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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Binge Drinking
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Accession:DOID:9006302 term browser browse the term
Definition:Drinking an excessive amount of ALCOHOLIC BEVERAGES in a short period of time.
Synonyms:primary_id: MESH:D063425;   RDO:0012117


show annotations for term's descendants           Sort by:
Binge Drinking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide ISO mRNA:altered exxpression:liver (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 8:121,225,485...121,259,262
NCBI chr  X:98,582,002...98,583,002
Ensembl chr 8:121,225,656...121,261,746 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO mRNA:altered exxpression:liver (rat)
protein:increased expression, increased nitration 		RGD PMID:23413777 PMID:25236742 PMID:29404485 RGD:14700891 RGD:14700911 RGD:405100715 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817 		JBrowse link
G DNMT1 DNA methyltransferase 1 ISO protein:increased expression:nucleus accumbens: RGD PMID:23423140 RGD:9588287 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844 		JBrowse link
G DRD1 dopamine receptor D1 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr16:49,189,555...49,193,722
Ensembl chr16:49,189,602...49,191,976 		JBrowse link
G DRD2 dopamine receptor D2 ISO mRNA:altered exxpression:spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 9:41,068,618...41,135,262
Ensembl chr 9:41,068,779...41,133,599 		JBrowse link
G DRD3 dopamine receptor D3 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr13:145,769,294...145,817,997
Ensembl chr13:145,771,774...145,819,168 		JBrowse link
G DRD4 dopamine receptor D4 susceptibility ISO DNA:repeats:exon:
mRNA:altered exxpression:spleen (rat)		 RGD PMID:19393859 PMID:23413777 RGD:401960068 RGD:405100715 NCBI chr 2:398,766...401,539
Ensembl chr 2:398,766...402,433 		JBrowse link
G EFHD2 EF-hand domain family member D2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28397836 NCBI chr 6:74,651,814...74,668,352
Ensembl chr 6:74,651,809...74,668,409 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:prefrontal cortex RGD PMID:29407478 RGD:405295494 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554 		JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr16:61,656,583...61,723,428
Ensembl chr16:61,656,590...61,723,448 		JBrowse link
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 8:36,344,633...36,474,840
Ensembl chr 8:36,347,040...36,474,627 		JBrowse link
G GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr  X:123,456,952...123,684,814
Ensembl chr  X:123,456,947...123,684,790 		JBrowse link
G GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 ISO mRNA:altered exxpression:spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr16:61,855,698...61,872,503
Ensembl chr16:61,855,468...61,872,279 		JBrowse link
G GPX1 glutathione peroxidase 1 ISO protein:decreased expression:liver RGD PMID:25864381 RGD:401827870 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433 		JBrowse link
G GPX3 glutathione peroxidase 3 ISO protein:decreased expression:serum RGD PMID:25864381 RGD:401827870 NCBI chr16:71,980,467...71,989,011
Ensembl chr16:71,980,475...71,989,026 		JBrowse link
G GPX4 glutathione peroxidase 4 ISO protein:decreased expression:liver RGD PMID:25864381 RGD:401827870 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931 		JBrowse link
G GRM2 glutamate metabotropic receptor 2 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr13:33,924,303...33,938,279
Ensembl chr13:33,926,804...33,938,269 		JBrowse link
G GRM5 glutamate metabotropic receptor 5 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 9:21,914,422...22,438,200
Ensembl chr 9:21,917,735...22,436,063 		JBrowse link
G LOC100512795 alcohol dehydrogenase class 4 mu/sigma chain ISO mRNA:altered exxpression:liver (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 8:121,020,683...121,041,735
Ensembl chr 8:121,020,969...121,041,506 		JBrowse link
G MIR125A microRNA mir-125a ISO RNA:decreased expression:neuron RGD PMID:27085842 RGD:26884454 NCBI chr 6:58,331,566...58,331,645
Ensembl chr 6:58,331,566...58,331,645 		JBrowse link
G NPY1R neuropeptide Y receptor Y1 ameliorates ISO protein:decreased expression:central amygdaloid nucleus (mouse) RGD PMID:22218088 PMID:30647448 RGD:402463940 RGD:405096664 NCBI chr 8:52,152,649...52,163,080
Ensembl chr 8:52,152,646...52,162,328 		JBrowse link
G OPRL1 opioid related nociceptin receptor 1 ISO RGD PMID:29197086 RGD:14348965 NCBI chr17:62,905,700...62,913,018
Ensembl chr17:62,905,082...62,913,754 		JBrowse link
G SIRT1 sirtuin 1 ISO RGD PMID:24416161 RGD:9495933 NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,167...71,123,297 		JBrowse link
G SLC23A2 solute carrier family 23 member 2 ISO RGD PMID:27085842 RGD:26884454 NCBI chr17:13,848,726...14,012,054
Ensembl chr17:13,848,728...14,011,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17415
    Chemically-Induced Disorders 1237
      substance-related disorder 596
        Alcohol-Related Disorders 308
          Binge Drinking 24
Path 2
Term Annotations click to browse term
  disease 17415
    disease of anatomical entity 14875
      nervous system disease 12962
        central nervous system disease 11612
          brain disease 10901
            disease of mental health 7881
              substance-related disorder 596
                Alcohol-Related Disorders 308
                  Binge Drinking 24
paths to the root