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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Endotoxemia
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Accession:DOID:9005930 term browser browse the term
Definition:A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
Synonyms:exact_synonym: Endotoxemias
 primary_id: MESH:D019446


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Endotoxemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 ISO RGD PMID:9828229 RGD:1598596 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A ISO mRNA:decreased expression:liver (rat) RGD PMID:26977098 RGD:11041000 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B ISO
EXP 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20300455 PMID:9828229 RGD:1598596 NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 ISO RGD PMID:16572733 RGD:1598611 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc8 ATP-binding cassette, sub-family C member 8 ISO RGD PMID:17285300 RGD:2301914 NCBI chr 7:45,753,952...45,829,441
Ensembl chr 7:45,753,947...45,829,457 		JBrowse link
G Ace angiotensin I converting enzyme ISO associated with Hemorrhage;protein:decreased activity:plasma (rat) RGD PMID:3028670 RGD:8142370 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Ache acetylcholinesterase ISO RGD PMID:17657467 RGD:5688055 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 ISO RGD PMID:11680626 RGD:1598729 NCBI chr 2:113,877,763...113,883,356
Ensembl chr 2:113,877,763...113,884,029 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif 1 ISO protein:increased expression:plasma, spleen RGD PMID:23025351 RGD:9681752 NCBI chr16:85,590,715...85,600,001
Ensembl chr16:85,590,715...85,600,001 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO associated with Obesity RGD PMID:23838384 RGD:8695926 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Adipor2 adiponectin receptor 2 severity ISO associated with obesity;mRNA:decreased expression:liver (rat) RGD PMID:23838384 RGD:8695926 NCBI chr 6:119,330,111...119,394,489
Ensembl chr 6:119,330,111...119,394,665 		JBrowse link
G Adra2a adrenergic receptor, alpha 2a onset ISO mRNA:increased expression:spleen RGD PMID:20302880 RGD:6480487 NCBI chr19:54,033,690...54,037,413
Ensembl chr19:54,032,582...54,037,413 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a ISO protein:increased expression:kidney RGD PMID:16725227 RGD:6903849 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 ISO protein:decreased expression:kidney RGD PMID:16725227 RGD:6903849 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403 		JBrowse link
G Ahr aryl-hydrocarbon receptor severity IMP RGD PMID:24930766 RGD:39939032 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Akp3 alkaline phosphatase 3, intestine, not Mn requiring IMP RGD PMID:23569246 RGD:14349049 NCBI chr 1:87,052,676...87,056,450
Ensembl chr 1:87,052,695...87,055,634 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 ISO RGD PMID:22824368 RGD:38676479 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Aldoa aldolase A, fructose-bisphosphate ISO RGD PMID:16930621 RGD:1599054 NCBI chr 7:126,394,406...126,399,537
Ensembl chr 7:126,394,406...126,399,923 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15328337 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139 		JBrowse link
G Apoa1 apolipoprotein A-I treatment ISO RGD PMID:18593575 PMID:23227448 RGD:7241573, RGD:7241868 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Apob apolipoprotein B ISO RGD PMID:16719989 RGD:1599165 NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835 		JBrowse link
G Apoe apolipoprotein E ISO rat model treated with human protein RGD PMID:9153287 RGD:6904216 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Asl argininosuccinate lyase ISO RGD PMID:10652239 RGD:1599265 NCBI chr 5:130,040,099...130,053,222
Ensembl chr 5:130,040,099...130,058,088 		JBrowse link
G Ass1 argininosuccinate synthetase 1 ISO RGD PMID:10652239 RGD:1599265 NCBI chr 2:31,360,282...31,410,682
Ensembl chr 2:31,360,219...31,410,684 		JBrowse link
G Atf2 activating transcription factor 2 treatment ISO protein:increased expression, increased activity:small intestine mucosa RGD PMID:21641970 PMID:24312512 RGD:5135029, RGD:10047418 NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr18:77,861,468...77,870,569
Ensembl chr18:77,861,429...77,870,569 		JBrowse link
G Bax BCL2-associated X protein ISO mRNA:increased expression:diaphragm RGD PMID:23940949 RGD:10054120 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bche butyrylcholinesterase ISO RGD PMID:17657467 RGD:5688055 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 ISO mRNA:decreased expression:diaphragm RGD PMID:23940949 RGD:10054120 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G C5ar1 complement component 5a receptor 1 ISO mRNA:increased expression:lung RGD PMID:9272704 RGD:70679 NCBI chr 7:15,980,668...15,993,465
Ensembl chr 7:15,980,668...15,993,465 		JBrowse link
G Casp1 caspase 1 ISO RGD PMID:17384935 RGD:2315892 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp3 caspase 3 ISO mRNA:increased expression:diaphragm RGD PMID:23940949 RGD:10054120 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 IMP RGD PMID:19168786 RGD:5684539 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casp9 caspase 9 treatment ISO RGD PMID:23214195 RGD:10400903 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cbs cystathionine beta-synthase severity IMP
IEP
ISO 		Protein:increased expression:spleen, lung (mouse)
mRNA:increased expression:liver (rat) 		RGD PMID:27748832 PMID:27748832 PMID:24702258 PMID:16100527 RGD:40903019, RGD:40903019, RGD:40903035, RGD:40903049 NCBI chr17:31,831,602...31,856,170
Ensembl chr17:31,827,868...31,856,212 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO protein:increased expression:plasma RGD PMID:19060786 RGD:2307004 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased expression:plasma RGD PMID:16215387 RGD:2307171 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 IMP RGD PMID:17016504 RGD:5688178 NCBI chr 9:123,762,163...123,768,729
Ensembl chr 9:123,762,161...123,768,729 		JBrowse link
G Cd14 CD14 antigen ISO protein:increased expression:liver, endothelial cell of sinusoid RGD PMID:12046090 RGD:724637 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851 		JBrowse link
G Cd40 CD40 antigen IDA protein:decreased nitrosylation:macrophage RGD PMID:20473113 RGD:5490974 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta treatment ISO
IDA 		RGD PMID:15192048 PMID:14659593 RGD:1625687, RGD:40903034 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Cps1 carbamoyl-phosphate synthetase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr 1:67,151,294...67,270,426
Ensembl chr 1:67,162,185...67,270,418 		JBrowse link
G Cs citrate synthase ISO protein:increased expression:gastrocnemius RGD PMID:25674200 RGD:329337350 NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348 		JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) treatment ISO RGD PMID:9514298 RGD:11039535 NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO protein:increased expression:atrium endocardium RGD PMID:19282612 RGD:4891965 NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 IEP mRNA:increased expression:multiple organs RGD PMID:9766630 RGD:5135254 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 IEP mRNA:increased expression:multiple organs RGD PMID:9766630 RGD:5135254 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797 		JBrowse link
G Cxcl5 C-X-C motif chemokine ligand 5 IEP mRNA:increased expression:multiple organs RGD PMID:9766630 RGD:5135254 NCBI chr 5:90,907,157...90,909,484
Ensembl chr 5:90,907,219...90,909,483 		JBrowse link
G Edn1 endothelin 1 ISO mRNA, protein:increased expression:liver (rat) RGD PMID:11206318 RGD:8662297 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Ep300 E1A binding protein p300 ISO associated with Kidney Reperfusion Injury; protein:altered localization:kidney (rat) RGD PMID:23936185 RGD:7257563 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic IMP RGD PMID:19154430 RGD:5688360 NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:23214195 RGD:10400903 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504 		JBrowse link
G F12 coagulation factor XII (Hageman factor) ISO RGD PMID:11092686 RGD:7394782 NCBI chr13:55,565,771...55,574,617
Ensembl chr13:55,565,771...55,574,606 		JBrowse link
G F2 coagulation factor II treatment
severity 		ISO associated with liver cirrhosis;protein:increased expression:blood plasma (human)
associated with liver cirrhosis;protein:increased expression:plasma (human) 		RGD PMID:21396682 PMID:10604885 PMID:7615203 PMID:10887118 PMID:9863491 More... RGD:5147765, RGD:40818436, RGD:14974253, RGD:40818427, RGD:14401592, RGD:10449434, RGD:6893482, RGD:5147779 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G F3 coagulation factor III, tissue factor treatment ISO
IMP 		associated with Protein C Deficiency RGD PMID:21396682 PMID:20858853 PMID:8956768 RGD:5147765, RGD:11341685, RGD:11340208 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G F5 coagulation factor V ISO RGD PMID:11092686 RGD:7394782 NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846 		JBrowse link
G F7 coagulation factor VII treatment ISO
IMP 		RGD PMID:11092686 PMID:16378835 RGD:7394782, RGD:11041650 NCBI chr 8:13,075,499...13,085,809
Ensembl chr 8:13,076,034...13,085,809 		JBrowse link
G F8 coagulation factor VIII ISO RGD PMID:11092686 RGD:7394782 NCBI chr  X:74,213,950...74,426,342
Ensembl chr  X:74,216,321...74,426,221 		JBrowse link
G Fas Fas cell surface death receptor ISO mRNA, protein:increased expression:spleen (rat) RGD PMID:20428798 RGD:8662930 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fga fibrinogen alpha chain treatment ISO RGD PMID:19295478 RGD:11040925 NCBI chr 3:82,933,460...82,940,934
Ensembl chr 3:82,933,383...82,940,934 		JBrowse link
G Foxp3 forkhead box P3 ISO protein:increased expression:intestinal mucosa RGD PMID:19998507 RGD:38455980 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Gch1 GTP cyclohydrolase 1 treatment ISO mRNA:increased expression:lung
associated with liver cirrhosis 		RGD PMID:9388472 PMID:16845913 PMID:14647062 RGD:329961576, RGD:401793756, RGD:401700399 NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration ISO RGD PMID:23073658 RGD:9685733 NCBI chr17:24,912,164...24,915,065
Ensembl chr17:24,912,161...24,915,503 		JBrowse link
G Ghr growth hormone receptor ISO mRNA:decreased expression:liver RGD PMID:12654216 PMID:12217886 RGD:2307380, RGD:625688 NCBI chr15:3,347,237...3,612,834
Ensembl chr15:3,347,242...3,612,974 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble treatment ISO RGD PMID:25514429 RGD:401717525 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gsr glutathione reductase treatment ISO RGD PMID:25469663 RGD:10401928 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hmgb1 high mobility group box 1 ISO protein:increased expression:heart, serum RGD PMID:18503231 RGD:10402065 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO RGD PMID:21396999 RGD:10755715 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hsf1 heat shock factor 1 treatment ISO RGD PMID:25571843 RGD:10402404 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113 		JBrowse link
G Hspa9 heat shock protein 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410 		JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) ISO mRNA, protein:increased expression:medulla oblongata
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:16741687 PMID:16675490 RGD:1624232 NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:lung (rat) RGD PMID:19776691 RGD:4145502 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 IMP RGD PMID:24930766 PMID:28077574 RGD:39939032, RGD:39939117 NCBI chr 8:25,074,148...25,086,987
Ensembl chr 8:25,074,152...25,087,025 		JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 IMP RGD PMID:24930766 RGD:39939032 NCBI chr 8:25,021,908...25,066,430
Ensembl chr 8:25,021,908...25,066,349 		JBrowse link
G Ifng interferon gamma ISO protein:increased expression:serum: RGD PMID:9195172 RGD:10755747 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO mRNA, protein:decreased expression:liver, serum RGD PMID:18492809 PMID:12217886 RGD:10402757, RGD:625688 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit ISO RGD PMID:12217886 RGD:625688 NCBI chr17:25,096,818...25,100,985
Ensembl chr17:25,084,971...25,100,984 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 ISO RGD PMID:12217886 RGD:625688 NCBI chr11:7,147,787...7,152,546
Ensembl chr11:7,147,782...7,152,546 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 ISO mRNA, protein:decreased expression:liver, serum RGD PMID:18492809 RGD:10402757 NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 ISO RGD PMID:12217886 RGD:625688 NCBI chr 1:72,897,224...72,914,024
Ensembl chr 1:72,897,091...72,914,043 		JBrowse link
G Il10 interleukin 10 treatment IEP RGD PMID:28664613 PMID:27943364 RGD:14975137, RGD:14975170 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il13 interleukin 13 treatment ISO RGD PMID:10674721 RGD:8549626 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il1a interleukin 1 alpha IEP
ISO 		protein:increased expression:plasma RGD PMID:9636192 PMID:22426124 RGD:6907109, RGD:7794786 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta ISO protein:increased expression:plasma RGD PMID:17201737 RGD:1626625 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO mRNA:increased expression:lung, spleen, liver (rat) RGD PMID:1385928 PMID:8855299 RGD:8551846, RGD:11522760 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506 		JBrowse link
G Il6 interleukin 6 ISO associated with Diabetes Mellitus, Experimental; Protein:increased expression:extracellular space (rat)
protein:increased expression:serum (rat) 		RGD PMID:19449282 PMID:21396682 PMID:22227956 RGD:2307179, RGD:5147765, RGD:6893482 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 ISO mRNA, protein:increased expression:blood (human) RGD PMID:17982103 RGD:36049802 NCBI chr10:119,977,553...120,038,035
Ensembl chr10:119,977,553...120,038,035 		JBrowse link
G Irs1 insulin receptor substrate 1 IDA protein:increased tyrosine nitration, decreased tyrosine phosphorylation:skeletal muscle RGD PMID:21206533 RGD:6483008 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137 		JBrowse link
G Itga2b integrin alpha 2b ISO RGD PMID:15280099 RGD:2316360 NCBI chr11:102,344,134...102,360,570
Ensembl chr11:102,344,123...102,360,948 		JBrowse link
G Itgb3 integrin beta 3 ISO RGD PMID:15280099 RGD:2316360 NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 IMP RGD PMID:22609006 RGD:6892951 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Lbp lipopolysaccharide binding protein treatment ISO
IMP 		mRNA:increased expression:hepatocyte RGD PMID:8418776 PMID:8593028 PMID:16307218 RGD:9685191, RGD:9685196, RGD:9685193 NCBI chr 2:158,148,413...158,174,772
Ensembl chr 2:158,148,413...158,174,772 		JBrowse link
G Lcn2 lipocalin 2 IEP mRNA:increased expression:brain,liver RGD PMID:21943033 RGD:126779582 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264 		JBrowse link
G Map2 microtubule-associated protein 2 IEP mRNA, protein:decreased expression:neuron RGD PMID:21421895 RGD:6483086 NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 treatment ISO protein:increased activity:small intestine mucosa RGD PMID:21641970 PMID:24312512 RGD:5135029, RGD:10047418 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO protein:increased phophorylation:hippocampus (rat) RGD PMID:12207162 RGD:150340687 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mc4r melanocortin 4 receptor ISO mRNA:increased expression:paraventricular nucleus (rat) RGD PMID:21343543 RGD:6484214 NCBI chr18:66,990,776...66,993,558
Ensembl chr18:66,990,775...66,993,577 		JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) ISO protein:increased expression:plasma RGD PMID:16601957 RGD:1641983 NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074 		JBrowse link
G Mir146 microRNA 146 treatment IEP miRNA:increased expression:spleen (mouse) RGD PMID:30867482 RGD:34888227 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288 		JBrowse link
G Mir155 microRNA 155 treatment IEP associated with familial hyperlipidemia RGD PMID:28970282 PMID:28264607 PMID:29079998 PMID:29979224 RGD:21079445, RGD:24922204, RGD:21081539, RGD:21081538 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Mme membrane metallo endopeptidase severity ISO RGD PMID:11078421 RGD:13801040 NCBI chr 3:63,202,632...63,291,134
Ensembl chr 3:63,148,958...63,293,451 		JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO RGD PMID:17083784 RGD:2290426 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975 		JBrowse link
G Mt2 metallothionein 2 ISO mRNA:increased expression:liver (rat) RGD PMID:22100509 RGD:6483852 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196 		JBrowse link
G Mt3 metallothionein 3 ISO RGD PMID:12135776 RGD:10412330 NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774 		JBrowse link
G Muc2 mucin 2 ISO RGD PMID:19099858 RGD:7349370 NCBI chr 7:141,276,583...141,308,428
Ensembl chr 7:141,276,583...141,308,430 		JBrowse link
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha ISO RGD PMID:7874842 RGD:12792976 NCBI chr14:55,179,378...55,205,553
Ensembl chr14:55,179,378...55,204,384 		JBrowse link
G Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta ISO RGD PMID:7874842 RGD:12792976 NCBI chr14:55,208,141...55,232,083
Ensembl chr14:55,208,141...55,232,083 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 treatment ISO RGD PMID:26646455 RGD:42722616 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha exacerbates
treatment 		IMP
IEP 		RGD PMID:19098124 PMID:10229101 RGD:126908017, RGD:126928139 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO mRNA, protein:increased expression:intestine
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:12620498 PMID:16787348 PMID:20519137 RGD:4891470, RGD:5147779 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell ISO protein:increased expression:aorta (rat) RGD PMID:10462376 RGD:7794732 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Npy neuropeptide Y treatment ISO RGD PMID:15342191 RGD:1580787 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 ISO RGD PMID:15640646 RGD:4892561 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474 		JBrowse link
G Otc ornithine transcarbamylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr  X:10,118,584...10,187,275
Ensembl chr  X:10,118,544...10,187,263 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic ISO RGD PMID:19268478 PMID:12217886 RGD:10427879, RGD:625688 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) ISO mRNA,protein:decreased expression,decreased activity:liver: RGD PMID:19268478 RGD:10427879 NCBI chr14:55,777,721...55,787,477
Ensembl chr14:55,777,723...55,788,699 		JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 ISO RGD PMID:16337011 RGD:6483567 NCBI chr13:75,237,407...75,282,980
Ensembl chr13:75,237,945...75,282,980 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 ISO RGD PMID:16337011 RGD:6483567 NCBI chr 2:143,388,053...143,658,204
Ensembl chr 2:143,388,076...143,658,205 		JBrowse link
G Pecam1 platelet/endothelial cell adhesion molecule 1 IMP RGD PMID:22119535 RGD:6771174 NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454 		JBrowse link
G Pf4 platelet factor 4 treatment ISO RGD PMID:20601223 RGD:329901905 NCBI chr 5:90,920,362...90,921,242
Ensembl chr 5:90,920,294...90,921,242 		JBrowse link
G Pgf placental growth factor IEP protein:increased expression:multiple RGD PMID:16702604 RGD:6483601 NCBI chr12:85,213,413...85,224,087
Ensembl chr12:85,213,409...85,224,564 		JBrowse link
G Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) ISO protein:increased expression: : RGD PMID:10748027 RGD:7248791 NCBI chr17:43,879,009...43,923,093
Ensembl chr17:43,878,989...43,923,092 		JBrowse link
G Plat plasminogen activator, tissue treatment ISO RGD PMID:9091588 RGD:11541073 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO protein:increased expression:small intestine mucosa RGD PMID:21641970 RGD:5135029 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit IEP mRNA:decreased expression:epididymal fat pad RGD PMID:20421294 RGD:6484543 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase IEP protein:increased expression:liver, mitochondrion (mouse) RGD PMID:28615325 RGD:13432559 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248 		JBrowse link
G Proc protein C treatment ISO RGD PMID:18205901 PMID:23170801 RGD:11100030, RGD:11100034 NCBI chr18:32,256,179...32,272,623
Ensembl chr18:32,256,179...32,272,623 		JBrowse link
G Ptafr platelet-activating factor receptor treatment ISO RGD PMID:2178565 RGD:10041063 NCBI chr 4:132,291,378...132,309,994
Ensembl chr 4:132,291,378...132,309,994 		JBrowse link
G Ptger4 prostaglandin E receptor 4 (subtype EP4) ISO protein:increased expression:paraventricular hypothalamic nucleus parvicellular division (rat) RGD PMID:11058222 RGD:10043329 NCBI chr15:5,262,880...5,273,668
Ensembl chr15:5,236,142...5,273,668 		JBrowse link
G Ptgis prostaglandin I2 (prostacyclin) synthase treatment ISO RGD PMID:11076704 RGD:401960076 NCBI chr 2:167,045,114...167,095,069
Ensembl chr 2:167,033,725...167,082,524 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:21641970 RGD:5135029 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Ren1 renin 1 structural IEP
ISO 		protein:increased activity:blood plasma (mouse)
protein:increased activity:blood plasma (rat) 		RGD PMID:30027346 PMID:16512638 RGD:125097481, RGD:125097499 NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063 		JBrowse link
G Serpinc1 serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 treatment ISO RGD PMID:16457847 PMID:21396682 PMID:20519137 PMID:15995859 RGD:1599326, RGD:5147765, RGD:5147779, RGD:1599332 NCBI chr 1:160,806,153...160,830,113
Ensembl chr 1:160,806,155...160,833,433 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 treatment ISO RGD PMID:21396682 PMID:25396762 RGD:5147765, RGD:10449434 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 ISO protein:increased expression:plasma (human) RGD PMID:12386642 RGD:36174005 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527 		JBrowse link
G Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 treatment ISO RGD PMID:18652771 RGD:8661643 NCBI chr 2:84,595,704...84,605,748
Ensembl chr 2:84,595,731...84,605,788 		JBrowse link
G Slc18a3 solute carrier family 18 (vesicular monoamine), member 3 ISO protein:decreased expression:parietal cortex RGD PMID:17306796 RGD:5686693 NCBI chr14:32,184,394...32,186,807
Ensembl chr14:32,184,395...32,186,807 		JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 treatment ISO RGD PMID:18313662 RGD:7243881 NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 treatment ISO RGD PMID:18313662 RGD:7243881 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Slc38a3 solute carrier family 38, member 3 ISO RGD PMID:20036385 RGD:9999227 NCBI chr 9:107,528,353...107,546,167
Ensembl chr 9:107,527,833...107,546,729 		JBrowse link
G Slc38a5 solute carrier family 38, member 5 ISO RGD PMID:20036385 RGD:9999227 NCBI chr  X:8,137,620...8,146,418
Ensembl chr  X:8,137,372...8,146,418 		JBrowse link
G Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 ISO RGD PMID:26337286 RGD:151361133 NCBI chr 8:122,607,885...122,634,425
Ensembl chr 8:122,607,889...122,634,433 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor ISO RGD PMID:25466948 RGD:9999425 NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 IEP mRNA:increased expression:liver, skeletal muscle RGD PMID:15169905 RGD:2298923 NCBI chr16:10,601,672...10,603,400
Ensembl chr16:10,600,104...10,603,400 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 IEP
ISO 		mRNA:increased expression:liver, skeletal muscle RGD PMID:15169905 PMID:12217886 RGD:2298923, RGD:625688 NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sparc secreted acidic cysteine rich glycoprotein ISO mRNA, protein:decreased expression:kidney RGD PMID:10703670 RGD:2300026 NCBI chr11:55,284,985...55,310,906
Ensembl chr11:55,285,326...55,314,009 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B ISO protein:decreased tyrosine phosphorylation:liver RGD PMID:17327369 RGD:1601383 NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550 		JBrowse link
G Tbxa2r thromboxane A2 receptor ISO RGD PMID:15647606 PMID:2580129 RGD:1601450, RGD:11059531 NCBI chr10:81,164,102...81,171,008
Ensembl chr10:81,164,565...81,171,006 		JBrowse link
G Tbxas1 thromboxane A synthase 1, platelet ISO RGD PMID:15647606 RGD:1601450 NCBI chr 6:38,817,897...39,061,524
Ensembl chr 6:38,852,338...39,061,519 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase severity IMP RGD PMID:24930766 RGD:39939032 NCBI chr 3:81,865,719...81,883,035
Ensembl chr 3:81,864,397...81,883,509 		JBrowse link
G Tfpi tissue factor pathway inhibitor treatment ISO RGD PMID:17537762 RGD:11062086 NCBI chr 2:84,263,199...84,307,119
Ensembl chr 2:84,263,199...84,307,119 		JBrowse link
G Thbd thrombomodulin ISO
IEP 		mRNA:decreased expression:endothelial cell RGD PMID:12611420 PMID:20348393 PMID:19487933 RGD:1601652, RGD:5685037, RGD:5684988 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108 		JBrowse link
G Timp3 tissue inhibitor of metalloproteinase 3 ISO RGD PMID:17083784 RGD:2290426 NCBI chr10:86,136,276...86,185,369
Ensembl chr10:86,136,236...86,185,370 		JBrowse link
G Tlr2 toll-like receptor 2 treatment ISO associated with liver cirrhosis RGD PMID:22172266 PMID:12610323 RGD:7241094, RGD:597538466 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tlr4 toll-like receptor 4 treatment
disease_progression 		ISO
IEP
IMP 		mRNA:increased expression:liver: RGD PMID:22172266 PMID:23977376 PMID:23977376 RGD:7241094, RGD:14697731, RGD:14697731 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor treatment ISO
IEP 		protein:increased expression:plasma
protein:increased expression:plasma (rat)
associated with liver cirrhosis
XCO:0000822 JTE-607 		RGD PMID:17324147 PMID:20519137 PMID:21396682 PMID:12813371 PMID:8283134 More... RGD:4891465, RGD:5147779, RGD:5147765, RGD:14995427, RGD:14995443, RGD:15023464, RGD:38501090, RGD:40903016 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 treatment IEP
ISO 		RGD PMID:21507332 PMID:15585833 RGD:126925982, RGD:126928122 NCBI chr17:48,539,763...48,553,955
Ensembl chr17:48,539,796...48,553,952 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO mRNA:increased expression:brain: RGD PMID:20061033 RGD:7240511 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vwf Von Willebrand factor ISO protein:increased expression:endothelial cell: RGD PMID:2650559 RGD:11079230 NCBI chr 6:125,529,911...125,663,642
Ensembl chr 6:125,523,737...125,663,642 		JBrowse link
endotoxin shock term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gch1 GTP cyclohydrolase 1 treatment ISO RGD PMID:8602831 RGD:329961578 NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870 		JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A treatment ISO RGD PMID:19318092 RGD:401901206 NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16273
    disease by infectious agent 2241
      Bacterial Infections and Mycoses 1087
        Toxemia 161
          Endotoxemia 161
            endotoxin shock 2
Path 2
Term Annotations click to browse term
  disease 16273
    disease of anatomical entity 15865
      Immune & Inflammatory Diseases 5369
        Inflammation 2608
          Systemic Inflammatory Response Syndrome 408
            Sepsis 406
              bacterial sepsis 177
                Bacteremia 177
                  Endotoxemia 161
                    endotoxin shock 2
paths to the root