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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Streptococcal Infections
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Accession:DOID:9006844 term browser browse the term
Definition:Infections with bacteria of the genus STREPTOCOCCUS.
Synonyms:exact_synonym: Streptococcal Infection
 primary_id: MESH:D013290
For additional species annotation, visit the Alliance of Genome Resources.


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Streptococcal Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 molecule ISO associated with Encephalomyelitis, Experimental Autoimmune; protein:increased expression:spleen, dendritic cell (mouse) RGD PMID:16861672 RGD:4892553 NCBI chrNW_004936536:8,414,491...8,481,712 JBrowse link
G Il17a interleukin 17A ISO protein:increased expression:serum (mouse) RGD PMID:22384827 RGD:8698662 NCBI chrNW_004936476:8,621,860...8,625,008 JBrowse link
G Lcn2 lipocalin 2 ISO mRNA,protein:increased expression:respiratory epithelium, olfactory mucosa epithelium RGD PMID:16153241 RGD:126781709 NCBI chrNW_004936487:15,721,752...15,725,396 JBrowse link
G Tlr2 toll like receptor 2 severity ISO RGD PMID:19179417 RGD:7240559 NCBI chrNW_004936576:522,234...531,660 JBrowse link
G Tnf tumor necrosis factor ISO associated with Otitis Media RGD PMID:8302123 RGD:11554174 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
immunodeficiency 33 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd1 ATP binding cassette subfamily D member 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:615,133...634,618 JBrowse link
G Arhgap4 Rho GTPase activating protein 4 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:791,275...807,448 JBrowse link
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:396,883...466,372 JBrowse link
G Atp6ap1 ATPase H+ transporting accessory protein 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:1,179,507...1,188,172 JBrowse link
G Avpr2 arginine vasopressin receptor 2 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:789,337...790,986 JBrowse link
G Bcap31 B cell receptor associated protein 31 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:582,689...614,800 JBrowse link
G Bgn biglycan ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:375,589...389,718 JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex subunit 3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936927:341,114...380,817 JBrowse link
G Ccnq cyclin Q ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:471,619...482,296 JBrowse link
G Clic2 chloride intracellular channel 2 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936927:514,989...543,691 JBrowse link
G Cmc4 C-X9-C motif containing 4 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936927:317,417...341,016 JBrowse link
G Dkc1 dyskerin pseudouridine synthase 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936927:134,770...144,057 JBrowse link
G Dnase1l1 deoxyribonuclease 1 like 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:1,151,312...1,159,017 JBrowse link
G Dusp9 dual specificity phosphatase 9 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:535,434...538,219 JBrowse link
G Emd emerin ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:1,127,701...1,130,195 JBrowse link
G F8 coagulation factor VIII ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936927:189,359...301,791 JBrowse link
G F8a1 coagulation factor VIII associated 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936927:234,162...236,881 JBrowse link
G Fam3a FAM3 metabolism regulating signaling molecule A ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:1,248,865...1,258,894 JBrowse link
G Fam50a family with sequence similarity 50 member A ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:1,195,479...1,202,126 JBrowse link
G Flna filamin A ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:1,097,288...1,123,206 JBrowse link
G Fundc2 FUN14 domain containing 2 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936927:304,162...318,271 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:1,269,900...1,285,853 JBrowse link
G Gab3 GRB2 associated binding protein 3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936927:68,506...93,899 JBrowse link
G Gdi1 GDP dissociation inhibitor 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:1,188,793...1,194,816 JBrowse link
G Haus7 HAUS augmin like complex subunit 7 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:321,906...350,105 JBrowse link
G Hcfc1 host cell factor C1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:827,008...853,689 JBrowse link
G Idh3g isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:666,231...675,279 JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO ClinVar Annotator: match by term: Immunodeficiency 33 | ClinVar Annotator: match by term: Immunodeficiency without anhidrotic ectodermal dysplasia OMIM
ClinVar
PMID:11590134 PMID:12459250 PMID:15229184 PMID:15356572 PMID:15577852 More... NCBI chrNW_004936809:1,280,254...1,306,964 JBrowse link
G Il9r interleukin 9 receptor ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936501:829,236...840,130 JBrowse link
G Irak1 interleukin 1 receptor associated kinase 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:891,407...900,311 JBrowse link
G L1cam L1 cell adhesion molecule ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:736,385...768,822 JBrowse link
G Lage3 L antigen family member 3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:1,229,933...1,232,448 JBrowse link
G LOC101967165 histone H2A-Bbd type 2/3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936927:232,353...232,857 JBrowse link
G Mecp2 methyl-CpG binding protein 2 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:902,938...967,771 JBrowse link
G Mpp1 MAGUK p55 scaffold protein 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936927:147,448...170,435 JBrowse link
G Mtcp1 mature T cell proliferation 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936927:334,017...341,016 JBrowse link
G Naa10 N-alpha-acetyltransferase 10, NatA catalytic subunit ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:812,454...817,226 JBrowse link
G Pdzd4 PDZ domain containing 4 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:681,412...707,932 JBrowse link
G Plxna3 plexin A3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:1,209,787...1,226,726 JBrowse link
G Plxnb3 plexin B3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:645,569...659,850 JBrowse link
G Pnck pregnancy up-regulated nonubiquitous CaM kinase ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:553,438...557,385 JBrowse link
G Rab39b RAB39B, member RAS oncogene family ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936927:492,114...498,030 JBrowse link
G Renbp renin binding protein ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:817,392...823,926 JBrowse link
G Rpl10 ribosomal protein L10 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:1,146,994...1,149,573 JBrowse link
G Slc10a3 solute carrier family 10 member 3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:1,241,980...1,245,986 JBrowse link
G Slc6a8 solute carrier family 6 member 8 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:571,234...578,298 JBrowse link
G Smim9 small integral membrane protein 9 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936927:171,867...186,718 JBrowse link
G Spry3 sprouty RTK signaling antagonist 3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936958:225,179...232,843 JBrowse link
G Srpk3 SRSF protein kinase 3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:661,264...666,198 JBrowse link
G Ssr4 signal sequence receptor subunit 4 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:675,178...679,245 JBrowse link
G Tafazzin tafazzin, phospholipid-lysophospholipid transacylase ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:1,160,265...1,168,956 JBrowse link
G Tex28 testis expressed 28 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:1,022,795...1,042,475 JBrowse link
G Tktl1 transketolase like 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:1,048,672...1,084,125 JBrowse link
G Tmlhe trimethyllysine hydroxylase, epsilon ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936958:64,713...113,627 JBrowse link
G Trex2 three prime repair exonuclease 2 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:317,655...319,293 JBrowse link
G Ubl4a ubiquitin like 4A ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936809:1,238,459...1,241,319 JBrowse link
G Vamp7 vesicle associated membrane protein 7 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936958:345,055...393,384 JBrowse link
G Vbp1 VHL binding protein 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chrNW_004936927:433,598...468,191 JBrowse link
Immunodeficiency 67 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irak4 interleukin 1 receptor associated kinase 4 ISO ClinVar Annotator: match by term: Immunodeficiency 67 | ClinVar Annotator: match by term: Invasive pneumococcal disease, recurrent isolated OMIM
ClinVar
PMID:9536098 PMID:9789052 PMID:12637671 PMID:12925671 PMID:15520784 More... NCBI chrNW_004936512:2,248,116...2,272,002 JBrowse link
G Tirap TIR domain containing adaptor protein ISO ClinVar Annotator: match by term: Invasive pneumococcal disease, protection against ClinVar PMID:16991088 PMID:17322885 PMID:18305471 NCBI chrNW_004936572:5,926,193...5,938,621 JBrowse link
Immunodeficiency 68 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myd88 MYD88 innate immune signal transduction adaptor ISO ClinVar Annotator: match by term: PYOGENIC BACTERIAL INFECTIONS, RECURRENT, DUE TO MYD88 DEFICIENCY OMIM
ClinVar
PMID:9536098 PMID:17576681 PMID:18669862 PMID:20538326 PMID:21179087 More... NCBI chrNW_004936473:27,672,237...27,676,339 JBrowse link
Pneumococcal Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il17a interleukin 17A susceptibility ISO associated with Bronchiolitis;DNA:SNP:promoter:rs2275913 (human) RGD PMID:20437253 RGD:4889139 NCBI chrNW_004936476:8,621,860...8,625,008 JBrowse link
G Il27 interleukin 27 ISO associated with influenza A;protein:increased expression:lung (mouse) RGD PMID:24408967 RGD:11556418 NCBI chrNW_004936501:11,972,715...11,978,152 JBrowse link
G Nfkbia NFKB inhibitor alpha susceptibility ISO DNA:SNP: :(rs1050851) (human)
DNA:SNPs:enhancers: (rs3138053, rs2233406) (human)
RGD PMID:17463416 PMID:29407193 RGD:127285388 RGD:127285391 NCBI chrNW_004936494:9,537,793...9,541,187 JBrowse link
G Tirap TIR domain containing adaptor protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:17322885 NCBI chrNW_004936572:5,926,193...5,938,621 JBrowse link
Pneumococcal Meningitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 treatment ISO RGD PMID:24491581 RGD:13703038 NCBI chrNW_004936532:5,864,851...5,904,005 JBrowse link
G Aqp4 aquaporin 4 treatment ISO protein:increased expression:brain: RGD PMID:15695511 RGD:8698660 NCBI chrNW_004936550:5,931,201...5,943,999 JBrowse link
G Atm ATM serine/threonine kinase ameliorates ISO RGD PMID:15529270 RGD:126781748 NCBI chrNW_004936551:359,134...534,672 JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 disease_progression ISO mRNA, protein:increased expression:brain (rat) RGD PMID:31933824 RGD:40903068 NCBI chrNW_004936547:479,261...504,757 JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 ISO mRNA, protein:increased expression:brain (rat) RGD PMID:31933824 RGD:40903068 NCBI chrNW_004936565:1,917,970...1,919,027 JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 treatment ISO RGD PMID:24844751 RGD:39939118 NCBI chrNW_004936843:658,058...672,662 JBrowse link
G Il6 interleukin 6 treatment ISO protein:increased expression:brain RGD PMID:8943431 PMID:11581077 PMID:25443778 RGD:11060264 RGD:11062107 RGD:9831197 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Lgals3 galectin 3 ISO mRNA, protein:increased expression:brain RGD PMID:17706429 RGD:9685206 NCBI chrNW_004936697:20,861...38,568 JBrowse link
G Lgals9 galectin 9 ISO RGD PMID:17706429 RGD:9685206 NCBI chrNW_004936538:4,034,467...4,050,240 JBrowse link
G Marco macrophage receptor with collagenous structure ISO protein:increased expression:meninges, astrocyte RGD PMID:21299846 RGD:41412190 NCBI chrNW_004936469:51,323,746...51,366,551 JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment ISO RGD PMID:24419461 RGD:8657111 NCBI chrNW_004936475:7,801,356...7,825,831 JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO protein:increased expression:cerebrospinal fluid RGD PMID:17371820 PMID:24419461 RGD:1642043 RGD:8657111 NCBI chrNW_004936514:7,038,240...7,045,873 JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 ISO mRNA, protein:increased expression:brain RGD PMID:25443778 RGD:9831197 NCBI chrNW_004936475:3,708,069...3,742,845 JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO mRNA:increased expression:brain RGD PMID:21603940 RGD:5684913 NCBI chrNW_004936680:267,850...621,467 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:brain, nucleus RGD PMID:25443778 RGD:9831197 NCBI chrNW_004936599:3,800,142...3,810,583 JBrowse link
G Serping1 serpin family G member 1 treatment ISO RGD PMID:17538891 RGD:8661645 NCBI chrNW_004936581:4,911,403...4,924,484 JBrowse link
G Tlr2 toll like receptor 2 ISO mRNA:increased expression: : RGD PMID:12781911 RGD:7794740 NCBI chrNW_004936576:522,234...531,660 JBrowse link
G Tlr4 toll like receptor 4 ISO mRNA:increased expression: : RGD PMID:12781911 RGD:7794740 NCBI chrNW_004936487:6,519,140...6,532,018 JBrowse link
G Tnf tumor necrosis factor disease_progression ISO protein:increased expression:brain
mRNA:increased expression:brain (rat)
RGD PMID:25443778 PMID:31933824 RGD:40903068 RGD:9831197 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
Pneumococcal Pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation induced cytidine deaminase ISO RGD PMID:26456931 RGD:11098923 NCBI chrNW_004936870:25,039...34,601 JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO RGD PMID:20231413 RGD:4890435 NCBI chrNW_004936554:7,807,914...7,848,691 JBrowse link
G Btk Bruton tyrosine kinase ameliorates ISO RGD PMID:30646846 RGD:124715470 NCBI chrNW_004936813:429,400...467,481 JBrowse link
G C3 complement C3 disease_progression ISO protein:decreased expression:serum
associated with Liver Cirrhosis, Experimental;protein:decreased expression:respiratory system fluid/secretion
RGD PMID:20405 PMID:15972516 PMID:17956621 RGD:5129509 RGD:5129523 RGD:5130163 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G C5 complement C5 severity ISO RGD PMID:7814608 RGD:5130159 NCBI chrNW_004936487:9,391,774...9,474,168 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 susceptibility ISO RGD PMID:16455992 RGD:4892130 NCBI chrNW_004936490:253,279...259,947 JBrowse link
G Cd14 CD14 molecule ISO RGD PMID:17185649 RGD:4144788 NCBI chrNW_004936531:9,572,392...9,575,771 JBrowse link
G Chi3l1 chitinase 3 like 1 ISO protein:increased secretion:serum (human) RGD PMID:10515841 RGD:4892626 NCBI chrNW_004936567:1,411,080...1,418,332 JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO RGD PMID:21774994 RGD:5147472 NCBI chrNW_004936541:2,288,847...2,333,129 JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 ISO RGD PMID:21774994 RGD:5147472 NCBI chrNW_004936478:6,901,098...6,947,719 JBrowse link
G Crp C-reactive protein disease_progression ISO RGD PMID:21281676 RGD:5131293 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:lung RGD PMID:20381636 RGD:5135285 NCBI chrNW_004936676:33,580...40,323 JBrowse link
G Hmox1 heme oxygenase 1 ISO associated with influenza;protein:increased expression:lung RGD PMID:17348295 RGD:4145366 NCBI chrNW_004936492:5,042,353...5,049,216 JBrowse link
G Il15 interleukin 15 ISO protein:increased expression:alveolar macrophage, bronchial epithelial cell RGD PMID:17611121 RGD:5000755 NCBI chrNW_004936535:6,344,348...6,358,803 JBrowse link
G Il15ra interleukin 15 receptor subunit alpha ISO RGD PMID:17611121 RGD:5000755 NCBI chrNW_004936484:8,590,945...8,623,478 JBrowse link
G Il17a interleukin 17A ISO RGD PMID:19995896 RGD:4888531 NCBI chrNW_004936476:8,621,860...8,625,008 JBrowse link
G Il18 interleukin 18 ISO RGD PMID:15770015 RGD:4889960 NCBI chrNW_004936612:2,306,963...2,325,086 JBrowse link
G Il6 interleukin 6 ISO RGD PMID:20643849 RGD:4143255 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Lep leptin ISO RGD PMID:17822444 RGD:5128869 NCBI chrNW_004936479:15,394,966...15,411,334 JBrowse link
G Lepr leptin receptor ISO RGD PMID:21148797 RGD:5128846 NCBI chrNW_004936591:5,771,371...5,846,177 JBrowse link
G LOC101964975 interleukin-8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chrNW_004936598:1,779,471...1,781,353 JBrowse link
G LOC101976500 haptoglobin ISO RGD PMID:19396720 RGD:5147385 NCBI chrNW_004936475:21,841,054...21,845,821 JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chrNW_004936619:1,889,841...1,932,646 JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chrNW_004936501:12,342,670...12,390,650 JBrowse link
G Masp2 MBL associated serine protease 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12904520 NCBI chrNW_004936474:100,584...113,781 JBrowse link
G Nos2 nitric oxide synthase 2 ISO RGD PMID:17056580 RGD:4891950 NCBI chrNW_004936538:4,052,277...4,097,051 JBrowse link
G Pten phosphatase and tensin homolog ameliorates ISO myeloid knockout RGD PMID:20505137 RGD:127285597 NCBI chrNW_004936735:1,252,414...1,338,318 JBrowse link
G Sftpd surfactant protein D severity ISO RGD PMID:16255775 RGD:4143519 NCBI chrNW_004936716:60,754...73,010 JBrowse link
G Sirt1 sirtuin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chrNW_004936521:10,296,097...10,316,673 JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 ISO RGD PMID:29263110 RGD:39128230 NCBI chrNW_004936531:8,555,966...8,562,829 JBrowse link
G Tlr2 toll like receptor 2 ISO RGD PMID:19956717 RGD:4145321 NCBI chrNW_004936576:522,234...531,660 JBrowse link
G Tnf tumor necrosis factor ISO associated with influenza;protein:increased expression:lung RGD PMID:9032201 PMID:17348295 RGD:4143479 RGD:4145366 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 ameliorates ISO RGD PMID:19596984 PMID:24752755 RGD:126928121 RGD:127229903 NCBI chrNW_004936476:18,577,825...18,583,675 JBrowse link
rheumatic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gc GC vitamin D binding protein ISO RGD PMID:2737695 RGD:5509933 NCBI chrNW_004936598:3,220,029...3,256,091 JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:serum RGD PMID:14567831 RGD:13702910 NCBI chrNW_004936659:616,570...627,172 JBrowse link
rheumatic heart disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd36 CD36 molecule ISO mRNA:decreased expression:blood, mononuclear cell RGD PMID:16741676 RGD:6893529 NCBI chrNW_004936810:791,823...838,303 JBrowse link
G Fcn3 ficolin 3 ISO ClinVar Annotator: match by term: Rheumatic heart disease ClinVar NCBI chrNW_004936474:11,680,166...11,685,214 JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase ISO RGD PMID:26823728 RGD:13792679 NCBI chrNW_004936709:1,243,149...1,247,782 JBrowse link
G Igf1 insulin like growth factor 1 ISO RGD PMID:16406300 RGD:1582623 NCBI chrNW_004936492:11,709,623...11,784,028 JBrowse link
G Il10 interleukin 10 no_association ISO RGD PMID:16043936 RGD:1598626 NCBI chrNW_004936557:5,834,874...5,838,502 JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:16406300 RGD:1582623 NCBI chrNW_004936514:7,038,240...7,045,873 JBrowse link
G Socs1 suppressor of cytokine signaling 1 treatment ISO RGD PMID:31894293 RGD:151347417 NCBI chrNW_004936530:9,312,965...9,315,593 JBrowse link
rheumatic myocarditis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Icam1 intercellular adhesion molecule 1 severity ISO protein:increased expression:serum RGD PMID:22987107 RGD:13702907 NCBI chrNW_004936659:616,570...627,172 JBrowse link
G Sele selectin E severity ISO protein:increased expression:serum RGD PMID:22987107 RGD:13702907 NCBI chrNW_004936481:16,915,203...16,921,840 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 severity ISO protein:increased expression:serum RGD PMID:22987107 RGD:13702907 NCBI chrNW_004936748:785,491...802,791 JBrowse link
Streptococcus pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase exacerbates ISO RGD PMID:27421701 RGD:126779562 NCBI chrNW_004936551:359,134...534,672 JBrowse link
G Btk Bruton tyrosine kinase ISO RGD PMID:30873567 RGD:124715473 NCBI chrNW_004936813:429,400...467,481 JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 ISO mRNA:increased expression:lung (mouse) RGD PMID:20385761 RGD:39938865 NCBI chrNW_004936843:658,058...672,662 JBrowse link
G Ifng interferon gamma ISO protein:increased expression:lung,natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
G Il6 interleukin 6 ISO protein:increased expression:lung,natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Irak3 interleukin 1 receptor associated kinase 3 severity ISO RGD PMID:22492852 RGD:35316076 NCBI chrNW_004936545:4,233,353...4,284,324 JBrowse link
G Itgb2 integrin subunit beta 2 susceptibility ISO RGD PMID:11390487 RGD:127345090 NCBI chrNW_004936778:1,286,475...1,311,184 JBrowse link
G Lamp1 lysosomal associated membrane protein 1 ISO protein:increased expression:lung, natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chrNW_004936472:377,359...389,121 JBrowse link
G Marco macrophage receptor with collagenous structure exacerbates ISO RGD PMID:15263032 RGD:41412189 NCBI chrNW_004936469:51,323,746...51,366,551 JBrowse link
G Pdcd1 programmed cell death 1 treatment ISO RGD PMID:25624454 RGD:40818422 NCBI chrNW_004936745:152,571...163,712 JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta treatment ISO associated with immunodeficiency 14 RGD PMID:30093657 RGD:40890269 NCBI chrNW_004936623:3,672,201...3,696,959 JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma severity ISO RGD PMID:17322108 RGD:38599154 NCBI chrNW_004936479:17,084,006...17,112,264 JBrowse link
G Ripk3 receptor interacting serine/threonine kinase 3 exacerbates ISO RGD PMID:33625952 RGD:127229925 NCBI chrNW_004936722:209,019...212,817 JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:lung,natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link

Term paths to the root
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Term Annotations click to browse term
  disease 13774
    disease by infectious agent 1893
      Bacterial Infections and Mycoses 870
        bacterial infectious disease 683
          Gram-Positive Bacterial Infections 318
            Streptococcal Infections 132
              Immune Suppression 0
              Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections 0
              Pneumococcal Infections + 112
              Streptococcus pneumonia 14
              ecthyma 0
              erysipelas 0
              impetigo + 0
              rheumatic fever + 11
              scarlet fever 0
              subacute bacterial endocarditis 0
paths to the root