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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Prenatal Injuries
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Accession:DOID:9007023 term browser browse the term
Definition:Damages to the EMBRYO, MAMMALIAN or the FETUS before BIRTH. Damages can be caused by any factors including biological, chemical, or physical.
Synonyms:exact_synonym: Prenatal Injury
 primary_id: MESH:D049188;   RDO:0006411



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Prenatal Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase ISO CTD Direct Evidence: marker/mechanism CTD PMID:14657522 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Atp7a ATPase copper transporting alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:25456742 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Lox lysyl oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20045017 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Loxl1 lysyl oxidase-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20045017 NCBI chr 8:58,691,763...58,716,365
Ensembl chr 8:58,692,593...58,716,356
JBrowse link
G Mt1 metallothionein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:12514265 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:24075420 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Prss8 serine protease 8 ISO CTD Direct Evidence: therapeutic CTD PMID:24722141 NCBI chr 1:182,536,229...182,540,745
Ensembl chr 1:182,536,229...182,540,815
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18956198 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18956198 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Slc39a4 solute carrier family 39 member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17483098 NCBI chr 7:108,333,368...108,337,553
Ensembl chr 7:108,333,381...108,337,553
JBrowse link
G Spint2 serine peptidase inhibitor, Kunitz type, 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24722141 NCBI chr 1:84,558,159...84,580,616
Ensembl chr 1:84,558,166...84,580,616
JBrowse link
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478334 NCBI chr 9:113,200,256...113,275,942
Ensembl chr 9:113,200,256...113,299,837
JBrowse link
Prenatal Exposure Delayed Effects term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme treatment IEP associated with hypertension RGD PMID:30127255 RGD:401793709 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin converting enzyme 2 treatment IEP associated with maternal adenine induced chronic kidney disease RGD PMID:32604820 RGD:401793718 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32715474 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide IEP mRNA:decreased expression:liver (rat) RGD PMID:22781937 RGD:405100969 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
JBrowse link
G Adora1 adenosine A1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19092996 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
JBrowse link
G Agt angiotensinogen treatment IEP associated with maternal adenine induced chronic kidney disease RGD PMID:32604820 RGD:401793718 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a treatment IEP associated with hypertension RGD PMID:30127255 RGD:401793709 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr1b angiotensin II receptor, type 1b ISO CTD Direct Evidence: marker/mechanism CTD PMID:22728133 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
JBrowse link
G Agtr2 angiotensin II receptor, type 2 treatment IEP associated with maternal adenine induced chronic kidney disease RGD PMID:32604820 RGD:401793718 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Ahr aryl hydrocarbon receptor treatment IEP associated with hypertension RGD PMID:30127255 PMID:31489946 RGD:401793709, RGD:401793758 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor treatment IEP associated with hypertension
associated with maternal adenine induced chronic kidney disease
RGD PMID:30127255 PMID:31489946 PMID:32604820 RGD:401793709, RGD:401793758, RGD:401793718 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673
JBrowse link
G Ank3 ankyrin 3 susceptibility ISO DNA:SNP: : rs9804190(human) RGD PMID:27824361 RGD:153344561 NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator treatment IEP RGD PMID:31489946 RGD:401793758 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Asip agouti signaling protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:32937126 NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171
JBrowse link
G Atm ATM serine/threonine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21177254 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 treatment IEP associated with maternal adenine induced chronic kidney disease RGD PMID:32604820 RGD:401793718 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918
JBrowse link
G Bdnf brain-derived neurotrophic factor treatment
sexual_dimorphism
IEP associated with alcohol use disorder;mRNA, protein:decreased expression:hippocampus, serum
associated with stress-related disorder
mRNA:altered expression:hippocampus|hypothalamus (rat)
RGD PMID:32497709 PMID:25442671 PMID:26180184 RGD:401950485, RGD:408361837, RGD:11074449 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bmp2 bone morphogenetic protein 2 ISO CTD Direct Evidence: therapeutic CTD PMID:29800642 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Cbs cystathionine beta synthase sexual_dimorphism IEP mRNA:altered expression:hippocampus|hypothalamus (rat) RGD PMID:26180184 RGD:11074449 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
JBrowse link
G Ccn2 cellular communication network factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21258935 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Creb1 cAMP responsive element binding protein 1 IDA associated with morphine withdrawal disorder RGD PMID:33915201 RGD:401959752 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 sexual_dimorphism IEP mRNA:altered expr:brain (rat) RGD PMID:29990678 RGD:401976282 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 treatment IEP associated with hypertension RGD PMID:30127255 PMID:31489946 RGD:401793709, RGD:401793758 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15570195 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 IEP mRNA:increased expression:liver (rat) RGD PMID:22781937 RGD:405100969 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Egr1 early growth response 1 IEP protein:decreased expression:hippocampus (rat) RGD PMID:26180184 RGD:11074449 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Fgf2 fibroblast growth factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19014962 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:26411935 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Maoa monoamine oxidase A ISO CTD Direct Evidence: marker/mechanism CTD PMID:22340208 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor treatment IEP associated with maternal adenine induced chronic kidney disease RGD PMID:32604820 RGD:401793718 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
JBrowse link
G Mat2a methionine adenosyltransferase 2A sexual_dimorphism IEP mRNA:altered expression:hippocampus|hypothalamus (rat) RGD PMID:26180184 RGD:11074449 NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493
JBrowse link
G Mthfr methylenetetrahydrofolate reductase sexual_dimorphism IEP mRNA:altered expression:hippocampus|hypothalamus (rat) RGD PMID:26180184 RGD:11074449 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase sexual_dimorphism IEP mRNA:altered expression:hippocampus|hypothalamus (rat) RGD PMID:26180184 RGD:11074449 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
JBrowse link
G Myod1 myogenic differentiation 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21258934 NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554
JBrowse link
G Nos1 nitric oxide synthase 1 treatment IEP RGD PMID:31489946 RGD:401793758 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP RGD PMID:31489946 RGD:401793758 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Notch2 notch receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32715474 NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 sexual_dimorphism
sexual_dimorphism
treatment
IEP
IDA
associated with alcohol use disorder;mRNA:decreased expression:hippocampus
associated with alcohol use disorder;mRNA:altered expression:prefrontal cortex
associated with stress-related disorder
DNA, RNA, protein:hypermethylation, decreased expression:promoter, hippocampus
associated with alcohol use disorder;mRNA:decreased expression:amygdala
associated with alcohol use disorder mRNA:altered expression:brain
associated with alcohol use disorder;mRNA:increased expression:hippocampus
associated with alcohol use disorder;mRNA:decreased expression:prefrontal cortex
RGD PMID:26180184 PMID:30367959 PMID:25442671 PMID:28086911 PMID:32497709 More... RGD:11074449, RGD:401966864, RGD:408361837, RGD:408345237, RGD:401950485, RGD:408345230, RGD:408345228, RGD:408345195, RGD:401976282, RGD:401965484 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 sexual_dimorphism IEP mRNA:altered expression:hippocampus|hypothalamus (rat)
associated with females; mRNA:decreased expression:hippocampus (rat)
associated with stress-related disorder; mRNA:decreased expression:hippocampus (rat)
mRNA:altered expr:brain (rat)
associated with chronic stress, female fetus; protein:increased expression:hippocampus, amygdala (rat)
RGD PMID:26180184 PMID:23579081 PMID:16925589 PMID:29990678 PMID:26342748 RGD:11074449, RGD:401976414, RGD:401976289, RGD:401976282, RGD:401965481 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Nrgn neurogranin IEP RGD PMID:17579784 RGD:9835426 NCBI chr 8:37,255,462...37,263,659
Ensembl chr 8:37,256,930...37,257,516
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18768699 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Per1 period circadian regulator 1 IEP associated with alcohol use disorder;mRNA:altered expression: arcuate nucleus of hypothalamus, suprachiasmatic nucleus RGD PMID:16686691 RGD:405866367 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Per2 period circadian regulator 2 IEP associated with alcohol use disorder;mRNA:altered expression: arcuate nucleus of hypothalamus, suprachiasmatic nucleus RGD PMID:16686691 RGD:405866367 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
JBrowse link
G Per3 period circadian regulator 3 IEP associated with alcohol use disorder;mRNA:altered expression: arcuate nucleus of hypothalamus, suprachiasmatic nucleus RGD PMID:16686691 RGD:405866367 NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607
JBrowse link
G Pomc proopiomelanocortin sexual_dimorphism IDA
IEP
associated with alcohol use disorder;DNA:hypermethylation:hypothalamus, promoter
associated with alcohol use disorder;DNA, mRNA:hypermethylation, decreased expression:promoter, hypothalamus
associated with alcohol use disorder;mRNA:altered expression: arcuate nucleus of hypothalamus
RGD PMID:22622000 PMID:35143549 PMID:16686691 RGD:405878080, RGD:407431645, RGD:405866367 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Pon1 paraoxonase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25463530 PMID:28396702 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha treatment IEP RGD PMID:31489946 RGD:401793758 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ren renin treatment IEP associated with hypertension
associated with maternal adenine induced chronic kidney disease
RGD PMID:30127255 PMID:32604820 RGD:401793709, RGD:401793718 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:15451042 NCBI chr 5:56,904,155...56,907,012
Ensembl chr 5:56,904,159...56,907,017
JBrowse link
G Slc6a4 solute carrier family 6 member 4 sexual_dimorphism IEP
IAGP
mRNA:altered expression:hippocampus|hypothalamus (rat)
DNA:altered methylation:hypothalamus (rat)
RGD PMID:26180184 PMID:26180184 RGD:11074449, RGD:11074449 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link

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Term Annotations click to browse term
  disease 19055
    disease of anatomical entity 18391
      Urogenital Diseases 5266
        Female Urogenital Diseases and Pregnancy Complications 2499
          Pregnancy Complications 800
            Prenatal Injuries 61
              Prenatal Exposure Delayed Effects 50
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