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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Binge Drinking
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Accession:DOID:9006302 term browser browse the term
Definition:Drinking an excessive amount of ALCOHOLIC BEVERAGES in a short period of time.
Synonyms:primary_id: MESH:D063425;   RDO:0012117

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Binge Drinking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide ISO mRNA:altered exxpression:liver (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 7:47,226,787...47,248,518
Ensembl chr 7:47,226,191...47,248,234 		JBrowse link
G BDNF brain derived neurotrophic factor ISO protein:altered expression:amygdala, pyriform cortex, bed nucleus of stria terminalis RGD PMID:23588198 RGD:405849391 NCBI chr 1:37,386,825...37,451,380
Ensembl chr 1:37,449,593...37,450,336 		JBrowse link
G CA3 carbonic anhydrase 3 ISO associated with Alcoholic Liver Diseases;protein:decreased expression:liver RGD PMID:22545783 RGD:7495839 NCBI chr 8:80,805,296...80,816,127
Ensembl chr 8:80,805,134...80,816,190 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO associated with Alcoholic Liver Diseases;protein:increased expression:liver
mRNA:altered exxpression:liver (rat)
protein:increased expression, increased nitration 		RGD PMID:22545783 PMID:23413777 PMID:25236742 PMID:29404485 RGD:14700891 RGD:14700911 RGD:405100715 RGD:7495839 NCBI chr26:53,390,054...53,403,309
Ensembl chr26:53,390,089...53,404,211 		JBrowse link
G DNMT1 DNA methyltransferase 1 ISO protein:increased expression:nucleus accumbens: RGD PMID:23423140 RGD:9588287 NCBI chr 6:9,199,006...9,263,890
Ensembl chr 6:9,199,003...9,263,607 		JBrowse link
G DRD1 dopamine receptor D1 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr23:77,587,340...77,591,434 JBrowse link
G DRD2 dopamine receptor D2 ISO mRNA:altered exxpression:spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 1:104,774,632...104,843,417
Ensembl chr 1:104,774,180...104,842,736 		JBrowse link
G DRD3 dopamine receptor D3 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr22:66,683,987...66,737,645
Ensembl chr22:66,691,177...66,736,690 		JBrowse link
G DRD4 dopamine receptor D4 susceptibility ISO DNA:repeats:exon:
mRNA:altered exxpression:spleen (rat)		 RGD PMID:19393859 PMID:23413777 RGD:401960068 RGD:405100715 NCBI chr 1:454,018...459,582 JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:prefrontal cortex RGD PMID:29407478 RGD:405295494 NCBI chr24:52,497,465...52,501,161
Ensembl chr24:52,497,521...52,501,514 		JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr23:64,199,372...64,255,996
Ensembl chr23:64,200,752...64,255,996 		JBrowse link
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr27:3,858,741...4,013,385
Ensembl chr27:3,858,910...4,006,582 		JBrowse link
G GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr  X:126,735,146...126,999,990
Ensembl chr  X:126,735,288...127,000,017 		JBrowse link
G GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 ISO mRNA:altered exxpression:spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr23:64,020,770...64,038,419
Ensembl chr23:64,021,842...64,039,563 		JBrowse link
G GDNF glial cell derived neurotrophic factor ISO protein:altered expression:amygdala, pyriform cortex, bed nucleus of stria terminalis RGD PMID:23298382 PMID:23588198 RGD:405849390 RGD:405849391 NCBI chr 4:36,662,033...36,691,761
Ensembl chr 4:36,665,009...36,684,257 		JBrowse link
G GPX1 glutathione peroxidase 1 ISO protein:decreased expression:liver RGD PMID:25864381 RGD:401827870 NCBI chr22:10,754,976...10,756,617 JBrowse link
G GPX3 glutathione peroxidase 3 ISO protein:decreased expression:serum RGD PMID:25864381 RGD:401827870 NCBI chr23:53,576,950...53,585,321 JBrowse link
G GPX4 glutathione peroxidase 4 ISO protein:decreased expression:liver RGD PMID:25864381 RGD:401827870 NCBI chr 6:873,867...876,225 JBrowse link
G GRM2 glutamate metabotropic receptor 2 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr22:13,044,974...13,056,469
Ensembl chr22:13,046,641...13,056,453 		JBrowse link
G GRM5 glutamate metabotropic receptor 5 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 1:79,636,636...80,206,471 JBrowse link
G LOC103225553 EF-hand domain-containing protein D2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28397836 NCBI chr20:116,843,362...116,863,017
Ensembl chr20:116,843,218...116,863,010 		JBrowse link
G LOC103243260 corticotropin-releasing factor receptor 1 ISO mRNA:decreased expression:adenohypophysis RGD PMID:11045867 RGD:407431640 NCBI chr16:60,070,156...60,120,857
Ensembl chr16:60,070,066...60,120,712 		JBrowse link
G NPY1R neuropeptide Y receptor Y1 ameliorates ISO protein:decreased expression:central amygdaloid nucleus (mouse) RGD PMID:22218088 PMID:30647448 RGD:402463940 RGD:405096664 NCBI chr 7:109,774,700...109,794,543
Ensembl chr 7:109,774,918...109,776,905 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 treatment ISO RGD PMID:22500955 RGD:408361838 NCBI chr23:45,904,926...46,031,804
Ensembl chr23:45,904,873...46,031,125 		JBrowse link
G PER2 period circadian regulator 2 ISO DNA, mRNA:hypermethylation, decreased expression:blood RGD PMID:30597578 RGD:405878075 NCBI chr10:124,270,917...124,316,031
Ensembl chr10:124,269,543...124,315,904 		JBrowse link
G POMC proopiomelanocortin ISO DNA, mRNA:hypermethylation, decreased expression:blood
protein:decreased expression:central amygdaloid nucleus, arcuate and paraventricular nucleus of hypothalamus
mRNA:decreased expression:hypothalamus		 RGD PMID:11045867 PMID:23792540 PMID:30597578 RGD:405878075 RGD:407431640 RGD:407571694 NCBI chr14:82,491,296...82,499,289
Ensembl chr14:82,494,323...82,499,447 		JBrowse link
G SIRT1 sirtuin 1 ISO RGD PMID:24416161 RGD:9495933 NCBI chr 9:63,463,059...63,497,893
Ensembl chr 9:63,462,389...63,497,867 		JBrowse link
G SLC23A2 solute carrier family 23 member 2 ISO RGD PMID:27085842 RGD:26884454 NCBI chr 2:33,092,619...33,209,258
Ensembl chr 2:33,128,061...33,212,255 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15388
    Chemically-Induced Disorders 1194
      substance-related disorder 614
        Alcohol-Related Disorders 347
          Binge Drinking 28
Path 2
Term Annotations click to browse term
  disease 15388
    disease of anatomical entity 15074
      nervous system disease 13213
        central nervous system disease 11794
          brain disease 11073
            disease of mental health 7954
              substance-related disorder 614
                Alcohol-Related Disorders 347
                  Binge Drinking 28
paths to the root