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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Metabolic Syndrome
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Accession:DOID:9006646 term browser browse the term
Definition:A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
Synonyms:exact_synonym: Cardiovascular Syndromes, Metabolic;   Insulin Resistance Syndrome X;   Metabolic Cardiovascular Syndrome;   Metabolic Syndrome X;   Reaven syndrome X;   dysmetabolic syndrome X
 narrow_synonym: SIM1-ASSOCIATED METABOLIC SYNDROME
 related_synonym: METABOLIC SYNDROME, SUSCEPTIBILITY TO
 primary_id: MESH:D024821
 xref: EFO:0000195


show annotations for term's descendants           Sort by:
Metabolic Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 susceptibility ISO DNA:SNP:exon:p.R230C (rs9282541) (human) RGD PMID:17287470 RGD:1601092 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895 		JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha ameliorates IEP
ISO		 mRNA:increased expression:liver (mouse) RGD PMID:29684438 PMID:27821167 RGD:329333017, RGD:401799622 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477 		JBrowse link
G Acacb acetyl-Coenzyme A carboxylase beta IEP mRNA:increased expression:liver (mouse) RGD PMID:29684438 RGD:329333017 NCBI chr 5:114,284,748...114,388,822
Ensembl chr 5:114,284,596...114,388,822 		JBrowse link
G Acadvl acyl-Coenzyme A dehydrogenase, very long chain treatment ISO RGD PMID:25191539 RGD:10047118 NCBI chr11:69,901,009...69,906,254
Ensembl chr11:69,901,009...69,906,237 		JBrowse link
G Acat2 acetyl-Coenzyme A acetyltransferase 2 susceptibility ISO DNA:polymorphism RGD PMID:14557872 RGD:1581921 NCBI chr17:13,161,929...13,179,612
Ensembl chr17:13,161,777...13,179,634 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO
IMP		 associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNP: :276G>T (human)
protein:decreased expression:serum
associated with vascular diseases; protein:decreased expression:plasma
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16793964 PMID:17618945 PMID:18162013 PMID:20833989 PMID:19690575 More... RGD:2313234, RGD:5686407, RGD:5686428, RGD:5686800 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Adrb2 adrenergic receptor, beta 2 susceptibility ISO DNA:polymorphisms: :p.R16G, p.Q27E RGD
GAD		 PMID:14557466 PMID:15118671 RGD:1601127, RGD:1331525 NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030 		JBrowse link
G Agt angiotensinogen ISO mRNA, protein:increased expression:adipose tissue RGD PMID:17260464 RGD:1601134 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a susceptibility ISO DNA:snp:3' utr:c.5186A>C RGD PMID:17211857 RGD:1601146 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Akp3 alkaline phosphatase 3, intestine, not Mn requiring IMP RGD PMID:23569246 RGD:14349049 NCBI chr 1:87,052,676...87,056,450
Ensembl chr 1:87,052,695...87,055,634 		JBrowse link
G Aldoa aldolase A, fructose-bisphosphate ISO mRNA:increased expression:aorta RGD PMID:21890532 RGD:13673877 NCBI chr 7:126,394,406...126,399,537
Ensembl chr 7:126,394,406...126,399,923 		JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney susceptibility ISO protein:increased expression:serum RGD PMID:16249437 RGD:1601174 NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695 		JBrowse link
G Apoa1 apolipoprotein A-I ISO protein:decreased expression:serum (human)
DNA: polymorphism: :G2, G3 and G5		 RGD PMID:17217166 PMID:21410987 RGD:1601183, RGD:5508220 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Apoa2 apolipoprotein A-II ISO protein:decreased expression:serum RGD PMID:19817643 RGD:2313955 NCBI chr 1:171,049,133...171,053,948
Ensembl chr 1:171,052,623...171,053,948 		JBrowse link
G Apoa5 apolipoprotein A-V susceptibility ISO DNA:polymorphism: :p.S19W (human) RGD PMID:18789138 RGD:2313315 NCBI chr 9:46,179,906...46,183,219
Ensembl chr 9:46,179,931...46,183,217 		JBrowse link
G Apob apolipoprotein B ISO protein:increased expression:plasma RGD PMID:16828905 RGD:1601198 NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835 		JBrowse link
G Apoc3 apolipoprotein C-III susceptibility ISO protein:increased expression:serum (human)
DNA:polymorphism:promoter:-482C>T, -455T>C		 RGD PMID:16298371 PMID:17416293 RGD:2306766, RGD:1601223 NCBI chr 9:46,144,348...46,146,934
Ensembl chr 9:46,144,231...46,146,934 		JBrowse link
G Apom apolipoprotein M ISO protein:decreased expression:plasma RGD PMID:19539616 RGD:2314236 NCBI chr17:35,347,973...35,350,777
Ensembl chr17:35,347,973...35,351,026 		JBrowse link
G Atm ataxia telangiectasia mutated IDA RGD PMID:17084711 RGD:1601248 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040 		JBrowse link
G Atp12a ATPase, H+/K+ transporting, nongastric, alpha polypeptide ISO RGD PMID:23320804 RGD:13838660 NCBI chr14:56,602,525...56,626,008
Ensembl chr14:56,602,525...56,626,007 		JBrowse link
G Bche butyrylcholinesterase ISO protein:increased expression:serum RGD PMID:15907830 RGD:1601317 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748 		JBrowse link
G Bdnf brain derived neurotrophic factor ISO RGD PMID:11935372 RGD:1580935 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Bglap bone gamma carboxyglutamate protein ISO protein:decreased expression:serum RGD PMID:21760737 RGD:6483594 NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771 		JBrowse link
G C3 complement component 3 ISO RGD PMID:16488421 RGD:2314030 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G Capn10 calpain 10 ISO DNA:polymorphism RGD PMID:16546286 RGD:1625050 NCBI chr 1:92,862,130...92,875,670
Ensembl chr 1:92,862,098...92,875,663 		JBrowse link
G Cck cholecystokinin ISO RGD PMID:17443025 RGD:1625798 NCBI chr 9:121,318,890...121,324,728
Ensembl chr 9:121,318,890...121,324,760 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16188961 PMID:18486454 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased secretion:plasma (rat) RGD PMID:19905967 RGD:4889977 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Cd163 CD163 antigen susceptibility ISO protein:increased expression:blood serum (human) RGD PMID:31027316 RGD:127345132 NCBI chr 6:124,281,596...124,307,488
Ensembl chr 6:124,281,615...124,307,486 		JBrowse link
G Cd36 CD36 molecule ISO DNA:SNPs: :multiple (human) RGD PMID:9916795 PMID:18305138 RGD:619666, RGD:2307208 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:serum RGD PMID:16423632 PMID:20006362 RGD:2314214, RGD:5490591 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Cela2a chymotrypsin-like elastase family, member 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:31358993 NCBI chr 4:141,542,265...141,553,316
Ensembl chr 4:141,542,273...141,553,471 		JBrowse link
G Chek2 checkpoint kinase 2 ISO mRNA:increased expression:heart left ventricle (rat) RGD PMID:25129990 RGD:10400905 NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011 		JBrowse link
G Ciita class II transactivator ISO DNA:polymorphism:promoter:-168A>G (human) RGD PMID:17183695 RGD:5491201 NCBI chr16:10,297,877...10,348,928
Ensembl chr16:10,297,923...10,346,282 		JBrowse link
G Crp C-reactive protein, pentraxin-related ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16644639 PMID:21357282 RGD:6482318 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Cst3 cystatin C ISO protein:increased expression:serum (human) RGD PMID:19887833 RGD:2314295 NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612 		JBrowse link
G Cyba cytochrome b-245, alpha polypeptide ISO RGD PMID:16741160 RGD:2317864 NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 susceptibility ISO DNA:polymorphism:promoter:-344C>T (human) RGD PMID:17261471 RGD:2307294 NCBI chr15:74,722,467...74,728,080
Ensembl chr15:74,722,859...74,728,167 		JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633 		JBrowse link
G Ddr1 discoidin domain receptor family, member 1 IMP RGD PMID:32360427 RGD:151347874 NCBI chr17:35,992,459...36,015,633
Ensembl chr17:35,992,459...36,015,513 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 treatment IMP RGD PMID:21990351 RGD:10401057 NCBI chr15:76,386,215...76,396,167
Ensembl chr15:76,386,215...76,396,153 		JBrowse link
G Dio2 deiodinase, iodothyronine, type II ISO DNA:polymorphism: :p.T92A (human) RGD PMID:18198294 RGD:2313696 NCBI chr12:90,691,326...90,705,812
Ensembl chr12:90,691,326...90,705,812 		JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic ISO RGD PMID:22007192 RGD:5688391 NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949 		JBrowse link
G F3 coagulation factor III ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:12417540 RGD:2313865 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G Fabp2 fatty acid binding protein 2, intestinal ISO RGD PMID:16919542 RGD:1626401 NCBI chr 3:122,688,721...122,693,155
Ensembl chr 3:122,688,721...122,693,155 		JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte ISO protein:increased expression:serum RGD PMID:16919044 RGD:1625406 NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636 		JBrowse link
G Fadd Fas associated via death domain ISO protein:increased expression:heart left ventricle RGD PMID:23657904 RGD:11344884 NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200 		JBrowse link
G Fas Fas cell surface death receptor ISO mRNA:increased expression:liver (rat) RGD PMID:11934685 RGD:628329 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasn fatty acid synthase ameliorates IEP
ISO		 mRNA:increased expression:liver (mouse) RGD PMID:29684438 PMID:27821167 PMID:31353547 RGD:329333017, RGD:401799622, RGD:401850595 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Fgf15 fibroblast growth factor 15 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28673684 NCBI chr 7:144,450,269...144,454,690
Ensembl chr 7:144,450,268...144,454,690 		JBrowse link
G Fgf21 fibroblast growth factor 21 treatment IDA RGD PMID:25306889 RGD:10401890 NCBI chr 7:45,263,314...45,264,914
Ensembl chr 7:45,263,310...45,264,914 		JBrowse link
G Fto FTO alpha-ketoglutarate dependent dioxygenase ISO DNA:SNPs: :rs1421085, rs1558902, rs8050136, rs9939609 (human)
DNA:SNP: :rs9939973 (human)		 RGD PMID:21796137 PMID:32061761 RGD:329853776, RGD:329901771 NCBI chr 8:92,039,995...92,395,061
Ensembl chr 8:92,040,153...92,395,067 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 ameliorates ISO RGD PMID:27821167 RGD:401799622 NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked treatment ISO RGD PMID:19374165 PMID:24868532 RGD:2307350, RGD:10449117 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Gcg glucagon ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr 2:62,304,874...62,313,997
Ensembl chr 2:62,304,874...62,313,994 		JBrowse link
G Gch1 GTP cyclohydrolase 1 treatment ISO RGD PMID:34200262 RGD:329970293 NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870 		JBrowse link
G Gck glucokinase ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr11:5,850,816...5,900,081
Ensembl chr11:5,850,820...5,900,081 		JBrowse link
G Gckr glucokinase regulatory protein ISO RGD PMID:19861489 RGD:7242423 NCBI chr 5:31,454,594...31,484,646
Ensembl chr 5:31,454,787...31,484,658 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 susceptibility ISO RGD PMID:17095717 PMID:24847614 RGD:1601300, RGD:14747015 NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034 		JBrowse link
G Ghrl ghrelin ISO associated with Kidney Diseases;protein:decreased expression:serum
DNA:polymorphisms
In peritoneal dialysis patients
ClinVar Annotator: match by term: Metabolic syndrome, susceptibility to		 ClinVar
RGD		 PMID:11502844 PMID:12050239 PMID:12161552 PMID:16204371 PMID:25741868 More... RGD:2313748, RGD:1625021, RGD:7242555 NCBI chr 6:113,693,080...113,696,872
Ensembl chr 6:113,693,080...113,696,841 		JBrowse link
G Gpr17 G protein-coupled receptor 17 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34144038 NCBI chr18:32,076,052...32,082,925
Ensembl chr18:32,076,050...32,082,689 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO protein:increased expression:serum RGD PMID:24819036 RGD:401827122 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Gsn gelsolin severity IMP RGD PMID:29684438 RGD:329333017 NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 ISO RGD PMID:29452132 RGD:14700976 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Hdac3 histone deacetylase 3 ISO RGD PMID:21763752 RGD:9590183 NCBI chr18:38,070,024...38,088,073
Ensembl chr18:38,068,897...38,088,069 		JBrowse link
G Hgf hepatocyte growth factor ISO RGD PMID:15713721 RGD:1642702 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150 		JBrowse link
G Hmga1 high mobility group AT-hook 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23512162 NCBI chr17:27,774,798...27,782,649
Ensembl chr17:27,775,471...27,782,648 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase ameliorates ISO
IEP		 RGD PMID:19461650 PMID:27821167 PMID:31353547 RGD:5508692, RGD:401799622, RGD:401850595 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO RGD PMID:22193921 RGD:10763276 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hnf4a hepatic nuclear factor 4, alpha ISO RGD PMID:16804065 RGD:1601642 NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830 		JBrowse link
G Hp haptoglobin treatment ISO protein:increased expression RGD PMID:17007284 PMID:20508159 RGD:1626341, RGD:11041859 NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 susceptibility
disease_progression		 ISO DNA:SNP:: (rs846910) (human)
DNA:SNPs:5'utr,enhancer: (rs846910,rs12086634) (human)
DNA:SNP: (rs12086634)T>G (human)
mRNA:increased expression:ascending aorta,epicardial fat (human)		 RGD PMID:14697232 PMID:28750217 PMID:21622477 PMID:23869418 PMID:23007990 RGD:1625074, RGD:329901909, RGD:329901919, RGD:329901929, RGD:329901930 NCBI chr 1:192,903,917...192,946,345
Ensembl chr 1:192,903,942...192,946,383 		JBrowse link
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C ISO CTD Direct Evidence: marker/mechanism CTD PMID:17632216 PMID:18515891 PMID:19142101 NCBI chr  X:145,745,509...145,980,273
Ensembl chr  X:145,745,509...145,980,273 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:serum RGD PMID:19394054 RGD:2313467 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial susceptibility IMP RGD PMID:31064654 RGD:14985252 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140 		JBrowse link
G Igf2 insulin-like growth factor 2 ISO DNA:insertion RGD PMID:18418699 RGD:2311520 NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 ISO RGD PMID:16915540 RGD:1626481 NCBI chr 1:72,863,650...72,891,633
Ensembl chr 1:72,863,662...72,891,633 		JBrowse link
G Il18 interleukin 18 treatment ISO protein:increased expression:serum
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16644639 PMID:19717152 PMID:24456735 RGD:4889401, RGD:8655985 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16644639 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Il6ra interleukin 6 receptor, alpha susceptibility ISO DNA:polymorphism: :p.D358A RGD PMID:16817825 RGD:1625430 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 ISO DNA:SNPs: :rs2276047,snp8(human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:15220217 PMID:15220217 RGD:1626127 NCBI chr 7:101,471,839...101,487,419
Ensembl chr 7:101,471,839...101,487,436 		JBrowse link
G Ins2 insulin II ISO CTD Direct Evidence: marker/mechanism CTD PMID:11274935 PMID:16259526 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Insr insulin receptor ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617 		JBrowse link
G Irs1 insulin receptor substrate 1 ameliorates ISO
IDA		 protein:decreased expression:skeletal muscle RGD PMID:10842668 PMID:31353547 RGD:6482864, RGD:401850595 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137 		JBrowse link
G Irs2 insulin receptor substrate 2 ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458 		JBrowse link
G Itgav integrin alpha V ISO RGD PMID:16784924 RGD:1627640 NCBI chr 2:83,554,796...83,637,261
Ensembl chr 2:83,554,741...83,637,260 		JBrowse link
G Kl klotho ISO
IMP		 mRNA:decreased expression:kidney: RGD PMID:11027545 PMID:11027545 RGD:10403056, RGD:10403056 NCBI chr 5:150,876,072...150,917,282
Ensembl chr 5:150,876,072...150,917,282 		JBrowse link
G Lbp lipopolysaccharide binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:23349936 NCBI chr 2:158,148,413...158,174,772
Ensembl chr 2:158,148,413...158,174,772 		JBrowse link
G Ldlr low density lipoprotein receptor ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Lep leptin ISO protein:increased expression:plasma (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16793964 PMID:18515891 PMID:19462476 PMID:25380250 RGD:2311125, RGD:10053625 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lepr leptin receptor ISO DNA:mutations:cds: : (rat)
DNA:mutations::cds: : (rat)		 RGD PMID:32710530 PMID:28746409 PMID:10901178 RGD:401960103, RGD:401965413, RGD:401965414 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Lipe lipase, hormone sensitive IEP mRNA:increased expression:liver (mouse) RGD PMID:29684438 RGD:329333017 NCBI chr 7:25,078,952...25,097,911
Ensembl chr 7:25,078,952...25,098,135 		JBrowse link
G Lipg lipase, endothelial ISO RGD PMID:16354105 RGD:1580865 NCBI chr18:75,072,393...75,095,380
Ensembl chr18:75,072,393...75,094,334 		JBrowse link
G Lmna lamin A ISO DNA:SNP: :c.138747C>T (human) RGD PMID:15205219 RGD:2306121 NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263 		JBrowse link
G Lrp6 low density lipoprotein receptor-related protein 6 ISO DNA:missense mutation:cds RGD PMID:17332414 RGD:2298725 NCBI chr 6:134,423,439...134,543,876
Ensembl chr 6:134,423,439...134,543,928 		JBrowse link
G Lrpap1 low density lipoprotein receptor-related protein associated protein 1 susceptibility ISO associated with Coronary Disease;DNA:SNP:exon RGD PMID:14557872 RGD:1581921 NCBI chr 5:35,248,834...35,263,043
Ensembl chr 5:35,248,845...35,263,110 		JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 ISO mRNA:decreased expression:blood, leukocyte (human) RGD PMID:26956845 RGD:155791561 NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809 		JBrowse link
G Mir122 microRNA 122 ISO miRNA:increased expression:serum RGD PMID:27899485 RGD:14401601 NCBI chr18:65,381,932...65,381,997
Ensembl chr18:65,381,932...65,381,997 		JBrowse link
G Mlxipl MLX interacting protein-like ameliorates ISO RGD PMID:27821167 RGD:401799622 NCBI chr 5:135,118,744...135,168,622
Ensembl chr 5:135,118,744...135,167,236 		JBrowse link
G Mtmr9 myotubularin related protein 9 ISO DNA:SNP: :rs2293855 (human) RGD PMID:21796137 RGD:329853776 NCBI chr14:63,757,100...63,781,402
Ensembl chr14:63,757,100...63,781,431 		JBrowse link
G Mttp microsomal triglyceride transfer protein ISO ClinVar Annotator: match by term: Metabolic syndrome X ClinVar PMID:8533758 PMID:9671739 PMID:16199547 PMID:16721486 PMID:21394827 More... NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase ISO DNA:repeats:intron
protein:increased expression:plasma		 RGD PMID:15922301 PMID:17556870 RGD:1642345, RGD:1642337 NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348 		JBrowse link
G Neil1 nei endonuclease VIII-like 1 (E. coli) ISO CTD Direct Evidence: marker/mechanism CTD PMID:16446448 PMID:17389588 NCBI chr 9:57,050,072...57,055,973
Ensembl chr 9:57,050,084...57,055,589 		JBrowse link
G Ngf nerve growth factor ISO RGD PMID:11935372 RGD:1580935 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Nnmt nicotinamide N-methyltransferase ISO mRNA,protein:increased expression,increased activity:adipose tissue (rat) RGD PMID:25719492 RGD:401793724 NCBI chr 9:48,448,905...48,518,958
Ensembl chr 9:48,503,177...48,516,453 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell treatment ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Metabolic syndrome, susceptibility to		 CTD
ClinVar
RGD		 PMID:12947532 PMID:15269839 PMID:20876122 PMID:28361419 PMID:29127233 More... RGD:13450928, RGD:13461762 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nox1 NADPH oxidase 1 ISO protein:increased expression, increased activity:peripheral blood mononuclear cell (human) RGD PMID:16380495 RGD:1580973 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 ameliorates ISO RGD PMID:27821167 RGD:401799622 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20869355 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20869355 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic ameliorates ISO RGD PMID:27821167 RGD:401799622 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr 4:106,299,531...106,321,522
Ensembl chr 4:106,299,526...106,321,526 		JBrowse link
G Pde9a phosphodiesterase 9A treatment IMP RGD PMID:34618683 RGD:242170038 NCBI chr17:31,605,079...31,695,284
Ensembl chr17:31,605,184...31,695,284 		JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) ISO mRNA:decreased expression:liver RGD PMID:21172452 RGD:6482748 NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041 		JBrowse link
G Pla2g6 phospholipase A2, group VI ISO mRNA:decreased expression:liver RGD PMID:21172452 RGD:6482748 NCBI chr15:79,170,428...79,212,915
Ensembl chr15:79,170,428...79,212,590 		JBrowse link
G Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) ISO mRNA:increased expression:liver RGD PMID:21172452 RGD:6482748 NCBI chr17:43,879,009...43,923,093
Ensembl chr17:43,878,989...43,923,092 		JBrowse link
G Plat plasminogen activator, tissue ISO protein:increased expression:serum RGD PMID:18249307 RGD:2311664 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Pon1 paraoxonase 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:21573798 PMID:14602783 RGD:1642618 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ameliorates ISO
IEP		 mRNA:decreased expression:liver (rat) RGD PMID:11934685 PMID:31353547 RGD:628329, RGD:401850595 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma no_association
ameliorates		 ISO
IEP		 DNA:SNP: :p.P12A (human) RGD PMID:18959602 PMID:16183630 PMID:16186413 PMID:31353547 RGD:2301843, RGD:1580683, RGD:1580686, RGD:401850595 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha ISO mRNA:decreased expression:gastrocnemius muscle (rat) RGD PMID:20383225 RGD:10059661 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087 		JBrowse link
G Prl prolactin ISO RGD PMID:16303834 RGD:1642558 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO protein:increased expression:liver RGD PMID:17883899 RGD:1642586 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rbp4 retinol binding protein 4, plasma disease_progression ISO protein:increased expression:blood serum (human)
associated with obstructive sleep apnea;protein:increased expression:blood plasma (human)		 RGD PMID:19339013 PMID:19003725 RGD:329845591, RGD:329853307 NCBI chr19:38,105,068...38,113,769
Ensembl chr19:38,105,077...38,113,729 		JBrowse link
G Reg1 regenerating islet-derived 1 treatment ISO RGD PMID:21685239 RGD:10044029 NCBI chr 6:78,402,966...78,405,651
Ensembl chr 6:78,399,694...78,405,650 		JBrowse link
G Retn resistin ISO DNA:SNP:promoter:-420G>C (rs1862513) (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:18328350 PMID:17598818 RGD:7207155 NCBI chr 8:3,705,770...3,709,818
Ensembl chr 8:3,705,770...3,710,110 		JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 ameliorates ISO
IEP		 RGD PMID:27821167 PMID:31353547 RGD:401799622, RGD:401850595 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318 		JBrowse link
G Scg3 secretogranin III ISO DNA:SNP: :rs3764220 (human) RGD PMID:21796137 RGD:329853776 NCBI chr 9:75,550,648...75,591,733
Ensembl chr 9:75,550,471...75,591,338 		JBrowse link
G Selp selectin, platelet ISO RGD PMID:19061719 RGD:2312292 NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595 		JBrowse link
G Serpina12 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 treatment ISO human protein in a mouse model RGD PMID:16030142 RGD:1547845 NCBI chr12:103,995,028...104,010,702
Ensembl chr12:103,995,028...104,010,702 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 treatment ISO RGD PMID:26084260 RGD:11073736 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Shbg sex hormone binding globulin ISO protein:decreased expression:serum
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16968811 PMID:17992261 PMID:17884445 RGD:2313785 NCBI chr11:69,501,108...69,508,852
Ensembl chr11:69,505,630...69,508,731 		JBrowse link
G Sim1 single-minded family bHLH transcription factor 1 ISO ClinVar Annotator: match by term: SIM1-associated metabolic syndrome ClinVar NCBI chr10:50,770,794...50,865,252
Ensembl chr10:50,770,850...50,865,248 		JBrowse link
G Sirt1 sirtuin 1 treatment ISO protein:decreased expression:hippocampus (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:20068143 PMID:21514307 PMID:25356430 RGD:9585758, RGD:10053569 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Slc27a1 solute carrier family 27 (fatty acid transporter), member 1 susceptibility IAGP DNA:gene knockout::Slc27a1-/- mice resistant to diet-induced obesity and metabolic syndrome RGD PMID:16611988 RGD:1642790 NCBI chr 8:72,021,372...72,039,951
Ensembl chr 8:72,021,526...72,039,946 		JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 ameliorates IEP RGD PMID:31353547 RGD:401850595 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Soat2 sterol O-acyltransferase 2 susceptibility ISO DNA:SNPs RGD PMID:14557872 RGD:1581921 NCBI chr15:102,058,853...102,071,871
Ensembl chr15:102,058,961...102,071,904 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial treatment IEP RGD PMID:28875871 RGD:26923956 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 disease_progression
ameliorates		 IEP
ISO		 protein:increased expression:liver (mouse)
mRNA:increased expression:liver (rat)		 RGD PMID:29173234 PMID:11934685 PMID:31353547 RGD:401827867, RGD:628329, RGD:401850595 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO mRNA:increased expression:left heart ventricle RGD PMID:18692559 RGD:2306739 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Thbd thrombomodulin ISO associated with Diabetic Nephropathies;protein:increased expression:plasma RGD PMID:16567841 RGD:1601641 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108 		JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:24441717 RGD:10450604 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a ISO associated with obesity;protein:increased expression:plasma RGD PMID:17200772 RGD:1624178 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Trf transferrin susceptibility ISO protein:increased expression:serum RGD PMID:17416791 RGD:1601514 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643 		JBrowse link
G Trib3 tribbles pseudokinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18497449 NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952 		JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) ISO mRNA:decreased expression:liver (rat) RGD PMID:11934685 RGD:628329 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227 		JBrowse link
G Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) treatment ISO RGD PMID:11934685 RGD:628329 NCBI chr 7:100,122,198...100,135,639
Ensembl chr 7:100,122,197...100,135,639 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO RGD PMID:18718174 RGD:2313109 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:plasma: RGD PMID:22206010 RGD:7483588 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vwf Von Willebrand factor ISO protein:increased expression:plasma RGD PMID:16764036 RGD:1625709 NCBI chr 6:125,529,911...125,663,642
Ensembl chr 6:125,523,737...125,663,642 		JBrowse link
abdominal obesity-metabolic syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctf1 cardiotrophin 1 IAGP MouseDO NCBI chr 7:127,311,872...127,317,360
Ensembl chr 7:127,311,908...127,317,364 		JBrowse link
G Gucy2c guanylate cyclase 2c IAGP MouseDO NCBI chr 6:136,674,282...136,758,740
Ensembl chr 6:136,674,282...136,758,763 		JBrowse link
G Lep leptin IAGP MouseDO NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Neil1 nei endonuclease VIII-like 1 (E. coli) IAGP MouseDO NCBI chr 9:57,050,072...57,055,973
Ensembl chr 9:57,050,084...57,055,589 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:15309680 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma IAGP MouseDO NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha ISO mRNA:increased expression:gastrocnemius muscle (rat) RGD PMID:23320128 RGD:7241841 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Prkci protein kinase C, iota IAGP MouseDO NCBI chr 3:31,049,893...31,106,889
Ensembl chr 3:31,049,896...31,107,108 		JBrowse link
G Sirt3 sirtuin 3 IAGP MouseDO NCBI chr 7:140,443,576...140,462,222
Ensembl chr 7:140,443,579...140,462,222 		JBrowse link
G Slc2a9 solute carrier family 2 (facilitated glucose transporter), member 9 IAGP MouseDO NCBI chr 5:38,506,616...38,660,488
Ensembl chr 5:38,506,616...38,660,486 		JBrowse link
abdominal obesity-metabolic syndrome 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 ISO protein:increased oxidation:cardiac muscle cell RGD PMID:23997093 RGD:13782087 NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288 		JBrowse link
G Bax BCL2-associated X protein treatment ISO RGD PMID:27131981 RGD:13792503 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 treatment ISO RGD PMID:27131981 RGD:13792503 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Fadd Fas associated via death domain treatment ISO RGD PMID:27131981 RGD:13792503 NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200 		JBrowse link
G Fas Fas cell surface death receptor ISO RGD PMID:30172001 RGD:13792561 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Lep leptin IAGP OMIM:605552 MouseDO NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lpl lipoprotein lipase treatment ISO RGD PMID:26996629 RGD:13794382 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100 		JBrowse link
G Mttp microsomal triglyceride transfer protein ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 1 ClinVar PMID:8533758 PMID:9671739 PMID:16199547 PMID:16721486 PMID:21394827 More... NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729 		JBrowse link
G Tlr2 toll-like receptor 2 susceptibility IMP RGD PMID:19841034 RGD:15090861 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Trp53inp1 transformation related protein 53 inducible nuclear protein 1 IAGP OMIM:605552 MouseDO NCBI chr 4:11,156,441...11,174,379
Ensembl chr 4:11,156,431...11,174,379 		JBrowse link
abdominal obesity-metabolic syndrome 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahdc1 AT hook, DNA binding motif, containing 1 ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 3 ClinVar PMID:25741868 PMID:29696776 PMID:33644933 NCBI chr 4:132,738,797...132,805,421
Ensembl chr 4:132,738,571...132,805,421 		JBrowse link
G Dyrk1b dual-specificity tyrosine phosphorylation regulated kinase 1b ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 3 | ClinVar Annotator: match by term: DYRK1B-related condition OMIM
ClinVar		 PMID:9536098 PMID:17576681 PMID:24827035 PMID:25741868 PMID:28492532 More... NCBI chr 7:27,878,880...27,896,896
Ensembl chr 7:27,878,894...27,886,719 		JBrowse link
abdominal obesity-metabolic syndrome 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cela2a chymotrypsin-like elastase family, member 2A ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 4 OMIM
ClinVar		 PMID:25741868 PMID:31358993 NCBI chr 4:141,542,265...141,553,316
Ensembl chr 4:141,542,273...141,553,471 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16180
    syndrome 10680
      Metabolic Syndrome 165
        abdominal obesity-metabolic syndrome + 22
Path 2
Term Annotations click to browse term
  disease 16180
    Developmental Disease 13926
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 12946
        genetic disease 12636
          inherited metabolic disorder 6057
            carbohydrate metabolic disorder 2966
              glucose metabolism disease 1684
                hyperinsulinism 394
                  Insulin Resistance 328
                    Metabolic Syndrome 165
                      abdominal obesity-metabolic syndrome + 22
paths to the root