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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Liver Metastasis
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Accession:DOID:9006618 term browser browse the term
Definition:Transfer of a neoplasm from its primary site to the liver.
Synonyms:exact_synonym: liver metastases;   metastatic liver disease;   secondary liver cancer

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Liver Metastasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase severity ISO associated with colorectal cancer;DNA:missense mutation:cds:p.V600E (human)
associated with skin melanoma;DNA:missense mutations:cds:
associated with colorectal cancer;DNA:mutations:multiple
associated with colorectal cancer;DNA:mutation:cds:
associated with colorectal cancer;DNA:missense mutations:cds:pV599E,p.V600E (human)		 RGD PMID:22331825 PMID:23010994 PMID:26775732 PMID:27737491 PMID:28787433 RGD:11554843 RGD:14696791 RGD:15039394 RGD:18337264 RGD:18337265 NCBI chrNW_004936592:4,728,371...4,833,830
Ensembl chrNW_004936592:4,737,011...4,834,664 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 treatment ISO associated with Animal Mammary Neoplasms; RGD PMID:15692764 RGD:14995455 NCBI chrNW_004936490:253,279...259,947
Ensembl chrNW_004936490:253,034...259,965 		JBrowse link
G Ccnd2 cyclin D2 ISO associated with colorectal cancer;protein:increased expression:colorectum RGD PMID:19508551 RGD:151665111 NCBI chrNW_004936606:4,474,801...4,496,158
Ensembl chrNW_004936606:4,474,749...4,496,810 		JBrowse link
G Ccng1 cyclin G1 treatment ISO human cells in mouse model RGD PMID:10910035 RGD:151356987 NCBI chrNW_004936515:614,287...621,213
Ensembl chrNW_004936515:614,290...619,963 		JBrowse link
G Cd44 CD44 molecule (IN blood group) ISO associated with Breast Neoplasm;protein:increased expression:liver RGD PMID:17991717 RGD:2289349 NCBI chrNW_004936533:2,949,026...3,033,166 JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 ameliorates ISO associated with human colon adenocarcinoma cells in a mouse model RGD PMID:28486105 RGD:153323299 NCBI chrNW_004936709:1,183,243...1,214,144
Ensembl chrNW_004936709:1,183,254...1,214,149 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 treatment ISO associated with colon carcinoma; RGD PMID:30381616 RGD:27095891 NCBI chrNW_004936676:60,869...63,028
Ensembl chrNW_004936676:60,621...63,106 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 ameliorates ISO associated with colorectal cancer; human cells in mouse model RGD PMID:30789971 RGD:151893289 NCBI chrNW_004936617:4,224,131...4,239,080
Ensembl chrNW_004936617:4,224,131...4,238,796 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ameliorates ISO associated with colorectal cancer; human cells in mouse model
human cells in mouse model; associated with colorectal cancer		 RGD PMID:29436696 PMID:30789971 RGD:151893289 RGD:152023643 NCBI chrNW_004936469:39,794,613...39,798,448
Ensembl chrNW_004936469:39,794,584...39,798,459 		JBrowse link
G Daxx death domain associated protein exacerbates ISO associated with colon cancer; mRNA:decreased expression:liver (human)
associated with pancreatic endocrine carcinoma;DNA:mutations:CDS:multiple (human)
associated with neuroendocrine tumor;DNA:mutations:CDS:multiple (human)		 RGD PMID:30339629 PMID:30342802 PMID:31942198 RGD:152025194 RGD:152025199 RGD:152025203 NCBI chrNW_004936476:25,546,091...25,550,390
Ensembl chrNW_004936476:25,546,036...25,550,392 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 treatment ISO human cells in mouse model; nilotinib
mRNA:increased expression:liver (mouse)		 RGD PMID:29438985 PMID:30666650 PMID:33110221 RGD:151347537 RGD:151347685 RGD:151347840 NCBI chrNW_004936837:523,227...538,799
Ensembl chrNW_004936837:523,266...538,833 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 ameliorates ISO associated with colon carcinoma
associated with melanoma;		 RGD PMID:21701781 PMID:22071959 RGD:150429701 RGD:150429713 NCBI chrNW_004936831:799,948...946,139
Ensembl chrNW_004936831:865,965...946,139 		JBrowse link
G Dock6 dedicator of cytokinesis 6 ameliorates ISO associated with stomach cancer; RGD PMID:29587866 RGD:155791564 NCBI chrNW_004936659:1,341,144...1,394,484
Ensembl chrNW_004936659:1,341,331...1,379,728 		JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 disease_progression ISO associated with colorectal cancer; RGD PMID:28846828 RGD:21408566 NCBI chrNW_004936689:2,261,163...2,449,951
Ensembl chrNW_004936689:2,259,477...2,344,764 		JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO associated with colorectal cancer;mRNA:increased expression:colorectal mucosa: RGD PMID:19082464 RGD:25330357 NCBI chrNW_004936710:1,760,365...1,815,269
Ensembl chrNW_004936710:1,760,089...1,815,508 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit ISO human cells in mouse model RGD PMID:30114390 RGD:153344554 NCBI chrNW_004936493:4,308,683...4,327,102
Ensembl chrNW_004936493:4,304,395...4,327,179 		JBrowse link
G Gpc3 glypican 3 ISO protein:increased expression:blood serum (human) RGD PMID:28801286 RGD:243065135 NCBI chrNW_004936691:1,060,013...1,459,736
Ensembl chrNW_004936691:1,059,994...1,459,740 		JBrowse link
G Hmbs hydroxymethylbilane synthase ISO associated with colon adenocarcinoma;protein:decreased activity:liver(rat) RGD PMID:1386052 RGD:25440496 NCBI chrNW_004936542:4,037,888...4,046,089
Ensembl chrNW_004936542:4,037,201...4,050,810 		JBrowse link
G Il2 interleukin 2 treatment ISO associated with Colorectal Neoplasms, Carcinoma, Hepatocellular;
associated with colon carcinoma		 RGD PMID:9354462 PMID:11591892 RGD:14928215 RGD:8663446 NCBI chrNW_004936662:1,594,953...1,599,625
Ensembl chrNW_004936662:1,594,953...1,599,625 		JBrowse link
G Iqsec1 IQ motif and Sec7 domain ArfGEF 1 ISO human cells in mouse model RGD PMID:22662237 RGD:153344589 NCBI chrNW_004936898:318,564...425,785
Ensembl chrNW_004936898:337,400...425,859 		JBrowse link
G LOC101964975 interleukin-8 ISO associated with colorectal cancer; human colon adenocarcinoma cells in a mouse model RGD PMID:29679563 RGD:26884358 NCBI chrNW_004936598:1,779,471...1,781,353
Ensembl chrNW_004936598:1,779,471...1,781,353 		JBrowse link
G LOC101968921 angiotensin-converting enzyme ISO associated with colorectal cancer;mRNA:increased expression:liver (mouse) RGD PMID:20380732 RGD:25671446 NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177 		JBrowse link
G Map2k7 mitogen-activated protein kinase kinase 7 ISO associated with colon cancer;protein:increased expression:colon (human) RGD PMID:24533778 RGD:155259116 NCBI chrNW_004936588:4,882,191...4,891,807
Ensembl chrNW_004936588:4,882,184...4,892,071 		JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor exacerbates
severity		 ISO associated with pancreatic cancer; protein:increased expression:liver, pancreas (human)
associated with pancreatic ductal adenocarcinoma; human cells in mouse model
associated with colorectal carcinoma;protein:increased expression:colorectum (human)		 RGD PMID:23747337 PMID:30770989 RGD:126925751 RGD:126925752 NCBI chrNW_004936474:24,744,673...24,757,189
Ensembl chrNW_004936474:24,744,673...24,757,085 		JBrowse link
G Nras NRAS proto-oncogene, GTPase susceptibility ISO human gene in a mouse model;DNA:missense mutations:cds:p.G12V, p.Q61K (human)
associated with melanoma;DNA:mutations: exons (human)
associated with colorectal cancer;DNA:mutations:exons (human)		 RGD PMID:26799184 PMID:28011498 PMID:28787433 RGD:14696774 RGD:14696791 RGD:14696792 NCBI chrNW_004936627:73,413...82,590
Ensembl chrNW_004936627:73,413...82,590 		JBrowse link
G Ptprb protein tyrosine phosphatase receptor type B treatment ISO mouse tumor cells in mouse recipient RGD PMID:31348125 RGD:151660353 NCBI chrNW_004936545:8,150,766...8,235,674
Ensembl chrNW_004936545:8,147,291...8,235,715 		JBrowse link
G Rictor RPTOR independent companion of MTOR complex 2 disease_progression ISO mRNA:increased expression:liver (human) RGD PMID:30404068 RGD:152995463 NCBI chrNW_004936518:3,198,312...3,314,393
Ensembl chrNW_004936518:3,198,337...3,310,000 		JBrowse link
G Rnf43 ring finger protein 43 ISO associated with colorectal adenocarcinoma;mRNA:increased expression:liver (human) RGD PMID:28789449 RGD:151361221 NCBI chrNW_004936490:4,660,904...4,742,669
Ensembl chrNW_004936490:4,683,725...4,741,828 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 severity ISO associated with colon adenocarcinoma RGD PMID:11745822 RGD:151361130 NCBI chrNW_004936581:424,801...441,592 JBrowse link
G Slc7a5 solute carrier family 7 member 5 severity ISO associated with colon adenocarcinoma
associated with colon cancer		 RGD PMID:11718450 PMID:11745822 RGD:151361129 RGD:151361130 NCBI chrNW_004936641:1,513,110...1,538,955 JBrowse link
G Smad4 SMAD family member 4 treatment ISO associated with colorectal carcinoma;protein:decreased expression:colorectum:
associated with colorectal carcinoma; DNA:mutations: :		 RGD PMID:17390050 PMID:29551247 RGD:18937000 RGD:21066338 NCBI chrNW_004936497:12,242,869...12,278,012
Ensembl chrNW_004936497:12,249,140...12,278,123 		JBrowse link
G Sox30 SRY-box transcription factor 30 ameliorates ISO RGD PMID:29739711 RGD:151660333 NCBI chrNW_004936515:5,501,315...5,537,946
Ensembl chrNW_004936515:5,458,393...5,537,946 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase disease_progression ISO associated with colon cancer;protein:increased activity:colon RGD PMID:7678609 RGD:150521542 NCBI chrNW_004936561:3,826,802...3,844,406
Ensembl chrNW_004936561:3,825,787...3,844,483 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO associated with colorectal carcinoma;mRNA,protein:increased expression:liver: RGD PMID:22156924 RGD:15014782 NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16465
    disease of cellular proliferation 6811
      Neoplastic Processes 641
        Neoplasm Metastasis 437
          Liver Metastasis 34
Path 2
Term Annotations click to browse term
  disease 16465
    disease of anatomical entity 14117
      gastrointestinal system disease 6071
        Digestive System Neoplasms 3459
          Gastrointestinal Neoplasms 3342
            gastrointestinal system cancer 2622
              hepatobiliary system cancer 973
                liver cancer 896
                  Liver Metastasis 34
paths to the root