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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Kidney Reperfusion Injury
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Accession:DOID:9006223 term browser browse the term
Definition:Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the kidney, including swelling; hemorrhage; necrosis; and damage from free radicals.
Synonyms:exact_synonym: Kidney Ischemia-Reperfusion Injury;   Renal Ischemia-Reperfusion Injury;   Renal Reperfusion Injury


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Kidney Reperfusion Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO RGD PMID:21680852 RGD:6893484 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Ace2 angiotensin converting enzyme 2 ISO mRNA:decreased expression:kidney RGD PMID:20528771 RGD:9685432 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Acta1 actin alpha 1, skeletal muscle ameliorates IEP RGD PMID:24920753 RGD:329845564 NCBI chr 8:124,618,497...124,621,514
Ensembl chr 8:124,618,508...124,621,490 		JBrowse link
G Acvr2b activin receptor IIB treatment ISO human construct in rat model RGD PMID:27732750 RGD:329322881 NCBI chr 9:119,231,081...119,271,214
Ensembl chr 9:119,231,184...119,264,061 		JBrowse link
G Adam17 a disintegrin and metallopeptidase domain 17 treatment ISO RGD PMID:22015440 RGD:13703100 NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633 		JBrowse link
G Adam2 a disintegrin and metallopeptidase domain 2 ISO RGD PMID:11967014 RGD:10047130 NCBI chr14:66,264,778...66,315,300
Ensembl chr14:66,264,778...66,315,182 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif 1 ISO RGD PMID:18272597 RGD:9684850 NCBI chr16:85,590,715...85,600,001
Ensembl chr16:85,590,715...85,600,001 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing treatment ISO RGD PMID:21412771 RGD:8695946 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Adm adrenomedullin treatment ISO protein:increased expression:serum: RGD PMID:20538296 PMID:20538296 RGD:7364948, RGD:7364948 NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027 		JBrowse link
G Akr1a1 aldo-keto reductase family 1, member A1 IMP RGD PMID:31089212 RGD:27226686 NCBI chr 4:116,493,707...116,508,871
Ensembl chr 4:116,493,707...116,508,877 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial IMP RGD PMID:22022451 RGD:7241603 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G Anxa1 annexin A1 treatment ISO RGD PMID:20953576 RGD:7421585 NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308 		JBrowse link
G Anxa5 annexin A5 ISO RGD PMID:21918686 RGD:7242028 NCBI chr 3:36,503,072...36,530,036
Ensembl chr 3:36,503,072...36,530,043 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 treatment ISO RGD PMID:26362957 RGD:13703110 NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632 		JBrowse link
G Apoa1 apolipoprotein A-I treatment ISO RGD PMID:18535924 RGD:7241574 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Atm ataxia telangiectasia mutated ISO protein:increased expression:kidney RGD PMID:22768306 RGD:10053607 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040 		JBrowse link
G Bax BCL2-associated X protein treatment ISO RGD PMID:23151253 RGD:10054101 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 treatment ISO RGD PMID:18221257 PMID:29285062 RGD:2293026, RGD:13792599 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bdkrb1 bradykinin receptor, beta 1 IMP RGD PMID:18725957 RGD:7241559 NCBI chr12:105,570,350...105,571,770
Ensembl chr12:105,569,344...105,571,687 		JBrowse link
G Becn1 beclin 1, autophagy related treatment ISO RGD PMID:26412257 RGD:11561958 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Bmi1 Bmi1 polycomb ring finger oncogene IEP mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr 2:18,681,953...18,691,440
Ensembl chr 2:18,681,829...18,691,440 		JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 ISO mRNA, protein:increased expression:kidney RGD PMID:23698117 RGD:11561968 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248 		JBrowse link
G C3 complement component 3 treatment ISO RGD PMID:19691975 RGD:7411689 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha ISO RGD PMID:19194162 RGD:7204479 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592 		JBrowse link
G Casp3 caspase 3 treatment ISO RGD PMID:23151253 RGD:10054101 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 ISO RGD PMID:17596683 RGD:5684536 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 treatment IDA RGD PMID:22160777 RGD:7247742 NCBI chr11:81,948,658...81,953,781
Ensembl chr11:81,948,649...81,953,781 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment
ameliorates		 IEP
ISO		 mRNA, protein:increased expression:kidney, lung, serum RGD PMID:20396927 PMID:18650485 PMID:24920753 RGD:4891433, RGD:11526113, RGD:329845564 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccn1 cellular communication network factor 1 ameliorates IMP RGD PMID:24920753 RGD:329845564 NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736 		JBrowse link
G Cd14 CD14 antigen IEP mRNA,protein:increased expression:kidney RGD PMID:10966493 RGD:7204444 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851 		JBrowse link
G Cd40 CD40 antigen treatment ISO RGD PMID:25993320 RGD:11251055 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cfb complement factor B IMP RGD PMID:16467447 PMID:12538716 RGD:7242709, RGD:7242734 NCBI chr17:35,075,350...35,081,492
Ensembl chr17:35,075,350...35,081,494 		JBrowse link
G Cfh complement component factor h treatment ISO protein:decreased expression:serum: RGD PMID:20538296 PMID:20538296 RGD:7364948, RGD:7364948 NCBI chr 1:140,013,593...140,111,149
Ensembl chr 1:140,012,446...140,111,502 		JBrowse link
G Ciita class II transactivator IEP RGD PMID:14569092 RGD:7242896 NCBI chr16:10,297,877...10,348,928
Ensembl chr16:10,297,923...10,346,282 		JBrowse link
G Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 IEP mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr  X:101,290,984...101,295,787
Ensembl chr  X:101,290,987...101,295,787 		JBrowse link
G Col1a1 collagen, type I, alpha 1 ameliorates IEP RGD PMID:24920753 RGD:329845564 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Col3a1 collagen, type III, alpha 1 ameliorates IEP RGD PMID:24920753 RGD:329845564 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866 		JBrowse link
G Csf1 colony stimulating factor 1 (macrophage) IMP
ISO		 mRNA:increased expression:kidney RGD PMID:23143303 PMID:19196448 RGD:7257565, RGD:7257570 NCBI chr 3:107,648,364...107,668,048
Ensembl chr 3:107,648,364...107,667,785 		JBrowse link
G Csf1r colony stimulating factor 1 receptor IMP RGD PMID:23143303 RGD:7257565 NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 IMP
ISO		 RGD PMID:22189844 PMID:9407517 RGD:7204675, RGD:7204727 NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 ameliorates IEP RGD PMID:24920753 RGD:329845564 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 IMP RGD PMID:20038794 RGD:7257679 NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO protein:increased expression:kidney RGD PMID:29073721 RGD:13825150 NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 treatment ISO RGD PMID:23552495 RGD:7244372 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394 		JBrowse link
G Daxx Fas death domain-associated protein IEP
ISO		 protein:increased expression:kidney: RGD PMID:18480747 PMID:18480747 RGD:9587836, RGD:9587836 NCBI chr17:34,128,379...34,134,564
Ensembl chr17:34,128,388...34,134,564 		JBrowse link
G Ddr1 discoidin domain receptor family, member 1 IEP protein:increased expression:kidney (mouse) RGD PMID:31383731 RGD:151347540 NCBI chr17:35,992,459...36,015,633
Ensembl chr17:35,992,459...36,015,513 		JBrowse link
G Dhfr dihydrofolate reductase treatment ISO mRNA,protein:decreased expression:kidney: RGD PMID:18408363 RGD:11040540 NCBI chr13:92,491,291...92,525,561
Ensembl chr13:92,491,234...92,525,561 		JBrowse link
G Drd3 dopamine receptor D3 treatment ISO RGD PMID:25989500 RGD:13506961 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295 		JBrowse link
G Eed embryonic ectoderm development IEP mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr 7:89,603,862...89,630,184
Ensembl chr 7:89,603,862...89,630,191 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 ISO mRNA, protein:decreased expression:kidney RGD PMID:19349364 RGD:11252083 NCBI chr 8:125,635,325...125,676,063
Ensembl chr 8:125,635,326...125,676,063 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 ISO mRNA, protein:decreased expression:kidney RGD PMID:19349364 RGD:11252083 NCBI chr12:54,225,767...54,250,660
Ensembl chr12:54,225,767...54,250,646 		JBrowse link
G Elane elastase, neutrophil expressed treatment ISO RGD PMID:16980042 RGD:10450580 NCBI chr10:79,722,146...79,724,050
Ensembl chr10:79,722,081...79,724,049 		JBrowse link
G Eng endoglin ISO
IMP		 mRNA, protein:increased expression:kidney (rat) RGD PMID:16751653 PMID:16751653 RGD:7248779, RGD:7248779 NCBI chr 2:32,536,607...32,572,681
Ensembl chr 2:32,536,607...32,572,681 		JBrowse link
G Ep300 E1A binding protein p300 ISO protein:altered localization:kidney (rat) RGD PMID:23936185 RGD:7257563 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:19961832 PMID:25581532 RGD:10401077, RGD:11041698 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit IEP mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr 6:47,507,208...47,613,843
Ensembl chr 6:47,507,073...47,572,275 		JBrowse link
G F3 coagulation factor III ISO protein:decreased expression:lung RGD PMID:25883098 RGD:11341735 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G Fas Fas cell surface death receptor treatment ISO RGD PMID:29285062 RGD:13792599 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasl Fas ligand treatment ISO RGD PMID:29285062 RGD:13792599 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Fcgr1 Fc receptor, IgG, high affinity I treatment ISO RGD PMID:22402584 RGD:9685699 NCBI chr 3:96,190,225...96,201,285
Ensembl chr 3:96,190,225...96,201,285 		JBrowse link
G Fga fibrinogen alpha chain ISO mRNA,protein:increased expression:kidney RGD PMID:21685370 RGD:7175292 NCBI chr 3:82,933,460...82,940,934
Ensembl chr 3:82,933,383...82,940,934 		JBrowse link
G Fgb fibrinogen beta chain treatment ISO mRNA, protein:increased expression:kidney RGD PMID:21685370 PMID:21685370 RGD:7175292, RGD:7175292 NCBI chr 3:82,949,553...82,957,170
Ensembl chr 3:82,947,448...82,957,170 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 exacerbates
ameliorates		 IEP
IMP
ISO		 protein:increased phosphorylation:kidney (mouse) RGD PMID:20591940 PMID:32523960 PMID:29344510 PMID:22688984 RGD:155663667, RGD:155782882, RGD:155782904, RGD:155882537 NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079 		JBrowse link
G Fgg fibrinogen gamma chain ISO mRNA,protein:increased expression:kidney RGD PMID:21685370 RGD:7175292 NCBI chr 3:82,915,031...82,922,363
Ensembl chr 3:82,915,031...82,922,356 		JBrowse link
G Fn1 fibronectin 1 ISO RGD PMID:11352844 RGD:7205629 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Fos FBJ osteosarcoma oncogene IEP RGD PMID:19095962 RGD:7242184 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration treatment ISO protein:increased expression:kidney: RGD PMID:20332418 PMID:20332418 RGD:9685723, RGD:9685723 NCBI chr17:24,912,164...24,915,065
Ensembl chr17:24,912,161...24,915,503 		JBrowse link
G Glo1 glyoxalase 1 ISO RGD PMID:19211689 PMID:19211689 RGD:7242566, RGD:7242566 NCBI chr17:30,811,835...30,831,633
Ensembl chr17:30,803,910...30,845,845 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO protein:decreased expression:kidney
mRNA:decreased expression:kidney		 RGD PMID:37033969 PMID:22442209 RGD:401827821, RGD:401827906 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Gsr glutathione reductase treatment ISO RGD PMID:24630969 RGD:10401866 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 ISO mRNA, protein:decreased expression:kidney RGD PMID:29137244 RGD:158014894 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Gstt1 glutathione S-transferase, theta 1 ISO protein:decreased expression:kidney RGD PMID:37033969 RGD:401827821 NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418 		JBrowse link
G H2ax H2A.X variant histone treatment ISO RGD PMID:23726287 RGD:8693706 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374 		JBrowse link
G Has1 hyaluronan synthase 1 ISO RGD PMID:22529164 RGD:9588636 NCBI chr17:18,063,588...18,075,450
Ensembl chr17:18,063,585...18,075,467 		JBrowse link
G Has2 hyaluronan synthase 2 ISO RGD PMID:22529164 RGD:9588636 NCBI chr15:56,529,023...56,557,942
Ensembl chr15:56,529,023...56,557,935 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 ISO
IEP		 protein:increased expression:urine: RGD PMID:23552495 PMID:23085062 PMID:23019274 RGD:7244372, RGD:7245489, RGD:7245495 NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit treatment
severity		 ISO RGD PMID:17519789 PMID:22432008 RGD:1626334, RGD:9068883 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO RGD PMID:21291499 RGD:10755580 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hsf1 heat shock factor 1 ISO protein:increased expression:kidney (rat) RGD PMID:23102208 RGD:10402775 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113 		JBrowse link
G Hspa8 heat shock protein 8 ISO RGD PMID:7569112 RGD:7242788 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383 		JBrowse link
G Hyal1 hyaluronoglucosaminidase 1 ISO RGD PMID:22529164 RGD:9588636 NCBI chr 9:107,454,149...107,458,898
Ensembl chr 9:107,454,126...107,458,909 		JBrowse link
G Hyal2 hyaluronoglucosaminidase 2 ISO RGD PMID:22529164 RGD:9588636 NCBI chr 9:107,445,096...107,449,975
Ensembl chr 9:107,445,144...107,449,978 		JBrowse link
G Ifng interferon gamma treatment IEP RGD PMID:28355607 RGD:14975115 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Igf1r insulin-like growth factor I receptor ISO mRNA: increased expression: kidney: 3 and 5 days post ischemia RGD PMID:10990448 RGD:7242905 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta treatment ISO RGD PMID:19546526 RGD:7495779 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Il10 interleukin 10 treatment ISO
IEP		 RGD PMID:24079335 PMID:28664613 RGD:7364864, RGD:14975137 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il12b interleukin 12b ameliorates IEP RGD PMID:24920753 RGD:329845564 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il18 interleukin 18 treatment ISO RGD PMID:22089199 RGD:8655971 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1b interleukin 1 beta ameliorates ISO
IEP		 RGD PMID:20030532 PMID:24920753 RGD:7175501, RGD:329845564 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO
IMP		 rat model treated with human protein
mouse model treated with human protein		 RGD PMID:18363573 PMID:16849996 PMID:9555664 RGD:6907101, RGD:6907359, RGD:6909149 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506 		JBrowse link
G Il6 interleukin 6 ameliorates IEP RGD PMID:24920753 RGD:329845564 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Inhbb inhibin beta-B ISO protein:increased expression:serum (rat) RGD PMID:27732750 RGD:329322881 NCBI chr 1:119,343,193...119,349,978
Ensembl chr 1:119,343,195...119,349,978 		JBrowse link
G Itgb2 integrin beta 2 ISO Associated with renal transplant patients RGD PMID:20504838 PMID:11007822 RGD:6907049, RGD:6907073 NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542 		JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 ISO protein:decreased expression:kidney RGD PMID:21250976 RGD:7297045 NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188 		JBrowse link
G Kl klotho treatment ISO
IMP		 mRNA,protein:decreased expression:renal tubule: RGD PMID:16204278 PMID:16204278 RGD:10403064, RGD:10403064 NCBI chr 5:150,876,072...150,917,282
Ensembl chr 5:150,876,072...150,917,282 		JBrowse link
G Kmt2a lysine (K)-specific methyltransferase 2A IEP protein:increased expression:kidney (mouse) RGD PMID:31570196 RGD:155888490 NCBI chr 9:44,714,652...44,793,492
Ensembl chr 9:44,714,652...44,792,594 		JBrowse link
G Lcn2 lipocalin 2 ISO
IEP		 protein:increased expression:urine:
mRNA,protein:increased expression:kidney:
mRNA,protein:increased expression:kidney,urine		 RGD PMID:23364806 PMID:23085062 PMID:20181666 PMID:27800610 RGD:7245469, RGD:7245489, RGD:126779563, RGD:126790572 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264 		JBrowse link
G Lep leptin resistance ISO RGD PMID:22969992 RGD:6909133 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lgals3 lectin, galactose binding, soluble 3 ISO mRNA:increased expression:kidney RGD PMID:10980121 RGD:9685228 NCBI chr14:47,611,317...47,623,624
Ensembl chr14:47,605,208...47,623,617 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha treatment IEP
ISO		 RGD PMID:20075199 PMID:26412257 RGD:11561916, RGD:11561958 NCBI chr 2:155,118,284...155,119,993
Ensembl chr 2:155,118,217...155,119,993 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 treatment ISO RGD PMID:23952292 RGD:10412647 NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499 		JBrowse link
G Mc1r melanocortin 1 receptor ISO protein:decreased expression:kidney outer medulla RGD PMID:18790174 RGD:5687322 NCBI chr 8:124,133,839...124,137,483
Ensembl chr 8:124,133,846...124,137,483 		JBrowse link
G Mir146 microRNA 146 treatment ISO RGD PMID:27760486 RGD:155882556 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288 		JBrowse link
G Mir320 microRNA 320 treatment ISO RGD PMID:31089916 PMID:27760486 RGD:155882543, RGD:155882556 NCBI chr14:70,680,950...70,681,031
Ensembl chr14:70,680,950...70,681,031 		JBrowse link
G Mir381 microRNA 381 ISO RNA:decreased expression:kidney RGD PMID:29073721 RGD:13825150 NCBI chr12:109,693,256...109,693,330
Ensembl chr12:109,693,256...109,693,330 		JBrowse link
G Mir423 microRNA 423 treatment ISO RGD PMID:29137244 RGD:158014894 NCBI chr11:76,968,890...76,968,998
Ensembl chr11:76,968,890...76,968,998 		JBrowse link
G Mir494 microRNA 494 ameliorates IMP RGD PMID:23160513 RGD:155883172 NCBI chr12:109,681,752...109,681,836
Ensembl chr12:109,681,752...109,681,836 		JBrowse link
G Mpo myeloperoxidase ISO
IMP		 protein:increased activity:kidney RGD PMID:22950848 PMID:18055546 RGD:6909167, RGD:7174699 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Muc1 mucin 1, transmembrane treatment ISO RGD PMID:22019164 RGD:7245959 NCBI chr 3:89,136,363...89,140,688
Ensembl chr 3:89,136,364...89,140,688 		JBrowse link
G Myc myelocytomatosis oncogene ISO mRNA:increased expression:kidney (rat) RGD PMID:17220792 RGD:7207777 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 ISO
IEP		 RGD PMID:24096033 PMID:22160772 RGD:13801197, RGD:13801199 NCBI chr19:44,537,010...44,543,881
Ensembl chr19:44,537,011...44,543,879 		JBrowse link
G Nes nestin ISO RGD PMID:24503548 RGD:11570523 NCBI chr 3:87,878,400...87,887,758
Ensembl chr 3:87,878,385...87,887,758 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 treatment ISO RGD PMID:31089916 RGD:155882543 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible treatment ISO RGD PMID:18408363 RGD:11040540 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell treatment ISO RGD PMID:29291552 PMID:18408363 RGD:13504682, RGD:11040540 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nox1 NADPH oxidase 1 treatment ISO RGD PMID:34244746 RGD:329955363 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705 		JBrowse link
G Nppa natriuretic peptide type A ISO RGD PMID:20471588 RGD:7247717 NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 treatment ISO RGD PMID:21545725 RGD:11035217 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 severity IEP
IMP		 mRNA:increased expression:kidney RGD PMID:22343121 PMID:22343121 RGD:14700869, RGD:14700869 NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676 		JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 ISO RGD PMID:12531391 RGD:2317150 NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029 		JBrowse link
G Pax2 paired box 2 ISO mRNA, protein:increased expression:kidney RGD PMID:12444203 RGD:727468 NCBI chr19:44,735,040...44,826,708
Ensembl chr19:44,735,057...44,826,310 		JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide ISO mRNA,protein:increased expression:tubule, S3 segment: RGD PMID:10550325 RGD:8554477 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178 		JBrowse link
G Pdgfra platelet derived growth factor receptor, alpha polypeptide ISO mRNA:increased expression:kidney RGD PMID:10550325 RGD:8554477 NCBI chr 5:75,311,988...75,358,867
Ensembl chr 5:75,312,953...75,358,876 		JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide ISO mRNA:increased expression:kidney RGD PMID:12819032 PMID:10550325 RGD:1580850, RGD:8554477 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133 		JBrowse link
G Peg10 paternally expressed 10 IEP mRNA:increased expression:kidney (mouse) RGD PMID:16778176 RGD:401851077 NCBI chr 6:4,747,306...4,760,517
Ensembl chr 6:4,747,306...4,760,517 		JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel ISO protein:increased expression:kidney (rat) RGD PMID:12454224 RGD:1580868 NCBI chr 5:104,599,379...104,653,685
Ensembl chr 5:104,607,316...104,653,685 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha treatment ISO RGD PMID:24918615 RGD:10059636 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Ptgis prostaglandin I2 (prostacyclin) synthase IEP mRNA:increased expression:kidney (mouse) RGD PMID:30413885 RGD:401959745 NCBI chr 2:167,045,114...167,095,069
Ensembl chr 2:167,033,725...167,082,524 		JBrowse link
G Rnls renalase, FAD-dependent amine oxidase ISO
IEP
IMP		 mRNA,protein:decreased expression:kidney,plasma: RGD PMID:23393318 PMID:23393318 PMID:23393318 RGD:7327166, RGD:7327166, RGD:7327166 NCBI chr19:33,115,140...33,369,695
Ensembl chr19:33,115,147...33,369,665 		JBrowse link
G Serpinc1 serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 severity ISO RGD PMID:26108065 PMID:26108065 RGD:11354006, RGD:11354006 NCBI chr 1:160,806,153...160,830,113
Ensembl chr 1:160,806,155...160,833,433 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 ameliorates IEP RGD PMID:24920753 RGD:329845564 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Shh sonic hedgehog IEP mRNA, protein:increased expression:kidney RGD PMID:24744439 RGD:12859042 NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254 		JBrowse link
G Sirt1 sirtuin 1 treatment ISO RGD PMID:22324445 RGD:9495930 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Six2 sine oculis-related homeobox 2 IEP mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr17:85,970,276...85,995,682
Ensembl chr17:85,991,705...85,995,702 		JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 ISO RGD PMID:21835768 RGD:7243877 NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 ISO RGD PMID:21835768 RGD:7243877 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Slc34a1 solute carrier family 34 (sodium phosphate), member 1 ISO protein:decreased expression:renal proximal tubule, brush border membrane (rat) RGD PMID:15775707 RGD:2311304 NCBI chr13:55,547,435...55,562,508
Ensembl chr13:55,546,000...55,563,405 		JBrowse link
G Src Rous sarcoma oncogene ISO RGD PMID:12819032 RGD:1580850 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 severity IMP RGD PMID:12709397 RGD:7244143 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826 		JBrowse link
G Suz12 SUZ12 polycomb repressive complex 2 subunit IEP mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr11:79,883,932...79,924,949
Ensembl chr11:79,883,932...79,924,949 		JBrowse link
G Tfpi tissue factor pathway inhibitor ISO RGD PMID:11796005 RGD:11062062 NCBI chr 2:84,263,199...84,307,119
Ensembl chr 2:84,263,199...84,307,119 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ameliorates IEP RGD PMID:24920753 RGD:329845564 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tlr2 toll-like receptor 2 treatment
severity		 ISO
IDA
IMP
IEP		 RGD PMID:23239000 PMID:23023072 PMID:22750071 PMID:20130923 PMID:11801667 RGD:7207892, RGD:7207894, RGD:7207896, RGD:7240552, RGD:7241087 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tlr4 toll-like receptor 4 treatment ISO
IMP
IEP		 RGD PMID:23239000 PMID:20130923 PMID:11801667 RGD:7207892, RGD:7240552, RGD:7241087 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor ameliorates ISO
IEP		 protein:increased expression:serum RGD PMID:19925291 PMID:24920753 RGD:2315112, RGD:329845564 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a IEP mRNA:increased expression:lung RGD PMID:22728466 RGD:7245543 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO protein:increased expression:kidney RGD PMID:20164827 RGD:7240507 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vwf Von Willebrand factor ISO protein:increased expression:serum: RGD PMID:12684225 RGD:11080744 NCBI chr 6:125,529,911...125,663,642
Ensembl chr 6:125,523,737...125,663,642 		JBrowse link
G Wt1 WT1 transcription factor IEP mRNA:altered expression:kidney (mouse) RGD PMID:18467665 RGD:155631277 NCBI chr 2:104,956,874...105,003,959
Ensembl chr 2:104,956,874...105,003,961 		JBrowse link
G Xdh xanthine dehydrogenase treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:22995295 PMID:20616412 RGD:7247637, RGD:7247695 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191 		JBrowse link
G Zfp667 zinc finger protein 667 ameliorates IEP RGD PMID:24920753 RGD:329845564 NCBI chr 7:6,289,187...6,310,882
Ensembl chr 7:6,289,578...6,310,882 		JBrowse link
Chronic Allograft Nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 ISO RGD PMID:20176611 RGD:11541086 NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338 		JBrowse link
G Alb albumin disease_progression ISO RGD PMID:24370342 RGD:11035281 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 ISO RGD PMID:17298994 RGD:7241819 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181 		JBrowse link
G Ccn2 cellular communication network factor 2 disease_progression ISO mRNA, protein:increased expression:kidney (rat) RGD PMID:19921985 RGD:150517553 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581 		JBrowse link
G Clu clusterin treatment ISO RGD PMID:22494435 RGD:9068431 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996 		JBrowse link
G Cs citrate synthase treatment ISO RGD PMID:20005400 RGD:243048470 NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348 		JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO RGD PMID:22845765 RGD:7241226 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975 		JBrowse link
G Mmp7 matrix metallopeptidase 7 treatment ISO RGD PMID:18209025 RGD:9685339 NCBI chr 9:7,692,095...7,699,587
Ensembl chr 9:7,692,091...7,699,587 		JBrowse link
G Pdgfa platelet derived growth factor, alpha ISO RGD PMID:11889420 RGD:11080974 NCBI chr 5:138,961,761...138,986,336
Ensembl chr 5:138,961,769...138,983,125 		JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide ISO mRNA:increased expression:kidney: RGD PMID:15785371 PMID:11889420 RGD:10449491, RGD:11080974 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178 		JBrowse link
G Pdgfra platelet derived growth factor receptor, alpha polypeptide ISO RGD PMID:11889420 RGD:11080974 NCBI chr 5:75,311,988...75,358,867
Ensembl chr 5:75,312,953...75,358,876 		JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide ISO RGD PMID:11889420 RGD:11080974 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133 		JBrowse link
G Plau plasminogen activator, urokinase ISO protein:increased secretion:T lymphocyte (human) RGD PMID:16387096 RGD:7241259 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO protein:increased expression:kidney: RGD PMID:16221712 RGD:13208600 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 treatment ISO protein:increased expression:kidney: RGD PMID:16221712 PMID:18192922 RGD:13208600, RGD:13208601 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16180
    disease of anatomical entity 15794
      cardiovascular system disease 4673
        vascular disease 3251
          Reperfusion Injury 829
            Kidney Reperfusion Injury 162
              Chronic Allograft Nephropathy 15
Path 2
Term Annotations click to browse term
  disease 16180
    disease of anatomical entity 15794
      Urogenital Diseases 4946
        urinary system disease 2505
          kidney disease 2255
            kidney failure 550
              acute kidney failure 324
                Kidney Reperfusion Injury 162
                  Chronic Allograft Nephropathy 15
paths to the root