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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Enterovirus Infections
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Accession:DOID:9006549 term browser browse the term
Definition:Diseases caused by ENTEROVIRUS.
Synonyms:exact_synonym: Enterovirus Infection
 primary_id: MESH:D004769;   RDO:0001633
For additional species annotation, visit the Alliance of Genome Resources.


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Enterovirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTK Bruton tyrosine kinase treatment ISO Associated with X-linked agammaglobulinemia RGD PMID:10508272 RGD:124715472 NCBI chr  X:101,349,450...101,390,796
Ensembl chr  X:101,349,447...101,390,796
JBrowse link
G COG1 component of oligomeric golgi complex 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr17:73,193,055...73,208,507
Ensembl chr17:73,192,632...73,208,507
JBrowse link
G COG5 component of oligomeric golgi complex 5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr 7:107,201,372...107,564,361
Ensembl chr 7:107,201,372...107,564,261
JBrowse link
G IL10 interleukin 10 severity IAGP DNA:SNP:promoter:-592A>C (rs1800872) (human) RGD PMID:28843383 RGD:14975146 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G MGAT5 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase EXP CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr 2:134,119,922...134,454,621
Ensembl chr 2:134,119,983...134,454,621
JBrowse link
G MIR146A microRNA 146a ameliorates IEP
ISO
miRNA:increased expression:blood serum, exosome (human) RGD PMID:28910400, PMID:24561744 RGD:126925164, RGD:126925173 NCBI chr 5:160,485,352...160,485,450
Ensembl chr 5:160,485,352...160,485,450
JBrowse link
G MX1 MX dynamin like GTPase 1 susceptibility IAGP DNA:SNPs:promoter:g.-123C>A, g.-88G>T (rs17000900, rs2071430) (human) RGD PMID:24085612 RGD:126777678 NCBI chr21:41,420,329...41,459,214
Ensembl chr21:41,420,020...41,470,071
JBrowse link
G SLC22A4 solute carrier family 22 member 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21641380 NCBI chr 5:132,294,384...132,344,199
Ensembl chr 5:132,294,394...132,344,190
JBrowse link
G ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr 8:133,454,848...133,572,534
Ensembl chr 8:133,454,848...133,571,940
JBrowse link
G ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr11:126,355,686...126,414,638
Ensembl chr11:126,355,640...126,440,344
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO Rhinovirus Infections RGD PMID:19864593 RGD:5131210 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
JBrowse link
anogenital venereal wart term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL20 C-C motif chemokine ligand 20 IEP protein:decreased expression:skin RGD PMID:17545018 RGD:7483603 NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564
JBrowse link
G CD8A CD8a molecule HEP mRNA:decreased expression:zone of skin (human) RGD PMID:25774455 RGD:36174028 NCBI chr 2:86,784,605...86,808,396
Ensembl chr 2:86,784,610...86,808,396
JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 IEP mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,867,771...203,873,965
JBrowse link
G FOXP3 forkhead box P3 IEP mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr  X:49,250,436...49,264,932
Ensembl chr  X:49,250,438...49,270,477
JBrowse link
G IFNA6 interferon alpha 6 treatment IEP RGD PMID:25774455 RGD:36174028 NCBI chr 9:21,350,318...21,350,887
Ensembl chr 9:21,349,835...21,351,378
JBrowse link
G IL10 interleukin 10 IEP mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL12B interleukin 12B treatment IEP protein:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:16114559, PMID:23754510 RGD:7829774, RGD:40400714 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G IL2 interleukin 2 IEP protein:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:23754510 RGD:40400714 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL21 interleukin 21 IEP protein:decreased expression:blood serum (human) RGD PMID:31414711 RGD:127285371 NCBI chr 4:122,610,108...122,621,066
Ensembl chr 4:122,610,108...122,621,066
JBrowse link
G IL4 interleukin 4 treatment IEP protein:increased expression:peripheral blood mononuclear cells (human) RGD PMID:16114559, PMID:23754510 RGD:7829774, RGD:40400714 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 IEP protein:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:23754510 RGD:40400714 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G KLRK1 killer cell lectin like receptor K1 IEP mRNA,protein:decreased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr12:10,372,353...10,390,041
Ensembl chr12:10,372,353...10,391,874
JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor IEP mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,478...38,143,022
JBrowse link
G NCR1 natural cytotoxicity triggering receptor 1 IEP mRNA,protein:decreased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr19:54,906,063...54,938,211
Ensembl chr19:54,906,148...54,916,140
JBrowse link
G PDCD1 programmed cell death 1 IEP mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 2:241,849,881...241,858,908
Ensembl chr 2:241,849,884...241,858,894
JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 IEP protein:increased expression:foreskin RGD PMID:18543080 RGD:39128248 NCBI chr12:112,418,915...112,509,918
Ensembl chr12:112,418,351...112,509,918
JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 IEP protein:increased expression:foreskin RGD PMID:18543080 RGD:39128248 NCBI chr12:6,946,577...6,961,316
Ensembl chr12:6,946,468...6,961,316
JBrowse link
G SERPINF1 serpin family F member 1 disease_progression IEP mRNA, protein:decreased expression:skin of body (human) RGD PMID:23569025 RGD:27226706 NCBI chr17:1,762,060...1,777,565
Ensembl chr17:1,762,029...1,777,565
JBrowse link
G TGFB1 transforming growth factor beta 1 IEP mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TLR2 toll like receptor 2 IEP mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 4:153,684,080...153,710,643
Ensembl chr 4:153,684,070...153,706,260
JBrowse link
G TLR3 toll like receptor 3 IEP mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 4:186,069,156...186,088,073
Ensembl chr 4:186,069,155...186,088,073
JBrowse link
G TLR4 toll like receptor 4 IEP mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TLR7 toll like receptor 7 IEP mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr  X:12,867,072...12,890,361
Ensembl chr  X:12,867,072...12,890,361
JBrowse link
G TLR8 toll like receptor 8 IEP mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr  X:12,906,620...12,923,169
Ensembl chr  X:12,906,620...12,923,169
JBrowse link
G TLR9 toll like receptor 9 IEP mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 3:52,221,080...52,225,645
Ensembl chr 3:52,221,080...52,225,645
JBrowse link
G TNF tumor necrosis factor IEP protein:increased expression:peripheral blood mononuclear cells (human) RGD PMID:23754510 RGD:40400714 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF18 TNF receptor superfamily member 18 IEP mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 1:1,203,508...1,207,901
Ensembl chr 1:1,203,508...1,206,592
JBrowse link
Coxsackievirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD1D CD1d molecule ISO protein:increased expression:spleen, mononuclear cell (mouse) RGD PMID:16817758 RGD:127345109 NCBI chr 1:158,178,030...158,186,427
Ensembl chr 1:158,178,030...158,186,427
JBrowse link
G CD274 CD274 molecule treatment ISO RGD PMID:30904424 RGD:40818421 NCBI chr 9:5,450,542...5,470,554
Ensembl chr 9:5,450,503...5,470,566
JBrowse link
G IL6 interleukin 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25396421 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G PDCD1LG2 programmed cell death 1 ligand 2 treatment ISO RGD PMID:30904424 RGD:40818421 NCBI chr 9:5,510,438...5,571,282
Ensembl chr 9:5,510,531...5,571,282
JBrowse link
G SIVA1 SIVA1 apoptosis inducing factor EXP CTD Direct Evidence: marker/mechanism CTD PMID:16683188 NCBI chr14:104,752,420...104,759,659
Ensembl chr14:104,753,147...104,768,494
JBrowse link
G SLC22A3 solute carrier family 22 member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21641380 NCBI chr 6:160,348,378...160,454,982
Ensembl chr 6:160,348,378...160,452,577
JBrowse link
G SLC22A4 solute carrier family 22 member 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21641380 NCBI chr 5:132,294,384...132,344,199
Ensembl chr 5:132,294,394...132,344,190
JBrowse link
G SLC22A5 solute carrier family 22 member 5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21641380 NCBI chr 5:132,369,704...132,395,614
Ensembl chr 5:132,369,710...132,395,613
JBrowse link
G TNF tumor necrosis factor EXP CTD Direct Evidence: marker/mechanism CTD PMID:25396421 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFSF8 TNF superfamily member 8 EXP CTD Direct Evidence: marker/mechanism CTD PMID:11745696 NCBI chr 9:114,893,343...114,930,674
Ensembl chr 9:114,893,343...114,930,595
JBrowse link
G TNFSF9 TNF superfamily member 9 EXP CTD Direct Evidence: marker/mechanism CTD PMID:11745696 NCBI chr19:6,531,026...6,535,924
Ensembl chr19:6,531,026...6,535,924
JBrowse link
hand, foot and mouth disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTB actin beta IEP protein:increased expression:serum RGD PMID:30817906 RGD:36947391 NCBI chr 7:5,527,148...5,530,601
Ensembl chr 7:5,526,409...5,563,902
JBrowse link
G REN renin treatment IDA RGD PMID:31638922 RGD:127285374 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
hepatitis A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme IAGP DNA:insertion/deletion:intron 16: RGD PMID:12458570 RGD:39939119 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 disease_progression IEP RGD PMID:26347518 RGD:40818419 NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,867,771...203,873,965
JBrowse link
G PDCD1 programmed cell death 1 disease_progression IEP RGD PMID:26347518 RGD:40818419 NCBI chr 2:241,849,881...241,858,908
Ensembl chr 2:241,849,884...241,858,894
JBrowse link
G TNF tumor necrosis factor IEP protein:increased expression:serum (human) RGD PMID:9047083 RGD:14995307 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G XRCC1 X-ray repair cross complementing 1 susceptibility IAGP DNA:missense mutation:cds:p.R194W (rs1799782) (human)
DNA:SNP:intron: (rs1001581) (human)
RGD PMID:22135187, PMID:29558945 RGD:15014793, RGD:15036793 NCBI chr19:43,543,311...43,575,527
Ensembl chr19:43,543,311...43,580,473
JBrowse link
Keshan disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 IEP mRNA,protein:increased expression:blood cells, serum: RGD PMID:26893848 RGD:124713562 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 IEP mRNA,protein:increased expression:blood cells, serum: RGD PMID:26893848 RGD:124713562 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G GPX1 glutathione peroxidase 1 IAGP DNA:polymorphism: :p.P198L (human) RGD PMID:21055077 RGD:11352821 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,353
JBrowse link
poliomyelitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PVR PVR cell adhesion molecule EXP CTD Direct Evidence: marker/mechanism CTD PMID:3020560 PMID:28446605 NCBI chr19:44,643,910...44,666,162
Ensembl chr19:44,643,798...44,666,162
JBrowse link
vestibular neuronitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRP C-reactive protein disease_progression IEP RGD PMID:14636287 RGD:9491594 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 20175
    disease by infectious agent 2234
      viral infectious disease 1914
        RNA Virus Infections 1695
          Picornaviridae Infections 78
            Enterovirus Infections 54
              Coxsackievirus Infections + 38
              Echovirus Infections + 27
              Encephalomyelitis, Enzootic Porcine 0
              Keshan disease 3
              Swine Vesicular Disease 0
              acute hemorrhagic conjunctivitis 0
              hepatitis A 5
              poliomyelitis + 2
paths to the root