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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Viral Bronchiolitis
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Accession:DOID:9006928 term browser browse the term
Definition:An acute inflammatory disease of the lower RESPIRATORY TRACT, caused by paramyxoviruses, occurring primarily in infants and young children; the viruses most commonly implicated are PARAINFLUENZA VIRUS TYPE 3; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; and METAPNEUMOVIRUS.
Synonyms:exact_synonym: Viral Bronchiolitides
 primary_id: MESH:D001990
For additional species annotation, visit the Alliance of Genome Resources.



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Viral Bronchiolitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam33 a disintegrin and metallopeptidase domain 33 susceptibility ISO DNA:SNP: :rs2787094 c.2891G>C (human) RGD PMID:19258923 RGD:4142862 NCBI chr 2:130,892,739...130,905,734
Ensembl chr 2:130,892,511...130,905,734
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 severity ISO protein:increased expression:natural killer cell, T cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 severity ISO protein:increased expression:natural killer cell,t cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 2:152,600,652...152,675,723
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G C3 complement component 3 resistance ISO
IMP
RGD PMID:19258923 PMID:12235218 RGD:4142862, RGD:5129513 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
JBrowse link
G Casp1 caspase 1 ISO RGD PMID:15196254 RGD:5130189 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Cat catalase IEP protein:decreased expression:lung RGD PMID:21471094 RGD:5130770 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 susceptibility ISO protein:increased secretion:serum (human)
DNA:snp:5' utr:g.-28C>G (human)
RGD PMID:19005677 PMID:19099677 RGD:4891884, RGD:4891881 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
JBrowse link
G Cd14 CD14 antigen ISO DNA:polymorphism:promoter:c.-550C>T (human) RGD PMID:17471431 RGD:4144210 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851
JBrowse link
G Cd274 CD274 antigen treatment IEP
IMP
mRNA:increased expression:lung RGD PMID:22797302 PMID:22797302 RGD:40818270, RGD:40818270 NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) ISO protein:increased expression:nasal mucus RGD PMID:20088864 RGD:4143440 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
JBrowse link
G Cx3cr1 chemokine (C-X3-C motif) receptor 1 ISO DNA:SNP: :p.T280M (human) RGD PMID:18257903 PMID:16645504 RGD:4891891, RGD:4891905 NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,730,682...119,898,945
JBrowse link
G Cxcl10 chemokine (C-X-C motif) ligand 10 ISO mRNA:increased expression:lung
protein:increased expression:plasma
RGD PMID:12909590 PMID:20561238 RGD:2311388, RGD:5135493 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
JBrowse link
G Cxcr3 chemokine (C-X-C motif) receptor 3 ISO RGD PMID:20561238 RGD:5135493 NCBI chr  X:100,775,141...100,777,753
Ensembl chr  X:100,775,141...100,777,875
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Flt3 FMS-like tyrosine kinase 3 severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 5:147,267,551...147,337,299
Ensembl chr 5:147,267,551...147,337,299
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 6:125,138,815...125,143,430
Ensembl chr 6:125,138,678...125,143,430
JBrowse link
G Il15 interleukin 15 severity ISO mRNA,protein:increased expression:peripheral blood mononuclear cell,serum,dendritic cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851
JBrowse link
G Il17a interleukin 17A susceptibility ISO DNA:SNP: :rs7747909(human) RGD PMID:17703412 RGD:4889847 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720
JBrowse link
G Il1rn interleukin 1 receptor antagonist susceptibility ISO DNA:SNP: :c.390T>C (rs315952) (human) RGD PMID:19258923 RGD:4142862 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506
JBrowse link
G Il33 interleukin 33 ISO protein:increased expression:nasal mucus RGD PMID:28471975 RGD:38596342 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118
JBrowse link
G Il4ra interleukin 4 receptor, alpha susceptibility ISO
IMP
associated with respiratory syncystial virus infection; DNA:polymorphism:cds:p. Q551R (human)
DNA:SNPs: :rs1805011,rs2057768 (human)
RGD PMID:12508140 PMID:20404812 PMID:17703412 RGD:4890022, RGD:4889996, RGD:4889847 NCBI chr 7:125,151,443...125,178,646
Ensembl chr 7:125,151,292...125,178,646
JBrowse link
G Il6 interleukin 6 ISO mRNA, protein:increased expression:respiratory system fluid/secretion RGD PMID:14738241 RGD:5128668 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Il9 interleukin 9 ISO RGD PMID:15051283 RGD:5128692 NCBI chr13:56,627,090...56,630,070
Ensembl chr13:56,627,090...56,630,059
JBrowse link
G Jak3 Janus kinase 3 severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 8:72,129,027...72,143,221
Ensembl chr 8:72,128,940...72,143,219
JBrowse link
G Klrk1 killer cell lectin-like receptor subfamily K, member 1 susceptibility ISO DNA:SNP,haplotypes:3'utr: (rs10772271) (human) RGD PMID:29967528 RGD:39128159 NCBI chr 6:129,587,286...129,600,863
Ensembl chr 6:129,587,286...129,600,827
JBrowse link
G Mpo myeloperoxidase ISO RGD PMID:7841728 RGD:5130995 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Muc1 mucin 1, transmembrane severity ISO protein:increased expression:serum RGD PMID:19856476 RGD:5131164 NCBI chr 3:89,136,363...89,140,688
Ensembl chr 3:89,136,364...89,140,688
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 3:135,290,416...135,397,728
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha susceptibility ISO associated with respiratory syncytial virus infectious disease;DNA:SNP:promoter: (rs2233406) (human) RGD PMID:23487427 RGD:40902982 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Nos2 nitric oxide synthase 2, inducible susceptibility ISO DNA:SNP: :rs1060826(human) RGD PMID:17703412 RGD:4889847 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Pdcd1 programmed cell death 1 IEP protein:increased expression:CD8 T cell RGD PMID:22797302 RGD:40818270 NCBI chr 1:93,966,027...93,980,278
Ensembl chr 1:93,966,027...93,980,278
JBrowse link
G Postn periostin, osteoblast specific factor ISO mRNA,protein:increased expression:nasal mucus RGD PMID:28471975 RGD:38596342 NCBI chr 3:54,266,688...54,298,462
Ensembl chr 3:54,268,530...54,298,458
JBrowse link
G Stat5a signal transducer and activator of transcription 5A severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995
JBrowse link
G Tlr4 toll-like receptor 4 ISO protein:increased expression:monocyte
protein:decreased expression:neutrophil
RGD PMID:14738455 PMID:19497921 RGD:4144819, RGD:4144183 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tlr5 toll-like receptor 5 susceptibility ISO DNA:snp:cds:p.F616L rs5744174 (human) RGD PMID:19258923 RGD:4142862 NCBI chr 1:182,782,317...182,804,010
Ensembl chr 1:182,782,353...182,804,010
JBrowse link
G Tnf tumor necrosis factor susceptibility ISO DNA:SNP: :rs1799724(human)
protein:increased expression:nasal lavage fluid
DNA:polymorphism:promoter: c. -308A>G (human)
RGD PMID:17703412 PMID:20088864 PMID:19849941 RGD:4889847, RGD:4143440, RGD:4143441 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr14:70,004,921...70,021,860
Ensembl chr14:70,004,921...70,021,860
JBrowse link
G Tslp thymic stromal lymphopoietin severity ISO mRNA, protein:increased expression:nasal mucus (human) RGD PMID:28471975 RGD:38596342 NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor susceptibility ISO DNA:SNP (human)
DNA:SNP: :rs10735810 (human)
RGD PMID:18266602 PMID:17703412 RGD:4889843, RGD:4889847 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15244
    disease by infectious agent 2126
      viral infectious disease 1690
        Viral Bronchiolitis 39
Path 2
Term Annotations click to browse term
  disease 15244
    disease of anatomical entity 14892
      respiratory system disease 3258
        lower respiratory tract disease 2195
          lung disease 2153
            obstructive lung disease 451
              bronchitis 91
                bronchiolitis 78
                  Viral Bronchiolitis 39
paths to the root