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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Neuralgia
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Accession:DOID:9005968 term browser browse the term
Definition:Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
Synonyms:exact_synonym: Atypical Neuralgia;   Atypical Neuralgias;   Iliohypogastric Nerve Neuralgia;   Iliohypogastric Nerve Neuralgias;   Ilioinguinal Neuralgia;   Ilioinguinal Neuralgias;   Nerve Pain;   Nerve Pains;   Neuralgias;   Neurodynia;   Neurodynias;   Neuropathic Pain;   Neuropathic Pains;   Paroxysmal Nerve Pain;   Paroxysmal Nerve Pains;   Perineal Neuralgia;   Perineal Neuralgias;   Stump Neuralgia;   Stump Neuralgias;   Supraorbital Neuralgia;   Supraorbital Neuralgias;   Vidian Neuralgia;   Vidian Neuralgias
 primary_id: MESH:D009437;   RDO:0004660
For additional species annotation, visit the Alliance of Genome Resources.



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Neuralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A ISO RGD PMID:12946573 RGD:6893571 NCBI chr14:121,469,572...121,470,924
Ensembl chr14:121,469,527...121,470,924
JBrowse link
G ADRA2C adrenoceptor alpha 2C ISO RGD PMID:12946573 RGD:6893571 NCBI chr 8:2,320,125...2,322,162
Ensembl chr 8:2,320,226...2,321,608
JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25014009 NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,116...24,228,756
JBrowse link
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17442347 PMID:18400411 PMID:19339603 PMID:24133248 NCBI chr 9:97,781,057...98,265,925
Ensembl chr 9:97,780,742...98,266,573
JBrowse link
G CFL1 cofilin 1 treatment ISO associated with Sciatic Neuropathy RGD PMID:27216618 RGD:11568694 NCBI chr 2:6,471,558...6,475,019
Ensembl chr 2:6,469,254...6,475,035
JBrowse link
G CTSS cathepsin S ISO RGD PMID:17551020 PMID:18700000 RGD:5686878 RGD:5686911 NCBI chr 4:98,415,273...98,442,952
Ensembl chr 4:98,390,250...98,442,936
JBrowse link
G CTSZ cathepsin Z ISO RGD PMID:18700000 RGD:5686878 NCBI chr17:59,141,497...59,149,377
Ensembl chr17:59,141,501...59,149,298
JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr15:120,219,657...120,230,203 JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17292584 NCBI chr15:15,663,652...15,666,706
Ensembl chr15:15,663,494...15,667,233
JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17720801 NCBI chr14:113,805,616...113,820,445
Ensembl chr14:113,805,611...113,812,041
JBrowse link
G DRD1 dopamine receptor D1 ISO RGD PMID:22171983 RGD:6907447 NCBI chr16:49,189,555...49,193,722
Ensembl chr16:49,188,936...49,193,709
JBrowse link
G DRD2 dopamine receptor D2 ISO RGD PMID:22171983 PMID:22902996 RGD:6907443 RGD:6907447 NCBI chr 9:41,068,618...41,135,262
Ensembl chr 9:41,068,779...41,133,599
JBrowse link
G FOXP3 forkhead box P3 treatment ISO mRNA:increased expression: L4-L5 of the spinal cord RGD PMID:30858084 RGD:38599004 NCBI chr  X:43,303,777...43,328,164
Ensembl chr  X:43,303,782...43,328,735
JBrowse link
G GAL galanin and GMAP prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 2:4,351,113...4,357,167
Ensembl chr 2:4,350,909...4,357,170
JBrowse link
G GFRA1 GDNF family receptor alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr14:126,273,558...126,499,957
Ensembl chr14:126,277,857...126,499,465
JBrowse link
G GJA1 gap junction protein alpha 1 ISO associated with Spinal Cord Injuries; RGD PMID:22951907 RGD:7364890 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,515...41,002,137
JBrowse link
G GRK1 G protein-coupled receptor kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr11:78,793,670...78,803,291
Ensembl chr11:78,793,777...78,803,297
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 treatment ISO RGD PMID:24216329 RGD:13792703 NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,436...5,227,748
JBrowse link
G GRM5 glutamate metabotropic receptor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19840219 NCBI chr 9:21,914,422...22,438,200
Ensembl chr 9:21,916,815...22,436,063
JBrowse link
G HMGB1 high mobility group box 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25014009 NCBI chr11:7,195,556...7,321,071 JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C ISO CTD Direct Evidence: marker/mechanism CTD PMID:28011743 NCBI chr  X:94,053,415...94,313,352
Ensembl chr  X:94,053,456...94,313,356
JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:16949747 PMID:24077211 PMID:25078297 RGD:11049468 RGD:1598632 RGD:7364865 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,727...67,405,711
JBrowse link
G IL12B interleukin 12B ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr16:64,143,268...64,158,929
Ensembl chr16:64,147,247...64,158,952
JBrowse link
G KDR kinase insert domain receptor ISO RGD PMID:20705122 RGD:5684389 NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,116...41,856,339
JBrowse link
G MIR135-2 microRNA mir-135-2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr 5:86,141,185...86,141,284
Ensembl chr 5:86,141,185...86,141,284
JBrowse link
G NOS1 nitric oxide synthase 1 treatment ISO RGD PMID:23342771 RGD:7257658 NCBI chr14:35,112,898...35,299,297
Ensembl chr14:35,113,184...35,295,972
JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 4:93,219,509...93,237,944
Ensembl chr 4:93,219,516...93,237,930
JBrowse link
G OPRM1 opioid receptor mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14718584 PMID:18400411 NCBI chr 1:12,634,125...12,702,295
Ensembl chr 1:12,528,672...12,702,443
JBrowse link
G P2RY12 purinergic receptor P2Y12 ISO RGD PMID:20665560 RGD:6480524 NCBI chr13:91,522,754...91,572,195
Ensembl chr13:91,427,197...91,572,170
JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30152261 NCBI chr14:97,558,531...98,793,080
Ensembl chr14:97,560,785...98,793,318
JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr13:23,481,537...23,570,454
Ensembl chr13:23,481,999...23,570,452
JBrowse link
G SCN9A sodium voltage-gated channel alpha subunit 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19557861 NCBI chr15:72,745,706...72,912,352
Ensembl chr15:72,748,692...72,912,407
JBrowse link
G TAC1 tachykinin precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 9:77,197,403...77,206,529
Ensembl chr 9:77,197,535...77,206,526
JBrowse link
G TGFB1 transforming growth factor beta 1 treatment ISO RGD PMID:24979268 RGD:11073677 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
G TLR4 toll like receptor 4 ISO mRNA:increased expression:lumbar vertebra RGD PMID:15145554 RGD:1342461 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,059,004
JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20846523 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TNFSF8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr 1:255,436,206...255,459,020
Ensembl chr 1:255,432,969...255,459,073
JBrowse link
amyotrophic neuralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SEPTIN9 septin 9 ISO ClinVar Annotator: match by term: Hereditary Neuralgic Amyotrophy (HNA)
ClinVar Annotator: match by term: Amyotrophy, hereditary neuralgic
ClinVar Annotator: match by term: Hereditary neuralgic amyotrophy
ClinVar PMID:16186812 PMID:17546647 PMID:18492087 PMID:19139049 PMID:19204161 More... NCBI chr12:4,254,771...4,347,526
Ensembl chr12:4,254,775...4,405,628
JBrowse link
Postherpetic Neuralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11280320 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G SCN8A sodium voltage-gated channel alpha subunit 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23382806 NCBI chr 5:16,977,468...17,173,831
Ensembl chr 5:16,977,700...17,169,564
JBrowse link
G SCN9A sodium voltage-gated channel alpha subunit 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23382806 NCBI chr15:72,745,706...72,912,352
Ensembl chr15:72,748,692...72,912,407
JBrowse link
Sciatica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BLOC1S2 biogenesis of lysosomal organelles complex 1 subunit 2 ISO RGD PMID:16176350 RGD:2302154 NCBI chr14:111,391,083...111,397,609
Ensembl chr14:111,388,898...111,397,622
JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B treatment ISO RGD PMID:22425187 RGD:7245944 NCBI chr 6:72,195,420...72,231,146
Ensembl chr 6:72,195,435...72,231,149
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13630
    disease of anatomical entity 13298
      nervous system disease 11013
        peripheral nervous system disease 2431
          Neuralgia 42
            Morton Neuroma 0
            Piriformis Muscle Syndrome + 0
            Postherpetic Neuralgia 3
            Pudendal Neuralgia 0
            Sciatica + 2
            amyotrophic neuralgia 1
            causalgia 0
Path 2
Term Annotations click to browse term
  disease 13630
    disease of anatomical entity 13298
      nervous system disease 11013
        Neurologic Manifestations 5153
          Pain 289
            Neuralgia 42
              Morton Neuroma 0
              Piriformis Muscle Syndrome + 0
              Postherpetic Neuralgia 3
              Pudendal Neuralgia 0
              Sciatica + 2
              amyotrophic neuralgia 1
              causalgia 0
paths to the root