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ONTOLOGY REPORT - ANNOTATIONS


Term:Retroviridae Infections
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Accession:DOID:9006644 term browser browse the term
Definition:Virus diseases caused by the RETROVIRIDAE.
Synonyms:exact_synonym: Retroviridae Infection;   Retrovirus Infection;   Retrovirus Infections
 primary_id: MESH:D012192;   RDO:0001493
For additional species annotation, visit the Alliance of Genome Resources.


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Retroviridae Infections term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BST2 bone marrow stromal cell antigen 2 JBrowse link 19 17,863,991 17,866,728 RGD:9068941
G IL10 interleukin 10 JBrowse link 1 186,648,289 186,653,155 RGD:9068941
acquired immunodeficiency syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BST2 bone marrow stromal cell antigen 2 JBrowse link 19 17,863,991 17,866,728 RGD:9068941
G CCL11 C-C motif chemokine ligand 11 JBrowse link 17 22,789,235 22,791,272 RGD:9068941
G CCL2 C-C motif chemokine ligand 2 JBrowse link 17 22,821,336 22,823,271 RGD:9068941
G CCR5 C-C motif chemokine receptor 5 JBrowse link 3 47,377,564 47,383,625 RGD:9068941
G CD40LG CD40 ligand JBrowse link X 136,042,849 136,055,158 RGD:9068941
G CX3CR1 C-X3-C motif chemokine receptor 1 JBrowse link 3 39,439,009 39,456,797 RGD:9068941
G CXCL12 C-X-C motif chemokine ligand 12 JBrowse link 10 44,476,962 44,564,231 RGD:9068941
G CXCR1 C-X-C motif chemokine receptor 1 JBrowse link 2B 224,027,533 224,031,675 RGD:9068941
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit JBrowse link 19 50,897,004 50,915,849 RGD:9068941
G IFNG interferon gamma JBrowse link 12 68,448,861 68,453,829 RGD:9068941
G IGF2 insulin like growth factor 2 JBrowse link 11 2,202,764 2,228,890 RGD:9068941
G IL10 interleukin 10 JBrowse link 1 186,648,289 186,653,155 RGD:9068941
G IL2 interleukin 2 JBrowse link 4 125,782,563 125,787,819 RGD:9068941
G IL4R interleukin 4 receptor JBrowse link 16 27,686,760 27,737,445 RGD:9068941
G TLR3 toll like receptor 3 JBrowse link 4 190,446,487 190,462,728 RGD:9068941
G TNF tumor necrosis factor JBrowse link 6 32,126,618 32,129,389 RGD:9068941
G TNFRSF1A TNF receptor superfamily member 1A JBrowse link 12 6,374,256 6,387,613 RGD:9068941
G TNFRSF1B TNF receptor superfamily member 1B JBrowse link 1 12,130,663 12,172,646 RGD:9068941
G VDR vitamin D receptor JBrowse link 12 41,661,688 41,766,192 RGD:9068941
AIDS Dementia Complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADRB2 adrenoceptor beta 2 JBrowse link 5 150,267,321 150,269,339 RGD:9068941
G EPO erythropoietin JBrowse link 7 106,148,062 106,150,974 RGD:9068941
G GC GC vitamin D binding protein JBrowse link 4 58,749,384 58,792,073 RGD:9068941
G IL1B interleukin 1 beta JBrowse link 2A 113,846,299 113,853,424 RGD:9068941
G INSR insulin receptor JBrowse link 19 7,255,444 7,411,916 RGD:9068941
G IRS1 insulin receptor substrate 1 JBrowse link 2B 232,785,822 232,853,997 RGD:9068941
G NPY neuropeptide Y JBrowse link 7 24,566,963 24,574,657 RGD:9068941
G OPRM1 opioid receptor mu 1 JBrowse link 6 156,517,666 156,627,758 RGD:9068941
G PDGFB platelet derived growth factor subunit B JBrowse link 22 37,944,018 37,964,883 RGD:9068941
AIDS-Associated Nephropathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AGTR1 angiotensin II receptor type 1 JBrowse link 3 153,301,331 153,346,268 RGD:9068941
G AGTR2 angiotensin II receptor type 2 JBrowse link X 115,670,022 115,674,287 RGD:9068941
G EGF epidermal growth factor JBrowse link 4 112,977,565 113,075,761 RGD:9068941
G MTOR mechanistic target of rapamycin kinase JBrowse link 1 11,093,765 11,249,841 RGD:9068941
G MYH9 myosin heavy chain 9 JBrowse link 22 35,039,461 35,121,618 RGD:9068941
G NOTCH4 notch receptor 4 JBrowse link 6 32,722,112 32,750,978 RGD:9068941
AIDS-Related Kaposi Sarcoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BCL2 BCL2 apoptosis regulator JBrowse link 18 59,797,184 59,993,298 RGD:9068941
AIDS-Related Opportunistic Infections term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CD4 CD4 molecule JBrowse link 12 6,834,011 6,864,204 RGD:9068941
Coronary Artery Disease, Development of, in HIV term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CCL2 C-C motif chemokine ligand 2 JBrowse link 17 22,821,336 22,823,271 RGD:9068941
HIV Encephalitis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G APP amyloid beta precursor protein JBrowse link 21 25,683,236 25,995,262 RGD:9068941
G BACE1 beta-secretase 1 JBrowse link 11 116,054,303 116,084,813 RGD:9068941
G CDK5 cyclin dependent kinase 5 JBrowse link 7 154,793,344 154,797,499 RGD:9068941
G MFN1 mitofusin 1 JBrowse link 3 184,552,108 184,596,763 RGD:9068941
HIV Seropositivity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ALB albumin JBrowse link 4 56,605,322 56,622,418 RGD:9068941
G APH1B aph-1 homolog B, gamma-secretase subunit JBrowse link 15 60,520,031 60,551,599 RGD:9068941
HIV Wasting Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL1A interleukin 1 alpha JBrowse link 2A 113,784,854 113,795,801 RGD:9068941
G IL1B interleukin 1 beta JBrowse link 2A 113,846,299 113,853,424 RGD:9068941
G IL6 interleukin 6 JBrowse link 7 23,027,560 23,032,419 RGD:9068941
G TNF tumor necrosis factor JBrowse link 6 32,126,618 32,129,389 RGD:9068941
HIV-Associated Lipodystrophy Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADIPOQ adiponectin, C1Q and collagen domain containing JBrowse link 3 192,341,471 192,354,885 RGD:9068941
G ADRB3 adrenoceptor beta 3 JBrowse link 8 34,440,099 34,444,043 RGD:9068941
G IL18 interleukin 18 JBrowse link 11 110,867,586 110,888,371 RGD:9068941
G LMNA lamin A/C JBrowse link 1 135,253,700 135,311,542 RGD:9068941
G MMP1 matrix metallopeptidase 1 JBrowse link 11 101,221,393 101,230,104 RGD:9068941
G ZMPSTE24 zinc metallopeptidase STE24 JBrowse link 1 40,869,076 40,912,747 RGD:9068941
human immunodeficiency virus infectious disease term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCB1 ATP binding cassette subfamily B member 1 JBrowse link 7 93,147,217 93,355,231 RGD:9068941
G ABCE1 ATP binding cassette subfamily E member 1 JBrowse link 4 149,105,912 149,137,028 RGD:9068941
G ADRB2 adrenoceptor beta 2 JBrowse link 5 150,267,321 150,269,339 RGD:9068941
G ALB albumin JBrowse link 4 56,605,322 56,622,418 RGD:9068941
G ALYREF Aly/REF export factor JBrowse link 17 81,995,578 82,000,836 RGD:9068941
G APOA1 apolipoprotein A1 JBrowse link 11 115,606,136 115,608,335 RGD:9068941
G ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 JBrowse link 5 143,126,866 143,153,941 RGD:9068941
G ARHGAP4 Rho GTPase activating protein 4 JBrowse link X 153,349,050 153,367,709 RGD:9068941
G ARHGDIA Rho GDP dissociation inhibitor alpha JBrowse link 17 81,975,340 81,978,447 RGD:9068941
G ARHGDIB Rho GDP dissociation inhibitor beta JBrowse link 12 15,341,489 15,361,160 RGD:9068941
G BAG3 BAG cochaperone 3 JBrowse link 10 119,654,366 119,665,964 RGD:9068941
G BAX BCL2 associated X, apoptosis regulator JBrowse link 19 54,793,594 54,800,466 RGD:9068941
G BIRC2 baculoviral IAP repeat containing 2 JBrowse link 11 100,793,036 100,818,455 RGD:9068941
G BIRC3 baculoviral IAP repeat containing 3 JBrowse link 11 100,763,274 100,785,194 RGD:9068941
G BST2 bone marrow stromal cell antigen 2 JBrowse link 19 17,863,991 17,866,728 RGD:9068941
G C3 complement C3 JBrowse link 19 6,629,240 6,674,786 RGD:9068941
G CCL11 C-C motif chemokine ligand 11 JBrowse link 17 22,789,235 22,791,272 RGD:9068941
RGD:7240710
G CCL2 C-C motif chemokine ligand 2 JBrowse link 17 22,821,336 22,823,271 RGD:9068941
RGD:7240710
G CCL5 C-C motif chemokine ligand 5 JBrowse link 17 21,210,798 21,219,172 RGD:9068941
G CCR2 C-C motif chemokine receptor 2 JBrowse link 3 47,361,118 47,368,312 RGD:9068941
G CCR3 C-C motif chemokine receptor 3 JBrowse link 3 47,253,878 47,278,630 RGD:9068941
G CCR5 C-C motif chemokine receptor 5 JBrowse link 3 47,377,564 47,383,625 RGD:9068941
G CCT3 chaperonin containing TCP1 subunit 3 JBrowse link 1 135,482,012 135,508,983 RGD:9068941
G CCT5 chaperonin containing TCP1 subunit 5 JBrowse link 5 10,424,157 10,440,613 RGD:9068941
G CCT7 chaperonin containing TCP1 subunit 7 JBrowse link 2A 74,775,781 74,794,515 RGD:9068941
G CD28 CD28 molecule JBrowse link 2B 209,076,388 209,111,213 RGD:9068941
G CD40 CD40 molecule JBrowse link 20 43,541,619 43,552,994 RGD:9068941
G CD40LG CD40 ligand JBrowse link X 136,042,849 136,055,158 RGD:9068941
G CDC42 cell division cycle 42 JBrowse link 1 22,188,722 22,228,351 RGD:9068941
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 6 37,436,963 37,445,599 RGD:9068941
G CLIC1 chloride intracellular channel 1 JBrowse link 6 32,280,645 32,286,621 RGD:9068941
G COPS6 COP9 signalosome subunit 6 JBrowse link 7 105,557,778 105,560,998 RGD:9068941
G CRP C-reactive protein JBrowse link 1 138,858,353 138,860,652 RGD:9068941
G CX3CR1 C-X3-C motif chemokine receptor 1 JBrowse link 3 39,439,009 39,456,797 RGD:7240710
RGD:9068941
G CXCL10 C-X-C motif chemokine ligand 10 JBrowse link 4 54,020,204 54,022,606 RGD:9068941
G CXCL12 C-X-C motif chemokine ligand 12 JBrowse link 10 44,476,962 44,564,231 RGD:9068941
RGD:7240710
G CXCR1 C-X-C motif chemokine receptor 1 JBrowse link 2B 224,027,533 224,031,675 RGD:7240710
RGD:9068941
G DNAJC7 DnaJ heat shock protein family (Hsp40) member C7 JBrowse link 17 15,516,882 15,561,227 RGD:9068941
G EIF3B eukaryotic translation initiation factor 3 subunit B JBrowse link 7 2,718,582 2,743,944 RGD:9068941
G EIF4A1 eukaryotic translation initiation factor 4A1 JBrowse link 17 7,590,569 7,596,876 RGD:9068941
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 8 34,513,276 34,539,170 RGD:9068941
G EIF6 eukaryotic translation initiation factor 6 JBrowse link 20 32,731,097 32,737,136 RGD:9068941
G EMG1 EMG1 N1-specific pseudouridine methyltransferase JBrowse link 12 7,018,291 7,023,807 RGD:9068941
G FAS Fas cell surface death receptor JBrowse link 10 89,199,070 89,244,884 RGD:9068941
G FCER2 Fc fragment of IgE receptor II JBrowse link 19 7,833,851 7,843,510 RGD:9068941
G GADD45A growth arrest and DNA damage inducible alpha JBrowse link 1 68,880,912 68,884,188 RGD:9068941
G GC GC vitamin D binding protein JBrowse link 4 58,749,384 58,792,073 RGD:9068941
G GRPEL1 GrpE like 1, mitochondrial JBrowse link 4 7,126,043 7,135,388 RGD:9068941
G GTF3A general transcription factor IIIA JBrowse link 13 27,059,129 27,070,098 RGD:9068941
G HDGF heparin binding growth factor JBrowse link 1 135,907,119 135,932,709 RGD:9068941
G HSP90AA1 heat shock protein 90 alpha family class A member 1 JBrowse link 14 102,519,033 102,524,639 RGD:9068941
G HSP90AB1 heat shock protein 90 alpha family class B member 1 JBrowse link 6 45,126,060 45,132,972 RGD:9068941
G HSPA9 heat shock protein family A (Hsp70) member 9 JBrowse link 5 140,064,207 140,084,551 RGD:9068941
G HSPB1 heat shock protein family B (small) member 1 JBrowse link 7 82,751,385 82,753,109 RGD:9068941
G HSPD1 heat shock protein family D (Hsp60) member 1 JBrowse link 2B 202,623,497 202,637,045 RGD:9068941
G HSPH1 heat shock protein family H (Hsp110) member 1 JBrowse link 13 30,845,938 30,871,455 RGD:9068941
G IFNG interferon gamma JBrowse link 12 68,448,861 68,453,829 RGD:9068941
RGD:7240710
G IL10 interleukin 10 JBrowse link 1 186,648,289 186,653,155 RGD:9068941
RGD:7240710
G IL15 interleukin 15 JBrowse link 4 145,307,339 145,416,622 RGD:9068941
G IL18 interleukin 18 JBrowse link 11 110,867,586 110,888,371 RGD:9068941
G IL19 interleukin 19 JBrowse link 1 186,680,606 186,724,748 RGD:9068941
G IL2 interleukin 2 JBrowse link 4 125,782,563 125,787,819 RGD:9068941
G IL21R interleukin 21 receptor JBrowse link 16 27,774,864 27,821,769 RGD:9068941
G IL2RA interleukin 2 receptor subunit alpha JBrowse link 10 6,037,664 6,086,018 RGD:9068941
G IL4R interleukin 4 receptor JBrowse link 16 27,686,760 27,737,445 RGD:7240710
RGD:9068941
G IL6 interleukin 6 JBrowse link 7 23,027,560 23,032,419 RGD:9068941
G ILF2 interleukin enhancer binding factor 2 JBrowse link 1 132,647,296 132,656,361 RGD:9068941
G IPO7 importin 7 JBrowse link 11 9,256,060 9,318,610 RGD:9068941
G KMT2E lysine methyltransferase 2E JBrowse link 7 109,734,825 109,832,851 RGD:9068941
G KPNB1 karyopherin subunit beta 1 JBrowse link 17 10,035,738 10,068,401 RGD:9068941
G LCK LCK proto-oncogene, Src family tyrosine kinase JBrowse link 1 32,567,712 32,579,923 RGD:9068941
G LOC100972994 HLA class II histocompatibility antigen, DQ beta 1 chain JBrowse link 6 33,353,599 33,360,284 RGD:9068941
G LOC100987081 HLA class II histocompatibility antigen, DR alpha chain JBrowse link 6 32,982,228 32,987,417 RGD:9068941
G LYN LYN proto-oncogene, Src family tyrosine kinase JBrowse link 8 49,755,745 49,825,287 RGD:9068941
G MAP2 microtubule associated protein 2 JBrowse link 2B 215,085,476 215,395,439 RGD:9068941
G MBL2 mannose binding lectin 2 JBrowse link 10 51,537,129 51,543,041 RGD:9068941
G MDM2 MDM2 proto-oncogene JBrowse link 12 69,102,083 69,133,278 RGD:9068941
G MKI67 marker of proliferation Ki-67 JBrowse link 10 128,933,508 128,963,280 RGD:9068941
G MVB12A multivesicular body subunit 12A JBrowse link 19 17,880,073 17,885,546 RGD:9068941
G MYH9 myosin heavy chain 9 JBrowse link 22 35,039,461 35,121,618 RGD:9068941
G NUP88 nucleoporin 88 JBrowse link 17 5,426,379 5,460,375 RGD:9068941
G NUTF2 nuclear transport factor 2 JBrowse link 16 67,575,435 67,601,053 RGD:9068941
G ODC1 ornithine decarboxylase 1 JBrowse link 2A 10,598,125 10,607,152 RGD:9068941
G OGG1 8-oxoguanine DNA glycosylase JBrowse link 3 9,940,955 9,972,658 RGD:9068941
G OPRM1 opioid receptor mu 1 JBrowse link 6 156,517,666 156,627,758 RGD:9068941
G PLA2G2A phospholipase A2 group IIA JBrowse link 1 19,973,352 19,977,627 RGD:9068941
G PPIB peptidylprolyl isomerase B JBrowse link 15 61,400,275 61,406,758 RGD:9068941
G PRF1 perforin 1 JBrowse link 10 69,597,574 69,603,070 RGD:9068941
G PRPF8 pre-mRNA processing factor 8 JBrowse link 17 1,532,579 1,565,254 RGD:9068941
G PSMA4 proteasome 20S subunit alpha 4 JBrowse link 15 76,431,890 76,440,661 RGD:9068941
G PSMA5 proteasome 20S subunit alpha 5 JBrowse link 1 111,013,553 111,031,944 RGD:9068941
G PSMA6 proteasome 20S subunit alpha 6 JBrowse link 14 34,227,495 34,252,354 RGD:9068941
G PSMB10 proteasome 20S subunit beta 10 JBrowse link 16 67,663,344 67,666,359 RGD:9068941
G PSMB4 proteasome 20S subunit beta 4 JBrowse link 1 130,404,234 130,406,638 RGD:9068941
G PSMC3 proteasome 26S subunit, ATPase 3 JBrowse link 11 47,920,295 47,927,654 RGD:9068941
G PSMC5 proteasome 26S subunit, ATPase 5 JBrowse link 17 63,051,050 63,055,911 RGD:9068941
G PSMD13 proteasome 26S subunit, non-ATPase 13 JBrowse link 11 278,353 294,685 RGD:9068941
G PSMD3 proteasome 26S subunit, non-ATPase 3 JBrowse link 17 17,511,189 17,528,506 RGD:9068941
G PSMD6 proteasome 26S subunit, non-ATPase 6 JBrowse link 3 65,291,810 65,304,861 RGD:9068941
G PSMD8 proteasome 26S subunit, non-ATPase 8 JBrowse link 19 44,040,252 44,049,265 RGD:9068941
G PSME1 proteasome activator subunit 1 JBrowse link 14 23,036,223 23,039,405 RGD:9068941
G PSME2 proteasome activator subunit 2 JBrowse link 14 23,043,807 23,047,296 RGD:9068941
G PSME3 proteasome activator subunit 3 JBrowse link 17 14,700,660 14,711,735 RGD:9068941
G PSME4 proteasome activator subunit 4 JBrowse link 2A 54,919,092 55,024,551 RGD:9068941
G PTCH1 patched 1 JBrowse link 9 94,668,792 94,741,517 RGD:9068941
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 166,355,845 166,364,517 RGD:9068941
G RAB11B RAB11B, member RAS oncogene family JBrowse link 19 8,526,294 8,540,147 RGD:9068941
G RAN RAN, member RAS oncogene family JBrowse link 12 132,694,498 132,699,668 RGD:9068941
G RANBP1 RAN binding protein 1 JBrowse link 22 18,550,699 18,560,875 RGD:9068941
G SELP selectin P JBrowse link 1 148,793,677 148,834,701 RGD:9068941
G SERPINA1 serpin family A member 1 JBrowse link 14 94,334,258 94,347,085 RGD:9068941
G SF3A3 splicing factor 3a subunit 3 JBrowse link 1 38,578,225 38,612,009 RGD:9068941
G SFPQ splicing factor proline and glutamine rich JBrowse link 1 35,624,862 35,641,551 RGD:9068941
G SIGMAR1 sigma non-opioid intracellular receptor 1 JBrowse link 9 35,280,777 35,283,672 RGD:9068941
G SIRT1 sirtuin 1 JBrowse link 10 66,681,983 66,714,065 RGD:9068941
G SLC11A1 solute carrier family 11 member 1 JBrowse link 2B 224,238,284 224,252,941 RGD:9068941
G SNRPD3 small nuclear ribonucleoprotein D3 polypeptide JBrowse link 22 22,227,328 22,255,511 RGD:9068941
G SOCS3 suppressor of cytokine signaling 3 JBrowse link 17 77,981,752 77,985,059 RGD:9068941
G SRF serum response factor JBrowse link 6 44,057,192 44,066,768 RGD:9068941
G SRSF1 serine and arginine rich splicing factor 1 JBrowse link 17 56,937,295 56,944,874 RGD:9068941
G SRSF9 serine and arginine rich splicing factor 9 JBrowse link 12 121,417,557 121,425,708 RGD:9068941
G TAF9 TATA-box binding protein associated factor 9 JBrowse link 5 46,201,985 46,207,254 RGD:9068941
G TLR3 toll like receptor 3 JBrowse link 4 190,446,487 190,462,728 RGD:9068941
RGD:7240710
G TNF tumor necrosis factor JBrowse link 6 32,126,618 32,129,389 RGD:9068941
G TRIM5 tripartite motif containing 5 JBrowse link 11 5,479,033 5,754,014 RGD:9068941
G U2AF1 U2 small nuclear RNA auxiliary factor 1 JBrowse link 21 42,707,738 42,719,086 RGD:9068941
G VDR vitamin D receptor JBrowse link 12 41,661,688 41,766,192 RGD:9068941
G YY1 YY1 transcription factor JBrowse link 14 100,173,287 100,217,651 RGD:9068941
Murine Acquired Immunodeficiency Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CD40 CD40 molecule JBrowse link 20 43,541,619 43,552,994 RGD:9068941
G CD40LG CD40 ligand JBrowse link X 136,042,849 136,055,158 RGD:9068941
G IL10 interleukin 10 JBrowse link 1 186,648,289 186,653,155 RGD:9068941
tropical spastic paraparesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C3 complement C3 JBrowse link 19 6,629,240 6,674,786 RGD:9068941
G HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 JBrowse link 12 35,182,164 35,188,651 RGD:9068941
G MMP2 matrix metallopeptidase 2 JBrowse link 16 54,817,228 54,844,279 RGD:9068941
G ZEB1 zinc finger E-box binding homeobox 1 JBrowse link 10 32,043,863 32,253,550 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 11950
    disease by infectious agent 738
      viral infectious disease 455
        RNA Virus Infections 337
          Retroviridae Infections 159
            Avian Leukosis 0
            Deltaretrovirus Infections + 4
            Feline Leukemia 0
            Human Spumaretrovirus Infection 0
            Lentivirus Infections + 156
            Murine Acquired Immunodeficiency Syndrome 3
            Ovine Pulmonary Adenomatosis 0
            Sarcoma, Avian 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.