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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Carotid Artery Injuries
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Accession:DOID:9006182 term browser browse the term
Definition:Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)
Synonyms:exact_synonym: Carotid Arteriopathies, Traumatic;   Carotid Artery Injury;   Carotid Artery Trauma;   Carotid False Aneurysm;   Carotid False Aneurysms;   Carotid Pseudoaneurysm;   Traumatic Carotid Arteriopathy
 primary_id: MESH:D020212


show annotations for term's descendants           Sort by:
Carotid Artery Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle ISO protein:decreased expression:vascular smooth muscle cell carotid artery (mouse) RGD PMID:25751394 RGD:329328927 NCBI chr26:38,700,434...38,714,915
Ensembl chr26:38,700,480...38,711,753 		JBrowse link
G ACVR1 activin A receptor type 1 ISO mRNA:increased expression:carotic artery (rat) RGD PMID:9622270 RGD:329845558 NCBI chr36:3,743,257...3,818,659
Ensembl chr36:3,744,163...3,818,652 		JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO RGD PMID:21680901 RGD:7245963 NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129 		JBrowse link
G AGTR1 angiotensin II receptor type 1 treatment ISO mRNA:increased expression:artery: RGD PMID:9918604 RGD:10047106 NCBI chr23:43,569,658...43,617,113
Ensembl chr23:43,614,035...43,616,238 		JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO RGD PMID:16118253 RGD:5509614 NCBI chr 5:32,026,193...32,038,698
Ensembl chr 5:31,882,501...32,038,119 		JBrowse link
G B9D2 B9 domain containing 2 treatment ISO mRNA:increased expression:carotic artery (rat) RGD PMID:9622270 PMID:30066831 RGD:329845558 RGD:597830142 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G CBL Cbl proto-oncogene ISO protein:hyperphosphorylation:tyrosine: RGD PMID:18663086 RGD:11038825 NCBI chr 5:14,600,409...14,676,974
Ensembl chr 5:14,607,013...14,676,956 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 treatment ISO RGD PMID:12223446 PMID:15353495 RGD:11526152 RGD:8549774 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G CCN2 cellular communication network factor 2 ISO protein:increased expression:arterial wall (rat) RGD PMID:19570811 RGD:2314490 NCBI chr 1:25,508,082...25,511,058
Ensembl chr 1:25,507,662...25,510,145 		JBrowse link
G CCNA2 cyclin A2 ISO mRNA:increased expression:artery: RGD PMID:18667424 RGD:10054494 NCBI chr19:18,317,866...18,324,592
Ensembl chr19:18,318,004...18,323,691 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator disease_progression ISO RGD PMID:10623660 RGD:11341688 NCBI chr37:10,268,407...10,307,803
Ensembl chr37:10,268,582...10,345,095 		JBrowse link
G CSF1R colony stimulating factor 1 receptor ISO mRNA, protein:increased expression: carotid artery endothelium (rat) RGD PMID:27135205 RGD:151665776 NCBI chr 4:58,980,699...59,010,683
Ensembl chr 4:58,980,788...59,010,510 		JBrowse link
G CSF3 colony stimulating factor 3 ISO protein:increased expression:smooth muscle cell: RGD PMID:15385271 RGD:11039423 NCBI chr 9:22,529,643...22,532,326
Ensembl chr 9:22,530,698...22,533,108 		JBrowse link
G DUSP1 dual specificity phosphatase 1 ISO RGD PMID:9546380 RGD:7771579 NCBI chr 4:39,588,833...39,591,065
Ensembl chr 4:39,588,339...39,590,514 		JBrowse link
G FOXO3 forkhead box O3 ISO RGD PMID:15662024 RGD:10402197 NCBI chr12:65,552,455...65,673,467
Ensembl chr12:65,552,310...65,670,198 		JBrowse link
G GC GC vitamin D binding protein ISO protein:decreased expression:plasma RGD PMID:21416056 RGD:5509868 NCBI chr13:60,795,305...60,828,038
Ensembl chr13:60,795,305...60,827,929 		JBrowse link
G GP6 glycoprotein VI platelet treatment ISO human protein in a mouse model RGD PMID:18566102 RGD:401824643 NCBI chr 1:102,586,229...102,612,067
Ensembl chr 1:102,585,544...102,613,905 		JBrowse link
G HDAC4 histone deacetylase 4 ISO protein:increased expression:carotid artery: RGD PMID:19389706 RGD:9681448 NCBI chr25:49,318,621...49,545,314
Ensembl chr25:49,317,349...49,453,478 		JBrowse link
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 ISO RGD PMID:11971902 RGD:625426 NCBI chr29:27,185,191...27,188,121
Ensembl chr29:27,185,191...27,188,121 		JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 ISO RGD PMID:11971902 RGD:625426 NCBI chr 1:64,630,656...64,646,546 JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO mRNA:increased expression:carotid artery (rat) RGD PMID:20368503 RGD:4145429 NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914 		JBrowse link
G IGF1 insulin like growth factor 1 ISO protein:increased expression:serum,carotid artery: RGD PMID:12490968 RGD:10046051 NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794 		JBrowse link
G IGF1R insulin like growth factor 1 receptor treatment ISO protein:increased phosphorylation:carotid artery: RGD PMID:17606126 RGD:10046006 NCBI chr 3:41,795,337...42,096,255
Ensembl chr 3:41,794,623...42,090,387 		JBrowse link
G IL18 interleukin 18 ISO protein:increased expression:carotid artery RGD PMID:16864728 PMID:19955748 RGD:4889159 RGD:4889500 NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO human gene in rat model RGD PMID:12754378 RGD:2316108 NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329 		JBrowse link
G ITGAV integrin subunit alpha V ISO mRNA:increased expression:carotic artery (rat) RGD PMID:9622270 RGD:329845558 NCBI chr36:28,815,215...28,890,569
Ensembl chr36:28,804,013...28,887,430 		JBrowse link
G ITGB3 integrin subunit beta 3 ISO protein:increased expression:carotid artery
mRNA:increased expression:carotic artery (rat)		 RGD PMID:9622270 PMID:17868879 RGD:329845558 RGD:4892652 NCBI chr 9:9,179,667...9,231,061
Ensembl chr 9:9,182,562...9,231,451 		JBrowse link
G JAG1 jagged canonical Notch ligand 1 ISO protein:increased expression:carotid artery RGD PMID:21330605 RGD:6482230 NCBI chr24:11,656,926...11,693,146
Ensembl chr24:11,657,416...11,692,199 		JBrowse link
G KLF4 KLF transcription factor 4 ameliorates ISO RGD PMID:29127880 RGD:155230825 NCBI chr11:62,881,840...62,886,676
Ensembl chr11:62,882,767...62,928,251 		JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 ISO protein:increased activity:carotid artery: RGD PMID:14638553 RGD:10412321 NCBI chr 1:29,107,813...29,306,437
Ensembl chr 1:29,108,591...29,306,503 		JBrowse link
G MIR145 microRNA mir-145 ISO miRNA:altered expression:wall of blood vessel (rat) RGD PMID:19542014 RGD:13210556 NCBI chr 4:59,533,128...59,533,210
Ensembl chr 4:59,533,128...59,533,210 		JBrowse link
G MIR223 microRNA mir-223 ISO RNA:increased expression:carotid artery RGD PMID:26065992 RGD:25824846 NCBI chr  X:50,838,131...50,838,233
Ensembl chr  X:50,838,131...50,838,233 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO RGD PMID:9327785 RGD:8547910 NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113 		JBrowse link
G MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) ISO RGD PMID:9327785 RGD:8547910 NCBI chr 5:28,949,631...28,957,915
Ensembl chr 5:28,949,631...28,958,222 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO RGD PMID:9327785 RGD:8547910 NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor treatment ISO mRNA:increased expression:carotid artery (rat) RGD PMID:8113414 PMID:22546228 PMID:23178522 RGD:10059612 RGD:7207861 RGD:7240535 NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309 		JBrowse link
G MYH9 myosin heavy chain 9 ISO protein:increased expression:carotid artery: RGD PMID:11003588 RGD:11533926 NCBI chr10:28,063,626...28,122,953
Ensembl chr10:28,063,624...28,122,953 		JBrowse link
G NONO non-POU domain containing octamer binding ameliorates ISO RGD PMID:33626912 RGD:155900763 NCBI chr  X:55,618,032...55,632,237
Ensembl chr  X:55,618,095...55,631,388 		JBrowse link
G NOS3 nitric oxide synthase 3 treatment ISO RGD PMID:29207649 RGD:13504723 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277 		JBrowse link
G NOTCH1 notch receptor 1 ISO RGD PMID:11971902 RGD:625426 NCBI chr 9:48,975,972...49,018,985
Ensembl chr 9:48,974,757...49,017,277 		JBrowse link
G NOTCH2 notch receptor 2 ISO RGD PMID:11971902 RGD:625426 NCBI chr17:56,854,825...57,020,157
Ensembl chr17:56,860,429...57,020,857 		JBrowse link
G NOTCH3 notch receptor 3 ISO mRNA:decreased expression:carotid artery RGD PMID:11971902 RGD:625426 NCBI chr20:46,946,654...46,978,821
Ensembl chr20:46,937,485...46,978,219 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 ISO protein:increased expression:blood vessel: RGD PMID:15044192 RGD:10413907 NCBI chr 7:38,503,072...38,542,556
Ensembl chr 7:38,503,067...38,542,127 		JBrowse link
G PCNA proliferating cell nuclear antigen ISO protein:increased expression:vascular smooth muscle cell carotid artery (mouse) RGD PMID:25751394 RGD:329328927 NCBI chr24:16,478,774...16,485,992
Ensembl chr24:16,478,769...16,484,992 		JBrowse link
G PCSK5 proprotein convertase subtilisin/kexin type 5 ISO mRNA,protein:increased expression:artery: RGD PMID:12649739 RGD:11556213 NCBI chr 1:82,088,090...82,506,131
Ensembl chr 1:82,090,664...82,555,145 		JBrowse link
G PDGFD platelet derived growth factor D ISO protein:increased expression:carotid artery: RGD PMID:18258854 RGD:9854624 NCBI chr 5:27,863,739...28,092,376
Ensembl chr 5:27,863,591...28,089,936 		JBrowse link
G PLAT plasminogen activator, tissue type ISO mRNA, protein:increased expression, increased activity:carotid artery (rat) RGD PMID:8343497 RGD:11537479 NCBI chr16:23,469,590...23,496,013 JBrowse link
G POSTN periostin ISO mRNA,protein:increased expression:artery: RGD PMID:15514205 RGD:10040973 NCBI chr25:3,167,319...3,208,970
Ensembl chr25:3,167,359...3,208,411 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma treatment ISO mouse gene in a rat model RGD PMID:19339015 RGD:8553019 NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha treatment ISO mouse gene in a rat model RGD PMID:19553562 PMID:22892143 RGD:2311405 RGD:7242065 NCBI chr 3:85,645,942...86,284,570
Ensembl chr 3:86,016,140...86,281,269 		JBrowse link
G PTGIS prostaglandin I2 synthase treatment ISO human gene in a rat model RGD PMID:9933282 PMID:10073980 PMID:10536678 PMID:17303142 RGD:401901254 RGD:401959382 RGD:401959739 RGD:401960092 NCBI chr24:36,129,091...36,162,525
Ensembl chr24:36,132,173...36,162,509 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 exacerbates ISO mRNA:increased expression:carotid artery (rat)
protein:increased expression:carotid artery (rat)		 RGD PMID:10807732 PMID:15271661 PMID:16373608 RGD:401965416 RGD:401965432 RGD:9590128 NCBI chr24:36,936,469...37,010,929
Ensembl chr24:36,936,298...37,003,720 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 ISO protein:increased expression:aorta tunica intima, aorta tunica media RGD PMID:12117720 RGD:39456082 NCBI chr26:9,989,218...10,072,245
Ensembl chr26:9,989,425...10,067,481 		JBrowse link
G RANGAP1 Ran GTPase activating protein 1 ISO protein:increased expression:carotid artery, intima (rat) RGD PMID:24988324 RGD:9835414 NCBI chr10:23,953,877...23,985,622
Ensembl chr10:23,953,912...24,003,162 		JBrowse link
G ROBO1 roundabout guidance receptor 1 ISO mRNA:increased expression:carotid artery RGD PMID:26841069 RGD:243048443 NCBI chr31:8,082,363...8,594,623
Ensembl chr31:7,626,126...8,593,728 		JBrowse link
G SCGB1A1 secretoglobin family 1A member 1 ISO RGD PMID:11107082 RGD:5144055 NCBI chr18:54,187,487...54,191,493
Ensembl chr18:54,187,487...54,191,482 		JBrowse link
G SERPINE1 serpin family E member 1 ISO mRNA:increased expression:carotid artery (rat) RGD PMID:25617690 RGD:11075082 NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301 		JBrowse link
G SERPINF1 serpin family F member 1 treatment ISO human gene in a rat model RGD PMID:17525281 RGD:8618841 NCBI chr 9:45,891,368...45,902,768
Ensembl chr 9:45,891,410...45,902,765 		JBrowse link
G SLIT2 slit guidance ligand 2 ISO mRNA:increased expression:carotid artery RGD PMID:26841069 RGD:243048443 NCBI chr 3:88,964,707...89,311,817
Ensembl chr 3:88,966,232...89,312,955 		JBrowse link
G SMAD3 SMAD family member 3 treatment ISO RGD PMID:30066831 RGD:597830142 NCBI chr30:31,246,313...31,360,098
Ensembl chr30:31,245,657...31,363,337 		JBrowse link
G SP1 Sp1 transcription factor ISO protein:increased phosphorylation:smooth muscle cell: RGD PMID:18258854 RGD:9854624 NCBI chr27:1,802,587...1,861,187
Ensembl chr27:1,805,184...1,847,226 		JBrowse link
G SPON2 spondin 2 ISO protein:decreased expression:vascular smooth muscle cell carotid artery (mouse) RGD PMID:25751394 RGD:329328927 NCBI chr 3:91,411,245...91,421,245 JBrowse link
G TAGLN transgelin ISO mRNA:decreased expression:carotid artery: RGD PMID:34694145 RGD:155883160 NCBI chr 5:16,390,259...16,395,471
Ensembl chr 5:16,390,573...16,397,207 		JBrowse link
G TFPI2 tissue factor pathway inhibitor 2 ISO mRNA,protein:increased expression:carotid artery: RGD PMID:20537494 RGD:11060271 NCBI chr14:19,399,259...19,403,890
Ensembl chr14:19,399,720...19,403,708 		JBrowse link
G TGFB3 transforming growth factor beta 3 ISO mRNA:increased expression:carotic artery (rat) RGD PMID:9622270 RGD:329845558 NCBI chr 8:48,920,874...48,946,037
Ensembl chr 8:48,923,423...48,945,816 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 ISO mRNA:increased expression:carotic artery (rat) RGD PMID:9622270 RGD:329845558 NCBI chr11:56,191,383...56,223,042
Ensembl chr11:56,161,772...56,218,594 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 ISO mRNA:increased expression:carotic artery (rat) RGD PMID:9622270 RGD:329845558 NCBI chr23:13,886,869...13,946,480
Ensembl chr23:13,889,000...13,977,636 		JBrowse link
carotid artery dissection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LDLR low density lipoprotein receptor ISO ClinVar Annotator: match by term: Carotid artery dissection ClinVar PMID:1301956 PMID:2088165 PMID:2318961 PMID:3263645 PMID:8882879 More... NCBI chr20:50,115,175...50,152,443
Ensembl chr20:50,048,736...50,152,355 		JBrowse link
G MYLK myosin light chain kinase ISO ClinVar Annotator: match by term: Carotid artery dissection ClinVar PMID:25326637 PMID:25741868 PMID:28492532 PMID:30755392 NCBI chr33:26,663,991...26,867,370
Ensembl chr33:26,664,800...26,843,181 		JBrowse link
Carotid Artery Dissection, Internal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LDLR low density lipoprotein receptor ISO ClinVar Annotator: match by term: Internal carotid artery dissection ClinVar PMID:1301956 PMID:2088165 PMID:2318961 PMID:3263645 PMID:8882879 More... NCBI chr20:50,115,175...50,152,443
Ensembl chr20:50,048,736...50,152,355 		JBrowse link
G MYLK myosin light chain kinase ISO ClinVar Annotator: match by term: Internal carotid artery dissection ClinVar PMID:25326637 PMID:25741868 PMID:28492532 PMID:30755392 NCBI chr33:26,663,991...26,867,370
Ensembl chr33:26,664,800...26,843,181 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15757
    Wounds and Injuries 967
      Nervous System Trauma 593
        Cerebrovascular Trauma 71
          Carotid Artery Injuries 69
            Carotid-Cavernous Sinus Fistula 0
            carotid artery dissection + 2
Path 2
Term Annotations click to browse term
  disease 15757
    disease of anatomical entity 15377
      nervous system disease 13506
        central nervous system disease 12077
          brain disease 11341
            cerebrovascular disease 956
              Cerebrovascular Trauma 71
                Carotid Artery Injuries 69
                  Carotid-Cavernous Sinus Fistula 0
                  carotid artery dissection + 2
paths to the root