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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Pinealoma
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Accession:DOID:9005957 term browser browse the term
Definition:Neoplasms which originate from pineal parenchymal cells that tend to enlarge the gland and be locally invasive. The two major forms are pineocytoma and the more malignant pineoblastoma. Pineocytomas have moderate cellularity and tend to form rosette patterns. Pineoblastomas are highly cellular tumors containing small, poorly differentiated cells. These tumors occasionally seed the neuroaxis or cause obstructive HYDROCEPHALUS or Parinaud's syndrome. GERMINOMA; CARCINOMA, EMBRYONAL; GLIOMA; and other neoplasms may arise in the pineal region with germinoma being the most common pineal region tumor. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2064; Adams et al., Principles of Neurology, 6th ed, p670)
Synonyms:exact_synonym: Mixed Pineocytoma Pineoblastoma;   Mixed Pineocytoma-Pineoblastomas;   Pineal Gland Tumor;   Pineal Gland Tumors;   Pineal Neoplasm;   Pineal Neoplasms;   Pineal Parenchymal Tumor;   Pineal Parenchymal Tumors;   Pineal Tumor;   Pineal Tumors;   Pinealocytoma;   Pinealocytomas;   Pinealomas;   pineocytoma;   pineocytomas;   tumor of the pineal region
 xref: EFO:1000476


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adult pineal parenchymal tumor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MKI67 marker of proliferation Ki-67 severity ISO RGD PMID:21696422 RGD:6483520 NCBI chr28:36,920,679...36,939,336
Ensembl chr28:36,913,023...36,939,486 		JBrowse link
papillary tumor of the pineal region term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTEN phosphatase and tensin homolog ISO ClinVar Annotator: match by term: Papillary tumor of the pineal region ClinVar PMID:10866302 PMID:11051241 PMID:12614768 PMID:17942903 PMID:21194675 More... NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176 		JBrowse link
pineoblastoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DICER1 dicer 1, ribonuclease III ISO ClinVar Annotator: match by term: Pineoblastoma ClinVar PMID:16199547 PMID:19556464 PMID:21266384 PMID:21882293 PMID:24909177 More... NCBI chr 8:63,970,245...64,029,438
Ensembl chr 8:63,972,027...64,019,879 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17773
    disease of anatomical entity 15145
      endocrine system disease 6018
        Endocrine Gland Neoplasms 2536
          Pinealoma 3
            papillary tumor of the pineal region 1
            pineocytoma + 3
Path 2
Term Annotations click to browse term
  disease 17773
    disease of anatomical entity 15145
      nervous system disease 13207
        central nervous system disease 11844
          brain disease 11124
            hypothalamic disease 475
              Pinealoma 3
                papillary tumor of the pineal region 1
                pineocytoma + 3
paths to the root