO DNA:SNP:intron: (rs12526453) (human) RGD PMID:23042660 RGD:401900685 NCBI chr 6:12,560,862...13,136,126
Ensembl chr 6:12,922,871...13,505,609 		JBrowse link
G PLA2G7 phospholipase A2 group VII ISO RGD PMID:18201705 RGD:6482775 NCBI chr 6:46,264,262...46,318,487
Ensembl chr 6:47,558,861...47,590,212 		JBrowse link
G PLAT plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:1579960 PMID:1899364 PMID:9183334 PMID:16148626 PMID:18195371 More... NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779 		JBrowse link
G PLAU plasminogen activator, urokinase ISO CTD Direct Evidence: therapeutic CTD PMID:12133459 PMID:16773802 NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136 		JBrowse link
G PON1 paraoxonase 1 susceptibility ISO DNA:missense mutation:cds:p.Q192R (human) RGD PMID:10729395 RGD:1580196 NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493 		JBrowse link
G PON2 paraoxonase 2 susceptibility ISO DNA:SNPs,haplotypes: (rs11545941, rs6954345) (human) RGD PMID:20458436 RGD:401794454 NCBI chr 7:87,362,447...87,392,795
Ensembl chr 7:100,950,074...100,980,433 		JBrowse link
G PRKCH protein kinase C eta susceptibility ISO ClinVar Annotator: match by term: Cerebral infarction, susceptibility to | ClinVar Annotator: match by term: Ischemic stroke ClinVar
OMIM		 PMID:12958323 PMID:17206144 PMID:25741868 NCBI chr14:41,882,022...42,151,305
Ensembl chr14:60,179,081...60,408,251 		JBrowse link
G PROC protein C, inactivator of coagulation factors Va and VIIIa ISO CTD Direct Evidence: marker/mechanism CTD PMID:33761690 NCBI chr2B:32,846,899...32,859,060
Ensembl chr2B:128,083,794...128,094,625 		JBrowse link
G PROS1 protein S ISO DNA:missense mutation:exon:p.R355C (1063C>T) (human) RGD PMID:21172841 RGD:11250416 NCBI chr 3:90,934,641...91,039,059
Ensembl chr 3:97,615,734...97,718,756 		JBrowse link
G PTGIS prostaglandin I2 synthase exacerbates
treatment 		ISO DNA:SNP, haplotype:3' utr: (rs5602) (human)
DNA:SNPs:exon, 3' utr: (rs5629, rs5602) (human)
DNA:repeat:promoter:g.-6(CCGCCAGCC)3-7 (human) 		RGD PMID:11130769 PMID:11997284 PMID:28108096 PMID:28478978 RGD:401901149 RGD:401901194 RGD:401901269 RGD:401959400 NCBI chr20:45,841,238...45,905,641
Ensembl chr20:46,905,665...46,971,612 		JBrowse link
G RBP4 retinol binding protein 4 exacerbates
severity 		ISO protein:increased expression:blood plasma (human)
protein:increased expression:blood serum (human)
associated with diabetes mellitus; protein:increased expression:blood serum (human) 		RGD PMID:19846170 PMID:30030781 PMID:30038059 RGD:329845582 RGD:329845588 RGD:329853305 NCBI chr10:90,337,879...90,347,530
Ensembl chr10:93,848,166...93,857,887 		JBrowse link
G SERPINE1 serpin family E member 1 treatment ISO RGD PMID:25702149 RGD:11075081 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450 		JBrowse link
G SERPING1 serpin family G member 1 treatment ISO associated with Venous Thrombosis RGD PMID:10446335 RGD:8661653 NCBI chr11:52,838,502...52,855,781
Ensembl chr11:56,309,686...56,326,639 		JBrowse link
G SLC6A1 solute carrier family 6 member 1 ISO mRNA:increased expression:cerebral cortex, neuron RGD PMID:15349978 RGD:1643205 NCBI chr 3:10,930,455...10,976,968
Ensembl chr 3:11,296,023...11,323,624 		JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO mRNA:increased expression:blood (human) RGD PMID:35041140 RGD:155598600 NCBI chr2A:39,019,046...39,162,248
Ensembl chr2A:39,773,760...39,911,961 		JBrowse link
G TBXAS1 thromboxane A synthase 1 susceptibility ISO DNA:polymorphisms: : RGD PMID:19403042 RGD:11059536 NCBI chr 7:131,772,947...131,958,647
Ensembl chr 7:144,255,211...144,439,523 		JBrowse link
G THBD thrombomodulin susceptibility ISO DNA:missense mutation:cds:p.A455V (human) RGD PMID:15574195 RGD:5685021 NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812 		JBrowse link
G TNF tumor necrosis factor treatment ISO RGD PMID:16173529 PMID:29111308 RGD:155260331 RGD:1580315 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b disease_progression ISO RGD PMID:19895657 RGD:7205492 NCBI chr 8:115,614,778...115,643,387
Ensembl chr 8:118,134,305...118,162,422 		JBrowse link
G TOMM40 translocase of outer mitochondrial membrane 40 ISO DNA:SNP: :rs2075650 (human) RGD PMID:26171154 RGD:13464126 NCBI chr19:41,839,025...41,851,491
Ensembl chr19:50,444,475...50,457,729 		JBrowse link
G TYMS thymidylate synthetase susceptibility ISO DNA:SNPs,haplotypes: (rs502396,rs16430,rs8423) RGD PMID:20458436 RGD:401794454 NCBI chr18:13,653,085...13,668,478
Ensembl chr18:17,295,182...17,310,320 		JBrowse link
G VIM vimentin ISO RGD PMID:18802758 RGD:6480442 NCBI chr10:17,546,389...17,554,702
Ensembl chr10:17,818,285...17,826,642 		JBrowse link
Lacunar Strokes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL4A2 collagen type IV alpha 2 chain susceptibility ISO DNA:SNPs:: RGD PMID:28954878 RGD:13450933 NCBI chr13:91,440,314...91,650,138
Ensembl chr13:110,563,119...110,767,530 		JBrowse link
lateral medullary syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FSHB follicle stimulating hormone subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:17344003 NCBI chr11:30,204,193...30,208,410
Ensembl chr11:30,095,486...30,100,167 		JBrowse link
middle cerebral artery infarction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 treatment ISO RGD PMID:23149556 PMID:24602692 RGD:12790979 RGD:12791996 NCBI chr11:17,447,564...17,531,513
Ensembl chr11:17,133,063...17,216,870 		JBrowse link
G ACE angiotensin I converting enzyme treatment ISO RGD PMID:24471927 RGD:11039026 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853 		JBrowse link
G ACE2 angiotensin converting enzyme 2 ISO mRNA, protein:increased expression:brain RGD PMID:24090950 RGD:9685436 NCBI chr  X:8,189,267...8,229,415
Ensembl chr  X:15,470,896...15,510,891 		JBrowse link
G ACVR1 activin A receptor type 1 ISO RGD PMID:33345977 RGD:329845521 NCBI chr2B:44,994,175...45,133,490
Ensembl chr2B:162,234,823...162,297,805 		JBrowse link
G ACVR2B activin A receptor type 2B ISO mRNA:increased expression:brain (mouse) RGD PMID:33763412 RGD:329849104 NCBI chr 3:38,350,838...38,389,839
Ensembl chr 3:38,633,093...38,662,063 		JBrowse link
G ADORA1 adenosine A1 receptor ISO CTD Direct Evidence: therapeutic CTD PMID:23437309 NCBI chr 1:178,728,751...178,769,066
Ensembl chr 1:183,023,466...183,063,760 		JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental 		CTD
RGD		 PMID:24211797 PMID:25446913 RGD:8696008 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641 		JBrowse link
G AGT angiotensinogen ISO protein:increased expression:brain, serum RGD PMID:24090950 RGD:9685436 NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044 		JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 ISO protein:altered localization: : RGD PMID:15181376 RGD:10047403 NCBI chr  X:119,256,425...119,292,612
Ensembl chr  X:129,550,287...129,586,271 		JBrowse link
G AK1 adenylate kinase 1 ISO protein:decreased expression:cerebral cortex (rat) RGD PMID:16468349 RGD:5508760 NCBI chr 9:98,987,348...98,997,252
Ensembl chr 9:127,657,338...127,678,245 		JBrowse link
G ALB albumin treatment ISO RGD PMID:22227456 RGD:11036100 NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19309543 NCBI chr10:42,461,398...42,531,576
Ensembl chr10:45,639,946...45,710,016 		JBrowse link
G AP2B1 adaptor related protein complex 2 subunit beta 1 ISO protein:increased degradation:brain RGD PMID:19240038 RGD:13461853 NCBI chr17:21,070,132...21,208,610
Ensembl chr17:21,363,121...21,501,721 		JBrowse link
G APAF1 apoptotic peptidase activating factor 1 treatment ISO RGD PMID:24012531 RGD:13703113 NCBI chr12:96,224,515...96,311,246
Ensembl chr12:99,637,622...99,726,939 		JBrowse link
G APOE apolipoprotein E ISO RGD PMID:19623195 RGD:6903926 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490 		JBrowse link
G APP amyloid beta precursor protein treatment ISO RGD PMID:28963051 RGD:13782054 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072 		JBrowse link
G AQP4 aquaporin 4 treatment ISO RGD PMID:20815926 PMID:33127515 RGD:155646130 RGD:8695955 NCBI chr18:20,108,607...20,122,381
Ensembl chr18:23,713,146...23,726,919 		JBrowse link
G ARC activity regulated cytoskeleton associated protein ISO RGD PMID:22645329 RGD:10395314 NCBI chr 8:139,320,366...139,323,802
Ensembl chr 8:142,367,995...142,369,185 		JBrowse link
G ATF3 activating transcription factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr 1:188,176,728...188,188,842
Ensembl chr 1:193,036,793...193,049,150 		JBrowse link
G BAD BCL2 associated agonist of cell death treatment ISO RGD PMID:21891976 PMID:22200499 RGD:10053665 RGD:10053704 NCBI chr11:59,626,981...59,641,824
Ensembl chr11:62,971,808...62,986,257 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:23143152 RGD:10054501 NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468 		JBrowse link
G BCAN brevican ISO RGD PMID:15869933 RGD:9590118 NCBI chr 1:131,985,310...132,003,068
Ensembl chr 1:135,808,783...135,826,344 		JBrowse link
G BCL2 BCL2 apoptosis regulator treatment ISO RGD PMID:23143152 RGD:10054501 NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100 		JBrowse link
G BDNF brain derived neurotrophic factor treatment ISO RGD PMID:20417695 PMID:28202057 PMID:31927682 PMID:35218623 RGD:401960864 RGD:405878057 RGD:4891138 RGD:596948420 NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239 		JBrowse link
G BECN1 beclin 1 treatment ISO RGD PMID:22108007 RGD:11561900 NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286 		JBrowse link
G BNIP3 BCL2 interacting protein 3 ISO protein:increased expression:brain RGD PMID:17379825 RGD:9685412 NCBI chr10:128,671,663...128,685,952
Ensembl chr10:132,858,211...132,871,634 		JBrowse link
G BNIP3L BCL2 interacting protein 3 like ISO RGD PMID:15902200 PMID:21029239 RGD:2314138 RGD:9068917 NCBI chr 8:25,661,629...25,685,878
Ensembl chr 8:22,567,428...22,593,004 		JBrowse link
G C1QTNF6 C1q and TNF related 6 ameliorates ISO RGD PMID:35322553 RGD:242905190 NCBI chr22:18,093,940...18,112,459
Ensembl chr22:35,928,835...35,937,021 		JBrowse link
G C3 complement C3 ISO protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:22103620 PMID:23199288 RGD:7175514 NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699 		JBrowse link
G CALCA calcitonin related polypeptide alpha treatment ISO RGD PMID:30531687 RGD:329849008 NCBI chr11:15,055,897...15,061,539
Ensembl chr11:14,745,588...14,751,267 		JBrowse link
G CAMK2A calcium/calmodulin dependent protein kinase II alpha ISO RGD PMID:14688616 RGD:1358416 NCBI chr 5:145,644,164...145,714,143
Ensembl chr 5:151,649,062...151,719,373 		JBrowse link
G CASP3 caspase 3 treatment ISO RGD PMID:21891976 PMID:23143152 PMID:26868427 RGD:10053704 RGD:10054501 RGD:13782346 NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185 		JBrowse link
G CASP6 caspase 6 ISO RGD PMID:26868427 RGD:13782346 NCBI chr 4:102,186,215...102,201,992
Ensembl chr 4:112,753,988...112,768,836 		JBrowse link
G CASP9 caspase 9 treatment ISO RGD PMID:26868427 RGD:13782346 NCBI chr 1:14,630,659...14,662,865
Ensembl chr 1:15,624,666...15,656,266 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:12374626 PMID:23043544 PMID:25257527 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G CD36 CD36 molecule (CD36 blood group) treatment ISO RGD PMID:25216018 RGD:11041113 NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865 		JBrowse link
G CD86 CD86 molecule ISO protein:increased expression:brain subventricular zone, microglial cell (rat) RGD PMID:19053043 RGD:2313025 NCBI chr 3:119,151,884...119,217,641
Ensembl chr 3:126,059,008...126,124,339 		JBrowse link
G CDK5 cyclin dependent kinase 5 ISO RGD PMID:24920629 RGD:13782375 NCBI chr 7:142,640,630...142,644,785
Ensembl chr 7:154,793,344...154,797,499 		JBrowse link
G CLDN5 claudin 5 treatment ISO RGD PMID:24842554 RGD:13204729 NCBI chr22:2,282,215...2,286,724
Ensembl chr22:17,958,182...17,959,093 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 treatment ISO RGD PMID:35218623 RGD:401960864 NCBI chr2B:94,762,796...94,836,304
Ensembl chr2B:212,891,261...212,958,130 		JBrowse link
G CRH corticotropin releasing hormone ISO protein:decreased expression:median eminence of hypothalamus (rat) RGD PMID:21741032 RGD:5490538 NCBI chr 8:62,714,721...62,716,979
Ensembl chr 8:64,383,419...64,384,009 		JBrowse link
G CRP C-reactive protein ISO RGD PMID:15545914 RGD:9585995 NCBI chr 1:135,062,102...135,064,402 JBrowse link
G CRTC1 CREB regulated transcription coactivator 1 treatment ISO RGD PMID:20417695 RGD:4891138 NCBI chr19:18,123,375...18,221,832
Ensembl chr19:19,131,484...19,228,980 		JBrowse link
G CSF3 colony stimulating factor 3 treatment ISO mRNA, protein:increased expression:brain: RGD PMID:15530654 PMID:19298757 RGD:11039420 RGD:11039425 NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO RGD PMID:10825390 RGD:632989 NCBI chr 4:48,182,355...48,184,733
Ensembl chr 4:54,020,204...54,022,606 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chr2B:105,387,198...105,400,533
Ensembl chr2B:223,997,066...223,998,148 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO mRNA:increased expression:cerebral cortex RGD PMID:10825390 RGD:632989 NCBI chr  X:60,880,759...60,883,355
Ensembl chr  X:70,933,160...70,935,756 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO RGD PMID:23002367 RGD:14700877 Ensembl chr10:134,839,025...134,852,719 JBrowse link
G DICER1 dicer 1, ribonuclease III ISO mRNA:decreased expression:brain: RGD PMID:26294080 RGD:11553310 NCBI chr14:75,709,029...75,780,779
Ensembl chr14:95,036,385...95,107,940 		JBrowse link
G DNMT1 DNA methyltransferase 1 ISO RGD PMID:11726790 RGD:9588643 NCBI chr19:9,681,847...9,745,334
Ensembl chr19:10,342,478...10,406,972 		JBrowse link
G DNMT3A DNA methyltransferase 3 alpha ISO RGD PMID:23516428 RGD:9589049 NCBI chr2A:25,229,593...25,344,733
Ensembl chr2A:25,331,095...25,412,605 		JBrowse link
G DYNLL1 dynein light chain LC8-type 1 ISO RGD PMID:9522364 RGD:13208524 NCBI chr12:118,078,401...118,080,822
Ensembl chr12:121,452,118...121,454,550 		JBrowse link
G EDN1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17197033 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545 		JBrowse link
G EGR1 early growth response 1 ISO RGD PMID:22645329 RGD:10395314 NCBI chr 5:133,845,305...133,849,291
Ensembl chr 5:139,975,635...139,979,260 		JBrowse link
G EGR2 early growth response 2 ISO RGD PMID:22645329 RGD:10395314 NCBI chr10:59,320,073...59,326,869
Ensembl chr10:61,648,364...61,652,846 		JBrowse link
G EGR4 early growth response 4 ISO RGD PMID:22645329 RGD:10395314 NCBI chr2A:73,343,705...73,346,476
Ensembl chr2A:74,831,326...74,834,246 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha treatment ISO RGD PMID:19763736 PMID:23669639 RGD:10395346 RGD:10755569 NCBI chr14:47,935,691...47,960,055
Ensembl chr14:66,813,953...66,839,866 		JBrowse link
G ELANE elastase, neutrophil expressed treatment ISO RGD PMID:10700596 RGD:10450546 NCBI chr19:276,499...280,598 JBrowse link
G ENG endoglin ISO RGD PMID:24876084 RGD:11041171 NCBI chr 9:98,934,080...98,973,862
Ensembl chr 9:127,605,608...127,644,641 		JBrowse link
G EPCAM epithelial cell adhesion molecule ISO RGD PMID:15950761 RGD:11038820 NCBI chr2A:47,490,748...47,508,418
Ensembl chr2A:48,413,520...48,432,038 		JBrowse link
G EPHB2 EPH receptor B2 treatment ISO mRNA,protein:increased expression: cortex, cerebral cortex subventricular zone RGD PMID:16321245 RGD:1642069 NCBI chr 1:21,895,961...22,107,649
Ensembl chr 1:22,912,570...23,047,118 		JBrowse link
G EPN1 epsin 1 ISO protein:increased degradation:brain RGD PMID:19240038 RGD:13461853 NCBI chr19:52,722,107...52,743,321
Ensembl chr19:61,408,695...61,427,647 		JBrowse link
G EPO erythropoietin treatment ISO RGD PMID:20547143 PMID:20833153 RGD:10400898 RGD:10401066 NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974 		JBrowse link
G ERCC6 ERCC excision repair 6, chromatin remodeling factor ISO RGD PMID:9974119 RGD:10401103 NCBI chr10:44,703,720...44,784,948 JBrowse link
G F11 coagulation factor XI ISO RGD PMID:16533887 RGD:11041786 NCBI chr 4:178,436,865...178,459,568
Ensembl chr 4:190,643,733...190,666,512 		JBrowse link
G F12 coagulation factor XII treatment ISO RGD PMID:16533887 RGD:11041786 NCBI chr 5:172,703,724...172,711,618
Ensembl chr 5:179,766,243...179,773,485 		JBrowse link
G F2 coagulation factor II, thrombin ISO CTD Direct Evidence: marker/mechanism CTD PMID:29651748 NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157 		JBrowse link
G FADD Fas associated via death domain treatment ISO RGD PMID:18950622 PMID:23378241 RGD:11341807 RGD:11344885 NCBI chr11:65,300,889...65,305,020 JBrowse link
G FGF2 fibroblast growth factor 2 treatment ISO RGD PMID:30531687 RGD:329849008 NCBI chr 4:115,005,136...115,076,369
Ensembl chr 4:126,149,813...126,214,942 		JBrowse link
G FGF21 fibroblast growth factor 21 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chr19:45,755,466...45,758,472 JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr14:55,832,570...55,835,984
Ensembl chr14:74,676,316...74,679,766 		JBrowse link
G GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chr 5:157,072,915...157,089,994
Ensembl chr 5:163,767,304...163,784,331 		JBrowse link
G GAP43 growth associated protein 43 treatment ISO RGD PMID:30531687 RGD:329849008 NCBI chr 3:112,765,576...112,863,118
Ensembl chr 3:119,734,942...119,780,290 		JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase ISO RGD PMID:25882840 RGD:13792686 NCBI chr12:6,665,218...6,669,170
Ensembl chr12:6,583,895...6,587,729 		JBrowse link
G GCH1 GTP cyclohydrolase 1 treatment ISO RGD PMID:24956890 RGD:401717568 NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393 		JBrowse link
G GDNF glial cell derived neurotrophic factor treatment ISO RGD PMID:20468049 PMID:21347705 PMID:28202057 PMID:29497380 RGD:405866359 RGD:405866363 RGD:405878057 RGD:40925919 NCBI chr 5:72,539,374...72,566,918
Ensembl chr 5:77,577,313...77,601,362 		JBrowse link
G GHRL ghrelin and obestatin prepropeptide treatment ISO RGD PMID:19352052 RGD:9850083 NCBI chr 3:10,221,829...10,229,229
Ensembl chr 3:10,573,537...10,580,723 		JBrowse link
G GHSR growth hormone secretagogue receptor ISO RGD PMID:19352052 RGD:9850083 NCBI chr 3:169,448,217...169,458,602
Ensembl chr 3:177,633,039...177,638,202 		JBrowse link
G GLUL glutamate-ammonia ligase treatment ISO protein:increased expression:eye
protein:increased expression:cerebrum, astrocyte 		RGD PMID:23595285 PMID:24518488 PMID:26024074 PMID:26093193 RGD:401794420 RGD:401794586 RGD:401794587 RGD:401794592 NCBI chr 1:157,882,258...157,891,562
Ensembl chr 1:161,534,106...161,543,411 		JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 treatment ISO RGD PMID:26674869 RGD:11068571 NCBI chr 9:108,198,350...108,228,887
Ensembl chr 9:137,168,722...137,197,382 		JBrowse link
G GRN granulin precursor treatment ISO RGD PMID:23972823 RGD:10401661 NCBI chr17:13,046,329...13,054,236
Ensembl chr17:13,211,784...13,219,609 		JBrowse link
G GRPEL1 GrpE like 1, mitochondrial ISO mRNA:increased expression:cerebral cortex RGD PMID:12505684 RGD:632868 Ensembl chr 4:7,126,043...7,135,388 JBrowse link
G GSK3B glycogen synthase kinase 3 beta treatment ISO RGD PMID:28440874 RGD:13792734 NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771 		JBrowse link
G GSN gelsolin ameliorates ISO RGD PMID:9927495 PMID:18234195 RGD:329333031 RGD:329333033 NCBI chr 9:92,413,819...92,460,483
Ensembl chr 9:120,741,148...120,805,831 		JBrowse link
G HAMP hepcidin antimicrobial peptide ISO mRNA, protein:increased expression:cerebral cortex, hippocampus, corpus striatum RGD PMID:21957487 RGD:11041635 NCBI chr19:32,228,701...32,231,494
Ensembl chr19:40,964,445...40,968,861 		JBrowse link
G HAS2 hyaluronan synthase 2 ISO mRNA:increased expression:brain RGD PMID:11283406 RGD:9588631 NCBI chr 8:118,313,186...118,342,160
Ensembl chr 8:121,072,154...121,089,365 		JBrowse link
G HDAC2 histone deacetylase 2 exacerbates ISO RGD PMID:32239566 RGD:155883173 NCBI chr 6:111,731,139...111,761,826
Ensembl chr 6:115,802,367...115,833,004 		JBrowse link
G HDAC4 histone deacetylase 4 treatment ISO mRNA,protein:decreased expression:brain: RGD PMID:23480850 RGD:9681449 NCBI chr2B:126,287,745...126,649,815
Ensembl chr2B:245,123,061...245,427,054 		JBrowse link
G HDAC5 histone deacetylase 5 treatment ISO mRNA,protein:decreased expression:brain: RGD PMID:23480850 RGD:9681449 NCBI chr17:13,273,052...13,319,695
Ensembl chr17:13,446,836...13,479,140 		JBrowse link
G HDAC9 histone deacetylase 9 ISO mRNA:increased expression:brain: RGD PMID:23480850 RGD:9681449 NCBI chr 7:18,740,580...19,653,615
Ensembl chr 7:18,138,761...18,970,717 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha treatment ISO RGD PMID:21029239 RGD:9068917 NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885 		JBrowse link
G HMGB1 high mobility group box 1 treatment ISO RGD PMID:23480850 RGD:9681449 NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527 		JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO RGD PMID:20888632 PMID:23870531 PMID:24252362 RGD:10755587 RGD:10755588 RGD:10755755 NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063 		JBrowse link
G HSPA4 heat shock protein family A (Hsp70) member 4 ISO rat gene in mouse model RGD PMID:17473852 PMID:21709150 RGD:5688754 RGD:6218961 NCBI chr 5:128,463,186...128,517,563
Ensembl chr 5:134,619,076...134,673,658 		JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr2B:84,729,615...84,743,352
Ensembl chr2B:202,623,497...202,636,959 		JBrowse link
G HTRA2 HtrA serine peptidase 2 ISO protein:increased expression:brain, cytosol (rat)
protein:increased expression:brain, cytosol (mouse) 		RGD PMID:15306124 PMID:16978742 RGD:2314385 RGD:5688372 NCBI chr2A:74,596,020...74,599,790
Ensembl chr2A:76,102,240...76,106,152 		JBrowse link
G HVCN1 hydrogen voltage gated channel 1 ISO RGD PMID:31250553 RGD:14985213 NCBI chr12:108,217,516...108,258,210
Ensembl chr12:111,591,050...111,645,632 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605 		JBrowse link
G IGF1 insulin like growth factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta treatment ISO RGD PMID:16286924 RGD:10045955 NCBI chr 8:41,515,613...41,576,229
Ensembl chr 8:38,960,594...39,020,971 		JBrowse link
G IL10 interleukin 10 ameliorates ISO RGD PMID:28630232 RGD:242905192 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL11 interleukin 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chr19:52,407,730...52,426,445
Ensembl chr19:61,096,275...61,101,837 		JBrowse link
G IL13 interleukin 13 ISO protein:increased expression:cerebral cortex RGD PMID:23028794 RGD:7204480 NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548 		JBrowse link
G IL1B interleukin 1 beta ameliorates
treatment 		ISO protein:increased expression:cerebral cortex (rat)
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:23028794 PMID:24916922 PMID:25257527 PMID:29498696 PMID:35322553 RGD:10450594 RGD:13792833 RGD:242905190 RGD:7204480 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL1RN interleukin 1 receptor antagonist treatment ISO human gene in a rat model RGD PMID:7790404 RGD:8551708 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839 		JBrowse link
G IL22 interleukin 22 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chr12:65,757,069...65,762,418
Ensembl chr12:68,542,076...68,547,421 		JBrowse link
G IL4 interleukin 4 ISO protein:increased expression:cerebral cortex RGD PMID:23028794 RGD:7204480 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G IL5 interleukin 5 ISO RGD PMID:23028794 RGD:7204480 NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675 		JBrowse link
G IL6 interleukin 6 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:12374626 PMID:21940958 PMID:25257527 PMID:29498696 RGD:13792833 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G IL6R interleukin 6 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:21940958 NCBI chr 1:129,761,914...129,824,386
Ensembl chr 1:133,374,078...133,433,089 		JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer ISO CTD Direct Evidence: marker/mechanism CTD PMID:21940958 NCBI chr 5:58,023,704...58,081,895
Ensembl chr 5:59,669,606...59,708,817 		JBrowse link
G IL7R interleukin 7 receptor ISO protein:increased expression:brain: RGD PMID:30676545 RGD:151347693 NCBI chr 5:74,489,188...74,516,330
Ensembl chr 5:79,769,859...79,792,612 		JBrowse link
G INA internexin neuronal intermediate filament protein alpha ISO RGD PMID:29967576 RGD:27226878 NCBI chr10:99,877,665...99,890,947
Ensembl chr10:103,340,438...103,353,888 		JBrowse link
G INHBA inhibin subunit beta A ISO RGD PMID:33345977 RGD:329845521 NCBI chr 7:42,538,591...42,556,578
Ensembl chr 7:42,580,730...42,595,097 		JBrowse link
G IRF4 interferon regulatory factor 4 ISO RGD PMID:25652434 RGD:11530061 NCBI chr 6:206,282...226,487
Ensembl chr 6:342,718...356,654 		JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr19:12,353,760...12,355,598
Ensembl chr19:13,097,931...13,098,974 		JBrowse link
G KCNN4 potassium calcium-activated channel subfamily N member 4 ameliorates ISO RGD PMID:21750563 PMID:25477223 PMID:26661208 RGD:329955444 RGD:329955572 RGD:401700383 NCBI chr19:40,715,621...40,735,025
Ensembl chr19:49,321,403...49,335,900 		JBrowse link
G LIG3 DNA ligase 3 ISO associated with transient cerebral ischemia;protein:increased expression:brain RGD PMID:17412650 RGD:2302580 NCBI chr17:21,776,483...21,805,706
Ensembl chr17:22,074,046...22,095,220 		JBrowse link
G LOC100974886 uncharacterized LOC100974886 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr 4:50,092,989...50,095,541
Ensembl chr 4:55,925,562...55,986,555 		JBrowse link
G MAG myelin associated glycoprotein treatment ISO RGD PMID:15678116 RGD:9685232 NCBI chr19:32,238,457...32,260,497
Ensembl chr19:40,975,763...40,997,401 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 treatment ISO RGD PMID:27152455 PMID:35218623 RGD:13800881 RGD:401960864 NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 treatment ISO RGD PMID:27152455 PMID:35218623 RGD:13800881 RGD:401960864 Ensembl chr16:30,489,362...30,498,017 JBrowse link
G MAPT microtubule associated protein tau treatment ISO RGD PMID:25903928 PMID:28886009 RGD:13800886 RGD:13800913 NCBI chr17:11,373,220...11,506,669
Ensembl chr17:11,458,159...11,523,129 		JBrowse link
G MMP9 matrix metallopeptidase 9 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:19309543 PMID:24842554 RGD:13204729 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129 		JBrowse link
G MT3 metallothionein 3 ISO protein:decreased expression:brain RGD PMID:8869568 RGD:9685807 NCBI chr16:36,875,919...36,877,558
Ensembl chr16:56,007,922...56,028,093 		JBrowse link
G MTOR mechanistic target of rapamycin kinase treatment ISO RGD PMID:21185267 PMID:23777415 PMID:24583056 RGD:10040971 RGD:10040974 RGD:10041016 NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841 		JBrowse link
G NAE1 NEDD8 activating enzyme E1 subunit 1 ISO RGD PMID:21386696 RGD:13801046 NCBI chr16:47,119,548...47,147,679
Ensembl chr16:66,221,829...66,246,865 		JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase treatment ISO RGD PMID:28495827 RGD:13781880 NCBI chr 7:98,227,071...98,262,254
Ensembl chr 7:110,952,876...110,981,967 		JBrowse link
G NCAM1 neural cell adhesion molecule 1 treatment ISO RGD PMID:29497380 PMID:32962079 RGD:40924633 RGD:40925919 NCBI chr11:107,845,507...108,160,441
Ensembl chr11:111,925,677...112,000,401 		JBrowse link
G NEFH neurofilament heavy chain ISO RGD PMID:29967576 RGD:27226878 NCBI chr22:10,525,738...10,536,788 JBrowse link
G NEFL neurofilament light chain ISO protein:increased expression:brain RGD PMID:29967576 RGD:27226878 NCBI chr 8:24,218,510...24,224,627
Ensembl chr 8:21,134,533...21,140,694 		JBrowse link
G NEFM neurofilament medium chain ISO protein:altered expression:brain RGD PMID:29967576 RGD:27226878 NCBI chr 8:24,181,335...24,186,701
Ensembl chr 8:21,098,005...21,107,468 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 treatment ISO RGD PMID:23880501 PMID:24466583 RGD:10412696 RGD:10412714 NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085 		JBrowse link
G NFKBIA NFKB inhibitor alpha treatment ISO RGD PMID:21122797 RGD:10413868 NCBI chr14:16,155,331...16,158,588 JBrowse link
G NGF nerve growth factor treatment ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:10408807 PMID:29409115 RGD:402463967 NCBI chr 1:87,223,597...87,276,759 JBrowse link
G NGFR nerve growth factor receptor treatment ISO RGD PMID:22678884 RGD:10413900 NCBI chr17:8,089,600...8,109,361
Ensembl chr17:8,075,316...8,094,966 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 treatment ISO RGD PMID:24842554 RGD:13204729 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO protein:increased expression:brain (rat)
mRNA:increased expression:brain (mouse) 		RGD PMID:21959178 PMID:22020035 RGD:5508751 RGD:5509037 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093 		JBrowse link
G NOX1 NADPH oxidase 1 treatment ISO RGD PMID:30816157 RGD:329955567 NCBI chr  X:90,046,023...90,076,968
Ensembl chr  X:100,182,398...100,215,192 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 treatment ISO protein:increased expression:brain RGD PMID:21120604 PMID:25069640 RGD:11035212 RGD:5133239 NCBI chr16:50,090,696...50,106,495
Ensembl chr16:69,470,288...69,489,731 		JBrowse link
G NRG1 neuregulin 1 treatment
ameliorates 		ISO RGD PMID:20691195 PMID:30206770 RGD:10449015 RGD:405650589 NCBI chr 8:30,954,852...32,084,411
Ensembl chr 8:29,050,222...29,263,977 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 treatment ISO mRNA:increased exprerssion:hippocampus RGD PMID:30981830 PMID:31927682 PMID:32992173 RGD:596948420 RGD:597015758 RGD:597538459 NCBI chr 9:39,663,986...40,208,770
Ensembl chr 9:84,021,837...84,372,678 		JBrowse link
G OGG1 8-oxoguanine DNA glycosylase treatment ISO associated with Hypertension RGD PMID:17920569 RGD:8657395 NCBI chr 3:9,702,311...9,742,283
Ensembl chr 3:9,940,955...9,947,335 		JBrowse link
G PARK7 Parkinsonism associated deglycase treatment ISO RGD PMID:17882163 RGD:13463450 NCBI chr 1:6,722,260...6,745,915
Ensembl chr 1:7,969,280...7,993,271 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 treatment ISO RGD PMID:21311064 PMID:23143152 PMID:23801245 PMID:25882840 RGD:10054501 RGD:11073732 RGD:13792686 RGD:5683909 NCBI chr 1:201,820,355...201,867,673
Ensembl chr 1:206,812,981...206,860,356 		JBrowse link
G PAWR pro-apoptotic WT1 regulator treatment ISO protein:increased expression:brain: RGD PMID:11323519 PMID:16403464 PMID:19352052 RGD:9835380 RGD:9835381 RGD:9850083 NCBI chr12:77,114,282...77,224,116
Ensembl chr12:79,969,517...80,070,796 		JBrowse link
G PDGFRA platelet derived growth factor receptor alpha treatment ISO RGD PMID:16917016 RGD:11084934 NCBI chr 4:69,639,081...69,709,870
Ensembl chr 4:76,199,382...76,271,097 		JBrowse link
G PDGFRB platelet derived growth factor receptor beta treatment ISO RGD PMID:16917016 RGD:11084934 NCBI chr 5:145,538,330...145,580,312
Ensembl chr 5:151,543,891...151,585,530 		JBrowse link
G PLAT plasminogen activator, tissue type ISO CTD Direct Evidence: therapeutic RGD
CTD		 PMID:12297567 PMID:14512838 PMID:17690543 PMID:18453163 PMID:20547619 More... RGD:1580876 NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779 		JBrowse link
G PLAU plasminogen activator, urokinase ISO CTD Direct Evidence: therapeutic CTD PMID:11677890 PMID:15181847 PMID:17702958 NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136 		JBrowse link
G PLD1 phospholipase D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr 3:168,606,342...168,816,383
Ensembl chr 3:176,790,753...176,961,033 		JBrowse link
G POLB DNA polymerase beta ISO associated with transient cerebral ischemia;protein:increased expression:brain RGD PMID:17412650 RGD:2302580 NCBI chr 8:41,582,370...41,615,950
Ensembl chr 8:39,026,991...39,060,464 		JBrowse link
G PRKCG protein kinase C gamma ISO RGD PMID:14688616 RGD:1358416 NCBI chr19:50,823,372...50,849,003
Ensembl chr19:59,672,097...59,695,977 		JBrowse link
G PROC protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:24159062 RGD:11100027 NCBI chr2B:32,846,899...32,859,060
Ensembl chr2B:128,083,794...128,094,625 		JBrowse link
G PTPRZ1 protein tyrosine phosphatase receptor type Z1 ISO mRNA:increased expression:cerebral cortex RGD PMID:15869933 RGD:9590118 NCBI chr 7:113,882,557...114,073,283
Ensembl chr 7:126,569,630...126,758,155 		JBrowse link
G RBFOX3 RNA binding fox-1 homolog 3 treatment ISO RGD PMID:30531687 RGD:329849008 NCBI chr17:73,163,818...73,690,675
Ensembl chr17:78,711,056...78,732,131 		JBrowse link
G RELN reelin severity ISO RGD PMID:16438965 RGD:13207538 NCBI chr 7:95,464,285...95,984,813
Ensembl chr 7:108,208,344...108,728,037 		JBrowse link
G RGMA repulsive guidance molecule BMP co-receptor a treatment ISO RGD PMID:21840379 PMID:23275173 RGD:9850121 RGD:9850122 NCBI chr15:71,728,669...71,774,447
Ensembl chr15:90,922,199...90,956,179 		JBrowse link
G RPL28 ribosomal protein L28 ISO RGD PMID:16805800 RGD:6480229 NCBI chr19:52,428,999...52,431,541
Ensembl chr19:61,116,514...61,135,785 		JBrowse link
G S100A5 S100 calcium binding protein A5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chr 1:128,892,317...128,896,879
Ensembl chr 1:132,521,394...132,525,991 		JBrowse link
G S100B S100 calcium binding protein B ISO protein:increased expression:cerebrum, astrocyte RGD PMID:23595285 RGD:401794586 NCBI chr21:33,063,845...33,070,073
Ensembl chr21:46,197,750...46,203,953 		JBrowse link
G SERPINE1 serpin family E member 1 ISO RGD PMID:14512838 RGD:1580876 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450 		JBrowse link
G SERPINF1 serpin family F member 1 treatment ISO RGD PMID:22714093 RGD:8655545 NCBI chr17:1,745,597...1,761,399
Ensembl chr17:1,638,556...1,653,568 		JBrowse link
G SERPINH1 serpin family H member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr11:70,621,893...70,632,570 JBrowse link
G SHH sonic hedgehog signaling molecule treatment ISO RGD PMID:22324418 RGD:12879461 NCBI chr 7:147,400,112...147,414,036
Ensembl chr 7:159,114,666...159,126,651 		JBrowse link
G SIRT1 sirtuin 1 treatment ISO RGD PMID:23600725 RGD:9585664 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069 		JBrowse link
G SLC12A2 solute carrier family 12 member 2 treatment ISO protein:increased expression:brain: RGD PMID:12535773 PMID:27798271 RGD:14398833 RGD:1580583 NCBI chr 5:123,499,267...123,603,777
Ensembl chr 5:129,262,134...129,364,563 		JBrowse link
G SLC1A2 solute carrier family 1 member 2 treatment ISO RGD PMID:20423712 RGD:401794585 NCBI chr11:35,223,811...35,392,799
Ensembl chr11:35,107,920...35,265,878 		JBrowse link
G SLC2A1 solute carrier family 2 member 1 treatment ISO RGD PMID:9419067 RGD:12879855 NCBI chr 1:42,224,273...42,257,184
Ensembl chr 1:43,600,733...43,634,143 		JBrowse link
G SLC9A1 solute carrier family 9 member A1 treatment ISO RGD PMID:31250553 RGD:14985213 NCBI chr 1:26,359,818...26,418,910
Ensembl chr 1:27,414,937...27,475,089 		JBrowse link
G SLPI secretory leukocyte peptidase inhibitor treatment ISO RGD PMID:14500739 RGD:9999390 NCBI chr20:41,583,429...41,585,773
Ensembl chr20:42,673,417...42,675,773 		JBrowse link
G SMO smoothened, frizzled class receptor treatment ISO RGD PMID:23499832 PMID:23696546 RGD:12832759 RGD:12879404 NCBI chr 7:121,143,968...121,168,873
Ensembl chr 7:133,668,304...133,693,048 		JBrowse link
G SMOX spermine oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:30576531 NCBI chr20:4,167,417...4,206,956
Ensembl chr20:3,965,616...4,004,468 		JBrowse link
G SNAP91 synaptosome associated protein 91 ISO protein:increased degradation:brain RGD PMID:19240038 RGD:13461853 NCBI chr 6:81,441,792...81,600,505
Ensembl chr 6:84,720,850...84,874,407 		JBrowse link
G SOD1 superoxide dismutase 1 treatment ISO mRNA, protein:increased expression:cerebral cortex (rat) RGD PMID:22001340 PMID:22133807 RGD:8657021 RGD:8657023 NCBI chr21:18,029,831...18,037,526 JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21940958 NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960 		JBrowse link
G SPHK2 sphingosine kinase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:23043544 NCBI chr19:45,620,980...45,631,786
Ensembl chr19:54,213,166...54,224,767 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21940958 NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067 		JBrowse link
G TGFB1 transforming growth factor beta 1 ameliorates ISO RGD PMID:28630232 PMID:31409163 RGD:14995477 RGD:242905192 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973 		JBrowse link
G TH tyrosine hydroxylase ISO protein:decreased expression:substantia nigra pars compacta, neuron (rat) RGD PMID:21366664 RGD:5128609 NCBI chr11:2,204,820...2,212,750
Ensembl chr11:2,231,248...2,242,433 		JBrowse link
G TLR2 toll like receptor 2 treatment ISO mRNA:increased expression:microglial cell RGD PMID:20859668 PMID:24723245 PMID:29039449 RGD:597538462 RGD:597538520 RGD:597538540 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR4 toll like receptor 4 treatment ISO RGD PMID:20859668 PMID:24723245 RGD:597538520 RGD:597538540 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TNF tumor necrosis factor treatment
ameliorates 		ISO RGD PMID:15647744 PMID:24916922 PMID:28630232 PMID:29498696 PMID:35322553 RGD:10450594 RGD:13792833 RGD:13825261 RGD:242905190 RGD:242905192 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFAIP6 TNF alpha induced protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr2B:38,669,652...38,692,037
Ensembl chr2B:155,933,842...155,956,382 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO RGD PMID:15647744 RGD:13825261 NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613 		JBrowse link
G TREM1 triggering receptor expressed on myeloid cells 1 ameliorates ISO RGD PMID:32736673 RGD:127284860 NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091 		JBrowse link
G UPP1 uridine phosphorylase 1 ISO mRNA, protein:increased expression:brain (rat) RGD PMID:18457515 RGD:2317094 NCBI chr 7:48,729,975...48,749,598
Ensembl chr 7:48,838,893...48,858,185 		JBrowse link
G VEGFA vascular endothelial growth factor A treatment ISO mRNA,protein:increased expression:cerebral cortex (rat) RGD PMID:27035554 PMID:29497380 PMID:30531687 RGD:329337377 RGD:329849008 RGD:40925919 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353 		JBrowse link
G XDH xanthine dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chr2A:31,356,011...31,435,111
Ensembl chr2A:31,425,183...31,504,455 		JBrowse link
G XRCC1 X-ray repair cross complementing 1 ISO associated with transient cerebral ischemia;protein:increased expression:brain RGD PMID:17412650 RGD:2302580 NCBI chr19:40,485,052...40,522,188
Ensembl chr19:49,094,014...49,125,520 		JBrowse link
Multi-Infarct Dementia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein ISO protein:decreased expression:cerebrospinal fluid: RGD PMID:1677459 RGD:10054257 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:18938189 RGD:10054050 NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468 		JBrowse link
G BCL2 BCL2 apoptosis regulator treatment ISO RGD PMID:18938189 RGD:10054050 NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase treatment ISO RGD PMID:21279683 RGD:10449132 NCBI chr  X:143,972,798...143,988,960
Ensembl chr  X:153,843,092...153,860,674 		JBrowse link
G IL2 interleukin 2 severity ISO protein:increased secretion:mononuclear cell: RGD PMID:8586980 RGD:10047081 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15857
    disease of anatomical entity 15504
      cardiovascular system disease 4489
        vascular disease 3073
          cerebrovascular disease 931
            Stroke 424
              Lacunar Strokes 1
              brain infarction + 297
              cardioembolic stroke 0
              hemorrhagic stroke 0
              large artery stroke 0
Path 2
Term Annotations click to browse term
  disease 15857
    disease of anatomical entity 15504
      nervous system disease 13588
        central nervous system disease 12157
          brain disease 11423
            cerebrovascular disease 931
              Stroke 424
                Lacunar Strokes 1
                brain infarction + 297
                cardioembolic stroke 0
                hemorrhagic stroke 0
                large artery stroke 0
paths to the root