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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Viral Bronchiolitis
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Accession:DOID:9006928 term browser browse the term
Definition:An acute inflammatory disease of the lower RESPIRATORY TRACT, caused by paramyxoviruses, occurring primarily in infants and young children; the viruses most commonly implicated are PARAINFLUENZA VIRUS TYPE 3; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; and METAPNEUMOVIRUS.
Synonyms:exact_synonym: Viral Bronchiolitides
 primary_id: MESH:D001990
For additional species annotation, visit the Alliance of Genome Resources.


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Viral Bronchiolitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM33 ADAM metallopeptidase domain 33 susceptibility ISO DNA:SNP: :rs2787094 c.2891G>C (human) RGD PMID:19258923 RGD:4142862 NCBI chr20:3,750,158...3,764,262
Ensembl chr20:3,508,620...3,521,628 		JBrowse link
G BCL2 BCL2 apoptosis regulator severity ISO protein:increased expression:natural killer cell, T cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100 		JBrowse link
G BCL2L1 BCL2 like 1 severity ISO protein:increased expression:natural killer cell,t cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr20:27,955,688...28,015,950
Ensembl chr20:29,088,055...29,146,585 		JBrowse link
G C3 complement C3 resistance ISO RGD PMID:12235218 PMID:19258923 RGD:4142862 RGD:5129513 NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699 		JBrowse link
G CASP1 caspase 1 ISO RGD PMID:15196254 RGD:5130189 NCBI chr11:99,965,964...99,975,640
Ensembl chr11:103,448,497...103,458,149
Ensembl chr11:103,448,497...103,458,149 		JBrowse link
G CAT catalase ISO protein:decreased expression:lung
protein:decreased expression:nasal mucus		 RGD PMID:21471094 RGD:5130770 NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 susceptibility ISO protein:increased secretion:serum (human)
DNA:snp:5' utr:g.-28C>G (human)		 RGD PMID:19005677 PMID:19099677 RGD:4891881 RGD:4891884 NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172 		JBrowse link
G CD14 CD14 molecule ISO DNA:polymorphism:promoter:c.-550C>T (human) RGD PMID:17471431 RGD:4144210 NCBI chr 5:135,996,265...135,997,909
Ensembl chr 5:142,113,082...142,118,966 		JBrowse link
G CD274 CD274 molecule treatment ISO mRNA:increased expression:lung RGD PMID:22797302 RGD:40818270 NCBI chr 9:5,269,270...5,289,629
Ensembl chr 9:5,454,391...5,474,402 		JBrowse link
G CSF2 colony stimulating factor 2 ISO protein:increased expression:nasal mucus RGD PMID:20088864 RGD:4143440 NCBI chr 5:127,496,951...127,499,325
Ensembl chr 5:133,660,775...133,663,146 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 ISO DNA:SNP: :p.T280M (human) RGD PMID:16645504 PMID:18257903 RGD:4891891 RGD:4891905 NCBI chr 3:39,158,346...39,176,604
Ensembl chr 3:39,440,955...39,457,219 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO mRNA:increased expression:lung
protein:increased expression:plasma		 RGD PMID:12909590 PMID:20561238 RGD:2311388 RGD:5135493 NCBI chr 4:48,182,355...48,184,733
Ensembl chr 4:54,020,204...54,022,606 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO RGD PMID:20561238 RGD:5135493 NCBI chr  X:60,880,759...60,883,355
Ensembl chr  X:70,933,160...70,935,756 		JBrowse link
G FAS Fas cell surface death receptor severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612 		JBrowse link
G FLT3 fms related receptor tyrosine kinase 3 severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr13:9,283,747...9,381,553
Ensembl chr13:27,627,178...27,723,940 		JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr12:6,665,218...6,669,170
Ensembl chr12:6,583,895...6,587,729 		JBrowse link
G IL15 interleukin 15 severity ISO mRNA,protein:increased expression:peripheral blood mononuclear cell,serum,dendritic cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 4:133,693,995...134,115,470
Ensembl chr 4:145,402,111...145,416,622 		JBrowse link
G IL17A interleukin 17A susceptibility ISO DNA:SNP: :rs7747909(human) RGD PMID:17703412 RGD:4889847 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074 		JBrowse link
G IL33 interleukin 33 ISO protein:increased expression:nasal mucus RGD PMID:28471975 RGD:38596342 NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624 		JBrowse link
G IL4R interleukin 4 receptor susceptibility ISO associated with respiratory syncystial virus infection; DNA:polymorphism:cds:p. Q551R (human)
DNA:SNPs: :rs1805011,rs2057768 (human)		 RGD PMID:12508140 PMID:17703412 PMID:20404812 RGD:4889847 RGD:4889996 RGD:4890022 Ensembl chr16:27,642,702...27,737,445 JBrowse link
G IL6 interleukin 6 ISO mRNA, protein:increased expression:respiratory system fluid/secretion RGD PMID:14738241 RGD:5128668 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G IL9 interleukin 9 ISO RGD PMID:15051283 RGD:5128692 NCBI chr 5:131,283,170...131,289,777
Ensembl chr 5:137,425,367...137,428,945 		JBrowse link
G JAK3 Janus kinase 3 severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964 		JBrowse link
G KLRK1 killer cell lectin like receptor K1 susceptibility ISO DNA:SNP,haplotypes:3'utr: (rs10772271) (human) RGD PMID:29967528 RGD:39128159 NCBI chr12:10,411,932...10,429,256
Ensembl chr12:10,662,424...10,699,078 		JBrowse link
G LOC100976419 interferon lambda-1 exacerbates ISO associated with respiratory syncytial virus infectious disease;mRNA:increased expression:mucosa of nasopharynx (human) RGD PMID:24389019 RGD:126848743 NCBI chr19:36,394,462...36,397,363
Ensembl chr19:44,942,186...44,944,519 		JBrowse link
G LOC100988550 signal transducer and activator of transcription 5A severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr17:15,005,025...15,029,110
Ensembl chr17:15,228,465...15,251,783 		JBrowse link
G LOC100991079 interleukin-1 receptor antagonist protein susceptibility ISO DNA:SNP: :c.390T>C (rs315952) (human) RGD PMID:19258923 RGD:4142862 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839 		JBrowse link
G MPO myeloperoxidase ISO RGD PMID:7841728 RGD:5130995 NCBI chr17:52,333,882...52,357,838
Ensembl chr17:57,201,073...57,212,111 		JBrowse link
G MUC1 mucin 1, cell surface associated severity ISO protein:increased expression:serum RGD PMID:19856476 RGD:5131164 NCBI chr 1:130,533,508...130,537,866
Ensembl chr 1:134,141,969...134,145,850 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 4:94,925,048...95,040,849
Ensembl chr 4:105,589,062...105,704,098 		JBrowse link
G NFKBIA NFKB inhibitor alpha susceptibility ISO associated with respiratory syncytial virus infectious disease;DNA:SNP:promoter: (rs2233406) (human) RGD PMID:23487427 RGD:40902982 NCBI chr14:16,155,331...16,158,588 JBrowse link
G NOS2 nitric oxide synthase 2 susceptibility ISO DNA:SNP: :rs1060826(human) RGD PMID:17703412 RGD:4889847 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093 		JBrowse link
G PDCD1 programmed cell death 1 ISO protein:increased expression:CD8 T cell RGD PMID:22797302 RGD:40818270 NCBI chr2B:129,111,509...129,121,127 JBrowse link
G POSTN periostin ISO mRNA,protein:increased expression:nasal mucus RGD PMID:28471975 RGD:38596342 NCBI chr13:18,779,297...18,815,207
Ensembl chr13:37,368,030...37,407,212 		JBrowse link
G TLR4 toll like receptor 4 ISO protein:decreased expression:neutrophil
protein:increased expression:monocyte		 RGD PMID:14738455 PMID:19497921 RGD:4144183 RGD:4144819 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TLR5 toll like receptor 5 susceptibility ISO DNA:snp:cds:p.F616L rs5744174 (human) RGD PMID:19258923 RGD:4142862 NCBI chr 1:198,787,046...198,819,537
Ensembl chr 1:203,798,767...203,801,343 		JBrowse link
G TNF tumor necrosis factor susceptibility ISO DNA:SNP: :rs1799724(human)
DNA:polymorphism:promoter: c. -308A>G (human)
protein:increased expression:nasal lavage fluid		 RGD PMID:17703412 PMID:19849941 PMID:20088864 RGD:4143440 RGD:4143441 RGD:4889847 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFRSF10A TNF receptor superfamily member 10a severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 8:22,440,502...22,476,790
Ensembl chr 8:19,378,547...19,414,724 		JBrowse link
G TSLP thymic stromal lymphopoietin severity ISO mRNA, protein:increased expression:nasal mucus (human) RGD PMID:28471975 RGD:38596342 NCBI chr 5:106,440,136...106,446,849
Ensembl chr 5:112,242,490...112,250,130 		JBrowse link
G VDR vitamin D receptor susceptibility ISO DNA:SNP: :rs10735810 (human)
DNA:SNP (human)		 RGD PMID:17703412 PMID:18266602 RGD:4889843 RGD:4889847 NCBI chr12:40,828,413...40,891,700
Ensembl chr12:41,702,742...41,766,192 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14598
    disease by infectious agent 1995
      viral infectious disease 1584
        Viral Bronchiolitis 40
Path 2
Term Annotations click to browse term
  disease 14598
    disease of anatomical entity 14308
      respiratory system disease 3058
        lower respiratory tract disease 2019
          lung disease 1983
            obstructive lung disease 420
              bronchitis 88
                bronchiolitis 76
                  Viral Bronchiolitis 40
paths to the root