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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Lyme Neuroborreliosis
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Accession:DOID:9006939 term browser browse the term
Definition:Nervous system infections caused by tick-borne spirochetes of the BORRELIA BURGDORFERI GROUP. The disease may affect elements of the central or peripheral nervous system in isolation or in combination. Common clinical manifestations include a lymphocytic meningitis, cranial neuropathy (most often a facial neuropathy), POLYRADICULOPATHY, and a mild loss of memory and other cognitive functions. Less often more extensive inflammation involving the central nervous system (encephalomyelitis) may occur. In the peripheral nervous system, B. burgdorferi infection is associated with mononeuritis multiplex and polyradiculoneuritis. (From J Neurol Sci 1998 Jan 8;153(2):182-91)
Synonyms:exact_synonym: Borrelia burgdorferi Neuroborreliosis;   Central Nervous System Lyme Disease;   Lyme Disease Encephalopathies;   Lyme Disease Encephalopathy;   Lyme Disease Mononeuritis Multiplex;   Lyme Meningoencephalitis;   Lyme Meningoradiculitis;   Lyme Polyradiculitides;   Lyme Polyradiculitis;   Lyme Polyradiculopathies;   Lyme Polyradiculopathy;   Nervous System Lyme Borreliosis;   Nervous System Lyme Disease;   Neuroborrelioses, Borrelia burgdorferi;   Peripheral Nervous System Lyme Disease
 primary_id: MESH:D020852


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Lyme Neuroborreliosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 IEP protein:increased expression:serum (human) RGD PMID:16358960 RGD:11528571 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CD40 CD40 molecule IEP protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863 		JBrowse link
G CD40LG CD40 ligand IEP protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 treatment IEP RGD PMID:24239846 RGD:39939054 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G IL1B interleukin 1 beta ISO RGD PMID:23134838 RGD:7193053 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 41189
    disease by infectious agent 2738
      Bacterial Infections and Mycoses 1246
        bacterial infectious disease 1003
          Central Nervous System Bacterial Infections 48
            Lyme Neuroborreliosis 5
Path 2
Term Annotations click to browse term
  disease 41189
    disease by infectious agent 2738
      Bacterial Infections and Mycoses 1246
        bacterial infectious disease 1003
          Spirochaetales Infections 22
            Borrelia Infections 10
              Lyme disease 10
                Lyme Neuroborreliosis 5
paths to the root