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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Fatigue
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Accession:DOID:9006617 term browser browse the term
Definition:The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
Synonyms:exact_synonym: Lassitude
 primary_id: MESH:D005221


show annotations for term's descendants           Sort by:
Fatigue term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALAD aminolevulinate dehydratase ISO mRNA, protein:decreased expression:liver (rat) RGD PMID:17204241 RGD:1599013 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290 		JBrowse link
G COMT catechol-O-methyltransferase severity IAGP associated with breast cancer;DNA:missense mutation:cds:p.V158M (human) RGD PMID:21898113 RGD:8662332 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975 		JBrowse link
G EPO erythropoietin EXP CTD Direct Evidence: therapeutic CTD PMID:18695134 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700 		JBrowse link
G IFNA2 interferon alpha 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:8759893 NCBI chr 9:21,384,255...21,385,398
Ensembl chr 9:21,384,255...21,385,398 		JBrowse link
G SOD1 superoxide dismutase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28123103 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16885183 NCBI chr 3:30,606,356...30,694,142
Ensembl chr 3:30,606,478...30,694,249 		JBrowse link
G TNFRSF10A TNF receptor superfamily member 10a EXP CTD Direct Evidence: marker/mechanism CTD PMID:19652058 NCBI chr 8:23,190,452...23,225,102
Ensembl chr 8:23,190,452...23,225,102 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B IEP protein:increased expression:serum RGD PMID:12140350 RGD:8661748 NCBI chr 1:12,166,991...12,209,220
Ensembl chr 1:12,166,991...12,209,228 		JBrowse link
corticosteroid-binding globulin deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SERPINA6 serpin family A member 6 IAGP
ISS
EXP		 ClinVar Annotator: match by term: Corticosteroid-binding globulin deficiency
ClinVar Annotator: match by term: Corticosteroid-binding globulin deficiency | ClinVar Annotator: match by term: SERPINA6-related condition
OMIM:611489
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: TRANSCORTIN DEFICIENCY		 ClinVar
MouseDO
CTD
OMIM		 PMID:1504007 PMID:7061486 PMID:8212073 PMID:10634411 PMID:11502797 More... NCBI chr14:94,304,248...94,323,336
Ensembl chr14:94,304,248...94,323,389 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 112207
    Pathological Conditions, Signs and Symptoms 63852
      Signs and Symptoms 42225
        Fatigue 9
          Mental Fatigue + 0
          corticosteroid-binding globulin deficiency 1
paths to the root