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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Carotid Artery Injuries
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Accession:DOID:9006182 term browser browse the term
Definition:Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)
Synonyms:exact_synonym: Carotid Arteriopathies, Traumatic;   Carotid Artery Injury;   Carotid Artery Trauma;   Carotid False Aneurysm;   Carotid False Aneurysms;   Carotid Pseudoaneurysm;   Traumatic Carotid Arteriopathy
 primary_id: MESH:D020212


show annotations for term's descendants           Sort by:
Carotid Artery Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle, aorta IEP protein:decreased expression:vascular smooth muscle cell carotid artery (mouse) RGD PMID:25751394 RGD:329328927 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Acvr1 activin A receptor, type 1 ISO mRNA:increased expression:carotic artery (rat) RGD PMID:9622270 RGD:329845558 NCBI chr 2:58,336,450...58,456,840
Ensembl chr 2:58,278,656...58,457,169 		JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO RGD PMID:21680901 RGD:7245963 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a treatment ISO mRNA:increased expression:artery: RGD PMID:9918604 RGD:10047106 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase ISO RGD PMID:16118253 RGD:5509614 NCBI chr11:70,132,283...70,146,206
Ensembl chr11:70,132,283...70,146,179 		JBrowse link
G Carmn cardiac mesoderm enhancer-associated non-coding RNA ISO mRNA:decreased expression:carotid artery: RGD PMID:34694145 RGD:155883160 NCBI chr18:61,778,947...61,798,481
Ensembl chr18:61,782,696...61,798,608 		JBrowse link
G Cbl Casitas B-lineage lymphoma ISO protein:hyperphosphorylation:tyrosine: RGD PMID:18663086 RGD:11038825 NCBI chr 9:44,054,273...44,145,556
Ensembl chr 9:44,054,273...44,145,346 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment ISO human gene in rat model RGD PMID:12223446 PMID:15353495 RGD:8549774, RGD:11526152 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccn2 cellular communication network factor 2 ISO protein:increased expression:arterial wall (rat) RGD PMID:19570811 RGD:2314490 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581 		JBrowse link
G Ccna2 cyclin A2 ISO mRNA:increased expression:artery: RGD PMID:18667424 RGD:10054494 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator disease_progression ISO RGD PMID:10623660 RGD:11341688 NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043 		JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO mRNA, protein:increased expression: carotid artery endothelium (rat) RGD PMID:27135205 RGD:151665776 NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221 		JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) ISO protein:increased expression:smooth muscle cell: RGD PMID:15385271 RGD:11039423 NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455 		JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO RGD PMID:9546380 RGD:7771579 NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102 		JBrowse link
G Foxo3 forkhead box O3 ISO RGD PMID:15662024 RGD:10402197 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Gc vitamin D binding protein ISO protein:decreased expression:plasma RGD PMID:21416056 RGD:5509868 NCBI chr 5:89,565,370...89,605,757
Ensembl chr 5:89,565,381...89,605,757 		JBrowse link
G Gp6 glycoprotein 6 (platelet) treatment ISO human protein in a mouse model RGD PMID:18566102 RGD:401824643 NCBI chr 7:4,365,852...4,400,849
Ensembl chr 7:4,366,964...4,400,743 		JBrowse link
G H19 H19, imprinted maternally expressed transcript ameliorates ISO RGD PMID:34487706 RGD:156430326 NCBI chr 7:142,129,267...142,131,883
Ensembl chr 7:142,129,262...142,131,917 		JBrowse link
G Hdac4 histone deacetylase 4 ISO protein:increased expression:carotid artery: RGD PMID:19389706 RGD:9681448 NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421 		JBrowse link
G Hey1 hairy/enhancer-of-split related with YRPW motif 1 ISO RGD PMID:11971902 RGD:625426 NCBI chr 3:8,728,419...8,732,098
Ensembl chr 3:8,728,419...8,732,316 		JBrowse link
G Hey2 hairy/enhancer-of-split related with YRPW motif 2 ISO RGD PMID:11971902 RGD:625426 NCBI chr10:30,708,355...30,718,779
Ensembl chr10:30,708,355...30,718,797 		JBrowse link
G Heyl hairy/enhancer-of-split related with YRPW motif-like ISO RGD PMID:11971902 RGD:625426 NCBI chr 4:123,127,349...123,143,663
Ensembl chr 4:123,127,349...123,143,668 		JBrowse link
G Hp haptoglobin ISO RGD PMID:19012726 RGD:11041814 NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO mRNA:increased expression:carotid artery (rat) RGD PMID:20368503 RGD:4145429 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Igf1 insulin-like growth factor 1 IEP protein:increased expression:serum,carotid artery: RGD PMID:12490968 RGD:10046051 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Igf1r insulin-like growth factor I receptor treatment ISO protein:increased phosphorylation:carotid artery: RGD PMID:17606126 RGD:10046006 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416 		JBrowse link
G Il18 interleukin 18 ISO protein:increased expression:carotid artery RGD PMID:19955748 PMID:16864728 RGD:4889159, RGD:4889500 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO human gene in rat model RGD PMID:12754378 RGD:2316108 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506 		JBrowse link
G Itgav integrin alpha V ISO mRNA:increased expression:carotic artery (rat) RGD PMID:9622270 RGD:329845558 NCBI chr 2:83,554,796...83,637,261
Ensembl chr 2:83,554,741...83,637,260 		JBrowse link
G Itgb3 integrin beta 3 ISO protein:increased expression:carotid artery
mRNA:increased expression:carotic artery (rat)		 RGD PMID:17868879 PMID:9622270 RGD:4892652, RGD:329845558 NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302 		JBrowse link
G Jag1 jagged 1 ISO protein:increased expression:carotid artery RGD PMID:21330605 RGD:6482230 NCBI chr 2:136,923,371...136,958,440
Ensembl chr 2:136,923,376...136,958,564 		JBrowse link
G Klf4 Kruppel-like transcription factor 4 (gut) ameliorates ISO RGD PMID:29127880 RGD:155230825 NCBI chr 4:55,527,137...55,536,984
Ensembl chr 4:55,527,143...55,532,466 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO protein:increased activity:carotid artery: RGD PMID:14638553 RGD:10412321 NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499 		JBrowse link
G Mir126b microRNA 126b exacerbates IMP RGD PMID:24584117 RGD:401850548 NCBI chr 2:26,481,375...26,481,432
Ensembl chr 2:26,481,375...26,481,432 		JBrowse link
G Mir145a microRNA 145a ISO miRNA:altered expression:wall of blood vessel (rat) RGD PMID:19542014 RGD:13210556 NCBI chr18:61,780,896...61,780,965
Ensembl chr18:61,780,896...61,780,965 		JBrowse link
G Mir223 microRNA 223 ISO RNA:increased expression:carotid artery RGD PMID:26065992 RGD:25824846 NCBI chr  X:95,286,423...95,286,532
Ensembl chr  X:95,286,423...95,286,532 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO RGD PMID:9327785 RGD:8547910 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO RGD PMID:9327785 RGD:8547910 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:9327785 RGD:8547910 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Myc myelocytomatosis oncogene treatment ISO mRNA:increased expression:carotid artery (rat) RGD PMID:23178522 PMID:22546228 RGD:7207861, RGD:7240535 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Myh9 myosin, heavy polypeptide 9, non-muscle ISO protein:increased expression:carotid artery: RGD PMID:11003588 RGD:11533926 NCBI chr15:77,644,788...77,726,315
Ensembl chr15:77,644,787...77,726,375 		JBrowse link
G Nono non-POU-domain-containing, octamer binding protein ameliorates IMP RGD PMID:33626912 RGD:155900763 NCBI chr  X:100,473,295...100,492,193
Ensembl chr  X:100,472,924...100,492,197 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell treatment ISO RGD PMID:29207649 RGD:13504723 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Notch1 notch 1 ISO RGD PMID:11971902 RGD:625426 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675 		JBrowse link
G Notch2 notch 2 ISO RGD PMID:11971902 RGD:625426 NCBI chr 3:97,920,854...98,057,683
Ensembl chr 3:97,920,843...98,057,677 		JBrowse link
G Notch3 notch 3 ISO RGD PMID:11971902 RGD:625426 NCBI chr17:32,339,794...32,385,869
Ensembl chr17:32,339,794...32,385,826 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 ISO protein:increased expression:blood vessel: RGD PMID:15044192 RGD:10413907 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pcna proliferating cell nuclear antigen IEP protein:increased expression:vascular smooth muscle cell carotid artery (mouse) RGD PMID:25751394 RGD:329328927 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 ISO mRNA,protein:increased expression:artery: RGD PMID:12649739 RGD:11556213 NCBI chr19:17,409,678...17,815,076
Ensembl chr19:17,409,683...17,814,996 		JBrowse link
G Pdgfd platelet-derived growth factor, D polypeptide ISO protein:increased expression:carotid artery: RGD PMID:18258854 RGD:9854624 NCBI chr 9:6,168,377...6,534,284
Ensembl chr 9:6,168,584...6,378,850 		JBrowse link
G Plat plasminogen activator, tissue ISO mRNA, protein:increased expression, increased activity:carotid artery (rat) RGD PMID:8343497 RGD:11537479 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Postn periostin, osteoblast specific factor ISO mRNA,protein:increased expression:artery: RGD PMID:15514205 RGD:10040973 NCBI chr 3:54,266,688...54,298,462
Ensembl chr 3:54,268,530...54,298,458 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma treatment IMP mouse gene in a rat model RGD PMID:19339015 RGD:8553019 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha treatment ISO
IMP		 mouse gene in a rat model RGD PMID:22892143 PMID:19553562 RGD:7242065, RGD:2311405 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Ptgis prostaglandin I2 (prostacyclin) synthase treatment ISO human gene in a rat model RGD PMID:9933282 PMID:10073980 PMID:10536678 PMID:17303142 RGD:401901254, RGD:401960092, RGD:401959739, RGD:401959382 NCBI chr 2:167,045,114...167,095,069
Ensembl chr 2:167,033,725...167,082,524 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 exacerbates ISO mRNA:increased expression:carotid artery (rat)
protein:increased expression:carotid artery (rat)		 RGD PMID:16373608 PMID:10807732 PMID:15271661 RGD:401965416, RGD:9590128, RGD:401965432 NCBI chr 2:167,772,670...167,821,305
Ensembl chr 2:167,773,977...167,821,305 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO protein:increased expression:aorta tunica intima, aorta tunica media RGD PMID:12117720 RGD:39456082 NCBI chr 5:121,268,596...121,329,460
Ensembl chr 5:121,268,596...121,329,460 		JBrowse link
G Rangap1 RAN GTPase activating protein 1 ISO protein:increased expression:carotid artery, intima (rat) RGD PMID:24988324 RGD:9835414 NCBI chr15:81,588,449...81,614,120
Ensembl chr15:81,588,449...81,629,731 		JBrowse link
G Robo1 roundabout guidance receptor 1 ISO mRNA:increased expression:carotid artery RGD PMID:26841069 RGD:243048443 NCBI chr16:71,824,406...72,844,379
Ensembl chr16:72,105,194...72,842,983 		JBrowse link
G Scgb1a1 secretoglobin, family 1A, member 1 ISO RGD PMID:11107082 RGD:5144055 NCBI chr19:9,061,006...9,065,320
Ensembl chr19:9,061,000...9,065,322 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 ISO mRNA:increased expression:carotid artery (rat) RGD PMID:25617690 RGD:11075082 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 treatment ISO human gene in a rat model RGD PMID:17525281 RGD:8618841 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527 		JBrowse link
G Slit2 slit guidance ligand 2 ISO mRNA:increased expression:carotid artery RGD PMID:26841069 RGD:243048443 NCBI chr 5:48,138,633...48,465,077
Ensembl chr 5:48,140,480...48,465,075 		JBrowse link
G Sp1 trans-acting transcription factor 1 ISO protein:increased phosphorylation:smooth muscle cell: RGD PMID:18258854 RGD:9854624 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839 		JBrowse link
G Spon2 spondin 2, extracellular matrix protein IEP protein:decreased expression:vascular smooth muscle cell carotid artery (mouse) RGD PMID:25751394 RGD:329328927 NCBI chr 5:33,370,862...33,375,596
Ensembl chr 5:33,355,528...33,375,799 		JBrowse link
G Tagln transgelin ISO mRNA:decreased expression:carotid artery: RGD PMID:34694145 RGD:155883160 NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356 		JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 ISO mRNA,protein:increased expression:carotid artery: RGD PMID:20537494 RGD:11060271 NCBI chr 6:3,962,589...3,988,977
Ensembl chr 6:3,962,595...3,988,919 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO mRNA:increased expression:carotic artery (rat) RGD PMID:9622270 RGD:329845558 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 ISO mRNA:increased expression:carotic artery (rat) RGD PMID:9622270 RGD:329845558 NCBI chr12:86,103,517...86,125,815
Ensembl chr12:86,103,519...86,125,815 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor I ISO mRNA:increased expression:carotic artery (rat) RGD PMID:9622270 RGD:329845558 NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II ISO mRNA:increased expression:carotic artery (rat) RGD PMID:9622270 RGD:329845558 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
carotid artery dissection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ldlr low density lipoprotein receptor ISO ClinVar Annotator: match by term: Carotid artery dissection ClinVar PMID:1301956 PMID:2088165 PMID:2318961 PMID:3263645 PMID:8882879 More... NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Mylk myosin, light polypeptide kinase ISO ClinVar Annotator: match by term: Carotid artery dissection ClinVar PMID:25326637 PMID:25741868 PMID:28492532 PMID:30755392 NCBI chr16:34,565,569...34,822,806
Ensembl chr16:34,565,580...34,822,790 		JBrowse link
Carotid Artery Dissection, Internal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ldlr low density lipoprotein receptor ISO ClinVar Annotator: match by term: Internal carotid artery dissection ClinVar PMID:1301956 PMID:2088165 PMID:2318961 PMID:3263645 PMID:8882879 More... NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Mylk myosin, light polypeptide kinase ISO ClinVar Annotator: match by term: Internal carotid artery dissection ClinVar PMID:25326637 PMID:25741868 PMID:28492532 PMID:30755392 NCBI chr16:34,565,569...34,822,806
Ensembl chr16:34,565,580...34,822,790 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16177
    Wounds and Injuries 996
      Nervous System Trauma 605
        Cerebrovascular Trauma 75
          Carotid Artery Injuries 73
            Carotid-Cavernous Sinus Fistula 0
            carotid artery dissection + 2
Path 2
Term Annotations click to browse term
  disease 16177
    disease of anatomical entity 15790
      nervous system disease 13691
        central nervous system disease 12273
          brain disease 11521
            cerebrovascular disease 998
              Cerebrovascular Trauma 75
                Carotid Artery Injuries 73
                  Carotid-Cavernous Sinus Fistula 0
                  carotid artery dissection + 2
paths to the root