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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Lyme Neuroborreliosis
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Accession:DOID:9006939 term browser browse the term
Definition:Nervous system infections caused by tick-borne spirochetes of the BORRELIA BURGDORFERI GROUP. The disease may affect elements of the central or peripheral nervous system in isolation or in combination. Common clinical manifestations include a lymphocytic meningitis, cranial neuropathy (most often a facial neuropathy), POLYRADICULOPATHY, and a mild loss of memory and other cognitive functions. Less often more extensive inflammation involving the central nervous system (encephalomyelitis) may occur. In the peripheral nervous system, B. burgdorferi infection is associated with mononeuritis multiplex and polyradiculoneuritis. (From J Neurol Sci 1998 Jan 8;153(2):182-91)
Synonyms:exact_synonym: Borrelia burgdorferi Neuroborreliosis;   Central Nervous System Lyme Disease;   Lyme Disease Encephalopathies;   Lyme Disease Encephalopathy;   Lyme Disease Mononeuritis Multiplex;   Lyme Meningoencephalitis;   Lyme Meningoradiculitis;   Lyme Polyradiculitides;   Lyme Polyradiculitis;   Lyme Polyradiculopathies;   Lyme Polyradiculopathy;   Nervous System Lyme Borreliosis;   Nervous System Lyme Disease;   Neuroborrelioses, Borrelia burgdorferi;   Peripheral Nervous System Lyme Disease
 primary_id: MESH:D020852



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Lyme Neuroborreliosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 ISO protein:increased expression:serum (human) RGD PMID:16358960 RGD:11528571 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd40 CD40 molecule ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Il1b interleukin 1 beta IDA RGD PMID:23134838 RGD:7193053 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19141
    disease by infectious agent 2253
      Bacterial Infections and Mycoses 1118
        bacterial infectious disease 824
          Central Nervous System Bacterial Infections 48
            Lyme Neuroborreliosis 4
Path 2
Term Annotations click to browse term
  disease 19141
    disease by infectious agent 2253
      Bacterial Infections and Mycoses 1118
        bacterial infectious disease 824
          Spirochaetales Infections 21
            Borrelia Infections 9
              Lyme disease 9
                Lyme Neuroborreliosis 4
paths to the root