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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Coma
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Accession:DOID:9006462 term browser browse the term
Definition:A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
Synonyms:exact_synonym: comas;   comatose
 narrow_synonym: episodic coma;   pseudocoma;   pseudocomas
 xref: MESH:D003128


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Coma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1e calcium voltage-gated channel subunit alpha1 E ISO ClinVar Annotator: match by term: Episodic coma ClinVar PMID:28492532 NCBI chr13:69,125,048...69,613,795
Ensembl chr13:69,132,305...69,612,983 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8438805 NCBI chr 9:76,063,863...76,186,739
Ensembl chr 9:76,000,754...76,186,734 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18359183 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G Gcg glucagon ISO CTD Direct Evidence: therapeutic CTD PMID:10464538 NCBI chr 3:67,522,489...67,531,533
Ensembl chr 3:67,522,489...67,531,533 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:292422 PMID:5067144 PMID:19397503 NCBI chr 3:138,235,754...138,236,594
Ensembl chr 3:138,235,754...138,236,594 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:24729111 NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:192,913,171...192,942,984 		JBrowse link
Brain Death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 treatment IEP
IMP 		mRNA, protein:increased expression:kidney RGD PMID:23356498 PMID:20819234 RGD:10755728, RGD:10766439 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP mRNA:increased expression:lung (rat) RGD PMID:20810760 RGD:4145365 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Inhbb inhibin subunit beta B IEP mRNA:increased expression:kidney (rat) RGD PMID:15808645 RGD:9743920 NCBI chr13:33,083,671...33,089,373
Ensembl chr13:33,083,671...33,089,609 		JBrowse link
G Itgam integrin subunit alpha M IEP protein:increased expression:neutrophil (rat) RGD PMID:18347540 RGD:329901924 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IDA RGD PMID:23157661 RGD:7495829 NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,844,034...50,947,185 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 IDA RGD PMID:23157661 RGD:7495829 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721 		JBrowse link
Post-Head Injury Coma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trh thyrotropin releasing hormone ISO CTD Direct Evidence: therapeutic CTD PMID:8690305 NCBI chr 4:126,299,236...126,301,762
Ensembl chr 4:126,299,236...126,301,762 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14566
    disease of anatomical entity 13676
      nervous system disease 8528
        Neurologic Manifestations 5934
          Neurobehavioral Manifestations 1646
            Consciousness Disorders 21
              Unconsciousness 21
                Coma 13
                  Brain Death 6
                  Insulin Coma 0
                  Post-Head Injury Coma 1
Path 2
Term Annotations click to browse term
  disease 14566
    disease of anatomical entity 13676
      nervous system disease 8528
        central nervous system disease 6393
          brain disease 5852
            disease of mental health 3944
              cognitive disorder 1355
                Consciousness Disorders 21
                  Unconsciousness 21
                    Coma 13
                      Brain Death 6
                      Insulin Coma 0
                      Post-Head Injury Coma 1
paths to the root