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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Streptococcal Infections
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Accession:DOID:9006844 term browser browse the term
Definition:Infections with bacteria of the genus STREPTOCOCCUS.
Synonyms:exact_synonym: Streptococcal Infection
 primary_id: MESH:D013290
For additional species annotation, visit the Alliance of Genome Resources.



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Streptococcal Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 antigen IEP associated with Encephalomyelitis, Experimental Autoimmune; protein:increased expression:spleen, dendritic cell (mouse) RGD PMID:16861672 RGD:4892553 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
JBrowse link
G Il17a interleukin 17A IEP protein:increased expression:serum (mouse) RGD PMID:22384827 RGD:8698662 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720
JBrowse link
G Lcn2 lipocalin 2 IEP mRNA,protein:increased expression:respiratory epithelium, olfactory mucosa epithelium RGD PMID:16153241 RGD:126781709 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264
JBrowse link
G Mx1 MX dynamin-like GTPase 1 ISO associated with pharyngitis;protein:increased expression:blood (human) RGD PMID:28077283 RGD:126777682 NCBI chr16:97,248,235...97,264,106
Ensembl chr16:97,248,235...97,264,107
JBrowse link
G Tlr2 toll-like receptor 2 severity IMP RGD PMID:19179417 RGD:7240559 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074
JBrowse link
G Tnf tumor necrosis factor ISO associated with Otitis Media RGD PMID:8302123 RGD:11554174 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
immunodeficiency 33 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd1 ATP-binding cassette, sub-family D (ALD), member 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,760,203...72,782,140
Ensembl chr  X:72,760,203...72,782,140
JBrowse link
G Arhgap4 Rho GTPase activating protein 4 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,937,958...72,954,945
Ensembl chr  X:72,935,048...72,965,476
JBrowse link
G Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,546,356...72,632,267
Ensembl chr  X:72,546,692...72,614,611
JBrowse link
G Atp6ap1 ATPase, H+ transporting, lysosomal accessory protein 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,340,703...73,348,327
Ensembl chr  X:73,340,703...73,348,327
JBrowse link
G Avpr2 arginine vasopressin receptor 2 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,935,371...72,938,034
Ensembl chr  X:72,935,708...72,939,108
JBrowse link
G Bcap31 B cell receptor associated protein 31 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,729,784...72,761,421
Ensembl chr  X:72,729,784...72,759,781
JBrowse link
G Bgn biglycan ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,527,207...72,539,542
Ensembl chr  X:72,527,208...72,539,539
JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:74,460,234...74,499,307
Ensembl chr  X:74,460,234...74,497,607
JBrowse link
G Ccnq cyclin Q ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr11:78,641,332...78,642,555
Ensembl chr11:78,641,332...78,642,555
JBrowse link
G Cmc4 C-x(9)-C motif containing 4 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:74,448,452...74,460,190
Ensembl chr  X:74,448,452...74,460,190
JBrowse link
G Ctag2l2 CTAG2 like 2 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,784,533...73,785,794
Ensembl chr  X:73,784,533...73,785,794
JBrowse link
G Dkc1 dyskeratosis congenita 1, dyskerin ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:74,139,460...74,153,382
Ensembl chr  X:74,139,460...74,153,383
JBrowse link
G Dnase1l1 deoxyribonuclease 1-like 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,316,823...73,325,939
Ensembl chr  X:73,316,823...73,325,943
JBrowse link
G Dusp9 dual specificity phosphatase 9 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,682,995...72,687,120
Ensembl chr  X:72,683,025...72,687,120
JBrowse link
G Emd emerin ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,298,272...73,305,169
Ensembl chr  X:73,298,293...73,305,154
JBrowse link
G F8 coagulation factor VIII ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:74,213,950...74,426,342
Ensembl chr  X:74,216,321...74,426,221
JBrowse link
G F8a factor 8-associated gene A ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,271,912...72,274,401
Ensembl chr  X:72,271,897...72,274,401
JBrowse link
G Fam3a FAM3 metabolism regulating signaling molecule A ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,427,816...73,436,880
Ensembl chr  X:73,428,325...73,436,878
JBrowse link
G Fam50a family with sequence similarity 50, member A ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,356,589...73,363,761
Ensembl chr  X:73,356,639...73,363,755
JBrowse link
G Flna filamin, alpha ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,267,067...73,293,787
Ensembl chr  X:73,267,067...73,293,426
JBrowse link
G Fundc2 FUN14 domain containing 2 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:74,426,005...74,440,764
Ensembl chr  X:74,426,005...74,440,065
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800
JBrowse link
G Gab3 growth factor receptor bound protein 2-associated protein 3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:74,032,151...74,128,511
Ensembl chr  X:74,010,449...74,129,064
JBrowse link
G Gdi1 guanosine diphosphate (GDP) dissociation inhibitor 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,348,618...73,355,473
Ensembl chr  X:73,348,604...73,355,468
JBrowse link
G H2ab2 H2A.B variant histone 2 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:115,590,875...115,591,222
Ensembl chr  X:115,590,875...115,591,222
JBrowse link
G H2ab3 H2A.B variant histone 3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:119,222,279...119,222,923
Ensembl chr  X:119,222,445...119,222,792
JBrowse link
G Haus7 HAUS augmin-like complex, subunit 7 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,480,921...72,502,635
Ensembl chr  X:72,480,921...72,502,650
JBrowse link
G Hcfc1 host cell factor C1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,986,398...73,011,430
Ensembl chr  X:72,986,398...73,009,963
JBrowse link
G Idh3g isocitrate dehydrogenase 3 (NAD+), gamma ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,822,569...72,830,503
Ensembl chr  X:72,822,569...72,830,503
JBrowse link
G Ikbkg inhibitor of kappaB kinase gamma ISO ClinVar Annotator: match by term: Immunodeficiency 33 | ClinVar Annotator: match by term: Immunodeficiency without anhidrotic ectodermal dysplasia OMIM
ClinVar
PMID:11590134 PMID:12459250 PMID:15229184 PMID:15356572 PMID:15577852 More... NCBI chr  X:73,436,883...73,498,013
Ensembl chr  X:73,436,896...73,497,460
JBrowse link
G Il9r interleukin 9 receptor ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr11:32,137,544...32,155,283
Ensembl chr11:32,137,541...32,150,279
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,057,520...73,067,527
Ensembl chr  X:73,057,520...73,067,524
JBrowse link
G L1cam L1 cell adhesion molecule ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,897,384...72,924,843
Ensembl chr  X:72,897,384...72,939,711
JBrowse link
G Lage3 L antigen family, member 3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,395,768...73,397,224
Ensembl chr  X:73,394,882...73,397,224
JBrowse link
G LOC107963956 green (M) opsin gene upstream regulatory region ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,166,107...73,171,117 JBrowse link
G Mecp2 methyl CpG binding protein 2 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,070,198...73,129,296
Ensembl chr  X:73,070,198...73,178,969
JBrowse link
G Mir664 microRNA 664 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr 1:184,975,172...184,975,240
Ensembl chr 1:184,975,172...184,975,240
JBrowse link
G Mir718 microRNA 718 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,067,455...73,067,542
Ensembl chr  X:73,067,455...73,067,542
JBrowse link
G Mpp1 membrane protein, palmitoylated ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:74,153,339...74,174,622
Ensembl chr  X:74,153,339...74,174,622
JBrowse link
G Mtcp1 mature T cell proliferation 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:74,454,048...74,460,190
Ensembl chr  X:74,454,050...74,460,194
JBrowse link
G Naa10 N(alpha)-acetyltransferase 10, NatA catalytic subunit ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,960,476...72,965,550
Ensembl chr  X:72,960,479...72,965,550
JBrowse link
G Opn1mw opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan) ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,171,072...73,194,362
Ensembl chr  X:73,171,070...73,194,366
JBrowse link
G Pdzd4 PDZ domain containing 4 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,836,963...72,868,649
Ensembl chr  X:72,836,965...72,868,575
JBrowse link
G Plxna3 plexin A3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,372,644...73,388,295
Ensembl chr  X:73,372,672...73,388,295
JBrowse link
G Plxnb3 plexin B3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,800,564...72,816,116
Ensembl chr  X:72,800,696...72,816,120
JBrowse link
G Pnck pregnancy upregulated non-ubiquitously expressed CaM kinase ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,699,598...72,703,723
Ensembl chr  X:72,699,600...72,703,723
JBrowse link
G Rab39b RAB39B, member RAS oncogene family ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:74,615,651...74,621,837
Ensembl chr  X:74,615,652...74,621,837
JBrowse link
G Renbp renin binding protein ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,965,727...72,974,465
Ensembl chr  X:72,965,727...72,974,456
JBrowse link
G Rpl10 ribosomal protein L10 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,314,422...73,316,741
Ensembl chr  X:73,314,418...73,316,741
JBrowse link
G Slc10a3 solute carrier family 10 (sodium/bile acid cotransporter family), member 3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,412,823...73,416,955
Ensembl chr  X:73,412,823...73,416,955
JBrowse link
G Slc6a8 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,716,739...72,726,108
Ensembl chr  X:72,716,756...72,726,108
JBrowse link
G Smim9 small integral membrane protein 9 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:74,189,663...74,207,362
Ensembl chr  X:74,189,662...74,207,376
JBrowse link
G Snora70 small nucleolar RNA, H/ACA box 70 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,316,098...73,316,226
Ensembl chr  X:73,316,090...73,316,226
JBrowse link
G Spry3 sprouty RTK signaling antagonist 3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868
G Srpk3 serine/arginine-rich protein specific kinase 3 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,817,966...72,822,531
Ensembl chr  X:72,818,011...72,822,531
JBrowse link
G Ssr4 signal sequence receptor, delta ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,830,629...72,834,434
Ensembl chr  X:72,830,634...72,834,436
JBrowse link
G Tafazzin tafazzin, phospholipid-lysophospholipid transacylase ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,325,498...73,340,182
Ensembl chr  X:73,325,518...73,333,757
JBrowse link
G Tex28 testis expressed 28 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,194,515...73,211,444
Ensembl chr  X:73,194,550...73,211,444
JBrowse link
G Tktl1 transketolase-like 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,220,865...73,252,104
Ensembl chr  X:73,220,865...73,252,106
JBrowse link
G Tmlhe trimethyllysine hydroxylase, epsilon ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868
G Trex2 three prime repair exonuclease 2 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:72,477,311...72,478,949
Ensembl chr  X:72,477,311...72,478,950
JBrowse link
G Ubl4a ubiquitin-like 4A ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:73,409,324...73,412,154
Ensembl chr  X:73,409,324...73,416,824
JBrowse link
G Vamp7 vesicle-associated membrane protein 7 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868
G Vbp1 von Hippel-Lindau binding protein 1 ISO ClinVar Annotator: match by term: Immunodeficiency 33 ClinVar PMID:25741868 NCBI chr  X:74,557,903...74,578,552
Ensembl chr  X:74,557,905...74,578,548
JBrowse link
Immunodeficiency 67 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irak4 interleukin-1 receptor-associated kinase 4 ISO ClinVar Annotator: match by term: Immunodeficiency 67 | ClinVar Annotator: match by term: Invasive pneumococcal disease, recurrent isolated OMIM
ClinVar
PMID:9536098 PMID:9789052 PMID:12637671 PMID:12925671 PMID:15520784 More... NCBI chr15:94,441,495...94,466,198
Ensembl chr15:94,441,524...94,479,696
JBrowse link
G Tirap toll-interleukin 1 receptor (TIR) domain-containing adaptor protein ISO ClinVar Annotator: match by term: Invasive pneumococcal disease, protection against ClinVar PMID:16991088 PMID:17322885 PMID:18305471 NCBI chr 9:35,095,687...35,111,587
Ensembl chr 9:35,095,847...35,111,587
JBrowse link
Immunodeficiency 68 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myd88 myeloid differentiation primary response gene 88 ISO ClinVar Annotator: match by term: PYOGENIC BACTERIAL INFECTIONS, RECURRENT, DUE TO MYD88 DEFICIENCY OMIM
ClinVar
PMID:9536098 PMID:17576681 PMID:18669862 PMID:20538326 PMID:21179087 More... NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477
JBrowse link
Pneumococcal Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement component factor h exacerbates IMP
ISO
RGD PMID:26802141 PMID:26802141 RGD:108019050, RGD:108019050 NCBI chr 1:140,013,593...140,111,149
Ensembl chr 1:140,012,446...140,111,502
JBrowse link
G Il17a interleukin 17A susceptibility ISO associated with Bronchiolitis;DNA:SNP:promoter:rs2275913 (human) RGD PMID:20437253 RGD:4889139 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720
JBrowse link
G Il27 interleukin 27 IEP associated with influenza A;protein:increased expression:lung (mouse) RGD PMID:24408967 RGD:11556418 NCBI chr 7:126,188,181...126,194,197
Ensembl chr 7:126,188,182...126,194,113
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha susceptibility ISO DNA:SNPs:enhancers: (rs3138053, rs2233406) (human)
DNA:SNP: :(rs1050851) (human)
RGD PMID:17463416 PMID:29407193 RGD:127285388, RGD:127285391 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Tirap toll-interleukin 1 receptor (TIR) domain-containing adaptor protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:17322885 NCBI chr 9:35,095,687...35,111,587
Ensembl chr 9:35,095,847...35,111,587
JBrowse link
G Tlr9 toll-like receptor 9 IMP RGD PMID:17004992 RGD:5130710 NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082
JBrowse link
Pneumococcal Meningitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 a disintegrin and metallopeptidase domain 17 treatment ISO RGD PMID:24491581 RGD:13703038 NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633
JBrowse link
G Aqp4 aquaporin 4 treatment IEP
IMP
protein:increased expression:brain: RGD PMID:15695511 PMID:15695511 RGD:8698660, RGD:8698660 NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039
JBrowse link
G Atm ataxia telangiectasia mutated ameliorates IMP RGD PMID:15529270 RGD:126781748 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
JBrowse link
G Camp cathelicidin antimicrobial peptide ISO protein:increased expression:brain, coronal section (rat) RGD PMID:19879657 RGD:2316237 NCBI chr 9:109,676,445...109,678,524
Ensembl chr 9:109,676,447...109,678,685
JBrowse link
G Cxcl1 chemokine (C-X-C motif) ligand 1 ISO RGD PMID:21109308 RGD:5134982 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974
JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 disease_progression ISO mRNA, protein:increased expression:brain (rat) RGD PMID:31933824 RGD:40903068 NCBI chr  X:105,617,952...105,647,329
Ensembl chr  X:105,617,952...105,647,285
JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 ISO mRNA, protein:increased expression:brain (rat) RGD PMID:31933824 RGD:40903068 NCBI chr14:73,263,515...73,286,554
Ensembl chr14:73,263,043...73,286,554
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 treatment IMP RGD PMID:24844751 RGD:39939118 NCBI chr 8:25,074,149...25,086,968
Ensembl chr 8:25,074,152...25,087,025
JBrowse link
G Il6 interleukin 6 treatment ISO protein:increased expression:brain RGD PMID:25443778 PMID:8943431 PMID:11581077 RGD:9831197, RGD:11062107, RGD:11060264 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Lgals3 lectin, galactose binding, soluble 3 ISO mRNA, protein:increased expression:brain RGD PMID:17706429 RGD:9685206 NCBI chr14:47,611,317...47,623,624
Ensembl chr14:47,605,208...47,623,617
JBrowse link
G Lgals9 lectin, galactose binding, soluble 9 ISO RGD PMID:17706429 RGD:9685206 NCBI chr11:78,853,805...78,875,750
Ensembl chr11:78,853,800...78,875,772
JBrowse link
G Marco macrophage receptor with collagenous structure ISO protein:increased expression:meninges, astrocyte RGD PMID:21299846 RGD:41412190 NCBI chr 1:120,402,267...120,432,753
Ensembl chr 1:120,402,267...120,432,753
JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment ISO RGD PMID:24419461 RGD:8657111 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO protein:increased expression:cerebrospinal fluid RGD PMID:17371820 PMID:24419461 RGD:1642043, RGD:8657111 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 IEP mRNA, protein:increased expression:brain RGD PMID:25443778 RGD:9831197 NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102
JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 ISO mRNA:increased expression:brain RGD PMID:21603940 RGD:5684913 NCBI chr13:58,954,286...59,281,784
Ensembl chr13:58,954,383...59,281,784
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) ISO protein:increased expression:brain, nucleus RGD PMID:25443778 RGD:9831197 NCBI chr19:5,687,569...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 treatment ISO RGD PMID:17538891 RGD:8661645 NCBI chr 2:84,595,704...84,605,778
Ensembl chr 2:84,595,731...84,605,788
JBrowse link
G Tlr2 toll-like receptor 2 IEP mRNA:increased expression: : RGD PMID:12781911 RGD:7794740 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074
JBrowse link
G Tlr4 toll-like receptor 4 IEP mRNA:increased expression: : RGD PMID:12781911 RGD:7794740 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tlr9 toll-like receptor 9 IEP mRNA:increased expression: : RGD PMID:12781911 RGD:7794740 NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082
JBrowse link
G Tnf tumor necrosis factor disease_progression ISO protein:increased expression:brain
mRNA:increased expression:brain (rat)
RGD PMID:25443778 PMID:31933824 RGD:9831197, RGD:40903068 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
Pneumococcal Pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase IMP RGD PMID:26456931 RGD:11098923 NCBI chr 6:122,530,768...122,541,139
Ensembl chr 6:122,530,760...122,541,139
JBrowse link
G Alox5 arachidonate 5-lipoxygenase IMP RGD PMID:20231413 RGD:4890435 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139
JBrowse link
G Btk Bruton agammaglobulinemia tyrosine kinase ameliorates IMP RGD PMID:30646846 RGD:124715470 NCBI chr  X:133,443,083...133,484,366
Ensembl chr  X:133,443,085...133,484,319
JBrowse link
G C3 complement component 3 disease_progression IMP
ISO
protein:decreased expression:serum
associated with Liver Cirrhosis, Experimental;protein:decreased expression:respiratory system fluid/secretion
RGD PMID:15972516 PMID:20405 PMID:17956621 RGD:5129509, RGD:5130163, RGD:5129523 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 susceptibility IMP RGD PMID:16455992 RGD:4892130 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
JBrowse link
G Cd14 CD14 antigen IMP RGD PMID:17185649 RGD:4144788 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851
JBrowse link
G Chil1 chitinase-like 1 ISO protein:increased secretion:serum (human) RGD PMID:10515841 RGD:4892626 NCBI chr 1:134,109,894...134,117,769
Ensembl chr 1:134,109,914...134,117,919
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IMP RGD PMID:21774994 RGD:5147472 NCBI chr11:104,021,289...104,066,349
Ensembl chr11:104,023,681...104,066,349
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IMP RGD PMID:21774994 RGD:5147472 NCBI chr 6:55,067,033...55,110,001
Ensembl chr 6:55,067,034...55,110,001
JBrowse link
G Crp C-reactive protein, pentraxin-related disease_progression ISO RGD PMID:21281676 RGD:5131293 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
JBrowse link
G Cxcl1 chemokine (C-X-C motif) ligand 1 IEP protein:increased expression:respiratory system fluid/secretion RGD PMID:20958976 RGD:5134957 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cxcl9 chemokine (C-X-C motif) ligand 9 IEP protein:increased expression:lung RGD PMID:20381636 RGD:5135285 NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938
JBrowse link
G Defb4 defensin beta 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chr 8:19,248,720...19,251,563
Ensembl chr 8:19,248,722...19,251,561
JBrowse link
G Hc hemolytic complement severity IAGP RGD PMID:7814608 RGD:5130159 NCBI chr 2:34,873,341...34,958,518
Ensembl chr 2:34,873,343...34,951,450
JBrowse link
G Hmox1 heme oxygenase 1 IEP associated with influenza;protein:increased expression:lung RGD PMID:17348295 RGD:4145366 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hp haptoglobin ISO RGD PMID:19396720 RGD:5147385 NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804
JBrowse link
G Il15 interleukin 15 IEP protein:increased expression:alveolar macrophage, bronchial epithelial cell RGD PMID:17611121 RGD:5000755 NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851
JBrowse link
G Il15ra interleukin 15 receptor, alpha chain IEP RGD PMID:17611121 RGD:5000755 NCBI chr 2:11,709,992...11,738,796
Ensembl chr 2:11,710,101...11,739,128
JBrowse link
G Il17a interleukin 17A IDA RGD PMID:19995896 RGD:4888531 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720
JBrowse link
G Il18 interleukin 18 IMP RGD PMID:15770015 RGD:4889960 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il6 interleukin 6 IDA RGD PMID:20643849 RGD:4143255 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Lep leptin IMP RGD PMID:17822444 RGD:5128869 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
JBrowse link
G Lepr leptin receptor IMP RGD PMID:21148797 RGD:5128846 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Masp2 mannan-binding lectin serine peptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12904520 NCBI chr 4:148,679,079...148,699,939
Ensembl chr 4:148,687,011...148,699,956
JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 no_association ISO DNA:polymorphisms:5' utr, exon:multiple (human)
DNA:mutations:5' utr, exon:multiple (human)
RGD PMID:12047967 PMID:18641104 RGD:4889478, RGD:4889477 NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087
JBrowse link
G Nos2 nitric oxide synthase 2, inducible IMP RGD PMID:17056580 RGD:4891950 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Pten phosphatase and tensin homolog ameliorates IMP myeloid knockout RGD PMID:20505137 RGD:127285597 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560
JBrowse link
G Sftpd surfactant associated protein D severity IMP RGD PMID:16255775 RGD:4143519 NCBI chr14:40,894,169...40,907,155
Ensembl chr14:40,894,171...40,907,106
JBrowse link
G Sirt1 sirtuin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 IMP RGD PMID:29263110 RGD:39128230 NCBI chr18:35,866,731...35,873,607
Ensembl chr18:35,866,732...35,873,607
JBrowse link
G Tlr2 toll-like receptor 2 IMP RGD PMID:19956717 RGD:4145321 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074
JBrowse link
G Tnf tumor necrosis factor IMP
IEP
associated with influenza;protein:increased expression:lung RGD PMID:9032201 PMID:17348295 RGD:4143479, RGD:4145366 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 ameliorates IEP
IDA
RGD PMID:24752755 PMID:19596984 RGD:126928121, RGD:127229903 NCBI chr17:48,539,763...48,553,955
Ensembl chr17:48,539,796...48,553,952
JBrowse link
rheumatic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gc vitamin D binding protein ISO RGD PMID:2737695 RGD:5509933 NCBI chr 5:89,565,370...89,605,757
Ensembl chr 5:89,565,381...89,605,757
JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha susceptibility ISO DNA:polymorphisms, haplotypes:multiple
DNA:polymorphism: :HLA-DQA1*03 (human)
RGD PMID:17559688 PMID:15789899 RGD:5147792, RGD:127285392 NCBI chr17:34,501,718...34,506,797
Ensembl chr17:34,501,718...34,506,797
JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 ISO DNA:polymorphisms, haplotypes:multiple RGD PMID:17559688 RGD:5147792 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393
JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta ISO DNA:polymorphisms, haplotypes:multiple RGD PMID:17559688 RGD:5147792 NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:serum RGD PMID:14567831 RGD:13702910 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
rheumatic heart disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd36 CD36 molecule ISO mRNA:decreased expression:blood, mononuclear cell RGD PMID:16741676 RGD:6893529 NCBI chr 5:17,986,688...18,093,957
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Fcna ficolin A ISO ClinVar Annotator: match by term: Rheumatic heart disease ClinVar NCBI chr 2:25,514,677...25,525,448
Ensembl chr 2:25,514,678...25,518,042
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase ISO RGD PMID:26823728 RGD:13792679 NCBI chr 6:125,138,815...125,143,430
Ensembl chr 6:125,138,678...125,143,430
JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha susceptibility ISO DNA:polymorphisms, haplotypes:multiple
DNA:polymorphism, haplotype: :HLA-DQA1*0101, HLA-DQA1*0103, HLA-DQA1*0301 (human)
RGD PMID:17559688 PMID:29029143 RGD:5147792, RGD:126925989 NCBI chr17:34,501,718...34,506,797
Ensembl chr17:34,501,718...34,506,797
JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 ISO DNA:polymorphisms:cds:HLA-DQB1*08 (human) RGD PMID:17578051 RGD:5147630 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393
JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta susceptibility ISO DNA:polymorphism (human)
DNA:polymorphism:cds:HLA-DRB1*13 (human)
RGD PMID:17578051 PMID:16426242 RGD:5147630, RGD:5147643 NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648
JBrowse link
G Igf1 insulin-like growth factor 1 ISO RGD PMID:16406300 RGD:1582623 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Il10 interleukin 10 no_association ISO RGD PMID:16043936 RGD:1598626 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Mir155 microRNA 155 ISO RGD PMID:31894293 RGD:151347417 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:16406300 RGD:1582623 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Socs1 suppressor of cytokine signaling 1 treatment ISO RGD PMID:31894293 RGD:151347417 NCBI chr16:10,601,672...10,603,400
Ensembl chr16:10,600,104...10,603,400
JBrowse link
rheumatic myocarditis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Icam1 intercellular adhesion molecule 1 severity ISO protein:increased expression:serum RGD PMID:22987107 RGD:13702907 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Sele selectin, endothelial cell severity ISO protein:increased expression:serum RGD PMID:22987107 RGD:13702907 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,803...163,885,246
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 severity ISO protein:increased expression:serum RGD PMID:22987107 RGD:13702907 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link
Streptococcus pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ataxia telangiectasia mutated exacerbates IMP RGD PMID:27421701 RGD:126779562 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
JBrowse link
G Btk Bruton agammaglobulinemia tyrosine kinase IMP RGD PMID:30873567 RGD:124715473 NCBI chr  X:133,443,083...133,484,366
Ensembl chr  X:133,443,085...133,484,319
JBrowse link
G Cd209b CD209b antigen severity IMP RGD PMID:16134084 RGD:39938986 NCBI chr 8:3,967,655...3,976,841
Ensembl chr 8:3,967,655...3,976,844
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 IEP mRNA:increased expression:lung (mouse) RGD PMID:20385761 RGD:39938865 NCBI chr 8:25,074,149...25,086,968
Ensembl chr 8:25,074,152...25,087,025
JBrowse link
G Ifng interferon gamma IEP protein:increased expression:lung,natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Il6 interleukin 6 IEP protein:increased expression:lung,natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 severity IMP RGD PMID:22492852 RGD:35316076 NCBI chr10:119,977,553...120,038,035
Ensembl chr10:119,977,553...120,038,035
JBrowse link
G Itgb2 integrin beta 2 susceptibility IMP RGD PMID:11390487 RGD:127345090 NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 IEP protein:increased expression:lung, natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chr 8:13,209,161...13,225,338
Ensembl chr 8:13,209,161...13,225,338
JBrowse link
G Marco macrophage receptor with collagenous structure exacerbates IMP RGD PMID:15263032 RGD:41412189 NCBI chr 1:120,402,267...120,432,753
Ensembl chr 1:120,402,267...120,432,753
JBrowse link
G Ncr1 natural cytotoxicity triggering receptor 1 severity IMP RGD PMID:21887255 RGD:40818252 NCBI chr 7:4,340,714...4,348,183
Ensembl chr 7:4,340,723...4,348,163
JBrowse link
G Pdcd1 programmed cell death 1 treatment IMP RGD PMID:25624454 RGD:40818422 NCBI chr 1:93,966,027...93,980,278
Ensembl chr 1:93,966,027...93,980,278
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta treatment IMP associated with immunodeficiency 14 RGD PMID:30093657 RGD:40890269 NCBI chr 4:149,733,625...149,787,023
Ensembl chr 4:149,733,625...149,787,028
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma severity IMP RGD PMID:17322108 RGD:38599154 NCBI chr12:32,223,128...32,258,675
Ensembl chr12:32,223,472...32,258,658
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 exacerbates IMP RGD PMID:33625952 RGD:127229925 NCBI chr14:56,022,452...56,026,314
Ensembl chr14:56,022,452...56,026,322
JBrowse link
G Tnf tumor necrosis factor IEP protein:increased expression:lung,natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  disease 15290
    disease by infectious agent 2122
      Bacterial Infections and Mycoses 965
        bacterial infectious disease 769
          Gram-Positive Bacterial Infections 370
            Streptococcal Infections 151
              Immune Suppression 0
              Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections 0
              Pneumococcal Infections + 124
              Streptococcus pneumonia 16
              ecthyma 0
              erysipelas 0
              impetigo + 0
              rheumatic fever + 15
              scarlet fever 0
              subacute bacterial endocarditis 0
paths to the root