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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Closed Head Injuries
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Accession:DOID:9006008 term browser browse the term
Definition:Traumatic injuries to the cranium where the integrity of the skull is not compromised and no bone fragments or other objects penetrate the skull and DURA MATER. This frequently results in mechanical injury being transmitted to intracranial structures which may produce TRAUMATIC BRAIN INJURIES, hemorrhage, or CRANIAL NERVE INJURIES. (From Rowland, Merritt's Textbook of Neurology, 9th ed, p417)
Synonyms:exact_synonym: Blunt Head Injuries;   Blunt Head Injury;   Closed Head Injury;   Closed Head Trauma;   Closed Head Traumas;   Nonpenetrating Head Injuries;   Nonpenetrating Head Injury
 primary_id: MESH:D016489



show annotations for term's descendants           Sort by:
Closed Head Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 ISO protein:increased expression:neuron RGD PMID:16004578 RGD:6483315 NCBI chr10:86,731,649...86,747,002 JBrowse link
G Gfap glial fibrillary acidic protein IEP RGD PMID:8833197 RGD:6480531 NCBI chr10:88,352,987...88,361,661 JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 ISO human protein in a rat model RGD PMID:17014847 RGD:13504858 NCBI chr 1:252,306,541...252,337,622 JBrowse link
G Igf1 insulin-like growth factor 1 ISO protein:decreased expression:serum: RGD PMID:12002507 RGD:8548865 NCBI chr 7:24,169,608...24,249,446 JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 ISO protein:decreased expression:serum: RGD PMID:12002507 RGD:8548865 NCBI chr14:86,270,208...86,277,944 JBrowse link
G Vim vimentin IEP RGD PMID:8833197 RGD:6480531 NCBI chr17:81,577,261...81,585,746 JBrowse link
Brain Concussion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 IEP RGD PMID:26448536 RGD:13506960 NCBI chr 8:58,605,403...58,669,339 JBrowse link
G Drd3 dopamine receptor D3 IEP RGD PMID:26448536 RGD:13506960 NCBI chr11:70,385,586...70,437,793 JBrowse link
G Drd4 dopamine receptor D4 IEP RGD PMID:26448536 RGD:13506960 NCBI chr 1:205,825,937...205,829,124 JBrowse link
G Il6 interleukin 6 treatment IDA RGD PMID:27113205 RGD:11062140 NCBI chr 4:5,889,999...5,894,575 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19139
    Wounds and Injuries 998
      Nonpenetrating Wounds 25
        Closed Head Injuries 10
          Brain Concussion + 4
Path 2
Term Annotations click to browse term
  disease 19139
    disease of anatomical entity 18450
      nervous system disease 14359
        Nervous System Trauma 610
          Craniocerebral Trauma 372
            Closed Head Injuries 10
              Brain Concussion + 4
paths to the root