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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:MPTP Poisoning
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Accession:DOID:9006854 term browser browse the term
Definition:A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)
Synonyms:exact_synonym: MPTP Induced Degeneration of the Striatum;   MPTP Induced Parkinsonism;   MPTP Neurotoxicity Syndrome;   MPTP Neurotoxicity Syndromes;   Poisoning, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
 primary_id: MESH:D020267;   RDO:0007382
For additional species annotation, visit the Alliance of Genome Resources.


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MPTP Poisoning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il17a interleukin 17A ISO CTD Direct Evidence: marker/mechanism CTD PMID:31351185 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Ins2 insulin 2 ISO CTD Direct Evidence: therapeutic CTD PMID:26364587 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16123
    syndrome 7053
      toxic encephalopathy 210
        MPTP Poisoning 2
Path 2
Term Annotations click to browse term
  disease 16123
    disease of anatomical entity 15370
      nervous system disease 10975
        central nervous system disease 9096
          brain disease 8405
            movement disease 1097
              Parkinsonism 338
                secondary Parkinson disease 14
                  MPTP Poisoning 2
paths to the root