RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Stroke
Accession: DOID:9007096
browse the term
Definition: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Synonyms: exact_synonym: Acute Cerebrovascular Accident; Acute Cerebrovascular Accidents; Acute Stroke; Acute Strokes; Apoplexy; Brain Vascular Accident; Brain Vascular Accidents; CVA; Cerebral Stroke; Cerebral Strokes; Cerebrovascular Accidents; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular Strokes; STRK1; cerebrovascular accident; strokes
narrow_synonym: post-operative stroke; small vessel stroke
related_synonym: stroke, susceptibility to, 1
primary_id: MESH:D020521
alt_id: MIM:606799
xref: EFO:0000712 ; EFO:0009956 ; EFO:1001504
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ABCC8
ATP binding cassette subfamily C member 8
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent
RGD
PMID:17673715
RGD:2301906
NCBI chr11:17,447,564...17,531,513
Ensembl chr11:17,133,063...17,216,870
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ABO
ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr 9:104,354,115...104,399,057
Ensembl chr 9:132,989,574...133,010,324
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ACAN
aggrecan
treatment
ISO
RGD
PMID:24664200
RGD:11570545
NCBI chr15:67,492,494...67,563,265
Ensembl chr15:86,733,853...86,771,420
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ACE
angiotensin I converting enzyme
treatment
ISO
ClinVar Annotator: match by term: CEREBROVASCULAR ACCIDENT
RGD ClinVar
PMID:1313972 PMID:1319114 PMID:1328889 PMID:1386652 PMID:1976655 PMID:2847529 PMID:2849100 PMID:7593601 PMID:7729604 PMID:7783416 PMID:7854377 PMID:7909524 PMID:8131299 PMID:8131300 PMID:8136829 PMID:8170965 PMID:8208911 PMID:8298638 PMID:8314010 PMID:8541160 PMID:8644984 PMID:8675669 PMID:9120002 PMID:9236417 PMID:9259580 PMID:9699903 PMID:9737775 PMID:9916793 PMID:10099885 PMID:10636736 PMID:10643899 PMID:10841123 PMID:11687636 PMID:11956052 PMID:12220450 PMID:12666117 PMID:14657821 PMID:14872014 PMID:15110771 PMID:15256675 PMID:15277638 PMID:15381116 PMID:15531537 PMID:15534175 PMID:15635071 PMID:19221299 More...
RGD:40400712
NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853
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ACHE
acetylcholinesterase (Yt blood group)
disease_progression
ISO
protein:decreased expression:serum
RGD
PMID:20464061
RGD:5688131
NCBI chr 7:92,915,065...92,922,079
Ensembl chr 7:106,311,944...106,318,184
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ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif 12
susceptibility
ISO
DNA:SNP::rs1364044(human)
RGD
PMID:22990015
RGD:9681739
NCBI chr 5:76,442,053...76,818,726
Ensembl chr 5:81,827,560...82,199,840
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ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif 2
susceptibility
ISO
DNA:SNP::rs469568(human)
RGD
PMID:22990015
RGD:9681739
NCBI chr 5:174,264,811...174,502,817
Ensembl chr 5:181,557,928...181,786,175
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ADIPOQ
adiponectin, C1Q and collagen domain containing
ISO
protein:increased expression:plasma,brain protein:decreased expression:serum
RGD
PMID:19699724 PMID:20047566
RGD:5686837 RGD:5686856
NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885
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ADM
adrenomedullin
ISO
protein:increased expression:plasma:
RGD
PMID:21695352
RGD:5508764
NCBI chr11:10,437,712...10,440,053
Ensembl chr11:10,165,418...10,167,842
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AGER
advanced glycosylation end-product specific receptor
treatment susceptibility
ISO
associated with Diabetes Mellitus, Experimental DNA:polymorphism:promoter:-374T>A (human)
RGD
PMID:16728681 PMID:21683770
RGD:1625333 RGD:7245961
NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641
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AGT
angiotensinogen
susceptibility
ISO
associated with hypertension;DNA:polymorphism: :p.M235T associated with sickle cell anemia;DNA:repeat:exon:
RGD
PMID:11754397 PMID:17299437
RGD:11039048 RGD:1601132
NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044
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AGTR2
angiotensin II receptor type 2
ISO
RGD
PMID:19246705
RGD:6903905
NCBI chr X:105,252,903...105,257,171
Ensembl chr X:115,671,594...115,672,685
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AGXT2
alanine--glyoxylate aminotransferase 2
ISO
DNA:SNP:cds:rs40200 (human)
RGD
PMID:25245031
RGD:329970278
NCBI chr 5:75,322,351...75,373,261
Ensembl chr 5:80,601,554...80,652,575
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AHSG
alpha 2-HS glycoprotein
ISO
protein:increased expression:plasma
RGD
PMID:19029462
RGD:2313810
NCBI chr 3:183,644,223...183,652,620
Ensembl chr 3:192,110,770...192,119,915
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AKT1
AKT serine/threonine kinase 1
disease_progression
ISO
RGD
PMID:19440551
RGD:5509077
NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756
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ALB
albumin
disease_progression
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD RGD
PMID:8291969 PMID:14514741 PMID:16174931 PMID:16809570 PMID:17270091
RGD:11036080
NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418
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ALDOC
aldolase, fructose-bisphosphate C
ISO
protein:increased expression:cerebrospinal fluid
RGD
PMID:17053973
RGD:2301133
NCBI chr17:28,198,895...28,202,950
Ensembl chr17:28,700,976...28,706,507
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ALOX5AP
arachidonate 5-lipoxygenase activating protein
ISO
mRNA:increased expression:leukocyte (rat) DNA:polymorphism: :2354T>A (human)
RGD
PMID:17922411 PMID:19373490
RGD:2313886 RGD:2313907
NCBI chr13:12,012,399...12,041,557
Ensembl chr13:30,425,510...30,476,607
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ANGPT1
angiopoietin 1
ISO
RGD
PMID:11822892 PMID:17356562
RGD:1626162 RGD:704373
NCBI chr 8:103,893,234...104,137,661
Ensembl chr 8:106,042,041...106,286,783
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ANGPT2
angiopoietin 2
ISO
mRNA:increased expression:brain (rat)
RGD
PMID:15637314
RGD:1626166
NCBI chr 8:718,367...782,534
Ensembl chr 8:6,506,014...6,566,915
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ANK2
ankyrin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr 4:105,315,776...105,882,506
Ensembl chr 4:115,967,106...116,443,905
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APOA1
apolipoprotein A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19433014
NCBI chr11:111,673,539...111,675,428
Ensembl chr11:115,606,136...115,608,122
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APOD
apolipoprotein D
ISO
RGD
PMID:17851453
RGD:2311182
NCBI chr 3:192,852,887...192,868,233
Ensembl chr 3:203,152,476...203,168,060
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APOH
apolipoprotein H
ISO
RGD
PMID:14595478
RGD:2313986
NCBI chr17:60,154,389...60,171,762
Ensembl chr17:65,365,250...65,382,483
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ASCL1
achaete-scute family bHLH transcription factor 1
ISO
RGD
PMID:16730914
RGD:2314146
NCBI chr12:100,536,895...100,539,737
Ensembl chr12:103,932,302...103,932,999
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AVP
arginine vasopressin
ISO
protein:decreased expression:plasma
RGD
PMID:15897635
RGD:1601304
NCBI chr20:3,169,094...3,172,900
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BCHE
butyrylcholinesterase
ISO
protein:increased expression:serum
RGD
PMID:20464061
RGD:5688131
NCBI chr 3:162,794,184...162,858,574
Ensembl chr 3:170,845,494...170,911,481
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BCL2L1
BCL2 like 1
ISO
protein:altered localization:cerebral cortex (mouse)
RGD
PMID:17301160
RGD:11353792
NCBI chr20:27,955,688...28,015,950
Ensembl chr20:29,088,055...29,146,585
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BDNF
brain derived neurotrophic factor
treatment
ISO
associated with middle cerebral artery infarction
RGD
PMID:34284448
RGD:597015748
NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239
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BMP4
bone morphogenetic protein 4
ISO
protein:increased expression:brain, astrocyte
RGD
PMID:16730912
RGD:2289004
NCBI chr14:34,542,132...34,549,286
Ensembl chr14:52,821,872...52,828,752
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C1H1orf167
chromosome 1 C1orf167 homolog
ISO
DNA:SNP: :rs56001051(human)
RGD
PMID:31175347
RGD:14696712
NCBI chr 1:10,524,980...10,551,759
Ensembl chr 1:11,741,083...11,769,155
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CASP2
caspase 2
ISO
RGD
PMID:12067235
RGD:4107080
NCBI chr 7:135,283,072...135,307,855
Ensembl chr 7:147,773,749...147,792,958
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CASP3
caspase 3
ISO
protein:increased activation:cerebral cortex
RGD
PMID:18463494
RGD:2293316
NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185
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CAST
calpastatin
ISO
RGD
PMID:20116408
RGD:5509801
NCBI chr 5:91,972,572...92,084,657
Ensembl chr 5:97,527,071...97,636,650
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CASZ1
castor zinc finger 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr 1:9,396,936...9,557,100
Ensembl chr 1:10,622,519...10,677,091
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CCL2
C-C motif chemokine ligand 2
ISO
protein:increased expression:brain, neuron DNA:snp:promoter:g.-2518A>G (human)
RGD
PMID:15308783 PMID:18473828
RGD:1581163 RGD:2307024
NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384
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CD40
CD40 molecule
ISO
associated with Hypertension
RGD
PMID:20456428
RGD:5490543
NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994
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CD44
CD44 molecule (IN blood group)
ISO
RGD
PMID:16837837
RGD:2289371
NCBI chr11:35,110,732...35,258,238
Ensembl chr11:34,985,634...35,079,009
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CD63
CD63 molecule
ISO
protein:increased expression:platelet
RGD
PMID:19233449
RGD:2314182
NCBI chr12:33,181,896...33,186,123
Ensembl chr12:33,906,314...33,910,595
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CDK6
cyclin dependent kinase 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr 7:84,603,419...84,835,082
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CFH
complement factor H
ISO
protein:decreased expression:plasma:
RGD
PMID:21695352
RGD:5508764
NCBI chr 1:172,155,882...172,251,632
Ensembl chr 1:176,455,247...176,525,521
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COL4A1
collagen type IV alpha 1 chain
ISO
RGD
PMID:16374828
RGD:1581205
NCBI chr13:91,282,617...91,440,187
Ensembl chr13:110,407,009...110,562,529
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CSF3
colony stimulating factor 3
ISO
RGD
PMID:17656664
RGD:5134350
NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729
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CSPG4
chondroitin sulfate proteoglycan 4
ISO
RGD
PMID:21951366
RGD:5686849
NCBI chr15:54,583,010...54,621,240
Ensembl chr15:74,177,909...74,200,498
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CTNNB1
catenin beta 1
ISO
protein:increased phosphorylation, decreased expression:brain
RGD
PMID:18241848
RGD:2289837
NCBI chr 3:41,104,940...41,145,934
Ensembl chr 3:41,373,726...41,414,030
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CXCR3
C-X-C motif chemokine receptor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr X:60,880,759...60,883,355
Ensembl chr X:70,933,160...70,935,756
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CYP11B2
cytochrome P450 family 11 subfamily B member 2
ISO
associated with Hypertension;DNA:polymorphism
RGD
PMID:15894891
RGD:2307308
NCBI chr 8:139,622,632...139,630,014
Ensembl chr 8:142,666,534...142,672,575
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EDN1
endothelin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20083630
NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545
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EDNRA
endothelin receptor type A
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17597600 PMID:29531354
RGD:4892584
NCBI chr 4:139,815,336...139,879,600
Ensembl chr 4:151,476,356...151,536,497
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ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
susceptibility
ISO
associated with Anemia, Sickle Cell;DNA:missense mutation:cds:p.K173Q (human)
RGD
PMID:23422753
RGD:13204735
NCBI chr 6:129,591,858...129,673,000
Ensembl chr 6:133,698,640...133,783,644
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EPHX2
epoxide hydrolase 2
susceptibility
ISO
DNA:missense mutation:cds:p.K55R (human) DNA:SNPs, haplotype:promoter:-255T>C, -111G>A, 25C>T (rat) DNA:SNP:intron:IVS16 (rs2291635) (human)
RGD
PMID:18086949 PMID:18323494 PMID:20065888
RGD:5688362 RGD:5688363 RGD:5688727
NCBI chr 8:26,761,090...26,818,436
Ensembl chr 8:23,964,094...24,017,749
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ERBB4
erb-b2 receptor tyrosine kinase 4
ISO
protein:increased expression:brain
RGD
PMID:15694257
RGD:2289956
NCBI chr2B:98,625,630...99,795,371
Ensembl chr2B:217,069,644...218,272,006
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ESR2
estrogen receptor 2
treatment
ISO
RGD
PMID:24406718
RGD:10045677
NCBI chr14:44,807,875...44,919,780
Ensembl chr14:63,064,402...63,131,303
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F12
coagulation factor XII
susceptibility
ISO
DNA:polymorphism::46C>T(human)
RGD
PMID:15232129
RGD:11041862
NCBI chr 5:172,703,724...172,711,618
Ensembl chr 5:179,766,243...179,773,485
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F13A1
coagulation factor XIII A chain
ISO
RGD
PMID:11692020
RGD:1581026
NCBI chr 6:5,978,505...6,156,705
Ensembl chr 6:6,157,926...6,513,961
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F2
coagulation factor II, thrombin
ISO
ClinVar Annotator: match by term: CEREBROVASCULAR ACCIDENT
ClinVar
PMID:2222810 PMID:2429850 PMID:2825773 PMID:6305407 PMID:6405779 PMID:8696333 PMID:8896550 PMID:8916933 PMID:9106528 PMID:9292507 PMID:9462220 PMID:9493607 PMID:9531249 PMID:9569177 PMID:9694698 PMID:9869612 PMID:10027711 PMID:10233438 PMID:10233439 PMID:10336270 PMID:10348710 PMID:10348711 PMID:10348712 PMID:10406905 PMID:10477778 PMID:10544935 PMID:11358905 PMID:11443298 PMID:11506076 PMID:11796466 PMID:11874997 PMID:11904676 PMID:14629473 PMID:15059842 PMID:15534175 PMID:16493002 PMID:16606808 PMID:19159930 PMID:19289024 PMID:19531787 PMID:19554541 PMID:19560233 PMID:19652888 PMID:20301327 PMID:21243428 PMID:21349849 PMID:23429074 PMID:24033266 PMID:25741868 PMID:27031503 PMID:28492532 PMID:28707429 PMID:30297698 PMID:31064749 PMID:31352677 PMID:34110897 PMID:34355501 PMID:38498041 More...
NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157
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F5
coagulation factor V
ISO
ClinVar Annotator: match by term: CEREBROVASCULAR ACCIDENT
ClinVar
PMID:7586244 PMID:7803250 PMID:7877648 PMID:7910348 PMID:7911872 PMID:7968118 PMID:8049422 PMID:8164730 PMID:8164741 PMID:8566967 PMID:8616100 PMID:8822583 PMID:9245936 PMID:9339109 PMID:9372726 PMID:9415695 PMID:9454741 PMID:9459326 PMID:9518910 PMID:9734642 PMID:10328130 PMID:10348711 PMID:10477778 PMID:10494770 PMID:10507841 PMID:10666427 PMID:11018168 PMID:11110695 PMID:11686338 PMID:11950065 PMID:12069454 PMID:12070000 PMID:12421138 PMID:12816860 PMID:14996674 PMID:15208046 PMID:15534175 PMID:15638861 PMID:15946211 PMID:16199547 PMID:16246256 PMID:16493002 PMID:16769590 PMID:16931580 PMID:19652888 PMID:20051284 PMID:21116184 PMID:21774968 PMID:22704462 PMID:22992668 PMID:23382263 PMID:23677252 PMID:23900608 PMID:24033266 PMID:25741868 PMID:25977387 PMID:26251307 PMID:26990548 PMID:27797270 PMID:28492532 PMID:28750087 PMID:30924984 PMID:31399523 PMID:34355501 More...
NCBI chr 1:144,996,757...145,070,046
Ensembl chr 1:148,718,897...148,790,915
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F8
coagulation factor VIII
ISO
RGD
PMID:15202164
RGD:1582360
NCBI chr X:144,316,192...144,505,773
Ensembl chr X:154,156,873...154,341,317
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FABP2
fatty acid binding protein 2
ISO
DNA:missense mutation:cds:p.A54T (human)
RGD
PMID:10946885
RGD:1300312
NCBI chr 4:111,505,269...111,510,197
Ensembl chr 4:122,055,544...122,060,461
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FBN1
fibrillin 1
ISO
ClinVar Annotator: match by term: CEREBROVASCULAR ACCIDENT
ClinVar
PMID:7611299 PMID:8894692 PMID:9401003 PMID:9536098 PMID:10533071 PMID:10874320 PMID:11700157 PMID:12402346 PMID:12938084 PMID:14695540 PMID:16220557 PMID:16222657 PMID:16835936 PMID:17253931 PMID:17576681 PMID:17657824 PMID:17663468 PMID:19159394 PMID:19293843 PMID:21542060 PMID:24033266 PMID:24161884 PMID:25741868 PMID:26133393 PMID:28492532 PMID:29357934 PMID:31098894 PMID:37684520 More...
NCBI chr15:27,358,780...27,593,539
Ensembl chr15:45,682,450...45,918,111
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FGA
fibrinogen alpha chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr 4:146,949,680...146,957,291
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FGB
fibrinogen beta chain
susceptibility
ISO
DNA:SNP:promoter:1038G>A (rs1800791) (human) DNA:polymorphism: :-455G>A(human)
RGD
PMID:18278190 PMID:24107890
RGD:10450767 RGD:5688760
NCBI chr 4:146,929,561...146,937,665
Ensembl chr 4:158,747,659...158,755,766
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FGG
fibrinogen gamma chain
susceptibility
ISO
DNA:SNP:promoter:902A>G (rs1800792) (human)
RGD
PMID:18278190
RGD:5688760
NCBI chr 4:146,970,671...146,979,348
Ensembl chr 4:158,788,966...158,797,237
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FOXF2
forkhead box F2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr 6:1,209,899...1,215,970
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GAS6
growth arrest specific 6
ISO
RGD
PMID:15108283
RGD:1579883
Ensembl chr13:113,968,843...114,009,562
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GFAP
glial fibrillary acidic protein
severity
ISO
protein:increased expression:cerebrospinal fluid
RGD
PMID:19959621
RGD:5508793
NCBI chr17:12,407,211...12,417,072
Ensembl chr17:12,579,754...12,591,961
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GFRA1
GDNF family receptor alpha 1
ISO
mRNA:increased expression:brain
RGD
PMID:11476594
RGD:6218974
NCBI chr10:112,645,574...112,862,413
Ensembl chr10:116,079,063...116,295,164
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GPX3
glutathione peroxidase 3
ISO
protein:decreased expression:plasma
RGD
PMID:10446087
RGD:401827831
NCBI chr 5:146,447,939...146,456,476
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GRN
granulin precursor
ISO
ClinVar Annotator: match by term: CEREBROVASCULAR ACCIDENT
ClinVar
PMID:18723524 PMID:25741868 PMID:28492532
NCBI chr17:13,046,329...13,054,236
Ensembl chr17:13,211,784...13,219,609
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GSTM1
glutathione S-transferase mu 1
susceptibility
ISO
associated with sickle cell anemia;
RGD
PMID:23590899
RGD:10450838
Ensembl chr 1:127,979,238...128,010,411
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HDAC1
histone deacetylase 1
ISO
RGD
PMID:24657831
RGD:9590303
NCBI chr 1:31,578,373...31,619,970
Ensembl chr 1:32,585,791...32,626,410
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HDAC2
histone deacetylase 2
ISO
mRNA:decreased expression:lymphocyte
RGD
PMID:24657831 PMID:31465536
RGD:156430320 RGD:9590303
NCBI chr 6:111,731,139...111,761,826
Ensembl chr 6:115,802,367...115,833,004
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HDAC4
histone deacetylase 4
ISO
RGD
PMID:24657831
RGD:9590303
NCBI chr2B:126,287,745...126,649,815
Ensembl chr2B:245,123,061...245,427,054
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HDAC9
histone deacetylase 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22306652
NCBI chr 7:18,740,580...19,653,615
Ensembl chr 7:18,138,761...18,970,717
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HGF
hepatocyte growth factor
treatment
ISO
RGD
PMID:16421510
RGD:8548626
NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811
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HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase
ISO
RGD
PMID:16316970
RGD:5508472
NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785
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HMOX1
heme oxygenase 1
ISO
RGD
PMID:14753445
RGD:1598410
NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063
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HTR4
5-hydroxytryptamine receptor 4
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:7886817
NCBI chr 5:143,918,925...144,208,779
Ensembl chr 5:149,889,969...150,108,357
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ICAM1
intercellular adhesion molecule 1
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:10066862 PMID:20083630
RGD:11522710
NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605
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IFNG
interferon gamma
ISO
mRNA:decreased expression:lymphocyte
RGD
PMID:31465536
RGD:156430320
NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829
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IGF1
insulin like growth factor 1
severity
ISO
RGD
PMID:15567334 PMID:16882751
RGD:1598413 RGD:1598423
NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177
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IGF1R
insulin like growth factor 1 receptor
ISO
DNA: SNP: : rs2229765
RGD
PMID:18477064
RGD:5686435
NCBI chr15:77,332,926...77,648,474
Ensembl chr15:96,535,164...96,832,974
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IL10
interleukin 10
treatment severity no_association
ISO
mRNA:increased expression:brain
RGD
PMID:15894335 PMID:16323614 PMID:23786953 PMID:23981596
RGD:1598623 RGD:1598629 RGD:7364869 RGD:7365015
NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
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IL18
interleukin 18
ISO
mRNA:increased expression:brain
RGD
PMID:21171972
RGD:4891154
NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371
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IL1B
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10950380
NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
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IL1RN
interleukin 1 receptor antagonist
ISO
CTD Direct Evidence: marker/mechanism rat model treated with human protein
CTD RGD
PMID:12374626 PMID:22781338
RGD:6909180
NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839
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IL4
interleukin 4
ISO
mRNA:increased expression:lymphocyte
RGD
PMID:31465536
RGD:156430320
NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581
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IL4R
interleukin 4 receptor
disease_progression susceptibility
ISO
associated with Anemia, Sickle Cell;DNA:polymorphism:cds:p.S503P(rs1805015)(human)
RGD
PMID:14615367 PMID:24386991
RGD:11529997 RGD:11530005
Ensembl chr16:27,642,702...27,737,445
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IL6
interleukin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:14512079 PMID:18319729
RGD:1580486
NCBI chr 7:23,415,922...23,420,767
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IRF1
interferon regulatory factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr 5:127,903,887...127,913,843
Ensembl chr 5:134,067,441...134,075,035
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ITGA2
integrin subunit alpha 2
susceptibility no_association
ISO
DNA:SNP::807C>T(human)
RGD
PMID:12871362 PMID:25207168
RGD:13592606 RGD:1582299
NCBI chr 5:60,935,452...61,040,726
Ensembl chr 5:62,555,370...62,659,720
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ITGA2B
integrin subunit alpha 2b
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:9445356 PMID:15678115
RGD:2316358
NCBI chr17:13,009,514...13,027,289
Ensembl chr17:13,176,843...13,193,269
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ITGAM
integrin subunit alpha M
treatment
ISO
RGD
PMID:12805500
RGD:329901938
NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406
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ITGAV
integrin subunit alpha V
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9445356
NCBI chr2B:73,880,962...73,972,486
Ensembl chr2B:191,680,655...191,773,028
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ITGB3
integrin subunit beta 3
ISO
associated with hypertension; DNA:polymorphism:exon CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:9445356 PMID:15678115 PMID:20846430
RGD:2316358 RGD:5128476
NCBI chr17:10,134,450...10,194,596
Ensembl chr17:10,353,111...10,392,382
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JAK2
Janus kinase 2
ISO
RGD
PMID:18079966
RGD:6483032
NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626
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KCNK3
potassium two pore domain channel subfamily K member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr2A:26,688,938...26,729,860
Ensembl chr2A:26,780,475...26,819,123
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KDR
kinase insert domain receptor
ISO
RGD
PMID:20101028
RGD:5684395
NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109
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KIF6
kinesin family member 6
ISO
DNA:SNP: :p.W719R (rs20455) (human)
RGD
PMID:19752551
RGD:2317144
NCBI chr 6:38,917,083...39,306,190
Ensembl chr 6:40,234,426...40,616,738
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KL
klotho
ISO
RGD
PMID:15677572
RGD:1581727
NCBI chr13:14,272,463...14,321,122
Ensembl chr13:32,702,336...32,751,458
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KNG1
kininogen 1
susceptibility
ISO
DNA:SNP: :rs710446(human)
RGD
PMID:26159646
RGD:10411883
NCBI chr 3:183,751,598...183,778,655
Ensembl chr 3:192,219,462...192,245,149
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LCN2
lipocalin 2
ISO
protein:increased expression:brain, neuron
RGD
PMID:24916903
RGD:126790489
NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798
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LDLR
low density lipoprotein receptor
susceptibility
ISO
DNA:SNPs:introns: (rs2738446, rs2738450) (human)
RGD
PMID:19589204
RGD:5490232
NCBI chr19:10,640,225...10,683,728
Ensembl chr19:11,357,311...11,396,791
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LIF
LIF interleukin 6 family cytokine
ISO
RGD
PMID:18042242
RGD:2326063
NCBI chr22:11,276,576...11,282,972
Ensembl chr22:29,078,862...29,095,608
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LOC100972994
HLA class II histocompatibility antigen, DQ beta 1 chain
susceptibility
ISO
DNA:polymorphism:cds:HLA-DQB1*0402 (human)
RGD
PMID:12373032
RGD:5147804
NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272
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LOC100976904
growth-regulated alpha protein
ISO
mRNA:increased expression:brain
RGD
PMID:21124781
RGD:5134994
NCBI chr 4:50,325,248...50,327,165
Ensembl chr 4:56,153,899...56,159,474
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LOC100991644
low affinity immunoglobulin gamma Fc region receptor II-a
susceptibility
ISO
DNA:SNPs:enhancers: (rs7512140, rs7535475) (human) DNA:SNPs:enhancers:multiple
RGD
PMID:19357503 PMID:20034444
RGD:5147920 RGD:5147924
NCBI chr 1:136,892,311...136,906,450
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LPA
lipoprotein(a)
ISO
DNA:SNP:CDS:rs3798220, g.160961137T>C, p.Ile1891Met CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:10484779 PMID:18775538
RGD:5509091
NCBI chr 6:158,434,394...158,628,028
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LRCH1
leucine rich repeats and calponin homology domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr13:27,697,684...27,897,762
Ensembl chr13:46,416,017...46,613,065
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MAP3K7
mitogen-activated protein kinase kinase kinase 7
treatment
ISO
RGD
PMID:33434616
RGD:155791452
NCBI chr 6:88,398,329...88,470,926
Ensembl chr 6:91,664,263...91,737,468
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MAPK8
mitogen-activated protein kinase 8
ISO
RGD
PMID:10773432
RGD:1582317
NCBI chr10:45,806,748...45,936,362
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MIF
macrophage migration inhibitory factor
ISO
mRNA,protein:increased expression:brain mRNA,protein:increased expression:leukocytes, mononuclear, plasma
RGD
PMID:19131653
RGD:4890976
NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009
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MMP1
matrix metallopeptidase 1
ISO
RGD
PMID:11720009
RGD:1582542
NCBI chr11:97,730,545...97,739,190
Ensembl chr11:101,221,393...101,230,104
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MMP12
matrix metallopeptidase 12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr11:97,809,644...97,822,063
Ensembl chr11:101,294,475...101,306,762
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MMP2
matrix metallopeptidase 2
ISO
protein:increased expression: :
RGD
PMID:16599837 PMID:19840223
RGD:1582617 RGD:2325713
NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279
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MMP3
matrix metallopeptidase 3
treatment
ISO
RGD
PMID:24194350
RGD:8694111
NCBI chr11:97,776,729...97,784,549
Ensembl chr11:101,267,566...101,275,354
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MMP9
matrix metallopeptidase 9
ISO
protein:increased expression, increased activity:brain, plasma
RGD
PMID:16051896 PMID:16690896 PMID:19556529
RGD:1582615 RGD:1582635 RGD:2325825
NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
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MTHFR
methylenetetrahydrofolate reductase
no_association
ISO
associated with Anemia, Sickle Cell;DNA:missense mutation:cds:677C>T (human) DNA:transition:cds:g.677C>T (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:9840906 PMID:15534175 PMID:15652605 PMID:16681562 PMID:19646848
RGD:10449417 RGD:6893467
NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419
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MYH15
myosin heavy chain 15
ISO
DNA:snp:exon:EX28T>C rs3900940 (human)
RGD
PMID:19752551
RGD:2317144
NCBI chr 3:105,498,196...105,635,979
Ensembl chr 3:112,432,417...112,586,559
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NDFIP1
Nedd4 family interacting protein 1
ISO
RGD
PMID:22417925
RGD:6893327
NCBI chr 5:137,467,161...137,511,569
Ensembl chr 5:143,600,789...143,622,913
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NDUFC2
NADH:ubiquinone oxidoreductase subunit C2
susceptibility
ISO
DNA:SNPs,haplotype::rs641836, rs11237379 (human) incidence 40% in heterozygous SHR-Ndufc2 rats vs 0% in parental SHR rats after 3 months of stroke-permissive diet
RGD
PMID:26888427
RGD:11040458
NCBI chr11:73,128,457...73,140,344
Ensembl chr11:76,720,094...76,763,098
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NEDD4L
NEDD4 like E3 ubiquitin protein ligase
ISO
RGD
PMID:22417925
RGD:6893327
NCBI chr18:51,428,077...51,792,995
Ensembl chr18:54,867,149...55,123,423
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NEFL
neurofilament light chain
ISO
RGD
PMID:29967576
RGD:27226878
NCBI chr 8:24,218,510...24,224,627
Ensembl chr 8:21,134,533...21,140,694
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NGF
nerve growth factor
ISO
RGD
PMID:19061539
RGD:2303801
NCBI chr 1:87,223,597...87,276,759
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NKX2-5
NK2 homeobox 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr 5:168,584,197...168,589,406
Ensembl chr 5:175,492,288...175,495,514
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NOS1
nitric oxide synthase 1
ISO
RGD
PMID:19408167
RGD:5132594
NCBI chr12:114,784,232...114,938,385
Ensembl chr12:118,163,655...118,314,005
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NOS2
nitric oxide synthase 2
ISO
mRNA:increased expression:brain CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:20083630 PMID:21171972
RGD:4891154
NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093
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NOS3
nitric oxide synthase 3
susceptibility treatment
ISO
associated with Anemia, Sickle Cell;DNA:repeats:intron:
RGD
PMID:18234158 PMID:25263931 PMID:29152647
RGD:11533931 RGD:13504814 RGD:2292103
NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233
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NOSTRIN
nitric oxide synthase trafficking
ISO
RGD
PMID:11489260
RGD:631971
NCBI chr2B:56,064,199...56,126,759
Ensembl chr2B:173,516,771...173,592,692
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NOTCH3
notch receptor 3
ISO
ClinVar Annotator: match by term: Stroke
ClinVar
PMID:8878478 PMID:9388399 PMID:12754354 PMID:15229130 PMID:15857853 PMID:20071773 PMID:21940951 PMID:24425116 PMID:24886907 PMID:25412914 PMID:25741868 PMID:26467025 PMID:27844030 PMID:28334938 PMID:28492532 PMID:31418856 PMID:32277177 PMID:32555735 PMID:32581362 PMID:34335700 More...
NCBI chr19:14,692,571...14,733,758
Ensembl chr19:15,678,674...15,715,080
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NPPA
natriuretic peptide A
susceptibility
ISO
DNA:missense:exon:rs5063(human) DNA:SNP, missense mutation:intron 2, CDS:1837G>A, 664G>A (p.V7M) (human) DNA:polymorphism:TC2238
RGD
PMID:10525492 PMID:15017020 PMID:25452597
RGD:14696737 RGD:149735577 RGD:1580137
NCBI chr 1:10,608,025...10,610,287
Ensembl chr 1:11,825,072...11,827,373
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NPY1R
neuropeptide Y receptor Y1
ISO
RGD
PMID:10891620
RGD:1642319
NCBI chr 4:155,583,870...155,604,336
Ensembl chr 4:167,372,310...167,381,597
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NR3C1
nuclear receptor subfamily 3 group C member 1
ISO
RGD
PMID:20858282
RGD:4892205
NCBI chr 5:138,634,278...139,089,171
Ensembl chr 5:144,741,452...144,865,269
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NTRK2
neurotrophic receptor tyrosine kinase 2
treatment
ISO
associated with middle cerebral artery infarction
RGD
PMID:34284448
RGD:597015748
NCBI chr 9:39,663,986...40,208,770
Ensembl chr 9:84,021,837...84,372,678
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PAK1
p21 (RAC1) activated kinase 1
ISO
mRNA, protein:increased expression:brain
RGD
PMID:17997827
RGD:2299171
NCBI chr11:72,372,577...72,524,817
Ensembl chr11:76,015,998...76,104,197
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PAOX
polyamine oxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16269634
Ensembl chr10:134,294,760...134,307,179
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PDE3A
phosphodiesterase 3A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr12:20,380,213...20,690,540
Ensembl chr12:20,763,999...21,064,391
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PDE4D
phosphodiesterase 4D
ISO
mRNA:increased expression:blood, leukocyte
RGD
PMID:14517540 PMID:16675738 PMID:16825591 PMID:16914755 PMID:17922411
RGD:1581003 RGD:1581004 RGD:1581005 RGD:1581007 RGD:2313907
NCBI chr 5:53,510,287...55,039,181
Ensembl chr 5:55,749,214...56,670,111
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PDE5A
phosphodiesterase 5A
ISO
RGD
PMID:19729580
RGD:2314459
NCBI chr 4:111,682,772...111,817,234
Ensembl chr 4:122,832,175...122,966,636
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PDGFRA
platelet derived growth factor receptor alpha
ISO
mRNA, protein:increased expression:cerebral cortex
RGD
PMID:15342968
RGD:2292165
NCBI chr 4:69,639,081...69,709,870
Ensembl chr 4:76,199,382...76,271,097
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PGF
placental growth factor
ISO
protein:increased expression:brain, astrocyte
RGD
PMID:11939589
RGD:6483603
NCBI chr14:55,494,152...55,508,066
Ensembl chr14:74,338,976...74,352,964
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PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
ISO
ClinVar Annotator: match by term: Stroke
ClinVar
PMID:15520168 PMID:22658544 PMID:22729222 PMID:23100325 PMID:23946963 PMID:25599672 PMID:25681199 PMID:25741868 PMID:26627007 PMID:27631024 PMID:29446767 PMID:34496175 PMID:34568242 PMID:34606700 PMID:37667289 More...
NCBI chr 3:176,182,765...176,272,024
Ensembl chr 3:184,355,785...184,441,977
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PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
ISO
RGD
PMID:21546487
RGD:6482678
NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614
G
PITX2
paired like homeodomain 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr 4:103,112,624...103,137,356
G
PLA2G7
phospholipase A2 group VII
ISO
CTD Direct Evidence: marker/mechanism protein:decreased expression:serum
CTD RGD
PMID:19644070 PMID:21356620
RGD:6482786
NCBI chr 6:46,264,262...46,318,487
Ensembl chr 6:47,558,861...47,590,212
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PLAT
plasminogen activator, tissue type
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD RGD
PMID:1598096 PMID:2124386 PMID:2514002 PMID:7477192 PMID:8427107 PMID:8598594 PMID:9056608 PMID:9259745 PMID:9400355 PMID:9472885 PMID:9479657 PMID:9479658 PMID:9566367 PMID:9633741 PMID:9707184 PMID:9836764 PMID:9933289 PMID:10171637 PMID:10346413 PMID:10436095 PMID:10572812 PMID:11061250 PMID:11108748 PMID:11113218 PMID:11239184 PMID:11739841 PMID:11940547 PMID:12221155 PMID:12230423 PMID:12384244 PMID:12511774 PMID:14581697 PMID:14657446 PMID:14986460 PMID:15016487 PMID:15017018 PMID:15087567 PMID:16126134 PMID:16184341 PMID:16763187 PMID:16809570 PMID:16908730 PMID:17086147 PMID:17525387 PMID:17612434 PMID:17689411 PMID:17903870 PMID:17903947 PMID:18346647 PMID:18369171 PMID:18560214 PMID:18753472 PMID:18753474 PMID:19286598 PMID:20123226 PMID:20212195 PMID:20488584 PMID:20536612 PMID:20705933 PMID:23876515 PMID:25245553 More...
RGD:2311666 RGD:9698433
NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779
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PLAU
plasminogen activator, urokinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12742636
NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136
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PON2
paraoxonase 2
ISO
large vessel disease (LVD) stroke;DNA:missense mutation:cds:p.C311S (human) associated with type 2 diabetes mellitus;DNA:missense mutation:cds:p.S311C (human)
RGD
PMID:12778447 PMID:17406108
RGD:1642614 RGD:2313491
NCBI chr 7:87,362,447...87,392,795
Ensembl chr 7:100,950,074...100,980,433
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PPP1R15A
protein phosphatase 1 regulatory subunit 15A
treatment
ISO
RGD
PMID:24573692
RGD:9999417
NCBI chr19:45,872,596...45,876,376
Ensembl chr19:54,880,141...54,883,003
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PRKAA2
protein kinase AMP-activated catalytic subunit alpha 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20847317
NCBI chr 1:55,928,577...55,998,628
Ensembl chr 1:57,664,237...57,702,227
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PRKAG2
protein kinase AMP-activated non-catalytic subunit gamma 2
ISO
ClinVar Annotator: match by term: Stroke
ClinVar
PMID:25741868 PMID:28492532 PMID:37198425
NCBI chr 7:143,143,556...143,463,492
Ensembl chr 7:155,293,748...155,610,078
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PRKCD
protein kinase C delta
ISO
RGD
PMID:17350602
RGD:1642524
NCBI chr 3:53,104,137...53,135,588
Ensembl chr 3:54,330,328...54,357,910
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PROZ
protein Z, vitamin K dependent plasma glycoprotein
ISO
RGD
PMID:15879328
RGD:1580691
NCBI chr13:94,294,846...94,314,458
Ensembl chr13:113,364,280...113,383,010
G
PRPF8
pre-mRNA processing factor 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr17:1,635,991...1,669,703
Ensembl chr17:1,532,579...1,565,254
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PTGER4
prostaglandin E receptor 4
ISO
RGD
PMID:21965326
RGD:6483526
NCBI chr 5:69,686,906...69,700,739
Ensembl chr 5:74,731,470...74,745,148
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PTGS2
prostaglandin-endoperoxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15138244 PMID:20083630
RGD:1581289
NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519
G
PTH
parathyroid hormone
ISO
protein:increased expression:serum (human)
RGD
PMID:23460043
RGD:7242420
NCBI chr11:13,653,777...13,657,901
Ensembl chr11:13,347,838...13,351,802
G
PTPN1
protein tyrosine phosphatase non-receptor type 1
ISO
protein:increased expression:cerebral cortex (mouse)
RGD
PMID:32788467
RGD:401976392
NCBI chr20:46,854,918...46,929,509
Ensembl chr20:47,983,098...48,057,421
G
RETN
resistin
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNP:promoter:-420G>C (rs1862513) (human)
RGD
PMID:19269054
RGD:2313497
NCBI chr19:6,958,536...6,960,032
Ensembl chr19:7,812,942...7,814,909
G
RGS7
regulator of G protein signaling 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr 1:216,329,373...216,919,898
Ensembl chr 1:221,313,924...221,899,627
G
RNLS
renalase, FAD dependent amine oxidase
ISO
DNA:SNP: : rs10887800 (human)
RGD
PMID:21964580
RGD:7327172
NCBI chr10:84,996,999...85,304,240
Ensembl chr10:88,503,683...88,808,990
G
S100B
S100 calcium binding protein B
severity
ISO
protein:increased expression:serum
RGD
PMID:17706250 PMID:19959621
RGD:5508793 RGD:5508838
NCBI chr21:33,063,845...33,070,073
Ensembl chr21:46,197,750...46,203,953
G
SCNN1A
sodium channel epithelial 1 subunit alpha
ISO
RGD
PMID:15734793
RGD:5509790
NCBI chr12:6,475,723...6,506,443
G
SELL
selectin L
susceptibility
ISO
DNA:missense mutation:cds:p.P213S (human)
RGD
PMID:21465128
RGD:5685695
NCBI chr 1:145,173,700...145,194,927
Ensembl chr 1:148,895,373...148,916,393
G
SELP
selectin P
ISO
RGD
PMID:20122276
RGD:6478688
NCBI chr 1:145,071,094...145,112,851
Ensembl chr 1:148,793,677...148,834,701
G
SERPINE1
serpin family E member 1
ISO
protein:increased expression:plasma
RGD
PMID:11450024
RGD:4144847
NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450
G
SH2B3
SH2B adaptor protein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr12:108,977,344...109,024,029
G
SH3PXD2A
SH3 and PX domains 2A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr10:100,193,961...100,455,200
Ensembl chr10:103,663,163...103,861,437
G
SMOX
spermine oxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16269634
NCBI chr20:4,167,417...4,206,956
Ensembl chr20:3,965,616...4,004,468
G
SOD1
superoxide dismutase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10698074
NCBI chr21:18,029,831...18,037,526
G
SRC
SRC proto-oncogene, non-receptor tyrosine kinase
ISO
RGD
PMID:19741150
RGD:2315083
NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634
G
TBX3
T-box transcription factor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr12:112,240,050...112,254,299
Ensembl chr12:115,620,002...115,631,316
G
TGFA
transforming growth factor alpha
ISO
RGD
PMID:19248822
RGD:2317476
NCBI chr2A:70,510,727...70,617,628
Ensembl chr2A:71,625,196...71,731,461
G
TGFB1
transforming growth factor beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973
G
THBD
thrombomodulin
ISO
RGD
PMID:20581778 PMID:21645225
RGD:5684982 RGD:5684986
NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812
G
TIMP1
TIMP metallopeptidase inhibitor 1
ISO
mRNA:increased expression:cerebral cortex
RGD
PMID:9472898
RGD:2290356
NCBI chr X:40,018,190...40,022,636
Ensembl chr X:47,914,906...47,919,419
G
TLR4
toll like receptor 4
ISO
associated with atherosclerosis;protein:increased expression:endothelial cell:
RGD
PMID:20001205
RGD:7794781
NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
G
TNF
tumor necrosis factor
susceptibility
ISO
mRNA:increased expression:brain CTD Direct Evidence: marker/mechanism associated with Anemia, Sickle Cell;DNA:polymorphism:promoter:-308G>A(rs1800629)(human)
RGD CTD
PMID:10950380 PMID:14615367 PMID:21171972
RGD:11529997 RGD:4891154
NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
G
TNFRSF11B
TNF receptor superfamily member 11b
ISO
protein:increased expression:serum
RGD
PMID:17258300
RGD:1620776
NCBI chr 8:115,614,778...115,643,387
Ensembl chr 8:118,134,305...118,162,422
G
TNNI3
troponin I3, cardiac type
ISO
RGD
PMID:15604421
RGD:1580421
NCBI chr19:52,193,061...52,198,782
Ensembl chr19:60,887,630...60,894,219
G
TSPAN2
tetraspanin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr 1:87,472,017...87,511,719
Ensembl chr 1:122,520,308...122,561,850
G
UCP2
uncoupling protein 2
ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:12858170
RGD:7204436
NCBI chr11:69,047,397...69,056,056
Ensembl chr11:72,354,529...72,363,185
G
VCAM1
vascular cell adhesion molecule 1
susceptibility
ISO
associated with sickle cell anemia;DNA:missense mutation:exon 6:1238G>C (human)
RGD
PMID:12393616
RGD:737738
NCBI chr 1:103,377,815...103,395,118
Ensembl chr 1:102,091,336...102,107,732
G
VEGFA
vascular endothelial growth factor A
ISO
protein:increased expression:brain:
RGD
PMID:11585245
RGD:7421577
NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
G
VKORC1
vitamin K epoxide reductase complex subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16549638
NCBI chr16:23,871,756...23,876,599
Ensembl chr16:31,459,560...31,464,897
G
WNT2B
Wnt family member 2B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr 1:115,119,360...115,177,942
Ensembl chr 1:125,173,906...125,230,675
G
ZCCHC14
zinc finger CCHC-type containing 14
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr16:68,078,237...68,165,406
Ensembl chr16:87,401,184...87,486,124
G
ZFHX3
zinc finger homeobox 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29531354
NCBI chr16:51,936,471...52,209,695
Ensembl chr16:72,635,666...72,808,360
G
ADIPOQ
adiponectin, C1Q and collagen domain containing
ISO
RGD
PMID:19362080
RGD:5686830
NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885
G
ADK
adenosine kinase
ISO
RGD
PMID:9731623 PMID:16685255
RGD:6482657 RGD:6482667
NCBI chr10:70,672,967...71,236,950
Ensembl chr10:73,342,900...73,902,490
G
ADM
adrenomedullin
treatment
ISO
RGD
PMID:21695352
RGD:5508764
NCBI chr11:10,437,712...10,440,053
Ensembl chr11:10,165,418...10,167,842
G
ADNP
activity dependent neuroprotector homeobox
ISO
RGD
PMID:11935065
RGD:1358226
NCBI chr20:47,233,696...47,276,075
Ensembl chr20:48,361,043...48,400,387
G
AIF1
allograft inflammatory factor 1
ISO
protein:increased expression:brain subventricular zone (rat) protein:increased expression:brain white matter (human)
RGD
PMID:10683518 PMID:19053043
RGD:2313025 RGD:2313026
NCBI chr 6:31,276,215...31,278,051
Ensembl chr 6:32,166,301...32,168,125
G
ALDH2
aldehyde dehydrogenase 2 family member
susceptibility
ISO
RGD
PMID:17388993
RGD:1601161
NCBI chr12:109,343,020...109,385,060
Ensembl chr12:112,734,243...112,776,471
G
ALOX5AP
arachidonate 5-lipoxygenase activating protein
ISO
associated with Metabolic Syndrome X; DNA:polymorphism:g.162A>C rs4769055 (human)
RGD
PMID:18506375
RGD:2311309
NCBI chr13:12,012,399...12,041,557
Ensembl chr13:30,425,510...30,476,607
G
ARRB2
arrestin beta 2
ISO
protein:increased expression:spleen
RGD
PMID:29636059
RGD:401938621
NCBI chr17:4,766,616...4,777,253
Ensembl chr17:4,757,048...4,767,517
G
ATP2B2
ATPase plasma membrane Ca2+ transporting 2
ISO
mRNA:decreased expression:brain (rat)
RGD
PMID:23251410
RGD:329845556
NCBI chr 3:10,260,556...10,643,346
Ensembl chr 3:10,611,619...10,738,006
G
BECN1
beclin 1
ISO
protein:increased expression:brain
RGD
PMID:22227058
RGD:6483057
NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286
G
CACNA2D1
calcium voltage-gated channel auxiliary subunit alpha2delta 1
ISO
mRNA:decreased expression:brain (rat)
RGD
PMID:23251410
RGD:329845556
NCBI chr 7:73,917,439...74,410,627
Ensembl chr 7:87,579,004...88,068,482
G
CALCRL
calcitonin receptor like receptor
ISO
mRNA:increased expression:brain (rat)
RGD
PMID:23251410
RGD:329845556
NCBI chr2B:74,622,892...74,728,067
Ensembl chr2B:192,422,283...192,463,064
G
CD8A
CD8 subunit alpha
ISO
mRNA:increased expression:brain (rat)
RGD
PMID:23251410
RGD:329845556
NCBI chr2A:86,832,559...86,855,772
Ensembl chr2A:88,377,722...88,382,635
G
CFH
complement factor H
treatment
ISO
RGD
PMID:21695352
RGD:5508764
NCBI chr 1:172,155,882...172,251,632
Ensembl chr 1:176,455,247...176,525,521
G
CORT
cortistatin
ISO
mRNA:decreased expression:brain (rat)
RGD
PMID:23251410
RGD:329845556
NCBI chr 1:9,210,186...9,212,201
G
CTSB
cathepsin B
ISO
protein:increased expression:cerebral cortical segment, cytoplasm (rat)
RGD
PMID:19941836
RGD:2315502
NCBI chr 8:7,333,498...7,359,264
G
CXCL10
C-X-C motif chemokine ligand 10
ISO
protein:increased expression:brain (rat)
RGD
PMID:19895873
RGD:2325193
NCBI chr 4:48,182,355...48,184,733
Ensembl chr 4:54,020,204...54,022,606
G
CYBB
cytochrome b-245 beta chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19417757
NCBI chr X:30,230,394...30,267,379
Ensembl chr X:37,939,704...37,973,183
G
CYP2R1
cytochrome P450 family 2 subfamily R member 1
ISO
DNA:variants:CDS:multiple (human)
RGD
PMID:36762557
RGD:401901151
NCBI chr11:14,960,651...14,989,083
Ensembl chr11:14,656,939...14,671,584
G
DCX
doublecortin
ISO
protein:altered expression:brain (rat)
RGD
PMID:12161747
RGD:155630606
NCBI chr X:100,411,871...100,529,833
Ensembl chr X:110,875,032...110,988,582
G
ECE1
endothelin converting enzyme 1
ISO
RGD
PMID:15485550
RGD:1580908
NCBI chr 1:20,166,019...20,290,803
Ensembl chr 1:21,206,199...21,278,909
G
FGF2
fibroblast growth factor 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17524524
NCBI chr 4:115,005,136...115,076,369
Ensembl chr 4:126,149,813...126,214,942
G
GPNMB
glycoprotein nmb
ISO
mRNA:increased expression:brain (rat)
RGD
PMID:23251410
RGD:329845556
NCBI chr 7:23,931,220...23,959,687
Ensembl chr 7:23,539,928...23,568,624
G
GPR17
G protein-coupled receptor 17
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18974869
NCBI chr2B:32,623,444...32,630,256
Ensembl chr2B:128,316,464...128,321,519
G
GZMB
granzyme B
ISO
protein:increased expression:brain (rat)
RGD
PMID:19895873
RGD:2325193
NCBI chr14:5,399,888...5,403,200
Ensembl chr14:23,523,619...23,526,931
G
HGF
hepatocyte growth factor
treatment
ISO
RGD
PMID:16421510
RGD:8548626
NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811
G
HIF1A
hypoxia inducible factor 1 subunit alpha
exacerbates
ISO
RGD
PMID:30052311
RGD:155663378
NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885
G
HMGB1
high mobility group box 1
ISO
RGD
PMID:19944723
RGD:2316741
NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527
G
HNMT
histamine N-methyltransferase
severity
ISO
RGD
PMID:16330002 PMID:21131122
RGD:5509772 RGD:5509773
NCBI chr2B:21,840,342...21,892,744
Ensembl chr2B:142,036,321...142,088,315
G
HTR2B
5-hydroxytryptamine receptor 2B
ISO
mRNA:increased expression:brain (rat)
RGD
PMID:23251410
RGD:329845556
NCBI chr2B:118,362,719...118,381,253
Ensembl chr2B:237,153,709...237,170,591
G
ICAM1
intercellular adhesion molecule 1
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:serum
RGD
PMID:18692933
RGD:2313474
NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605
G
IGF2
insulin like growth factor 2
ISO
mRNA, protein:increased expression:brain
RGD
PMID:7770004
RGD:5509999
NCBI chr11:2,170,190...2,199,442
Ensembl chr11:2,202,743...2,228,890
G
IL15
interleukin 15
ISO
associated with Hypertension;protein:increased expression:serum
RGD
PMID:16109314
RGD:1626610
NCBI chr 4:133,693,995...134,115,470
Ensembl chr 4:145,402,111...145,416,622
G
IL1B
interleukin 1 beta
ISO
protein:increased expression:cerebral cortex (rat)
RGD
PMID:17678971
RGD:1626644
NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
G
IL2
interleukin 2
ISO
protein:increased expression:brain (rat)
RGD
PMID:19895873
RGD:2325193
NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984
G
KCNK6
potassium two pore domain channel subfamily K member 6
ISO
mRNA:increased expression:brain (rat)
RGD
PMID:23251410
RGD:329845556
NCBI chr19:35,409,752...35,422,490
Ensembl chr19:43,985,074...43,995,374
G
MDK
midkine
ISO
RGD
PMID:15450683
RGD:1582478
NCBI chr11:46,339,365...46,342,388
Ensembl chr11:46,891,540...46,893,254
G
MEIS2
Meis homeobox 2
ISO
protein:altered expression:brain (rat)
RGD
PMID:12161747
RGD:155630606
NCBI chr15:15,814,739...16,025,512
Ensembl chr15:34,072,665...34,282,477
G
MGP
matrix Gla protein
ISO
mRNA:increased expression:brain (rat)
RGD
PMID:23251410
RGD:329845556
NCBI chr12:14,887,806...14,891,796
Ensembl chr12:15,284,883...15,288,523
G
MMP14
matrix metallopeptidase 14
ISO
mRNA:increased expression:brain (rat)
RGD
PMID:23251410
RGD:329845556
NCBI chr14:3,654,125...3,665,158
Ensembl chr14:21,753,305...21,764,058
G
MMP8
matrix metallopeptidase 8
ISO
mRNA:increased expression:brain (rat)
RGD
PMID:23251410
RGD:329845556
NCBI chr11:97,650,408...97,663,731
Ensembl chr11:101,143,268...101,156,736
G
MMP9
matrix metallopeptidase 9
ISO
RGD
PMID:16599837
RGD:1582617
NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
G
MSI1
musashi RNA binding protein 1
ISO
RGD
PMID:15250238
RGD:1582664
NCBI chr12:117,915,879...117,943,772
Ensembl chr12:121,289,281...121,316,276
G
NES
nestin
ISO
associated with Hypertension
RGD
PMID:16321245
RGD:1642069
NCBI chr 1:132,012,273...132,020,907
Ensembl chr 1:135,835,456...135,844,094
G
PARG
poly(ADP-ribose) glycohydrolase
ISO
associated with Reperfusion Injury
RGD
PMID:12834903
RGD:2316742
NCBI chr10:44,290,391...44,420,184
G
PBX1
PBX homeobox 1
ISO
protein:altered expression:brain (rat)
RGD
PMID:12161747
RGD:155630606
NCBI chr 1:139,985,392...140,311,845
Ensembl chr 1:143,778,701...144,104,797
G
PLAT
plasminogen activator, tissue type
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16190367
NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779
G
PPP1R1B
protein phosphatase 1 regulatory inhibitor subunit 1B
ISO
protein:altered expression:brain (rat)
RGD
PMID:12161747
RGD:155630606
NCBI chr17:17,652,216...17,662,085
Ensembl chr17:17,868,965...17,878,120
G
PRCP
prolylcarboxypeptidase
ISO
mRNA:increased expression:brain (rat)
RGD
PMID:23251410
RGD:329845556
NCBI chr11:77,890,115...77,967,056
Ensembl chr11:81,502,658...81,578,361
G
RBFOX3
RNA binding fox-1 homolog 3
ISO
protein:altered expression:brain (rat)
RGD
PMID:12161747
RGD:155630606
NCBI chr17:73,163,818...73,690,675
Ensembl chr17:78,711,056...78,732,131
G
SCN7A
sodium voltage-gated channel alpha subunit 7
ISO
mRNA:increased expression:brain (rat)
RGD
PMID:23251410
RGD:329845556
NCBI chr2B:53,676,298...53,768,289
Ensembl chr2B:171,151,969...171,243,717
G
SIRT1
sirtuin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22878646
NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069
G
TBXAS1
thromboxane A synthase 1
ISO
RGD
PMID:14650360
RGD:1601455
NCBI chr 7:131,772,947...131,958,647
Ensembl chr 7:144,255,211...144,439,523
G
TNF
tumor necrosis factor
ISO
protein:increased expression:brain (rat)
RGD
PMID:19895873
RGD:2325193
NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
G
TPCN2
two pore segment channel 2
ISO
mRNA:increased expression:brain (rat)
RGD
PMID:23251410
RGD:329845556
NCBI chr11:64,139,512...64,227,913
Ensembl chr11:67,438,635...67,478,106
G
ARMS2
age-related maculopathy susceptibility 2
ISO
ClinVar Annotator: match by term: CARASIL syndrome
ClinVar
PMID:18316707 PMID:20437615 PMID:25741868 PMID:26467025 PMID:28492532
NCBI chr10:119,022,726...119,026,201
Ensembl chr10:122,434,856...122,437,551
G
HTRA1
HtrA serine peptidase 1
ISO
ClinVar Annotator: match by term: CARASIL syndrome | ClinVar Annotator: match by term: Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy | ClinVar Annotator: match by term: Cerebrovascular disease with thin skin, alopecia, and disc disease | ClinVar Annotator: match by term: HTRA1-related cerebral small vessel disease
OMIM ClinVar
PMID:11889251 PMID:18316707 PMID:19387015 PMID:20437615 PMID:21115960 PMID:21482952 PMID:22900900 PMID:23963851 PMID:24500651 PMID:24535794 PMID:25506911 PMID:25712943 PMID:25741868 PMID:25770224 PMID:25772074 PMID:25957642 PMID:26063658 PMID:26467025 PMID:27164673 PMID:27353043 PMID:28402226 PMID:28492532 PMID:28782182 PMID:29546604 PMID:29561953 PMID:29895533 PMID:30447605 PMID:30859180 PMID:31316458 PMID:32017060 PMID:32042911 PMID:32101834 PMID:32581362 PMID:32719647 PMID:33268848 PMID:34220097 PMID:34626176 PMID:35307828 PMID:35606766 PMID:35946346 PMID:36047879 PMID:36253578 PMID:36261288 PMID:36380532 PMID:37348440 More...
NCBI chr10:119,030,409...119,083,682
Ensembl chr10:122,441,098...122,494,733
G
MECP2
methyl-CpG binding protein 2
ISO
ClinVar Annotator: match by term: CARASIL
ClinVar
PMID:9536098 PMID:15737703 PMID:17576681 PMID:20142466 PMID:24500651 PMID:24508304 PMID:25741868 PMID:26228846 PMID:26254891 PMID:28492532 PMID:28544139 PMID:30536762 PMID:34619114 PMID:34837432 More...
NCBI chr X:143,571,864...143,647,192
Ensembl chr X:153,465,204...153,527,854
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PURA
purine rich element binding protein A
ISO
ClinVar Annotator: match by term: Cerebrovascular disease with thin skin, alopecia, and disc disease
ClinVar
PMID:24500651 PMID:27148565
NCBI chr 5:135,541,865...135,610,526
Ensembl chr 5:141,659,224...141,727,870 Ensembl chr 5:141,659,224...141,727,870
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ACE
angiotensin I converting enzyme
ISO
ClinVar Annotator: match by term: Ischemic stroke, susceptibility to
ClinVar
PMID:1313972 PMID:1319114 PMID:1328889 PMID:1386652 PMID:1976655 PMID:2847529 PMID:2849100 PMID:7593601 PMID:7729604 PMID:7783416 PMID:7854377 PMID:7909524 PMID:8131299 PMID:8131300 PMID:8136829 PMID:8170965 PMID:8208911 PMID:8298638 PMID:8314010 PMID:8541160 PMID:8644984 PMID:8675669 PMID:9120002 PMID:9236417 PMID:9259580 PMID:9699903 PMID:9737775 PMID:9916793 PMID:10099885 PMID:10636736 PMID:10643899 PMID:10841123 PMID:11687636 PMID:11956052 PMID:12220450 PMID:12666117 PMID:14657821 PMID:14872014 PMID:15110771 PMID:15277638 PMID:15381116 PMID:15531537 PMID:15534175 PMID:15635071 PMID:19221299 More...
NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853
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ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15534263
NCBI chr 4:91,726,870...91,741,824
Ensembl chr 4:102,388,575...102,435,079
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ADORA1
adenosine A1 receptor
ISO
RGD
PMID:17067559
RGD:1625229
NCBI chr 1:178,728,751...178,769,066
Ensembl chr 1:183,023,466...183,063,760
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AGER
advanced glycosylation end-product specific receptor
ISO
protein:increased expression:plasma
RGD
PMID:23288172
RGD:8696004
NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641
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AGXT2
alanine--glyoxylate aminotransferase 2
onset
ISO
DNA:missense mutation:cds:V498L (rs16899974) (human)
RGD
PMID:26984639
RGD:329961314
NCBI chr 5:75,322,351...75,373,261
Ensembl chr 5:80,601,554...80,652,575
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AHSP
alpha hemoglobin stabilizing protein
ISO
mRNA:increased expression:venous blood (human)
RGD
PMID:29284304
RGD:329961296
NCBI chr16:23,436,746...23,438,184
Ensembl chr16:31,897,868...31,899,143
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ALOX5AP
arachidonate 5-lipoxygenase activating protein
susceptibility
ISO
OMIM
NCBI chr13:12,012,399...12,041,557
Ensembl chr13:30,425,510...30,476,607
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ANG
angiogenin
severity
ISO
protein:increased expression:serum
RGD
PMID:17823536
RGD:6892714
NCBI chr14:1,548,693...1,558,528
Ensembl chr14:19,614,950...19,615,393
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ANXA1
annexin A1
treatment
ISO
associated with Ischemic Attack, Transient
RGD
PMID:22617647
RGD:7483559
NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779
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APOA5
apolipoprotein A5
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :-1131T>C (human)
RGD
PMID:19107359
RGD:2313314
NCBI chr11:111,625,403...111,627,932
Ensembl chr11:115,559,231...115,562,286
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APOB
apolipoprotein B
ISO
protein:increased expression:serum
RGD
PMID:2352345
RGD:2313973
NCBI chr2A:20,986,464...21,029,004
Ensembl chr2A:21,100,356...21,145,129
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APOE
apolipoprotein E
susceptibility
ISO
DNA:polymorphism: :3932T>C (human)
RGD
PMID:17016617
RGD:1601237
NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490
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BHMT
betaine--homocysteine S-methyltransferase
susceptibility
ISO
DNA:SNPs,haplotypes:multiple
RGD
PMID:20458436
RGD:401794454
NCBI chr 5:36,181,183...36,201,833
Ensembl chr 5:36,670,854...36,728,993
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BRINP3
BMP/retinoic acid inducible neural specific 3
ISO
associated with diabetes mellitus;mRNA:protein:increased expression:blood mononuclear cell:
RGD
PMID:26717922
RGD:14398486
NCBI chr 1:165,586,510...165,972,173
Ensembl chr 1:169,873,541...170,258,015
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CARTPT
CART prepropeptide
ameliorates
ISO
RGD
PMID:16971488
RGD:407986645
NCBI chr 5:43,591,683...43,593,586
Ensembl chr 5:44,236,114...44,238,229
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CBS
cystathionine beta-synthase
susceptibility
ISO
DNA:SNPs,haplotypes:multiple
RGD
PMID:20458436
RGD:401794454
NCBI chr21:29,361,519...29,385,610
Ensembl chr21:42,670,530...42,690,932
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CCL2
C-C motif chemokine ligand 2
treatment
ISO
RGD
PMID:29111308
RGD:155260331
NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384
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CCR5
C-C motif chemokine receptor 5
ISO
RGD
PMID:23602964
RGD:8552262
NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379
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CD36
CD36 molecule (CD36 blood group)
ISO
associated with Hyperlipidemias
RGD
PMID:22718544
RGD:6893487
NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865
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EPHX2
epoxide hydrolase 2
ISO
RGD
PMID:16306811
RGD:1580986
NCBI chr 8:26,761,090...26,818,436
Ensembl chr 8:23,964,094...24,017,749
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F2
coagulation factor II, thrombin
susceptibility
ISO
ClinVar Annotator: match by term: Ischemic stroke | ClinVar Annotator: match by term: Ischemic stroke, susceptibility to
ClinVar OMIM
PMID:2222810 PMID:2429850 PMID:2825773 PMID:6305407 PMID:6405779 PMID:8696333 PMID:8896550 PMID:8916933 PMID:9106528 PMID:9292507 PMID:9462220 PMID:9493607 PMID:9531249 PMID:9569177 PMID:9694698 PMID:9869612 PMID:10027711 PMID:10233438 PMID:10233439 PMID:10336270 PMID:10348710 PMID:10348711 PMID:10348712 PMID:10406905 PMID:10477778 PMID:10544935 PMID:11358905 PMID:11443298 PMID:11506076 PMID:11796466 PMID:11874997 PMID:11904676 PMID:14629473 PMID:15059842 PMID:15534175 PMID:16493002 PMID:16606808 PMID:19159930 PMID:19289024 PMID:19531787 PMID:19554541 PMID:19560233 PMID:19652888 PMID:20301327 PMID:21243428 PMID:21349849 PMID:23429074 PMID:24033266 PMID:25741868 PMID:27031503 PMID:28492532 PMID:28707429 PMID:30297698 PMID:31064749 PMID:31352677 PMID:34110897 PMID:34355501 PMID:38498041 More...
NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157
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F5
coagulation factor V
ISO
ClinVar Annotator: match by term: Ischemic stroke | ClinVar Annotator: match by term: Ischemic stroke, susceptibility to
ClinVar OMIM
PMID:7586244 PMID:7803250 PMID:7877648 PMID:7910348 PMID:7911872 PMID:7968118 PMID:8049422 PMID:8164730 PMID:8164741 PMID:8566967 PMID:8616100 PMID:8822583 PMID:9245936 PMID:9339109 PMID:9372726 PMID:9415695 PMID:9454741 PMID:9459326 PMID:9518910 PMID:9734642 PMID:10328130 PMID:10348711 PMID:10477778 PMID:10494770 PMID:10507841 PMID:10666427 PMID:11018168 PMID:11110695 PMID:11686338 PMID:11950065 PMID:12069454 PMID:12070000 PMID:12421138 PMID:12816860 PMID:14996674 PMID:15208046 PMID:15534175 PMID:15638861 PMID:15946211 PMID:16199547 PMID:16246256 PMID:16493002 PMID:16769590 PMID:16931580 PMID:19652888 PMID:20051284 PMID:21116184 PMID:21774968 PMID:22704462 PMID:22992668 PMID:23382263 PMID:23677252 PMID:23900608 PMID:24033266 PMID:25741868 PMID:25977387 PMID:26251307 PMID:26990548 PMID:27797270 PMID:28492532 PMID:28750087 PMID:30924984 PMID:31064749 PMID:31399523 PMID:34355501 More...
NCBI chr 1:144,996,757...145,070,046
Ensembl chr 1:148,718,897...148,790,915
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F7
coagulation factor VII
treatment
ISO
human protein in a mouse model protein:increased expression, increased activity:plasma (human)
RGD
PMID:14733777 PMID:21998055
RGD:11049518 RGD:11049520
NCBI chr13:94,246,694...94,261,133
Ensembl chr13:113,315,868...113,329,995
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FBN1
fibrillin 1
ISO
ClinVar Annotator: match by term: Ischemic stroke
ClinVar
PMID:7611299 PMID:8894692 PMID:9401003 PMID:9536098 PMID:10533071 PMID:10874320 PMID:11700157 PMID:12402346 PMID:12938084 PMID:14695540 PMID:16220557 PMID:16222657 PMID:16835936 PMID:17253931 PMID:17576681 PMID:17657824 PMID:17663468 PMID:19159394 PMID:19293843 PMID:21542060 PMID:24033266 PMID:24161884 PMID:25741868 PMID:26133393 PMID:28492532 PMID:29357934 PMID:31098894 PMID:37684520 More...
NCBI chr15:27,358,780...27,593,539
Ensembl chr15:45,682,450...45,918,111
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GCH1
GTP cyclohydrolase 1
exacerbates treatment
ISO
DNA:SNP:3' UTR:+243C>T (human) DNA:SNP, haplotype:rs841 (human)
RGD
PMID:16282548 PMID:21181356 PMID:21963893
RGD:329961322 RGD:329961572 RGD:329961574
NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393
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GP6
glycoprotein VI platelet
ameliorates
ISO
RGD
PMID:34237320
RGD:401794450
NCBI chr19:52,051,138...52,071,673
Ensembl chr19:60,746,578...60,770,643
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GPX3
glutathione peroxidase 3
susceptibility
ISO
DNA, protein:SNP,decreased expression:promoter,plasma:-861A>T (human) DNA:SNPs, haplotype:promoter:-942 A>C, -927 T>C, -861 A>T, -302 A>T, -284 T>A, -568 T>C, -518 T>C, -65 T>C (human) DNA:SNPs, haplotypes:promoter:rs8177412, rs870407, rs870406 (human)
RGD
PMID:17122425 PMID:20946167 PMID:25126700
RGD:401827128 RGD:401827163 RGD:401827165
NCBI chr 5:146,447,939...146,456,476
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GRIN1
glutamate ionotropic receptor NMDA type subunit 1
severity
ISO
RGD
PMID:23723305
RGD:13792693
NCBI chr 9:108,198,350...108,228,887
Ensembl chr 9:137,168,722...137,197,382
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GRN
granulin precursor
ISO
ClinVar Annotator: match by term: Ischemic stroke
ClinVar
PMID:18723524 PMID:25741868 PMID:28492532
NCBI chr17:13,046,329...13,054,236
Ensembl chr17:13,211,784...13,219,609
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GSN
gelsolin
severity
ISO
protein:decreased expression:blood plasma (human)
RGD
PMID:21481565
RGD:329337334
NCBI chr 9:92,413,819...92,460,483
Ensembl chr 9:120,741,148...120,805,831
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HBA1
hemoglobin subunit alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1634355
Ensembl chr16:164,618...165,476
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HIF1A
hypoxia inducible factor 1 subunit alpha
severity
ISO
protein:increased expression:blood serum (human)
RGD
PMID:34708885
RGD:155260326
NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885
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HMGB1
high mobility group box 1
ISO
protein:increased expression:plasma
RGD
PMID:23288172
RGD:8696004
NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527
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HMOX1
heme oxygenase 1
ISO
RGD
PMID:23311871
RGD:10755574
NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063
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HNF1A
HNF1 homeobox A
susceptibility
ISO
DNA:SNPs,haplotypes:multiple
RGD
PMID:28035729
RGD:329901837
NCBI chr12:118,562,308...118,584,596
Ensembl chr12:121,932,671...121,955,911
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ICAM1
intercellular adhesion molecule 1
ISO
mRNA, protein:increased expression:cerebral cortex
RGD
PMID:20083630
RGD:8547724
NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605
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IFNB1
interferon beta 1
susceptibility no_association
ISO
DNA:SNP,haplotype: rs9333358(human)
RGD
PMID:16514094 PMID:31810024
RGD:401851921 RGD:401854228
NCBI chr 9:20,884,742...20,886,317
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IL10
interleukin 10
treatment
ISO
RGD
PMID:29111308
RGD:155260331
NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
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IL18
interleukin 18
treatment
ISO
RGD
PMID:20584315
RGD:8655991
NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371
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IL1B
interleukin 1 beta
treatment
ISO
RGD
PMID:29111308
RGD:155260331
NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
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IL6
interleukin 6
treatment
ISO
RGD
PMID:29111308
RGD:155260331
NCBI chr 7:23,415,922...23,420,767
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IRF8
interferon regulatory factor 8
exacerbates
ISO
RGD
PMID:24528256
RGD:329902074
NCBI chr16:66,568,370...66,591,949
Ensembl chr16:85,905,334...85,929,073
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ITGA9
integrin subunit alpha 9
susceptibility
ISO
DNA:SNPs,haplotype:rs189897,rs2212020(human)
RGD
PMID:21764681
RGD:13602007
NCBI chr 3:37,349,120...37,722,572
Ensembl chr 3:37,651,395...38,006,363
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ITGAM
integrin subunit alpha M
ISO
protein:increased expression:neutrophil (human)
RGD
PMID:31355307
RGD:329901831
NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406
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KALRN
kalirin RhoGEF kinase
susceptibility sexual_dimorphism
ISO
DNA:SNP:intron: (rs6438833) (human) DNA:SNPs::multiple (human) DNA:SNPs, haplotypes:intron,cds: (rs7620580, rs1708303) (human)
RGD
PMID:20107840 PMID:25917671 PMID:28706949
RGD:11085239 RGD:329955374 RGD:329956420
NCBI chr 3:121,138,136...121,828,723
Ensembl chr 3:128,225,413...128,720,441
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KCNN4
potassium calcium-activated channel subfamily N member 4
ameliorates
ISO
RGD
PMID:29037241
RGD:329969881
NCBI chr19:40,715,621...40,735,025
Ensembl chr19:49,321,403...49,335,900
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LIPG
lipase G, endothelial type
susceptibility
ISO
DNA:polymorphism: :584C>T (human)
RGD
PMID:17016617
RGD:1601237
NCBI chr18:42,942,132...42,972,112
Ensembl chr18:46,292,154...46,320,652
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LOC100979269
alpha-2-macroglobulin
disease_progression
ISO
RGD
PMID:28266892
RGD:13702087
NCBI chr12:9,154,457...9,202,833
Ensembl chr12:9,385,359...9,433,979
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LOC100982859
class I histocompatibility antigen, Gogo-B*0101 alpha chain
susceptibility
ISO
DNA:polymorphism::HLA-B37:01 (human)
RGD
PMID:24767290
RGD:401827096
NCBI chr 6:31,106,562...31,109,933
Ensembl chr 6:31,997,381...32,000,067
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LPA
lipoprotein(a)
ISO
protein:increased expression, alternative form:serum:increased levels overall and increased frequency of low molecular weight isoforms protein:increased expression:serum
RGD
PMID:1440702 PMID:12894903
RGD:5509894 RGD:5509897
NCBI chr 6:158,434,394...158,628,028
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LTA
lymphotoxin alpha
ISO
RGD
PMID:14593215
RGD:1580416
NCBI chr 6:31,233,411...31,235,409
Ensembl chr 6:32,123,353...32,125,375
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MAP2
microtubule associated protein 2
ISO
RGD
PMID:22444278
RGD:6483079
NCBI chr2B:96,681,268...96,991,650
Ensembl chr2B:215,314,857...215,391,728
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MAP3K5
mitogen-activated protein kinase kinase kinase 5
treatment
ISO
RGD
PMID:23968852
RGD:10412642
NCBI chr 6:134,316,841...134,582,843
Ensembl chr 6:138,406,398...138,641,727
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MMP2
matrix metallopeptidase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16846501
NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279
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MMP9
matrix metallopeptidase 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16846501
NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
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MTHFR
methylenetetrahydrofolate reductase
ISO
DNA:transition:cds:g.677C>T (human)
RGD
PMID:10929044
RGD:1580590
NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419
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MTR
5-methyltetrahydrofolate-homocysteine methyltransferase
susceptibility
ISO
DNA:SNPs,haplotypes:multiple
RGD
PMID:20458436
RGD:401794454
NCBI chr 1:212,353,195...212,463,304
Ensembl chr 1:217,358,050...217,460,946
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MYRF
myelin regulatory factor
ISO
DNA:SNP:exon:rs174535(human)
RGD
PMID:36193932
RGD:213230151
NCBI chr11:57,052,219...57,088,105
Ensembl chr11:60,412,780...60,448,579
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NOS3
nitric oxide synthase 3
ISO
ClinVar Annotator: match by term: Ischemic stroke
ClinVar
PMID:9737779 PMID:9894802 PMID:10475066 PMID:10510054 PMID:10514107 PMID:11026457 PMID:11354626 PMID:11394896 PMID:11745998 PMID:15007011 PMID:16059745 PMID:16813604 PMID:17165044 PMID:24033266 PMID:25741868 PMID:28492532 More...
NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233
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NOTCH3
notch receptor 3
ISO
ClinVar Annotator: match by term: Ischemic stroke
ClinVar
PMID:9388399 PMID:10371548 PMID:10802804 PMID:10854111 PMID:11102981 PMID:11755616 PMID:15364702 PMID:16009764 PMID:16193256 PMID:17729386 PMID:20301673 PMID:20329594 PMID:22422895 PMID:25623805 PMID:25741868 PMID:26308724 PMID:26467025 PMID:26843489 PMID:26912635 PMID:27206574 PMID:27890607 PMID:28492532 PMID:28710804 PMID:31915071 PMID:32277177 PMID:32457593 PMID:32581362 PMID:34335700 PMID:34691145 More...
NCBI chr19:14,692,571...14,733,758
Ensembl chr19:15,678,674...15,715,080
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NPY
neuropeptide Y
ISO
protein:increased expression:cerebral cortex CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:11821007 PMID:17123484
RGD:10448931
NCBI chr 7:24,963,056...24,970,803
Ensembl chr 7:24,568,041...24,574,657
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NR1H3
nuclear receptor subfamily 1 group H member 3
susceptibility
ISO
DNA:SNPs, haplotype:promoter:c.-115G>A, c.-840C>A (rs12221497, rs61896015) (human)
RGD
PMID:21903943
RGD:401842365
NCBI chr11:47,195,122...47,215,277
Ensembl chr11:47,748,353...47,768,672
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NTRK2
neurotrophic receptor tyrosine kinase 2
ISO
DNA:SNPs:peripheral blood, leukocyte, 3' utr
RGD
PMID:33209049
RGD:408418730
NCBI chr 9:39,663,986...40,208,770
Ensembl chr 9:84,021,837...84,372,678
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PARK7
Parkinsonism associated deglycase
treatment
ISO
RGD
PMID:18003894
RGD:13462069
NCBI chr 1:6,722,260...6,745,915
Ensembl chr 1:7,969,280...7,993,271
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PDX1
pancreatic and duodenal homeobox 1
ISO
associated with Metabolic Syndrome; DNA:duplication:5' utr:-108 3G>4G (human)
RGD
PMID:18506375
RGD:2311309
NCBI chr13:9,199,572...9,206,202
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PHACTR1
phosphatase and actin regulator 1
ISO
DNA:SNP:intron: (rs12526453) (human)
RGD
PMID:23042660
RGD:401900685
NCBI chr 6:12,560,862...13,136,126
Ensembl chr 6:12,922,871...13,505,609
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PLA2G7
phospholipase A2 group VII
ISO
RGD
PMID:18201705
RGD:6482775
NCBI chr 6:46,264,262...46,318,487
Ensembl chr 6:47,558,861...47,590,212
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PLAT
plasminogen activator, tissue type
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:1579960 PMID:1899364 PMID:9183334 PMID:16148626 PMID:18195371 PMID:18544249 More...
NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779
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PLAU
plasminogen activator, urokinase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12133459 PMID:16773802
NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136
G
PON1
paraoxonase 1
susceptibility
ISO
DNA:missense mutation:cds:p.Q192R (human)
RGD
PMID:10729395
RGD:1580196
NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493
G
PON2
paraoxonase 2
susceptibility
ISO
DNA:SNPs,haplotypes: (rs11545941, rs6954345) (human)
RGD
PMID:20458436
RGD:401794454
NCBI chr 7:87,362,447...87,392,795
Ensembl chr 7:100,950,074...100,980,433
G
PRKCH
protein kinase C eta
susceptibility
ISO
ClinVar Annotator: match by term: Cerebral infarction, susceptibility to | ClinVar Annotator: match by term: Ischemic stroke
ClinVar OMIM
PMID:12958323 PMID:17206144 PMID:25741868
NCBI chr14:41,882,022...42,151,305
Ensembl chr14:60,179,081...60,408,251
G
PROC
protein C, inactivator of coagulation factors Va and VIIIa
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33761690
NCBI chr2B:32,846,899...32,859,060
Ensembl chr2B:128,083,794...128,094,625
G
PROS1
protein S
ISO
DNA:missense mutation:exon:p.R355C (1063C>T) (human)
RGD
PMID:21172841
RGD:11250416
NCBI chr 3:90,934,641...91,039,059
Ensembl chr 3:97,615,734...97,718,756
G
PTGIS
prostaglandin I2 synthase
exacerbates treatment
ISO
DNA:SNP, haplotype:3' utr: (rs5602) (human) DNA:SNPs:exon, 3' utr: (rs5629, rs5602) (human) DNA:repeat:promoter:g.-6(CCGCCAGCC)3-7 (human)
RGD
PMID:11130769 PMID:11997284 PMID:28108096 PMID:28478978
RGD:401901149 RGD:401901194 RGD:401901269 RGD:401959400
NCBI chr20:45,841,238...45,905,641
Ensembl chr20:46,905,665...46,971,612
G
RBP4
retinol binding protein 4
exacerbates severity
ISO
protein:increased expression:blood plasma (human) protein:increased expression:blood serum (human) associated with diabetes mellitus; protein:increased expression:blood serum (human)
RGD
PMID:19846170 PMID:30030781 PMID:30038059
RGD:329845582 RGD:329845588 RGD:329853305
NCBI chr10:90,337,879...90,347,530
Ensembl chr10:93,848,166...93,857,887
G
SERPINE1
serpin family E member 1
treatment
ISO
RGD
PMID:25702149
RGD:11075081
NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450
G
SERPING1
serpin family G member 1
treatment
ISO
associated with Venous Thrombosis
RGD
PMID:10446335
RGD:8661653
NCBI chr11:52,838,502...52,855,781
Ensembl chr11:56,309,686...56,326,639
G
SLC6A1
solute carrier family 6 member 1
ISO
mRNA:increased expression:cerebral cortex, neuron
RGD
PMID:15349978
RGD:1643205
NCBI chr 3:10,930,455...10,976,968
Ensembl chr 3:11,296,023...11,323,624
G
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1
ISO
mRNA:increased expression:blood (human)
RGD
PMID:35041140
RGD:155598600
NCBI chr2A:39,019,046...39,162,248
Ensembl chr2A:39,773,760...39,911,961
G
TBXAS1
thromboxane A synthase 1
susceptibility
ISO
DNA:polymorphisms: :
RGD
PMID:19403042
RGD:11059536
NCBI chr 7:131,772,947...131,958,647
Ensembl chr 7:144,255,211...144,439,523
G
THBD
thrombomodulin
susceptibility
ISO
DNA:missense mutation:cds:p.A455V (human)
RGD
PMID:15574195
RGD:5685021
NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812
G
TNF
tumor necrosis factor
treatment
ISO
RGD
PMID:16173529 PMID:29111308
RGD:155260331 RGD:1580315
NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
G
TNFRSF11B
TNF receptor superfamily member 11b
disease_progression
ISO
RGD
PMID:19895657
RGD:7205492
NCBI chr 8:115,614,778...115,643,387
Ensembl chr 8:118,134,305...118,162,422
G
TOMM40
translocase of outer mitochondrial membrane 40
ISO
DNA:SNP: :rs2075650 (human)
RGD
PMID:26171154
RGD:13464126
NCBI chr19:41,839,025...41,851,491
Ensembl chr19:50,444,475...50,457,729
G
TYMS
thymidylate synthetase
susceptibility
ISO
DNA:SNPs,haplotypes: (rs502396,rs16430,rs8423)
RGD
PMID:20458436
RGD:401794454
NCBI chr18:13,653,085...13,668,478
Ensembl chr18:17,295,182...17,310,320
G
VIM
vimentin
ISO
RGD
PMID:18802758
RGD:6480442
NCBI chr10:17,546,389...17,554,702
Ensembl chr10:17,818,285...17,826,642
G
COL4A2
collagen type IV alpha 2 chain
susceptibility
ISO
DNA:SNPs::
RGD
PMID:28954878
RGD:13450933
NCBI chr13:91,440,314...91,650,138
Ensembl chr13:110,563,119...110,767,530
G
FSHB
follicle stimulating hormone subunit beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17344003
NCBI chr11:30,204,193...30,208,410
Ensembl chr11:30,095,486...30,100,167
G
ABCC8
ATP binding cassette subfamily C member 8
treatment
ISO
RGD
PMID:23149556 PMID:24602692
RGD:12790979 RGD:12791996
NCBI chr11:17,447,564...17,531,513
Ensembl chr11:17,133,063...17,216,870
G
ACE
angiotensin I converting enzyme
treatment
ISO
RGD
PMID:24471927
RGD:11039026
NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853
G
ACE2
angiotensin converting enzyme 2
ISO
mRNA, protein:increased expression:brain
RGD
PMID:24090950
RGD:9685436
NCBI chr X:8,189,267...8,229,415
Ensembl chr X:15,470,896...15,510,891
G
ACVR1
activin A receptor type 1
ISO
RGD
PMID:33345977
RGD:329845521
NCBI chr2B:44,994,175...45,133,490
Ensembl chr2B:162,234,823...162,297,805
G
ACVR2B
activin A receptor type 2B
ISO
mRNA:increased expression:brain (mouse)
RGD
PMID:33763412
RGD:329849104
NCBI chr 3:38,350,838...38,389,839
Ensembl chr 3:38,633,093...38,662,063
G
ADORA1
adenosine A1 receptor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:23437309
NCBI chr 1:178,728,751...178,769,066
Ensembl chr 1:183,023,466...183,063,760
G
AGER
advanced glycosylation end-product specific receptor
ISO
CTD Direct Evidence: marker/mechanism associated with Diabetes Mellitus, Experimental
CTD RGD
PMID:24211797 PMID:25446913
RGD:8696008
NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641
G
AGT
angiotensinogen
ISO
protein:increased expression:brain, serum
RGD
PMID:24090950
RGD:9685436
NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044
G
AIFM1
apoptosis inducing factor mitochondria associated 1
ISO
protein:altered localization: :
RGD
PMID:15181376
RGD:10047403
NCBI chr X:119,256,425...119,292,612
Ensembl chr X:129,550,287...129,586,271
G
AK1
adenylate kinase 1
ISO
protein:decreased expression:cerebral cortex (rat)
RGD
PMID:16468349
RGD:5508760
NCBI chr 9:98,987,348...98,997,252
Ensembl chr 9:127,657,338...127,678,245
G
ALB
albumin
treatment
ISO
RGD
PMID:22227456
RGD:11036100
NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418
G
ALOX5
arachidonate 5-lipoxygenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19309543
NCBI chr10:42,461,398...42,531,576
Ensembl chr10:45,639,946...45,710,016
G
AP2B1
adaptor related protein complex 2 subunit beta 1
ISO
protein:increased degradation:brain
RGD
PMID:19240038
RGD:13461853
NCBI chr17:21,070,132...21,208,610
Ensembl chr17:21,363,121...21,501,721
G
APAF1
apoptotic peptidase activating factor 1
treatment
ISO
RGD
PMID:24012531
RGD:13703113
NCBI chr12:96,224,515...96,311,246
Ensembl chr12:99,637,622...99,726,939
G
APOE
apolipoprotein E
ISO
RGD
PMID:19623195
RGD:6903926
NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490
G
APP
amyloid beta precursor protein
treatment
ISO
RGD
PMID:28963051
RGD:13782054
NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072
G
AQP4
aquaporin 4
treatment
ISO
RGD
PMID:20815926 PMID:33127515
RGD:155646130 RGD:8695955
NCBI chr18:20,108,607...20,122,381
Ensembl chr18:23,713,146...23,726,919
G
ARC
activity regulated cytoskeleton associated protein
ISO
RGD
PMID:22645329
RGD:10395314
NCBI chr 8:139,320,366...139,323,802
Ensembl chr 8:142,367,995...142,369,185
G
ATF3
activating transcription factor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr 1:188,176,728...188,188,842
Ensembl chr 1:193,036,793...193,049,150
G
BAD
BCL2 associated agonist of cell death
treatment
ISO
RGD
PMID:21891976 PMID:22200499
RGD:10053665 RGD:10053704
NCBI chr11:59,626,981...59,641,824
Ensembl chr11:62,971,808...62,986,257
G
BAX
BCL2 associated X, apoptosis regulator
treatment
ISO
RGD
PMID:23143152
RGD:10054501
NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468
G
BCAN
brevican
ISO
RGD
PMID:15869933
RGD:9590118
NCBI chr 1:131,985,310...132,003,068
Ensembl chr 1:135,808,783...135,826,344
G
BCL2
BCL2 apoptosis regulator
treatment
ISO
RGD
PMID:23143152
RGD:10054501
NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100
G
BDNF
brain derived neurotrophic factor
treatment
ISO
RGD
PMID:20417695 PMID:28202057 PMID:31927682 PMID:35218623
RGD:401960864 RGD:405878057 RGD:4891138 RGD:596948420
NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239
G
BECN1
beclin 1
treatment
ISO
RGD
PMID:22108007
RGD:11561900
NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286
G
BNIP3
BCL2 interacting protein 3
ISO
protein:increased expression:brain
RGD
PMID:17379825
RGD:9685412
NCBI chr10:128,671,663...128,685,952
Ensembl chr10:132,858,211...132,871,634
G
BNIP3L
BCL2 interacting protein 3 like
ISO
RGD
PMID:15902200 PMID:21029239
RGD:2314138 RGD:9068917
NCBI chr 8:25,661,629...25,685,878
Ensembl chr 8:22,567,428...22,593,004
G
C1QTNF6
C1q and TNF related 6
ameliorates
ISO
RGD
PMID:35322553
RGD:242905190
NCBI chr22:18,093,940...18,112,459
Ensembl chr22:35,928,835...35,937,021
G
C3
complement C3
ISO
protein:increased expression:plasma CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:22103620 PMID:23199288
RGD:7175514
NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699
G
CALCA
calcitonin related polypeptide alpha
treatment
ISO
RGD
PMID:30531687
RGD:329849008
NCBI chr11:15,055,897...15,061,539
Ensembl chr11:14,745,588...14,751,267
G
CAMK2A
calcium/calmodulin dependent protein kinase II alpha
ISO
RGD
PMID:14688616
RGD:1358416
NCBI chr 5:145,644,164...145,714,143
Ensembl chr 5:151,649,062...151,719,373
G
CASP3
caspase 3
treatment
ISO
RGD
PMID:21891976 PMID:23143152 PMID:26868427
RGD:10053704 RGD:10054501 RGD:13782346
NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185
G
CASP6
caspase 6
ISO
RGD
PMID:26868427
RGD:13782346
NCBI chr 4:102,186,215...102,201,992
Ensembl chr 4:112,753,988...112,768,836
G
CASP9
caspase 9
treatment
ISO
RGD
PMID:26868427
RGD:13782346
NCBI chr 1:14,630,659...14,662,865
Ensembl chr 1:15,624,666...15,656,266
G
CCL2
C-C motif chemokine ligand 2
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:12374626 PMID:23043544 PMID:25257527
NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384
G
CD36
CD36 molecule (CD36 blood group)
treatment
ISO
RGD
PMID:25216018
RGD:11041113
NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865
G
CD86
CD86 molecule
ISO
protein:increased expression:brain subventricular zone, microglial cell (rat)
RGD
PMID:19053043
RGD:2313025
NCBI chr 3:119,151,884...119,217,641
Ensembl chr 3:126,059,008...126,124,339
G
CDK5
cyclin dependent kinase 5
ISO
RGD
PMID:24920629
RGD:13782375
NCBI chr 7:142,640,630...142,644,785
Ensembl chr 7:154,793,344...154,797,499
G
CLDN5
claudin 5
treatment
ISO
RGD
PMID:24842554
RGD:13204729
NCBI chr22:2,282,215...2,286,724
Ensembl chr22:17,958,182...17,959,093
G
CREB1
cAMP responsive element binding protein 1
treatment
ISO
RGD
PMID:35218623
RGD:401960864
NCBI chr2B:94,762,796...94,836,304
Ensembl chr2B:212,891,261...212,958,130
G
CRH
corticotropin releasing hormone
ISO
protein:decreased expression:median eminence of hypothalamus (rat)
RGD
PMID:21741032
RGD:5490538
NCBI chr 8:62,714,721...62,716,979
Ensembl chr 8:64,383,419...64,384,009
G
CRP
C-reactive protein
ISO
RGD
PMID:15545914
RGD:9585995
NCBI chr 1:135,062,102...135,064,402
G
CRTC1
CREB regulated transcription coactivator 1
treatment
ISO
RGD
PMID:20417695
RGD:4891138
NCBI chr19:18,123,375...18,221,832
Ensembl chr19:19,131,484...19,228,980
G
CSF3
colony stimulating factor 3
treatment
ISO
mRNA, protein:increased expression:brain:
RGD
PMID:15530654 PMID:19298757
RGD:11039420 RGD:11039425
NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729
G
CXCL10
C-X-C motif chemokine ligand 10
ISO
RGD
PMID:10825390
RGD:632989
NCBI chr 4:48,182,355...48,184,733
Ensembl chr 4:54,020,204...54,022,606
G
CXCR2
C-X-C motif chemokine receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr2B:105,387,198...105,400,533
Ensembl chr2B:223,997,066...223,998,148
G
CXCR3
C-X-C motif chemokine receptor 3
ISO
mRNA:increased expression:cerebral cortex
RGD
PMID:10825390
RGD:632989
NCBI chr X:60,880,759...60,883,355
Ensembl chr X:70,933,160...70,935,756
G
CYP2E1
cytochrome P450 family 2 subfamily E member 1
ISO
RGD
PMID:23002367
RGD:14700877
Ensembl chr10:134,839,025...134,852,719
G
DICER1
dicer 1, ribonuclease III
ISO
mRNA:decreased expression:brain:
RGD
PMID:26294080
RGD:11553310
NCBI chr14:75,709,029...75,780,779
Ensembl chr14:95,036,385...95,107,940
G
DNMT1
DNA methyltransferase 1
ISO
RGD
PMID:11726790
RGD:9588643
NCBI chr19:9,681,847...9,745,334
Ensembl chr19:10,342,478...10,406,972
G
DNMT3A
DNA methyltransferase 3 alpha
ISO
RGD
PMID:23516428
RGD:9589049
NCBI chr2A:25,229,593...25,344,733
Ensembl chr2A:25,331,095...25,412,605
G
DYNLL1
dynein light chain LC8-type 1
ISO
RGD
PMID:9522364
RGD:13208524
NCBI chr12:118,078,401...118,080,822
Ensembl chr12:121,452,118...121,454,550
G
EDN1
endothelin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17197033
NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545
G
EGR1
early growth response 1
ISO
RGD
PMID:22645329
RGD:10395314
NCBI chr 5:133,845,305...133,849,291
Ensembl chr 5:139,975,635...139,979,260
G
EGR2
early growth response 2
ISO
RGD
PMID:22645329
RGD:10395314
NCBI chr10:59,320,073...59,326,869
Ensembl chr10:61,648,364...61,652,846
G
EGR4
early growth response 4
ISO
RGD
PMID:22645329
RGD:10395314
NCBI chr2A:73,343,705...73,346,476
Ensembl chr2A:74,831,326...74,834,246
G
EIF2S1
eukaryotic translation initiation factor 2 subunit alpha
treatment
ISO
RGD
PMID:19763736 PMID:23669639
RGD:10395346 RGD:10755569
NCBI chr14:47,935,691...47,960,055
Ensembl chr14:66,813,953...66,839,866
G
ELANE
elastase, neutrophil expressed
treatment
ISO
RGD
PMID:10700596
RGD:10450546
NCBI chr19:276,499...280,598
G
ENG
endoglin
ISO
RGD
PMID:24876084
RGD:11041171
NCBI chr 9:98,934,080...98,973,862
Ensembl chr 9:127,605,608...127,644,641
G
EPCAM
epithelial cell adhesion molecule
ISO
RGD
PMID:15950761
RGD:11038820
NCBI chr2A:47,490,748...47,508,418
Ensembl chr2A:48,413,520...48,432,038
G
EPHB2
EPH receptor B2
treatment
ISO
mRNA,protein:increased expression: cortex, cerebral cortex subventricular zone
RGD
PMID:16321245
RGD:1642069
NCBI chr 1:21,895,961...22,107,649
Ensembl chr 1:22,912,570...23,047,118
G
EPN1
epsin 1
ISO
protein:increased degradation:brain
RGD
PMID:19240038
RGD:13461853
NCBI chr19:52,722,107...52,743,321
Ensembl chr19:61,408,695...61,427,647
G
EPO
erythropoietin
treatment
ISO
RGD
PMID:20547143 PMID:20833153
RGD:10400898 RGD:10401066
NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974
G
ERCC6
ERCC excision repair 6, chromatin remodeling factor
ISO
RGD
PMID:9974119
RGD:10401103
NCBI chr10:44,703,720...44,784,948
G
F11
coagulation factor XI
ISO
RGD
PMID:16533887
RGD:11041786
NCBI chr 4:178,436,865...178,459,568
Ensembl chr 4:190,643,733...190,666,512
G
F12
coagulation factor XII
treatment
ISO
RGD
PMID:16533887
RGD:11041786
NCBI chr 5:172,703,724...172,711,618
Ensembl chr 5:179,766,243...179,773,485
G
F2
coagulation factor II, thrombin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29651748
NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157
G
FADD
Fas associated via death domain
treatment
ISO
RGD
PMID:18950622 PMID:23378241
RGD:11341807 RGD:11344885
NCBI chr11:65,300,889...65,305,020
G
FGF2
fibroblast growth factor 2
treatment
ISO
RGD
PMID:30531687
RGD:329849008
NCBI chr 4:115,005,136...115,076,369
Ensembl chr 4:126,149,813...126,214,942
G
FGF21
fibroblast growth factor 21
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr19:45,755,466...45,758,472
G
FOS
Fos proto-oncogene, AP-1 transcription factor subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr14:55,832,570...55,835,984
Ensembl chr14:74,676,316...74,679,766
G
GABRA6
gamma-aminobutyric acid type A receptor subunit alpha6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr 5:157,072,915...157,089,994
Ensembl chr 5:163,767,304...163,784,331
G
GAP43
growth associated protein 43
treatment
ISO
RGD
PMID:30531687
RGD:329849008
NCBI chr 3:112,765,576...112,863,118
Ensembl chr 3:119,734,942...119,780,290
G
GAPDH
glyceraldehyde-3-phosphate dehydrogenase
ISO
RGD
PMID:25882840
RGD:13792686
NCBI chr12:6,665,218...6,669,170
Ensembl chr12:6,583,895...6,587,729
G
GCH1
GTP cyclohydrolase 1
treatment
ISO
RGD
PMID:24956890
RGD:401717568
NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393
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GDNF
glial cell derived neurotrophic factor
treatment
ISO
RGD
PMID:20468049 PMID:21347705 PMID:28202057 PMID:29497380
RGD:405866359 RGD:405866363 RGD:405878057 RGD:40925919
NCBI chr 5:72,539,374...72,566,918
Ensembl chr 5:77,577,313...77,601,362
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GHRL
ghrelin and obestatin prepropeptide
treatment
ISO
RGD
PMID:19352052
RGD:9850083
NCBI chr 3:10,221,829...10,229,229
Ensembl chr 3:10,573,537...10,580,723
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GHSR
growth hormone secretagogue receptor
ISO
RGD
PMID:19352052
RGD:9850083
NCBI chr 3:169,448,217...169,458,602
Ensembl chr 3:177,633,039...177,638,202
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GLUL
glutamate-ammonia ligase
treatment
ISO
protein:increased expression:eye protein:increased expression:cerebrum, astrocyte
RGD
PMID:23595285 PMID:24518488 PMID:26024074 PMID:26093193
RGD:401794420 RGD:401794586 RGD:401794587 RGD:401794592
NCBI chr 1:157,882,258...157,891,562
Ensembl chr 1:161,534,106...161,543,411
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GRIN1
glutamate ionotropic receptor NMDA type subunit 1
treatment
ISO
RGD
PMID:26674869
RGD:11068571
NCBI chr 9:108,198,350...108,228,887
Ensembl chr 9:137,168,722...137,197,382
G
GRN
granulin precursor
treatment
ISO
RGD
PMID:23972823
RGD:10401661
NCBI chr17:13,046,329...13,054,236
Ensembl chr17:13,211,784...13,219,609
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GRPEL1
GrpE like 1, mitochondrial
ISO
mRNA:increased expression:cerebral cortex
RGD
PMID:12505684
RGD:632868
Ensembl chr 4:7,126,043...7,135,388
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GSK3B
glycogen synthase kinase 3 beta
treatment
ISO
RGD
PMID:28440874
RGD:13792734
NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771
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GSN
gelsolin
ameliorates
ISO
RGD
PMID:9927495 PMID:18234195
RGD:329333031 RGD:329333033
NCBI chr 9:92,413,819...92,460,483
Ensembl chr 9:120,741,148...120,805,831
G
HAMP
hepcidin antimicrobial peptide
ISO
mRNA, protein:increased expression:cerebral cortex, hippocampus, corpus striatum
RGD
PMID:21957487
RGD:11041635
NCBI chr19:32,228,701...32,231,494
Ensembl chr19:40,964,445...40,968,861
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HAS2
hyaluronan synthase 2
ISO
mRNA:increased expression:brain
RGD
PMID:11283406
RGD:9588631
NCBI chr 8:118,313,186...118,342,160
Ensembl chr 8:121,072,154...121,089,365
G
HDAC2
histone deacetylase 2
exacerbates
ISO
RGD
PMID:32239566
RGD:155883173
NCBI chr 6:111,731,139...111,761,826
Ensembl chr 6:115,802,367...115,833,004
G
HDAC4
histone deacetylase 4
treatment
ISO
mRNA,protein:decreased expression:brain:
RGD
PMID:23480850
RGD:9681449
NCBI chr2B:126,287,745...126,649,815
Ensembl chr2B:245,123,061...245,427,054
G
HDAC5
histone deacetylase 5
treatment
ISO
mRNA,protein:decreased expression:brain:
RGD
PMID:23480850
RGD:9681449
NCBI chr17:13,273,052...13,319,695
Ensembl chr17:13,446,836...13,479,140
G
HDAC9
histone deacetylase 9
ISO
mRNA:increased expression:brain:
RGD
PMID:23480850
RGD:9681449
NCBI chr 7:18,740,580...19,653,615
Ensembl chr 7:18,138,761...18,970,717
G
HIF1A
hypoxia inducible factor 1 subunit alpha
treatment
ISO
RGD
PMID:21029239
RGD:9068917
NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885
G
HMGB1
high mobility group box 1
treatment
ISO
RGD
PMID:23480850
RGD:9681449
NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527
G
HMOX1
heme oxygenase 1
treatment
ISO
RGD
PMID:20888632 PMID:23870531 PMID:24252362
RGD:10755587 RGD:10755588 RGD:10755755
NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063
G
HSPA4
heat shock protein family A (Hsp70) member 4
ISO
rat gene in mouse model
RGD
PMID:17473852 PMID:21709150
RGD:5688754 RGD:6218961
NCBI chr 5:128,463,186...128,517,563
Ensembl chr 5:134,619,076...134,673,658
G
HSPD1
heat shock protein family D (Hsp60) member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr2B:84,729,615...84,743,352
Ensembl chr2B:202,623,497...202,636,959
G
HTRA2
HtrA serine peptidase 2
ISO
protein:increased expression:brain, cytosol (rat) protein:increased expression:brain, cytosol (mouse)
RGD
PMID:15306124 PMID:16978742
RGD:2314385 RGD:5688372
NCBI chr2A:74,596,020...74,599,790
Ensembl chr2A:76,102,240...76,106,152
G
HVCN1
hydrogen voltage gated channel 1
ISO
RGD
PMID:31250553
RGD:14985213
NCBI chr12:108,217,516...108,258,210
Ensembl chr12:111,591,050...111,645,632
G
ICAM1
intercellular adhesion molecule 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605
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IGF1
insulin like growth factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177
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IKBKB
inhibitor of nuclear factor kappa B kinase subunit beta
treatment
ISO
RGD
PMID:16286924
RGD:10045955
NCBI chr 8:41,515,613...41,576,229
Ensembl chr 8:38,960,594...39,020,971
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IL10
interleukin 10
ameliorates
ISO
RGD
PMID:28630232
RGD:242905192
NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
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IL11
interleukin 11
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr19:52,407,730...52,426,445
Ensembl chr19:61,096,275...61,101,837
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IL13
interleukin 13
ISO
protein:increased expression:cerebral cortex
RGD
PMID:23028794
RGD:7204480
NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548
G
IL1B
interleukin 1 beta
ameliorates treatment
ISO
protein:increased expression:cerebral cortex (rat) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:23028794 PMID:24916922 PMID:25257527 PMID:29498696 PMID:35322553
RGD:10450594 RGD:13792833 RGD:242905190 RGD:7204480
NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
G
IL1RN
interleukin 1 receptor antagonist
treatment
ISO
human gene in a rat model
RGD
PMID:7790404
RGD:8551708
NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839
G
IL22
interleukin 22
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr12:65,757,069...65,762,418
Ensembl chr12:68,542,076...68,547,421
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IL4
interleukin 4
ISO
protein:increased expression:cerebral cortex
RGD
PMID:23028794
RGD:7204480
NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581
G
IL5
interleukin 5
ISO
RGD
PMID:23028794
RGD:7204480
NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675
G
IL6
interleukin 6
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12374626 PMID:21940958 PMID:25257527 PMID:29498696
RGD:13792833
NCBI chr 7:23,415,922...23,420,767
G
IL6R
interleukin 6 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21940958
NCBI chr 1:129,761,914...129,824,386
Ensembl chr 1:133,374,078...133,433,089
G
IL6ST
interleukin 6 cytokine family signal transducer
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21940958
NCBI chr 5:58,023,704...58,081,895
Ensembl chr 5:59,669,606...59,708,817
G
IL7R
interleukin 7 receptor
ISO
protein:increased expression:brain:
RGD
PMID:30676545
RGD:151347693
NCBI chr 5:74,489,188...74,516,330
Ensembl chr 5:79,769,859...79,792,612
G
INA
internexin neuronal intermediate filament protein alpha
ISO
RGD
PMID:29967576
RGD:27226878
NCBI chr10:99,877,665...99,890,947
Ensembl chr10:103,340,438...103,353,888
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INHBA
inhibin subunit beta A
ISO
RGD
PMID:33345977
RGD:329845521
NCBI chr 7:42,538,591...42,556,578
Ensembl chr 7:42,580,730...42,595,097
G
IRF4
interferon regulatory factor 4
ISO
RGD
PMID:25652434
RGD:11530061
NCBI chr 6:206,282...226,487
Ensembl chr 6:342,718...356,654
G
JUNB
JunB proto-oncogene, AP-1 transcription factor subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr19:12,353,760...12,355,598
Ensembl chr19:13,097,931...13,098,974
G
KCNN4
potassium calcium-activated channel subfamily N member 4
ameliorates
ISO
RGD
PMID:21750563 PMID:25477223 PMID:26661208
RGD:329955444 RGD:329955572 RGD:401700383
NCBI chr19:40,715,621...40,735,025
Ensembl chr19:49,321,403...49,335,900
G
LIG3
DNA ligase 3
ISO
associated with transient cerebral ischemia;protein:increased expression:brain
RGD
PMID:17412650
RGD:2302580
NCBI chr17:21,776,483...21,805,706
Ensembl chr17:22,074,046...22,095,220
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LOC100974886
uncharacterized LOC100974886
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr 4:50,092,989...50,095,541
Ensembl chr 4:55,925,562...55,986,555
G
MAG
myelin associated glycoprotein
treatment
ISO
RGD
PMID:15678116
RGD:9685232
NCBI chr19:32,238,457...32,260,497
Ensembl chr19:40,975,763...40,997,401
G
MAPK1
mitogen-activated protein kinase 1
treatment
ISO
RGD
PMID:27152455 PMID:35218623
RGD:13800881 RGD:401960864
NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335
G
MAPK3
mitogen-activated protein kinase 3
treatment
ISO
RGD
PMID:27152455 PMID:35218623
RGD:13800881 RGD:401960864
Ensembl chr16:30,489,362...30,498,017
G
MAPT
microtubule associated protein tau
treatment
ISO
RGD
PMID:25903928 PMID:28886009
RGD:13800886 RGD:13800913
NCBI chr17:11,373,220...11,506,669
Ensembl chr17:11,458,159...11,523,129
G
MMP9
matrix metallopeptidase 9
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:19309543 PMID:24842554
RGD:13204729
NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
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MT3
metallothionein 3
ISO
protein:decreased expression:brain
RGD
PMID:8869568
RGD:9685807
NCBI chr16:36,875,919...36,877,558
Ensembl chr16:56,007,922...56,028,093
G
MTOR
mechanistic target of rapamycin kinase
treatment
ISO
RGD
PMID:21185267 PMID:23777415 PMID:24583056
RGD:10040971 RGD:10040974 RGD:10041016
NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841
G
NAE1
NEDD8 activating enzyme E1 subunit 1
ISO
RGD
PMID:21386696
RGD:13801046
NCBI chr16:47,119,548...47,147,679
Ensembl chr16:66,221,829...66,246,865
G
NAMPT
nicotinamide phosphoribosyltransferase
treatment
ISO
RGD
PMID:28495827
RGD:13781880
NCBI chr 7:98,227,071...98,262,254
Ensembl chr 7:110,952,876...110,981,967
G
NCAM1
neural cell adhesion molecule 1
treatment
ISO
RGD
PMID:29497380 PMID:32962079
RGD:40924633 RGD:40925919
NCBI chr11:107,845,507...108,160,441
Ensembl chr11:111,925,677...112,000,401
G
NEFH
neurofilament heavy chain
ISO
RGD
PMID:29967576
RGD:27226878
NCBI chr22:10,525,738...10,536,788
G
NEFL
neurofilament light chain
ISO
protein:increased expression:brain
RGD
PMID:29967576
RGD:27226878
NCBI chr 8:24,218,510...24,224,627
Ensembl chr 8:21,134,533...21,140,694
G
NEFM
neurofilament medium chain
ISO
protein:altered expression:brain
RGD
PMID:29967576
RGD:27226878
NCBI chr 8:24,181,335...24,186,701
Ensembl chr 8:21,098,005...21,107,468
G
NFE2L2
NFE2 like bZIP transcription factor 2
treatment
ISO
RGD
PMID:23880501 PMID:24466583
RGD:10412696 RGD:10412714
NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085
G
NFKBIA
NFKB inhibitor alpha
treatment
ISO
RGD
PMID:21122797
RGD:10413868
NCBI chr14:16,155,331...16,158,588
G
NGF
nerve growth factor
treatment
ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:10408807 PMID:29409115
RGD:402463967
NCBI chr 1:87,223,597...87,276,759
G
NGFR
nerve growth factor receptor
treatment
ISO
RGD
PMID:22678884
RGD:10413900
NCBI chr17:8,089,600...8,109,361
Ensembl chr17:8,075,316...8,094,966
G
NOD2
nucleotide binding oligomerization domain containing 2
treatment
ISO
RGD
PMID:24842554
RGD:13204729
NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773
G
NOS2
nitric oxide synthase 2
ISO
protein:increased expression:brain (rat) mRNA:increased expression:brain (mouse)
RGD
PMID:21959178 PMID:22020035
RGD:5508751 RGD:5509037
NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093
G
NOX1
NADPH oxidase 1
treatment
ISO
RGD
PMID:30816157
RGD:329955567
NCBI chr X:90,046,023...90,076,968
Ensembl chr X:100,182,398...100,215,192
G
NQO1
NAD(P)H quinone dehydrogenase 1
treatment
ISO
protein:increased expression:brain
RGD
PMID:21120604 PMID:25069640
RGD:11035212 RGD:5133239
NCBI chr16:50,090,696...50,106,495
Ensembl chr16:69,470,288...69,489,731
G
NRG1
neuregulin 1
treatment ameliorates
ISO
RGD
PMID:20691195 PMID:30206770
RGD:10449015 RGD:405650589
NCBI chr 8:30,954,852...32,084,411
Ensembl chr 8:29,050,222...29,263,977
G
NTRK2
neurotrophic receptor tyrosine kinase 2
treatment
ISO
mRNA:increased exprerssion:hippocampus
RGD
PMID:30981830 PMID:31927682 PMID:32992173
RGD:596948420 RGD:597015758 RGD:597538459
NCBI chr 9:39,663,986...40,208,770
Ensembl chr 9:84,021,837...84,372,678
G
OGG1
8-oxoguanine DNA glycosylase
treatment
ISO
associated with Hypertension
RGD
PMID:17920569
RGD:8657395
NCBI chr 3:9,702,311...9,742,283
Ensembl chr 3:9,940,955...9,947,335
G
PARK7
Parkinsonism associated deglycase
treatment
ISO
RGD
PMID:17882163
RGD:13463450
NCBI chr 1:6,722,260...6,745,915
Ensembl chr 1:7,969,280...7,993,271
G
PARP1
poly(ADP-ribose) polymerase 1
treatment
ISO
RGD
PMID:21311064 PMID:23143152 PMID:23801245 PMID:25882840
RGD:10054501 RGD:11073732 RGD:13792686 RGD:5683909
NCBI chr 1:201,820,355...201,867,673
Ensembl chr 1:206,812,981...206,860,356
G
PAWR
pro-apoptotic WT1 regulator
treatment
ISO
protein:increased expression:brain:
RGD
PMID:11323519 PMID:16403464 PMID:19352052
RGD:9835380 RGD:9835381 RGD:9850083
NCBI chr12:77,114,282...77,224,116
Ensembl chr12:79,969,517...80,070,796
G
PDGFRA
platelet derived growth factor receptor alpha
treatment
ISO
RGD
PMID:16917016
RGD:11084934
NCBI chr 4:69,639,081...69,709,870
Ensembl chr 4:76,199,382...76,271,097
G
PDGFRB
platelet derived growth factor receptor beta
treatment
ISO
RGD
PMID:16917016
RGD:11084934
NCBI chr 5:145,538,330...145,580,312
Ensembl chr 5:151,543,891...151,585,530
G
PLAT
plasminogen activator, tissue type
ISO
CTD Direct Evidence: therapeutic
RGD CTD
PMID:12297567 PMID:14512838 PMID:17690543 PMID:18453163 PMID:20547619 PMID:29651748 More...
RGD:1580876
NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779
G
PLAU
plasminogen activator, urokinase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11677890 PMID:15181847 PMID:17702958
NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136
G
PLD1
phospholipase D1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr 3:168,606,342...168,816,383
Ensembl chr 3:176,790,753...176,961,033
G
POLB
DNA polymerase beta
ISO
associated with transient cerebral ischemia;protein:increased expression:brain
RGD
PMID:17412650
RGD:2302580
NCBI chr 8:41,582,370...41,615,950
Ensembl chr 8:39,026,991...39,060,464
G
PRKCG
protein kinase C gamma
ISO
RGD
PMID:14688616
RGD:1358416
NCBI chr19:50,823,372...50,849,003
Ensembl chr19:59,672,097...59,695,977
G
PROC
protein C, inactivator of coagulation factors Va and VIIIa
treatment
ISO
RGD
PMID:24159062
RGD:11100027
NCBI chr2B:32,846,899...32,859,060
Ensembl chr2B:128,083,794...128,094,625
G
PTPRZ1
protein tyrosine phosphatase receptor type Z1
ISO
mRNA:increased expression:cerebral cortex
RGD
PMID:15869933
RGD:9590118
NCBI chr 7:113,882,557...114,073,283
Ensembl chr 7:126,569,630...126,758,155
G
RBFOX3
RNA binding fox-1 homolog 3
treatment
ISO
RGD
PMID:30531687
RGD:329849008
NCBI chr17:73,163,818...73,690,675
Ensembl chr17:78,711,056...78,732,131
G
RELN
reelin
severity
ISO
RGD
PMID:16438965
RGD:13207538
NCBI chr 7:95,464,285...95,984,813
Ensembl chr 7:108,208,344...108,728,037
G
RGMA
repulsive guidance molecule BMP co-receptor a
treatment
ISO
RGD
PMID:21840379 PMID:23275173
RGD:9850121 RGD:9850122
NCBI chr15:71,728,669...71,774,447
Ensembl chr15:90,922,199...90,956,179
G
RPL28
ribosomal protein L28
ISO
RGD
PMID:16805800
RGD:6480229
NCBI chr19:52,428,999...52,431,541
Ensembl chr19:61,116,514...61,135,785
G
S100A5
S100 calcium binding protein A5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr 1:128,892,317...128,896,879
Ensembl chr 1:132,521,394...132,525,991
G
S100B
S100 calcium binding protein B
ISO
protein:increased expression:cerebrum, astrocyte
RGD
PMID:23595285
RGD:401794586
NCBI chr21:33,063,845...33,070,073
Ensembl chr21:46,197,750...46,203,953
G
SERPINE1
serpin family E member 1
ISO
RGD
PMID:14512838
RGD:1580876
NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450
G
SERPINF1
serpin family F member 1
treatment
ISO
RGD
PMID:22714093
RGD:8655545
NCBI chr17:1,745,597...1,761,399
Ensembl chr17:1,638,556...1,653,568
G
SERPINH1
serpin family H member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr11:70,621,893...70,632,570
G
SHH
sonic hedgehog signaling molecule
treatment
ISO
RGD
PMID:22324418
RGD:12879461
NCBI chr 7:147,400,112...147,414,036
Ensembl chr 7:159,114,666...159,126,651
G
SIRT1
sirtuin 1
treatment
ISO
RGD
PMID:23600725
RGD:9585664
NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069
G
SLC12A2
solute carrier family 12 member 2
treatment
ISO
protein:increased expression:brain:
RGD
PMID:12535773 PMID:27798271
RGD:14398833 RGD:1580583
NCBI chr 5:123,499,267...123,603,777
Ensembl chr 5:129,262,134...129,364,563
G
SLC1A2
solute carrier family 1 member 2
treatment
ISO
RGD
PMID:20423712
RGD:401794585
NCBI chr11:35,223,811...35,392,799
Ensembl chr11:35,107,920...35,265,878
G
SLC2A1
solute carrier family 2 member 1
treatment
ISO
RGD
PMID:9419067
RGD:12879855
NCBI chr 1:42,224,273...42,257,184
Ensembl chr 1:43,600,733...43,634,143
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SLC9A1
solute carrier family 9 member A1
treatment
ISO
RGD
PMID:31250553
RGD:14985213
NCBI chr 1:26,359,818...26,418,910
Ensembl chr 1:27,414,937...27,475,089
G
SLPI
secretory leukocyte peptidase inhibitor
treatment
ISO
RGD
PMID:14500739
RGD:9999390
NCBI chr20:41,583,429...41,585,773
Ensembl chr20:42,673,417...42,675,773
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SMO
smoothened, frizzled class receptor
treatment
ISO
RGD
PMID:23499832 PMID:23696546
RGD:12832759 RGD:12879404
NCBI chr 7:121,143,968...121,168,873
Ensembl chr 7:133,668,304...133,693,048
G
SMOX
spermine oxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30576531
NCBI chr20:4,167,417...4,206,956
Ensembl chr20:3,965,616...4,004,468
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SNAP91
synaptosome associated protein 91
ISO
protein:increased degradation:brain
RGD
PMID:19240038
RGD:13461853
NCBI chr 6:81,441,792...81,600,505
Ensembl chr 6:84,720,850...84,874,407
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SOD1
superoxide dismutase 1
treatment
ISO
mRNA, protein:increased expression:cerebral cortex (rat)
RGD
PMID:22001340 PMID:22133807
RGD:8657021 RGD:8657023
NCBI chr21:18,029,831...18,037,526
G
SOD2
superoxide dismutase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21940958
NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960
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SPHK2
sphingosine kinase 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:23043544
NCBI chr19:45,620,980...45,631,786
Ensembl chr19:54,213,166...54,224,767
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STAT3
signal transducer and activator of transcription 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21940958
NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067
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TGFB1
transforming growth factor beta 1
ameliorates
ISO
RGD
PMID:28630232 PMID:31409163
RGD:14995477 RGD:242905192
NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973
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TH
tyrosine hydroxylase
ISO
protein:decreased expression:substantia nigra pars compacta, neuron (rat)
RGD
PMID:21366664
RGD:5128609
NCBI chr11:2,204,820...2,212,750
Ensembl chr11:2,231,248...2,242,433
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TLR2
toll like receptor 2
treatment
ISO
mRNA:increased expression:microglial cell
RGD
PMID:20859668 PMID:24723245 PMID:29039449
RGD:597538462 RGD:597538520 RGD:597538540
NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331
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TLR4
toll like receptor 4
treatment
ISO
RGD
PMID:20859668 PMID:24723245
RGD:597538520 RGD:597538540
NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
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TNF
tumor necrosis factor
treatment ameliorates
ISO
RGD
PMID:15647744 PMID:24916922 PMID:28630232 PMID:29498696 PMID:35322553
RGD:10450594 RGD:13792833 RGD:13825261 RGD:242905190 RGD:242905192
NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
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TNFAIP6
TNF alpha induced protein 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr2B:38,669,652...38,692,037
Ensembl chr2B:155,933,842...155,956,382
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TNFRSF1A
TNF receptor superfamily member 1A
ISO
RGD
PMID:15647744
RGD:13825261
NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613
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TREM1
triggering receptor expressed on myeloid cells 1
ameliorates
ISO
RGD
PMID:32736673
RGD:127284860
NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091
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UPP1
uridine phosphorylase 1
ISO
mRNA, protein:increased expression:brain (rat)
RGD
PMID:18457515
RGD:2317094
NCBI chr 7:48,729,975...48,749,598
Ensembl chr 7:48,838,893...48,858,185
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VEGFA
vascular endothelial growth factor A
treatment
ISO
mRNA,protein:increased expression:cerebral cortex (rat)
RGD
PMID:27035554 PMID:29497380 PMID:30531687
RGD:329337377 RGD:329849008 RGD:40925919
NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
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XDH
xanthine dehydrogenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr2A:31,356,011...31,435,111
Ensembl chr2A:31,425,183...31,504,455
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XRCC1
X-ray repair cross complementing 1
ISO
associated with transient cerebral ischemia;protein:increased expression:brain
RGD
PMID:17412650
RGD:2302580
NCBI chr19:40,485,052...40,522,188
Ensembl chr19:49,094,014...49,125,520
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APP
amyloid beta precursor protein
ISO
protein:decreased expression:cerebrospinal fluid:
RGD
PMID:1677459
RGD:10054257
NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072
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BAX
BCL2 associated X, apoptosis regulator
treatment
ISO
RGD
PMID:18938189
RGD:10054050
NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468
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BCL2
BCL2 apoptosis regulator
treatment
ISO
RGD
PMID:18938189
RGD:10054050
NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100
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G6PD
glucose-6-phosphate dehydrogenase
treatment
ISO
RGD
PMID:21279683
RGD:10449132
NCBI chr X:143,972,798...143,988,960
Ensembl chr X:153,843,092...153,860,674
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IL2
interleukin 2
severity
ISO
protein:increased secretion:mononuclear cell:
RGD
PMID:8586980
RGD:10047081
NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984
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