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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Fibroadenoma
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Accession:DOID:9006947 term browser browse the term
Definition:An adenoma containing fibrous tissue. It should be differentiated from ADENOFIBROMA which is a tumor composed of connective tissue (fibroma) containing glandular (adeno-) structures. (From Dorland, 27th ed)
Synonyms:exact_synonym: fibroadenomas
 primary_id: MESH:D018226
 xref: EFO:1000254


show annotations for term's descendants           Sort by:
Fibroadenoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOSL1 FOS like 1, AP-1 transcription factor subunit ISO mRNA, protein:increased expression:breast RGD PMID:17254320 RGD:2293756 NCBI chr18:51,366,719...51,374,411
Ensembl chr18:51,368,352...51,373,748 		JBrowse link
G MED12 mediator complex subunit 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25038752 PMID:26437033 NCBI chr  X:55,487,629...55,508,941
Ensembl chr  X:55,482,013...55,509,992 		JBrowse link
G RARA retinoic acid receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:26437033 NCBI chr 9:22,254,803...22,298,614
Ensembl chr 9:22,254,806...22,289,459 		JBrowse link
G WNT2 Wnt family member 2 ISO mRNA:increased expression:breast RGD PMID:8168088 RGD:2291878 NCBI chr14:56,123,735...56,172,113
Ensembl chr14:56,129,248...56,172,069 		JBrowse link
G WNT4 Wnt family member 4 ISO breast fibroadenoma; mRNA:increased expression:tumor:increased vs normal and malignant breast tissue (p=0.001) RGD PMID:8168088 RGD:2291878 NCBI chr 2:77,112,045...77,129,702
Ensembl chr 2:77,101,300...77,127,111 		JBrowse link
breast fibroadenoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT7B Wnt family member 7B ISO mRNA:increased expression:tumor:increased in 10% of malignant neoplasms vs normal tissue and fibroadenomas RGD PMID:8168088 RGD:2291878 NCBI chr10:20,160,916...20,208,786
Ensembl chr10:20,160,206...20,243,160 		JBrowse link
Multiple Fibroadenomas of the Breast term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRLR prolactin receptor ISO ClinVar Annotator: match by term: Multiple fibroadenomas of the breast OMIM
ClinVar		 PMID:18779591 PMID:25741868 NCBI chr 4:73,147,919...73,280,970
Ensembl chr 4:73,110,858...73,273,916 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17774
    disease of cellular proliferation 7264
      benign neoplasm 2154
        cell type benign neoplasm 1900
          adenoma 682
            Fibroadenoma 7
              Eccrine Syringofibroadenomatosis with Eyelid Abnormalities 0
              breast fibroadenoma + 2
Path 2
Term Annotations click to browse term
  disease 17774
    disease of anatomical entity 15146
      Skin and Connective Tissue Diseases 6797
        connective tissue disease 5278
          Connective Tissue Neoplasms 1710
            Fibrous Tissue Neoplasms 59
              Fibroepithelial Neoplasms 7
                Fibroadenoma 7
                  Eccrine Syringofibroadenomatosis with Eyelid Abnormalities 0
                  breast fibroadenoma + 2
paths to the root