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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Triple Negative Breast Neoplasms
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Accession:DOID:9006728 term browser browse the term
Definition:Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.
Synonyms:exact_synonym: ER Negative PR Negative HER2 Negative Breast Cancer;   ER negative PR negative HER2 negative breast neoplasms;   Triple Negative Breast Cancer;   Triple-Negative Breast Cancers;   triple negative breast neoplasm
 primary_id: MESH:D064726


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Triple Negative Breast Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32512068 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cdk2 cyclin dependent kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33727089 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33727089 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33727089 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35048507 NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 exacerbates ISO protein:increased expression:breast (human) RGD PMID:29305962 RGD:153323306 NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541 		JBrowse link
G Chek2 checkpoint kinase 2 ISO ClinVar Annotator: match by term: Triple-negative breast cancer ClinVar PMID:26328243 PMID:28492532 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G E2f6 E2F transcription factor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35225430 NCBI chr 6:39,592,224...39,608,685
Ensembl chr 6:39,592,228...39,608,683 		JBrowse link
G Kifc1 kinesin family member C1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26177331 NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:30654191 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lrp6 LDL receptor related protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24552774 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
G Mir873 microRNA 873 ISO CTD Direct Evidence: therapeutic CTD PMID:30654191 NCBI chr 5:51,356,919...51,356,995
Ensembl chr 5:51,356,919...51,356,995 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease ISO ClinVar Annotator: match by term: Triple-negative breast cancer ClinVar PMID:26328243 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Palb2 partner and localizer of BRCA2 ISO ClinVar Annotator: match by term: Triple-negative breast cancer ClinVar PMID:25575445 PMID:25741868 PMID:26328243 PMID:26467025 PMID:28492532 More... NCBI chr 1:176,665,076...176,689,053
Ensembl chr 1:176,665,076...176,688,990 		JBrowse link
G Prmt5 protein arginine methyltransferase 5 ISO CTD Direct Evidence: therapeutic CTD PMID:30957988 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296 		JBrowse link
G Rad51 RAD51 recombinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:34998818 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rnf180 ring finger protein 180 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34998818 NCBI chr 2:36,330,285...36,511,168
Ensembl chr 2:36,330,292...36,512,614 		JBrowse link
G Tlr9 toll-like receptor 9 ISO CTD Direct Evidence: therapeutic CTD PMID:24273604 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:30703373 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21086
    disease of cellular proliferation 7656
      Neoplasms by Site 7120
        Breast Neoplasms 1379
          Triple Negative Breast Neoplasms 19
Path 2
Term Annotations click to browse term
  disease 21086
    disease of anatomical entity 18146
      nervous system disease 13993
        Neurologic Manifestations 9942
          sensory system disease 6847
            skin disease 3903
              breast disease 1390
                Breast Neoplasms 1379
                  Triple Negative Breast Neoplasms 19
paths to the root