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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Enterovirus Infections
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Accession:DOID:9006549 term browser browse the term
Definition:Diseases caused by ENTEROVIRUS.
Synonyms:exact_synonym: Enterovirus Infection
 primary_id: MESH:D004769;   RDO:0001633
For additional species annotation, visit the Alliance of Genome Resources.


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Enterovirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btk Bruton agammaglobulinemia tyrosine kinase treatment IMP Associated with X-linked agammaglobulinemia RGD PMID:10508272 RGD:124715472 NCBI chr  X:134,542,334...134,583,628
Ensembl chr  X:134,542,336...134,583,570
JBrowse link
G Cog1 component of oligomeric golgi complex 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr11:113,649,178...113,669,331
Ensembl chr11:113,649,169...113,667,054
JBrowse link
G Cog5 component of oligomeric golgi complex 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr12:31,654,819...31,937,630
Ensembl chr12:31,654,869...31,937,630
JBrowse link
G Il10 interleukin 10 severity ISO DNA:SNP:promoter:-592A>C (rs1800872) (human) RGD PMID:28843383 RGD:14975146 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Mgat5 mannoside acetylglucosaminyltransferase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr 1:127,204,919...127,488,334
Ensembl chr 1:127,205,015...127,488,336
JBrowse link
G Mir146 microRNA 146 ameliorates ISO
IMP
miRNA:increased expression:blood serum, exosome (human) RGD PMID:28910400, PMID:24561744 RGD:126925164, RGD:126925173 NCBI chr11:43,374,397...43,374,461
Ensembl chr11:43,374,397...43,374,461
JBrowse link
G Mx1 MX dynamin-like GTPase 1 susceptibility ISO DNA:SNPs:promoter:g.-123C>A, g.-88G>T (rs17000900, rs2071430) (human) RGD PMID:24085612 RGD:126777678 NCBI chr16:97,447,035...97,462,906
Ensembl chr16:97,447,035...97,462,907
JBrowse link
G Slc22a4 solute carrier family 22 (organic cation transporter), member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21641380 NCBI chr11:53,983,115...54,030,040
Ensembl chr11:53,983,123...54,028,090
JBrowse link
G St3gal1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr15:67,102,875...67,176,946
Ensembl chr15:67,102,875...67,176,830
JBrowse link
G St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr 9:35,046,576...35,116,864
Ensembl chr 9:35,046,576...35,119,268
JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a IMP Rhinovirus Infections RGD PMID:19864593 RGD:5131210 NCBI chr 6:125,349,723...125,362,483
Ensembl chr 6:125,349,362...125,362,484
JBrowse link
anogenital venereal wart term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl20 chemokine (C-C motif) ligand 20 ISO protein:decreased expression:skin RGD PMID:17545018 RGD:7483603 NCBI chr 1:83,116,766...83,119,167
Ensembl chr 1:83,116,766...83,119,167
JBrowse link
G Cd8a CD8 antigen, alpha chain ISO mRNA:decreased expression:zone of skin (human) RGD PMID:25774455 RGD:36174028 NCBI chr 6:71,373,427...71,379,171
Ensembl chr 6:71,373,427...71,379,173
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 1:60,909,025...60,915,832
Ensembl chr 1:60,887,000...60,915,832
JBrowse link
G Foxp3 forkhead box P3 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr  X:7,579,676...7,595,243
Ensembl chr  X:7,573,644...7,595,245
JBrowse link
G Ifna16 interferon alpha 16 treatment ISO RGD PMID:25774455 RGD:36174028 NCBI chr 4:88,676,287...88,676,856
Ensembl chr 4:88,675,915...88,676,924
JBrowse link
G Il10 interleukin 10 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il12b interleukin 12b treatment ISO protein:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:16114559, PMID:23754510 RGD:7829774, RGD:40400714 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Il2 interleukin 2 ISO protein:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:23754510 RGD:40400714 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il21 interleukin 21 ISO protein:decreased expression:blood serum (human) RGD PMID:31414711 RGD:127285371 NCBI chr 3:37,222,759...37,232,636
Ensembl chr 3:37,222,759...37,232,636
JBrowse link
G Il4 interleukin 4 treatment ISO protein:increased expression:peripheral blood mononuclear cells (human) RGD PMID:16114559, PMID:23754510 RGD:7829774, RGD:40400714 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il6 interleukin 6 ISO protein:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:23754510 RGD:40400714 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Klrk1 killer cell lectin-like receptor subfamily K, member 1 ISO mRNA,protein:decreased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 6:129,610,323...129,623,903
Ensembl chr 6:129,610,323...129,623,864
JBrowse link
G Myd88 myeloid differentiation primary response gene 88 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 9:119,335,934...119,340,018
Ensembl chr 9:119,335,934...119,341,411
JBrowse link
G Ncr1 natural cytotoxicity triggering receptor 1 ISO mRNA,protein:decreased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 7:4,337,715...4,345,184
Ensembl chr 7:4,337,724...4,345,164
JBrowse link
G Pdcd1 programmed cell death 1 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 1:94,038,305...94,052,553
Ensembl chr 1:94,038,305...94,052,553
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO protein:increased expression:foreskin RGD PMID:18543080 RGD:39128248 NCBI chr 5:121,130,533...121,191,397
Ensembl chr 5:121,130,533...121,191,397
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO protein:increased expression:foreskin RGD PMID:18543080 RGD:39128248 NCBI chr 6:124,720,707...124,738,709
Ensembl chr 6:124,720,707...124,738,714
JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 disease_progression ISO mRNA, protein:decreased expression:skin of body (human) RGD PMID:23569025 RGD:27226706 NCBI chr11:75,410,029...75,422,623
Ensembl chr11:75,409,769...75,422,701
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tlr2 toll-like receptor 2 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 3:83,836,272...83,841,824
Ensembl chr 3:83,836,272...83,841,767
JBrowse link
G Tlr3 toll-like receptor 3 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 8:45,395,665...45,411,075
Ensembl chr 8:45,395,665...45,411,080
JBrowse link
G Tlr4 toll-like receptor 4 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
G Tlr7 toll-like receptor 7 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr  X:167,303,380...167,330,574
Ensembl chr  X:167,304,929...167,330,558
JBrowse link
G Tlr8 toll-like receptor 8 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr  X:167,241,123...167,264,329
Ensembl chr  X:167,242,696...167,264,329
JBrowse link
G Tlr9 toll-like receptor 9 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 9:106,222,598...106,226,876
Ensembl chr 9:106,222,598...106,226,883
JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:peripheral blood mononuclear cells (human) RGD PMID:23754510 RGD:40400714 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfrsf18 tumor necrosis factor receptor superfamily, member 18 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 4:156,026,322...156,028,894
Ensembl chr 4:156,026,164...156,028,895
JBrowse link
Coxsackievirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 antigen IEP protein:increased expression:spleen, mononuclear cell (mouse) RGD PMID:16817758 RGD:127345109 NCBI chr 3:86,995,834...87,012,358
Ensembl chr 3:86,995,834...86,999,441
JBrowse link
G Cd274 CD274 antigen treatment IDA RGD PMID:30904424 RGD:40818421 NCBI chr19:29,362,107...29,388,095
Ensembl chr19:29,367,455...29,388,095
JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25396421 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 treatment IDA RGD PMID:30904424 RGD:40818421 NCBI chr19:29,410,919...29,472,927
Ensembl chr19:29,410,919...29,471,161
JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16683188 NCBI chr12:112,644,828...112,649,152
Ensembl chr12:112,644,679...112,649,149
JBrowse link
G Slc22a3 solute carrier family 22 (organic cation transporter), member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21641380 NCBI chr17:12,419,972...12,507,704
Ensembl chr17:12,418,960...12,507,704
JBrowse link
G Slc22a4 solute carrier family 22 (organic cation transporter), member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21641380 NCBI chr11:53,983,115...54,030,040
Ensembl chr11:53,983,123...54,028,090
JBrowse link
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21641380 NCBI chr11:53,864,542...53,891,796
Ensembl chr11:53,864,542...53,891,660
JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25396421 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfsf8 tumor necrosis factor (ligand) superfamily, member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11745696 NCBI chr 4:63,831,202...63,861,508
Ensembl chr 4:63,831,308...63,861,347
JBrowse link
G Tnfsf9 tumor necrosis factor (ligand) superfamily, member 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11745696 NCBI chr17:57,105,287...57,107,758
Ensembl chr17:57,105,325...57,107,757
JBrowse link
hand, foot and mouth disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta ISO protein:increased expression:serum RGD PMID:30817906 RGD:36947391 NCBI chr 5:142,903,115...142,907,976
Ensembl chr 5:142,903,115...142,906,754
JBrowse link
G Ren1 renin 1 structural treatment ISO RGD PMID:31638922 RGD:127285374 NCBI chr 1:133,350,674...133,360,320
Ensembl chr 1:133,350,510...133,360,325
JBrowse link
hepatitis A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ISO DNA:insertion/deletion:intron 16: RGD PMID:12458570 RGD:39939119 NCBI chr11:105,967,948...105,989,964
Ensembl chr11:105,967,945...105,989,964
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 disease_progression ISO RGD PMID:26347518 RGD:40818419 NCBI chr 1:60,909,025...60,915,832
Ensembl chr 1:60,887,000...60,915,832
JBrowse link
G Pdcd1 programmed cell death 1 disease_progression ISO RGD PMID:26347518 RGD:40818419 NCBI chr 1:94,038,305...94,052,553
Ensembl chr 1:94,038,305...94,052,553
JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:serum (human) RGD PMID:9047083 RGD:14995307 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Xrcc1 X-ray repair complementing defective repair in Chinese hamster cells 1 susceptibility ISO DNA:missense mutation:cds:p.R194W (rs1799782) (human)
DNA:SNP:intron: (rs1001581) (human)
RGD PMID:22135187, PMID:29558945 RGD:15014793, RGD:15036793 NCBI chr 7:24,546,699...24,573,438
Ensembl chr 7:24,546,289...24,573,440
JBrowse link
Keshan disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 ISO mRNA,protein:increased expression:blood cells, serum: RGD PMID:26893848 RGD:124713562 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 ISO mRNA,protein:increased expression:blood cells, serum: RGD PMID:26893848 RGD:124713562 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Gpx1 glutathione peroxidase 1 ISO DNA:polymorphism: :p.P198L (human) RGD PMID:21055077 RGD:11352821 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
poliomyelitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pvr poliovirus receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:3020560 PMID:28446605 NCBI chr 7:19,903,578...19,921,143
Ensembl chr 7:19,903,578...19,921,160
JBrowse link
vestibular neuronitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein, pentraxin-related disease_progression ISO RGD PMID:14636287 RGD:9491594 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14453
    disease by infectious agent 1895
      viral infectious disease 1585
        RNA Virus Infections 1383
          Picornaviridae Infections 79
            Enterovirus Infections 54
              Coxsackievirus Infections + 38
              Echovirus Infections + 27
              Encephalomyelitis, Enzootic Porcine 0
              Keshan disease 3
              Swine Vesicular Disease 0
              acute hemorrhagic conjunctivitis 0
              hepatitis A 5
              poliomyelitis + 2
paths to the root