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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Neuralgia
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Accession:DOID:9005968 term browser browse the term
Definition:Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
Synonyms:exact_synonym: Atypical Neuralgia;   Atypical Neuralgias;   Iliohypogastric Nerve Neuralgia;   Iliohypogastric Nerve Neuralgias;   Ilioinguinal Neuralgia;   Ilioinguinal Neuralgias;   Nerve Pain;   Nerve Pains;   Neuralgias;   Neurodynia;   Neurodynias;   Neuropathic Pain;   Neuropathic Pains;   Paroxysmal Nerve Pain;   Paroxysmal Nerve Pains;   Perineal Neuralgia;   Perineal Neuralgias;   Stump Neuralgia;   Stump Neuralgias;   Supraorbital Neuralgia;   Supraorbital Neuralgias;   Vidian Neuralgia;   Vidian Neuralgias
 primary_id: MESH:D009437;   RDO:0004660
For additional species annotation, visit the Alliance of Genome Resources.



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Neuralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A ISO RGD PMID:12946573 RGD:6893571 NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684
JBrowse link
G ADRA2C adrenoceptor alpha 2C ISO RGD PMID:12946573 RGD:6893571 NCBI chr 3:60,608,632...60,648,112
Ensembl chr 3:60,646,132...60,647,722
JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25014009 NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129
JBrowse link
G B9D2 B9 domain containing 2 treatment ISO RGD PMID:24979268 RGD:11073677 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885
JBrowse link
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17442347 PMID:18400411 PMID:19339603 PMID:24133248 NCBI chr18:21,561,091...21,949,970
Ensembl chr18:21,564,676...21,949,544
JBrowse link
G CFL1 cofilin 1 treatment ISO associated with Sciatic Neuropathy RGD PMID:27216618 RGD:11568694 NCBI chr18:51,404,649...51,408,240
Ensembl chr18:51,401,659...51,408,212
JBrowse link
G CTSS cathepsin S ISO RGD PMID:17551020 PMID:18700000 RGD:5686878 RGD:5686911 NCBI chr17:59,893,840...59,910,878
Ensembl chr17:59,893,840...59,910,849
JBrowse link
G CTSZ cathepsin Z ISO RGD PMID:18700000 RGD:5686878 NCBI chr24:43,743,291...43,750,154
Ensembl chr24:43,743,294...43,754,424
JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr37:24,831,351...24,846,387
Ensembl chr37:24,843,171...24,844,247
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17292584 NCBI chr19:38,874,650...38,877,740
Ensembl chr19:38,874,145...38,877,740
JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17720801 NCBI chr28:15,292,959...15,298,896
Ensembl chr28:15,293,106...15,298,852
JBrowse link
G DRD1 dopamine receptor D1 ISO RGD PMID:22171983 RGD:6907447 NCBI chr 4:37,550,454...37,554,641
Ensembl chr 4:37,549,708...37,553,287
JBrowse link
G DRD2 dopamine receptor D2 ISO RGD PMID:22171983 PMID:22902996 RGD:6907443 RGD:6907447 NCBI chr 5:19,732,842...19,795,241
Ensembl chr 5:19,732,836...19,795,241
JBrowse link
G FOXP3 forkhead box P3 treatment ISO mRNA:increased expression: L4-L5 of the spinal cord RGD PMID:30858084 RGD:38599004 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758
JBrowse link
G GAL galanin and GMAP prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr18:49,240,437...49,246,543
Ensembl chr18:49,240,437...49,246,950
JBrowse link
G GFRA1 GDNF family receptor alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr28:26,707,592...26,910,029
Ensembl chr28:26,709,645...26,909,992
JBrowse link
G GJA1 gap junction protein alpha 1 ISO associated with Spinal Cord Injuries; RGD PMID:22951907 RGD:7364890 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936
JBrowse link
G GRK1 G protein-coupled receptor kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr22:60,911,953...60,929,330
Ensembl chr22:60,911,953...60,926,146
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 treatment ISO RGD PMID:24216329 RGD:13792703 NCBI chr18:50,148,566...50,167,422
Ensembl chr18:50,148,598...50,167,428
JBrowse link
G GRM5 glutamate metabotropic receptor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19840219 NCBI chr21:10,980,186...11,496,539
Ensembl chr21:10,996,075...11,493,290
JBrowse link
G HMGB1 high mobility group box 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25014009 NCBI chr25:9,431,223...9,558,167
Ensembl chr25:9,431,218...9,558,165
JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C ISO CTD Direct Evidence: marker/mechanism CTD PMID:28011743 NCBI chr  X:87,342,800...87,641,224
Ensembl chr  X:87,342,792...87,638,579
JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:16949747 PMID:24077211 PMID:25078297 RGD:11049468 RGD:1598632 RGD:7364865 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057
JBrowse link
G IL12B interleukin 12B ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr 4:51,178,637...51,194,606
Ensembl chr 4:51,183,568...51,193,228
JBrowse link
G ITGAM integrin subunit alpha M ISO mRNA:increased expression:lumbar vertebra RGD PMID:15145554 RGD:1342461 NCBI chr 6:16,944,062...16,996,525
Ensembl chr 6:16,808,971...16,996,286
JBrowse link
G KDR kinase insert domain receptor ISO RGD PMID:20705122 RGD:5684389 NCBI chr13:47,442,861...47,484,574
Ensembl chr13:47,442,764...47,485,042
JBrowse link
G MIR135A-2 microRNA mir-135a-2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr15:37,181,419...37,181,480
Ensembl chr15:37,181,398...37,181,497
JBrowse link
G MIR135B microRNA mir-135b ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr38:1,926,558...1,926,646
Ensembl chr38:1,926,558...1,926,646
JBrowse link
G MIR208A microRNA mir-208a ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr 8:3,636,919...3,636,987
Ensembl chr 8:3,636,919...3,636,987
JBrowse link
G MIR223 microRNA mir-223 treatment ISO RGD PMID:28580822 RGD:25824768 NCBI chr  X:50,838,131...50,838,233
Ensembl chr  X:50,838,131...50,838,233
JBrowse link
G NOS1 nitric oxide synthase 1 treatment ISO RGD PMID:23342771 RGD:7257658 NCBI chr26:13,787,341...13,895,176
Ensembl chr26:13,786,309...13,962,332
JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 7:41,140,931...41,159,326
Ensembl chr 7:41,140,879...41,159,288
JBrowse link
G OPRM1 opioid receptor mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14718584 PMID:18400411 NCBI chr 1:43,972,915...44,037,477
Ensembl chr 1:43,972,219...44,141,238
JBrowse link
G P2RY12 purinergic receptor P2Y12 ISO RGD PMID:20665560 RGD:6480524 NCBI chr23:45,908,574...45,954,675
Ensembl chr23:45,909,485...45,910,526
JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30152261 NCBI chr26:35,732,974...36,932,744
Ensembl chr26:35,737,242...36,932,729
JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr23:8,420,468...8,527,414
Ensembl chr23:8,420,472...8,527,383
JBrowse link
G SCN9A sodium voltage-gated channel alpha subunit 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19557861 NCBI chr36:11,287,358...11,382,897
Ensembl chr36:11,290,625...11,383,255
JBrowse link
G TAC1 tachykinin precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr14:22,631,106...22,640,283
Ensembl chr14:22,632,642...22,640,258
JBrowse link
G TLR4 toll like receptor 4 ISO mRNA:increased expression:lumbar vertebra RGD PMID:15145554 RGD:1342461 NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165
JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20846523 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G TNFSF8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr11:68,979,498...69,006,898
Ensembl chr11:68,982,360...69,007,355
JBrowse link
amyotrophic neuralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SEPTIN9 septin 9 ISO ClinVar Annotator: match by term: Hereditary Neuralgic Amyotrophy (HNA)
ClinVar Annotator: match by term: Amyotrophy, hereditary neuralgic
ClinVar Annotator: match by term: Hereditary neuralgic amyotrophy
ClinVar PMID:16186812 PMID:17546647 PMID:18492087 PMID:19139049 PMID:19204161 More... NCBI chr 9:3,495,764...3,571,755
Ensembl chr 9:3,448,793...3,616,732
JBrowse link
Postherpetic Neuralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11280320 NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354
JBrowse link
G SCN8A sodium voltage-gated channel alpha subunit 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23382806 NCBI chr27:3,174,257...3,348,349
Ensembl chr27:3,176,013...3,296,482
JBrowse link
G SCN9A sodium voltage-gated channel alpha subunit 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23382806 NCBI chr36:11,287,358...11,382,897
Ensembl chr36:11,290,625...11,383,255
JBrowse link
Sciatica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BLOC1S2 biogenesis of lysosomal organelles complex 1 subunit 2 ISO RGD PMID:16176350 RGD:2302154 NCBI chr28:13,040,016...13,044,364
Ensembl chr28:13,040,573...13,044,323
JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B treatment ISO RGD PMID:22425187 RGD:7245944 NCBI chr 2:84,140,179...84,151,219
Ensembl chr 2:84,141,911...84,157,191
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13842
    disease of anatomical entity 13501
      nervous system disease 11192
        peripheral nervous system disease 2466
          Neuralgia 46
            Morton Neuroma 0
            Piriformis Muscle Syndrome + 0
            Postherpetic Neuralgia 3
            Pudendal Neuralgia 0
            Sciatica + 2
            amyotrophic neuralgia 1
            causalgia 0
Path 2
Term Annotations click to browse term
  disease 13842
    disease of anatomical entity 13501
      nervous system disease 11192
        Neurologic Manifestations 5229
          Pain 295
            Neuralgia 46
              Morton Neuroma 0
              Piriformis Muscle Syndrome + 0
              Postherpetic Neuralgia 3
              Pudendal Neuralgia 0
              Sciatica + 2
              amyotrophic neuralgia 1
              causalgia 0
paths to the root