RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Osteoarthritis, Hip
Accession: DOID:9006041
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Definition: Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old age. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion.
Synonyms: exact_synonym: Coxarthroses; Coxarthrosis; Hip Osteoarthritides; Osteoarthritis Of Hip; Osteoarthritis Of Hips
narrow_synonym: OSTEOARTHRITIS OF HIP, FEMALE-SPECIFIC, SUSCEPTIBILITY TO
primary_id: MESH:D015207 ; RDO:0006850
xref: EFO:1000786
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Adamts5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
IEP
mRNA:increased expression:cartilage
RGD
PMID:22670655
RGD:10043109
NCBI chr11:25,000,627...25,047,205
Ensembl chr11:25,000,637...25,047,205
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Aspn
asporin
ISO
mRNA:increased expression:cartilage:
RGD
PMID:15640800
RGD:9684965
NCBI chr17:15,079,910...15,104,369
Ensembl chr17:15,080,639...15,104,041
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Astn2
astrotactin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30374069
NCBI chr 5:78,758,142...79,744,021
Ensembl chr 5:78,758,142...79,748,273
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Chadl
chondroadherin-like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28319091 PMID:30374069
NCBI chr 7:113,205,323...113,218,678
Ensembl chr 7:113,210,748...113,217,272
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Col10a1
collagen type X alpha 1 chain
IEP
mRNA, protein:increased expression:cartilage
RGD
PMID:22670655
RGD:10043109
NCBI chr20:38,183,103...38,189,488
Ensembl chr20:38,182,494...38,189,494
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Col11a1
collagen type XI alpha 1 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30374069
NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853
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Col1a1
collagen type I alpha 1 chain
susceptibility no_association
ISO
DNA:SNP:intron:g.2046G>T (human)
RGD
PMID:17187661 PMID:15880349 PMID:9811048
RGD:5688305 , RGD:5688306 , RGD:5688330
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Comp
cartilage oligomeric matrix protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28319091
NCBI chr16:19,047,206...19,055,584
Ensembl chr16:19,047,207...19,055,845
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Crhr1
corticotropin releasing hormone receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30664745
NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481
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Diablo
diablo, IAP-binding mitochondrial protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30664745
NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
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Esr1
estrogen receptor 1
ISO
DNA:SNP:intron:g.-397T>C (human)
RGD
PMID:17419075
RGD:10045661
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Filip1
filamin A interacting protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30374069
NCBI chr 8:80,761,283...80,956,556
Ensembl chr 8:80,764,604...80,922,549
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Gdf5
growth differentiation factor 5
ISO
ClinVar Annotator: match by term: Osteoarthritis, hip
ClinVar
PMID:17384641 PMID:28492532
NCBI chr 3:144,454,316...144,458,508
Ensembl chr 3:144,454,338...144,458,612
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Ghr
growth hormone receptor
ISO
associated with Acromegaly;DNA:deletion:exon:
RGD
PMID:19864451
RGD:10003142
NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735
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Hdac9
histone deacetylase 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30374069
NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333
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Hfe
homeostatic iron regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30374069
NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
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Il11
interleukin 11
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30374069 PMID:30664745
NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
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Il4r
interleukin 4 receptor
susceptibility no_association
ISO
DNA:SNPs:multiple DNA:missense mutations:cds:p.S411L, p.S727A (rs1805013, rs1805016) (human)
RGD
PMID:14745651 PMID:19036616
RGD:10402782 , RGD:10402784
NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
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Itih1
inter-alpha trypsin inhibitor, heavy chain 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30374069
NCBI chr16:6,122,246...6,136,363
Ensembl chr16:6,122,248...6,136,363
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Lmx1b
LIM homeobox transcription factor 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30374069
NCBI chr 3:16,862,195...16,940,899
Ensembl chr 3:16,862,195...16,940,899
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Ltbp3
latent transforming growth factor beta binding protein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30374069
NCBI chr 1:203,029,412...203,045,975
Ensembl chr 1:203,029,877...203,045,975
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Mapt
microtubule-associated protein tau
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30664745
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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Mmp13
matrix metallopeptidase 13
IEP
mRNA, protein:increased expression:cartilage
RGD
PMID:22670655
RGD:10043109
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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Runx2
RUNX family transcription factor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30374069
NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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Smad3
SMAD family member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30374069
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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Smo
smoothened, frizzled class receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30374069
NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829
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Tnc
tenascin C
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30374069
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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