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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Enterovirus Infections
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Accession:DOID:9006549 term browser browse the term
Definition:Diseases caused by ENTEROVIRUS.
Synonyms:exact_synonym: Enterovirus Infection
 primary_id: MESH:D004769;   RDO:0001633
For additional species annotation, visit the Alliance of Genome Resources.


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Enterovirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTK Bruton tyrosine kinase treatment ISO Associated with X-linked agammaglobulinemia RGD PMID:10508272 RGD:124715472 NCBI chr  X:90,551,874...90,588,786
Ensembl chr  X:100,684,017...100,725,187
JBrowse link
G COG1 component of oligomeric golgi complex 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr17:67,120,989...67,136,480
Ensembl chr17:72,576,526...72,591,953
JBrowse link
G COG5 component of oligomeric golgi complex 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr 7:99,180,197...99,543,437
Ensembl chr 7:111,934,557...112,266,513
JBrowse link
G IL10 interleukin 10 severity ISO DNA:SNP:promoter:-592A>C (rs1800872) (human) RGD PMID:28843383 RGD:14975146 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
JBrowse link
G MGAT5 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr2B:25,394,435...25,724,420
Ensembl chr2B:138,344,539...138,538,857
JBrowse link
G MX1 MX dynamin like GTPase 1 susceptibility ISO DNA:SNPs:promoter:g.-123C>A, g.-88G>T (rs17000900, rs2071430) (human) RGD PMID:24085612 RGD:126777678 NCBI chr21:27,756,768...27,795,307
Ensembl chr21:41,095,928...41,123,019
JBrowse link
G SLC22A4 solute carrier family 22 member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21641380 NCBI chr 5:127,717,077...127,766,793
Ensembl chr 5:133,879,387...133,929,439
JBrowse link
G ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr 8:130,111,085...130,227,195
Ensembl chr 8:133,084,835...133,119,791
JBrowse link
G ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28446605 NCBI chr11:121,169,213...121,228,287
Ensembl chr11:125,079,260...125,141,737
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO Rhinovirus Infections RGD PMID:19864593 RGD:5131210 NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613
JBrowse link
anogenital venereal wart term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL20 C-C motif chemokine ligand 20 ISO protein:decreased expression:skin RGD PMID:17545018 RGD:7483603 NCBI chr2B:115,052,768...115,056,479
Ensembl chr2B:233,862,505...233,866,225
JBrowse link
G CD8A CD8a molecule ISO mRNA:decreased expression:zone of skin (human) RGD PMID:25774455 RGD:36174028 NCBI chr2A:86,832,559...86,855,772
Ensembl chr2A:88,377,722...88,382,635
JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498
JBrowse link
G FOXP3 forkhead box P3 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029
JBrowse link
G IFNA6 interferon alpha 6 treatment ISO RGD PMID:25774455 RGD:36174028 NCBI chr 9:21,211,046...21,211,734
Ensembl chr 9:21,828,719...21,829,288
JBrowse link
G IL10 interleukin 10 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
JBrowse link
G IL12B interleukin 12B treatment ISO protein:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:16114559 PMID:23754510 RGD:40400714 RGD:7829774 NCBI chr 5:154,706,467...154,722,231
Ensembl chr 5:161,325,303...161,335,381
JBrowse link
G IL2 interleukin 2 ISO protein:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:23754510 RGD:40400714 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984
JBrowse link
G IL21 interleukin 21 ISO protein:decreased expression:blood serum (human) RGD PMID:31414711 RGD:127285371 NCBI chr 4:114,795,979...114,806,936
Ensembl chr 4:125,943,495...125,951,915
JBrowse link
G IL4 interleukin 4 treatment ISO protein:increased expression:peripheral blood mononuclear cells (human) RGD PMID:16114559 PMID:23754510 RGD:40400714 RGD:7829774 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581
JBrowse link
G IL6 interleukin 6 ISO protein:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:23754510 RGD:40400714 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G KLRK1 killer cell lectin like receptor K1 ISO mRNA,protein:decreased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr12:10,411,932...10,429,256
Ensembl chr12:10,662,424...10,699,078
JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 3:38,036,565...38,041,014
Ensembl chr 3:38,319,024...38,323,572
JBrowse link
G NCR1 natural cytotoxicity triggering receptor 1 ISO mRNA,protein:decreased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr19:51,951,496...51,957,433
Ensembl chr19:60,645,677...60,652,274
JBrowse link
G PDCD1 programmed cell death 1 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr2B:129,111,509...129,121,127 JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 ISO protein:increased expression:foreskin RGD PMID:18543080 RGD:39128248 NCBI chr12:110,016,364...110,107,462
Ensembl chr12:113,435,669...113,503,762
JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 ISO protein:increased expression:foreskin RGD PMID:18543080 RGD:39128248 NCBI chr12:7,075,879...7,093,041
Ensembl chr12:6,991,099...7,008,830
JBrowse link
G SERPINF1 serpin family F member 1 disease_progression ISO mRNA, protein:decreased expression:skin of body (human) RGD PMID:23569025 RGD:27226706 NCBI chr17:1,745,597...1,761,399
Ensembl chr17:1,638,556...1,653,568
JBrowse link
G TGFB1 transforming growth factor beta 1 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973
JBrowse link
G TLR2 toll like receptor 2 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331
JBrowse link
G TLR3 toll like receptor 3 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 4:178,238,352...178,256,264
Ensembl chr 4:190,446,487...190,462,728
JBrowse link
G TLR4 toll like receptor 4 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
JBrowse link
G TLR7 toll like receptor 7 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr  X:5,479,247...5,504,810
Ensembl chr  X:12,767,981...12,790,517
JBrowse link
G TLR8 toll like receptor 8 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr  X:5,518,742...5,535,304 JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:peripheral blood mononuclear cells (human) RGD PMID:23754510 RGD:40400714 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
G TNFRSF18 TNF receptor superfamily member 18 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714
Coxsackievirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD1D CD1d molecule ISO protein:increased expression:spleen, mononuclear cell (mouse) RGD PMID:16817758 RGD:127345109 NCBI chr 1:133,549,258...133,557,752
Ensembl chr 1:137,341,690...137,348,173
JBrowse link
G CD274 CD274 molecule treatment ISO RGD PMID:30904424 RGD:40818421 NCBI chr 9:5,269,270...5,289,629
Ensembl chr 9:5,454,391...5,474,402
JBrowse link
G IL6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25396421 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G PDCD1LG2 programmed cell death 1 ligand 2 treatment ISO RGD PMID:30904424 RGD:40818421 NCBI chr 9:5,313,071...5,391,676
Ensembl chr 9:5,514,449...5,575,688
JBrowse link
G SIVA1 SIVA1 apoptosis inducing factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16683188 NCBI chr14:85,404,148...85,408,254
Ensembl chr14:105,196,118...105,202,678
JBrowse link
G SLC22A3 solute carrier family 22 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21641380 NCBI chr 6:158,240,390...158,344,338
Ensembl chr 6:163,247,643...163,349,735
JBrowse link
G SLC22A4 solute carrier family 22 member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21641380 NCBI chr 5:127,717,077...127,766,793
Ensembl chr 5:133,879,387...133,929,439
JBrowse link
G SLC22A5 solute carrier family 22 member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21641380 NCBI chr 5:127,791,984...127,817,870
Ensembl chr 5:133,954,678...133,979,066
JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25396421 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
G TNFSF8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11745696 NCBI chr 9:85,998,567...86,036,373
Ensembl chr 9:114,360,206...114,397,822
JBrowse link
G TNFSF9 TNF superfamily member 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11745696 NCBI chr19:5,558,021...5,562,901
Ensembl chr19:6,476,941...6,483,352
JBrowse link
hand, foot and mouth disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin treatment ISO RGD PMID:31638922 RGD:127285374 NCBI chr 1:179,757,653...179,769,530
Ensembl chr 1:184,046,117...184,057,393
JBrowse link
hepatitis A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme ISO DNA:insertion/deletion:intron 16: RGD PMID:12458570 RGD:39939119 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853
JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 disease_progression ISO RGD PMID:26347518 RGD:40818419 NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498
JBrowse link
G PDCD1 programmed cell death 1 disease_progression ISO RGD PMID:26347518 RGD:40818419 NCBI chr2B:129,111,509...129,121,127 JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:serum (human) RGD PMID:9047083 RGD:14995307 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
G XRCC1 X-ray repair cross complementing 1 susceptibility ISO DNA:SNP:intron: (rs1001581) (human)
DNA:missense mutation:cds:p.R194W (rs1799782) (human)
RGD PMID:22135187 PMID:29558945 RGD:15014793 RGD:15036793 NCBI chr19:40,485,052...40,522,188
Ensembl chr19:49,094,014...49,125,520
JBrowse link
Keshan disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO mRNA,protein:increased expression:blood cells, serum: RGD PMID:26893848 RGD:124713562 NCBI chr15:53,664,968...53,672,277
Ensembl chr15:73,284,566...73,290,636
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 ISO mRNA,protein:increased expression:blood cells, serum: RGD PMID:26893848 RGD:124713562 NCBI chr10:91,375,255...91,465,215
Ensembl chr10:94,884,472...94,970,065
JBrowse link
G GPX1 glutathione peroxidase 1 ISO DNA:polymorphism: :p.P198L (human) RGD PMID:21055077 RGD:11352821 NCBI chr 3:49,280,038...49,281,455
Ensembl chr 3:50,360,947...50,361,826
JBrowse link
poliomyelitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PVR PVR cell adhesion molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:3020560 PMID:28446605 NCBI chr19:41,592,042...41,614,397
Ensembl chr19:50,196,980...50,217,006
JBrowse link
vestibular neuronitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRP C-reactive protein disease_progression ISO RGD PMID:14636287 RGD:9491594 NCBI chr 1:135,062,102...135,064,402 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13787
    disease by infectious agent 1779
      viral infectious disease 1486
        RNA Virus Infections 1309
          Picornaviridae Infections 74
            Enterovirus Infections 51
              Coxsackievirus Infections + 36
              Echovirus Infections + 26
              Encephalomyelitis, Enzootic Porcine 0
              Keshan disease 3
              Swine Vesicular Disease 0
              acute hemorrhagic conjunctivitis 0
              hepatitis A 5
              poliomyelitis + 2
paths to the root