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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Endotoxemia
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Accession:DOID:9005930 term browser browse the term
Definition:A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
Synonyms:exact_synonym: Endotoxemias
 primary_id: MESH:D019446

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Endotoxemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1 ATP binding cassette subfamily B member 1 ISO mRNA:decreased expression:liver (rat) RGD PMID:26977098 RGD:11041000 NCBI chrNW_004955432:4,911,774...5,085,349 JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 ISO RGD PMID:9828229 RGD:1598596 NCBI chrNW_004955449:5,412,958...5,511,629
Ensembl chrNW_004955449:5,412,876...5,512,701 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO RGD PMID:16572733 RGD:1598611 NCBI chrNW_004955507:5,724,788...5,791,281
Ensembl chrNW_004955507:5,724,762...5,790,812 		JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 ISO RGD PMID:17285300 RGD:2301914 NCBI chrNW_004955414:32,216,243...32,289,028
Ensembl chrNW_004955414:32,216,196...32,289,053 		JBrowse link
G Ache acetylcholinesterase (Cartwright blood group) ISO RGD PMID:17657467 RGD:5688055 NCBI chrNW_004955573:79,606...85,799
Ensembl chrNW_004955573:80,298...85,799 		JBrowse link
G Actc1 actin alpha cardiac muscle 1 ISO RGD PMID:11680626 RGD:1598729 NCBI chrNW_004955416:2,139,541...2,144,678
Ensembl chrNW_004955416:2,137,101...2,145,416 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif 1 ISO protein:increased expression:plasma, spleen RGD PMID:23025351 RGD:9681752 NCBI chrNW_004955407:26,524,487...26,533,038
Ensembl chrNW_004955407:26,524,130...26,533,038 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO associated with Obesity RGD PMID:23838384 RGD:8695926 NCBI chrNW_004955420:20,911,181...20,922,992
Ensembl chrNW_004955420:20,912,348...20,914,402 		JBrowse link
G Adipor2 adiponectin receptor 2 severity ISO associated with obesity;mRNA:decreased expression:liver (rat) RGD PMID:23838384 RGD:8695926 NCBI chrNW_004955454:4,243,898...4,327,255
Ensembl chrNW_004955454:4,243,898...4,327,308 		JBrowse link
G Adra2a adrenoceptor alpha 2A onset ISO mRNA:increased expression:spleen RGD PMID:20302880 RGD:6480487 NCBI chrNW_004955485:384,405...387,332
Ensembl chrNW_004955485:385,800...387,240 		JBrowse link
G Agtr2 angiotensin II receptor type 2 ISO protein:decreased expression:kidney RGD PMID:16725227 RGD:6903849 NCBI chrNW_004955534:3,653,112...3,654,248
Ensembl chrNW_004955534:3,653,157...3,654,248 		JBrowse link
G Ahr aryl hydrocarbon receptor severity ISO RGD PMID:24930766 RGD:39939032 NCBI chrNW_004955410:20,428,531...20,459,482
Ensembl chrNW_004955410:20,428,546...20,456,836 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO RGD PMID:22824368 RGD:38676479 NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15328337 NCBI chrNW_004955546:2,495,226...2,550,909
Ensembl chrNW_004955546:2,494,819...2,550,909 		JBrowse link
G Apoa1 apolipoprotein A1 treatment ISO RGD PMID:18593575 PMID:23227448 RGD:7241573 RGD:7241868 NCBI chrNW_004955412:18,170,331...18,172,298
Ensembl chrNW_004955412:18,170,331...18,172,298 		JBrowse link
G Apob apolipoprotein B ISO RGD PMID:16719989 RGD:1599165 NCBI chrNW_004955469:3,437,422...3,478,408
Ensembl chrNW_004955469:3,436,450...3,478,424 		JBrowse link
G Apoe apolipoprotein E ISO rat model treated with human protein RGD PMID:9153287 RGD:6904216 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888 		JBrowse link
G Asl argininosuccinate lyase ISO RGD PMID:10652239 RGD:1599265 NCBI chrNW_004955456:8,409,767...8,419,915
Ensembl chrNW_004955456:8,411,220...8,416,992 		JBrowse link
G Ass1 argininosuccinate synthase 1 ISO RGD PMID:10652239 RGD:1599265 NCBI chrNW_004955513:443,372...485,190
Ensembl chrNW_004955513:445,462...485,190 		JBrowse link
G Atf2 activating transcription factor 2 treatment ISO protein:increased expression, increased activity:small intestine mucosa RGD PMID:21641970 PMID:24312512 RGD:10047418 RGD:5135029 NCBI chrNW_004955449:332,563...411,218
Ensembl chrNW_004955449:338,193...411,218 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chrNW_004955402:31,652,226...31,662,114
Ensembl chrNW_004955402:31,651,960...31,662,762 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator ISO mRNA:increased expression:diaphragm RGD PMID:23940949 RGD:10054120 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244 		JBrowse link
G Bche butyrylcholinesterase ISO RGD PMID:17657467 RGD:5688055 NCBI chrNW_004955448:15,327,374...15,396,827
Ensembl chrNW_004955448:15,329,273...15,396,970 		JBrowse link
G Bcl2 BCL2 apoptosis regulator ISO mRNA:decreased expression:diaphragm RGD PMID:23940949 RGD:10054120 NCBI chrNW_004955402:46,911,125...47,084,214
Ensembl chrNW_004955402:46,916,266...47,084,485 		JBrowse link
G C5ar1 complement C5a receptor 1 ISO mRNA:increased expression:lung RGD PMID:9272704 RGD:70679 NCBI chrNW_004955574:1,221,942...1,229,634
Ensembl chrNW_004955574:1,221,187...1,231,655 		JBrowse link
G Casp3 caspase 3 ISO mRNA:increased expression:diaphragm RGD PMID:23940949 RGD:10054120 NCBI chrNW_004955403:24,315,712...24,326,271 JBrowse link
G Casp7 caspase 7 ISO RGD PMID:19168786 RGD:5684539 NCBI chrNW_004955431:18,685,408...18,723,221
Ensembl chrNW_004955431:18,686,190...18,723,524 		JBrowse link
G Casp9 caspase 9 treatment ISO RGD PMID:23214195 RGD:10400903 NCBI chrNW_004955527:2,613,691...2,630,217
Ensembl chrNW_004955527:2,613,683...2,629,738 		JBrowse link
G Cbs cystathionine beta-synthase severity ISO mRNA:increased expression:liver (rat)
Protein:increased expression:spleen, lung (mouse)		 RGD PMID:16100527 PMID:24702258 PMID:27748832 RGD:40903019 RGD:40903035 RGD:40903049 NCBI chrNW_004955407:38,924,355...38,939,790
Ensembl chrNW_004955407:38,924,321...38,939,790 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased expression:plasma RGD PMID:16215387 RGD:2307171 NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143 		JBrowse link
G Cd14 CD14 molecule ISO protein:increased expression:liver, endothelial cell of sinusoid RGD PMID:12046090 RGD:724637 NCBI chrNW_004955418:73,736...75,345
Ensembl chrNW_004955418:73,897...75,224 		JBrowse link
G Cd40 CD40 molecule ISO protein:decreased nitrosylation:macrophage RGD PMID:20473113 RGD:5490974 NCBI chrNW_004955445:11,191,817...11,202,156
Ensembl chrNW_004955445:11,190,603...11,202,093 		JBrowse link
G Cebpb CCAAT enhancer binding protein beta treatment ISO RGD PMID:14659593 PMID:15192048 RGD:1625687 RGD:40903034 NCBI chrNW_004955445:8,060,432...8,061,289 JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chrNW_004955457:4,848,116...4,961,384
Ensembl chrNW_004955457:4,844,152...4,961,246 		JBrowse link
G Cs citrate synthase ISO protein:increased expression:gastrocnemius RGD PMID:25674200 RGD:329337350 NCBI chrNW_004955458:3,881,798...3,913,044
Ensembl chrNW_004955458:3,881,798...3,893,401 		JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:9514298 RGD:11039535 NCBI chrNW_004955451:14,688,181...14,690,126
Ensembl chrNW_004955451:14,688,181...14,690,126 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO protein:increased expression:atrium endocardium RGD PMID:19282612 RGD:4891965 NCBI chrNW_004955433:15,023,272...15,034,650
Ensembl chrNW_004955433:15,023,050...15,034,711 		JBrowse link
G Edn1 endothelin 1 ISO mRNA, protein:increased expression:liver (rat) RGD PMID:11206318 RGD:8662297 NCBI chrNW_004955465:2,287,906...2,314,945
Ensembl chrNW_004955465:2,287,798...2,314,753 		JBrowse link
G Ep300 E1A binding protein p300 ISO associated with Kidney Reperfusion Injury; protein:altered localization:kidney (rat) RGD PMID:23936185 RGD:7257563 NCBI chrNW_004955413:26,647,553...26,727,875
Ensembl chrNW_004955413:26,648,339...26,727,933 		JBrowse link
G Ephx2 epoxide hydrolase 2 ISO RGD PMID:19154430 RGD:5688360 NCBI chrNW_004955403:49,999,563...50,038,800
Ensembl chrNW_004955403:49,999,563...50,041,572 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:23214195 RGD:10400903 NCBI chrNW_004955573:203,875...206,078
Ensembl chrNW_004955573:203,441...206,355 		JBrowse link
G F12 coagulation factor XII ISO RGD PMID:11092686 RGD:7394782 NCBI chrNW_004955408:29,644,279...29,665,161
Ensembl chrNW_004955408:29,642,096...29,650,950 		JBrowse link
G F2 coagulation factor II, thrombin severity
treatment		 ISO associated with liver cirrhosis;protein:increased expression:plasma (human)
associated with liver cirrhosis;protein:increased expression:blood plasma (human)		 RGD PMID:7615203 PMID:9863491 PMID:10604885 PMID:10887118 PMID:20519137 More... RGD:10449434 RGD:14401592 RGD:14974253 RGD:40818427 RGD:40818436 RGD:5147765 RGD:5147779 RGD:6893482 NCBI chrNW_004955422:1,356,675...1,367,788
Ensembl chrNW_004955422:1,356,769...1,367,517 		JBrowse link
G F3 coagulation factor III, tissue factor treatment ISO associated with Protein C Deficiency RGD PMID:8956768 PMID:20858853 PMID:21396682 RGD:11340208 RGD:11341685 RGD:5147765 NCBI chrNW_004955423:254,060...264,448
Ensembl chrNW_004955423:254,189...264,159 		JBrowse link
G F5 coagulation factor V ISO RGD PMID:11092686 RGD:7394782 NCBI chrNW_004955462:7,695,004...7,757,832
Ensembl chrNW_004955462:7,694,939...7,757,463 		JBrowse link
G F7 coagulation factor VII treatment ISO RGD PMID:11092686 PMID:16378835 RGD:11041650 RGD:7394782 NCBI chrNW_004955404:685,170...692,797
Ensembl chrNW_004955404:680,594...693,665 		JBrowse link
G F8 coagulation factor VIII ISO RGD PMID:11092686 RGD:7394782 NCBI chrNW_004955594:658,686...800,101
Ensembl chrNW_004955594:658,523...802,865 		JBrowse link
G Fas Fas cell surface death receptor ISO mRNA, protein:increased expression:spleen (rat) RGD PMID:20428798 RGD:8662930 NCBI chrNW_004955425:3,961,671...3,987,513
Ensembl chrNW_004955425:3,961,013...3,987,455 		JBrowse link
G Fga fibrinogen alpha chain treatment ISO RGD PMID:19295478 RGD:11040925 NCBI chrNW_004955471:8,806,964...8,814,671
Ensembl chrNW_004955471:8,806,650...8,816,791 		JBrowse link
G Foxp3 forkhead box P3 ISO protein:increased expression:intestinal mucosa RGD PMID:19998507 RGD:38455980 NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606 		JBrowse link
G Gch1 GTP cyclohydrolase 1 treatment ISO mRNA:increased expression:lung
associated with liver cirrhosis		 RGD PMID:9388472 PMID:14647062 PMID:16845913 RGD:329961576 RGD:401700399 RGD:401793756 NCBI chrNW_004955409:8,624,225...8,670,436
Ensembl chrNW_004955409:8,624,468...8,668,614 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration ISO RGD PMID:23073658 RGD:9685733 NCBI chrNW_004955442:15,280,753...15,283,405
Ensembl chrNW_004955442:15,281,419...15,283,266 		JBrowse link
G Ghr growth hormone receptor ISO mRNA:decreased expression:liver RGD PMID:12217886 PMID:12654216 RGD:2307380 RGD:625688 NCBI chrNW_004955426:26,553,509...26,873,619
Ensembl chrNW_004955426:26,689,581...26,871,684 		JBrowse link
G Gpt glutamic--pyruvic transaminase treatment ISO RGD PMID:25514429 RGD:401717525 NCBI chrNW_004955454:3,127,997...3,132,459
Ensembl chrNW_004955454:3,127,997...3,132,459 		JBrowse link
G Gsr glutathione-disulfide reductase treatment ISO RGD PMID:25469663 RGD:10401928 NCBI chrNW_004955463:7,130,459...7,153,631
Ensembl chrNW_004955463:7,131,364...7,153,583 		JBrowse link
G Hmgb1 high mobility group box 1 ISO protein:increased expression:heart, serum RGD PMID:18503231 RGD:10402065 NCBI chrNW_004955431:15,373,207...15,377,339
Ensembl chrNW_004955431:15,373,207...15,377,339 		JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO RGD PMID:21396999 RGD:10755715 NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979 		JBrowse link
G Hsf1 heat shock transcription factor 1 treatment ISO RGD PMID:25571843 RGD:10402404 NCBI chrNW_004955454:2,907,265...2,932,352
Ensembl chrNW_004955454:2,907,265...2,932,351 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chrNW_004955418:1,915,985...1,931,017
Ensembl chrNW_004955418:1,915,985...1,931,017 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO mRNA, protein:increased expression:medulla oblongata
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:16675490 PMID:16741687 RGD:1624232 NCBI chrNW_004955403:3,062,724...3,073,419
Ensembl chrNW_004955403:3,063,133...3,073,419 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:lung (rat) RGD PMID:19776691 RGD:4145502 NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 ISO RGD PMID:24930766 PMID:28077574 RGD:39939032 RGD:39939117 NCBI chrNW_004955536:2,944,770...2,955,829
Ensembl chrNW_004955536:2,943,611...2,955,829 		JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 ISO RGD PMID:24930766 RGD:39939032 NCBI chrNW_004955536:2,894,410...2,938,862
Ensembl chrNW_004955536:2,894,308...2,939,016 		JBrowse link
G Ifng interferon gamma ISO protein:increased expression:serum: RGD PMID:9195172 RGD:10755747 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045 		JBrowse link
G Igf1 insulin like growth factor 1 ISO mRNA, protein:decreased expression:liver, serum RGD PMID:12217886 PMID:18492809 RGD:10402757 RGD:625688 NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152 		JBrowse link
G Igfals insulin like growth factor binding protein acid labile subunit ISO RGD PMID:12217886 RGD:625688 NCBI chrNW_004955442:15,469,602...15,482,115
Ensembl chrNW_004955442:15,478,202...15,482,115 		JBrowse link
G Igfbp1 insulin like growth factor binding protein 1 ISO RGD PMID:12217886 RGD:625688 NCBI chrNW_004955456:6,810,461...6,814,944
Ensembl chrNW_004955456:6,810,056...6,815,685 		JBrowse link
G Igfbp3 insulin like growth factor binding protein 3 ISO mRNA, protein:decreased expression:liver, serum RGD PMID:18492809 RGD:10402757 NCBI chrNW_004955456:6,795,560...6,802,147
Ensembl chrNW_004955456:6,795,604...6,800,845 		JBrowse link
G Igfbp5 insulin like growth factor binding protein 5 ISO RGD PMID:12217886 RGD:625688 NCBI chrNW_004955453:16,530,110...16,550,733
Ensembl chrNW_004955453:16,530,110...16,550,733 		JBrowse link
G Il10 interleukin 10 treatment ISO protein:increased expression:plasma RGD PMID:19302852 PMID:27943364 PMID:28664613 RGD:14975137 RGD:14975170 RGD:2311055 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779 		JBrowse link
G Il13 interleukin 13 treatment ISO RGD PMID:10674721 RGD:8549626 NCBI chrNW_004955408:4,046,406...4,049,795 JBrowse link
G Il1a interleukin 1 alpha ISO protein:increased expression:plasma RGD PMID:9636192 PMID:22426124 RGD:6907109 RGD:7794786 NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466 		JBrowse link
G Il1b interleukin 1 beta ISO protein:increased expression:plasma RGD PMID:17201737 RGD:1626625 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947 		JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO mRNA:increased expression:lung, spleen, liver (rat) RGD PMID:1385928 PMID:8855299 RGD:11522760 RGD:8551846 NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471 		JBrowse link
G Il6 interleukin 6 ISO associated with Diabetes Mellitus, Experimental; Protein:increased expression:extracellular space (rat)
protein:increased expression:serum (rat)		 RGD PMID:19449282 PMID:21396682 PMID:22227956 RGD:2307179 RGD:5147765 RGD:6893482 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Irak3 interleukin 1 receptor associated kinase 3 ISO mRNA, protein:increased expression:blood (human) RGD PMID:17982103 RGD:36049802 NCBI chrNW_004955458:12,839,995...12,880,285
Ensembl chrNW_004955458:12,846,237...12,879,316 		JBrowse link
G Irs1 insulin receptor substrate 1 ISO protein:increased tyrosine nitration, decreased tyrosine phosphorylation:skeletal muscle RGD PMID:21206533 RGD:6483008 NCBI chrNW_004955453:7,685,715...7,742,262
Ensembl chrNW_004955453:7,685,715...7,742,262 		JBrowse link
G Itga2b integrin subunit alpha 2b ISO RGD PMID:15280099 RGD:2316360 NCBI chrNW_004955451:17,381,323...17,392,122
Ensembl chrNW_004955451:17,382,779...17,391,859 		JBrowse link
G Itgb3 integrin subunit beta 3 ISO RGD PMID:15280099 RGD:2316360 NCBI chrNW_004955478:9,788,192...9,830,254
Ensembl chrNW_004955478:9,788,149...9,823,746 		JBrowse link
G Keap1 kelch like ECH associated protein 1 ISO RGD PMID:22609006 RGD:6892951 NCBI chrNW_004955495:1,704,695...1,711,339
Ensembl chrNW_004955495:1,704,695...1,711,290 		JBrowse link
G Map2 microtubule associated protein 2 ISO mRNA, protein:decreased expression:neuron RGD PMID:21421895 RGD:6483086 NCBI chrNW_004955457:5,678,826...5,816,114
Ensembl chrNW_004955457:5,678,436...5,875,024 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 treatment ISO protein:increased activity:small intestine mucosa RGD PMID:21641970 PMID:24312512 RGD:10047418 RGD:5135029 NCBI chrNW_004955437:3,836,331...3,884,083
Ensembl chrNW_004955437:3,838,232...3,884,083 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO protein:increased phophorylation:hippocampus (rat) RGD PMID:12207162 RGD:150340687 NCBI chrNW_004955556:1,593,552...1,705,543
Ensembl chrNW_004955556:1,593,494...1,665,784 		JBrowse link
G Mc4r melanocortin 4 receptor ISO mRNA:increased expression:paraventricular nucleus (rat) RGD PMID:21343543 RGD:6484214 NCBI chrNW_004955402:44,453,973...44,456,689
Ensembl chrNW_004955402:44,455,294...44,456,292 		JBrowse link
G Mif macrophage migration inhibitory factor ISO protein:increased expression:plasma RGD PMID:16601957 RGD:1641983 NCBI chrNW_004955455:8,367,566...8,368,460
Ensembl chrNW_004955455:8,367,566...8,368,460 		JBrowse link
G Mme membrane metalloendopeptidase severity ISO RGD PMID:11078421 RGD:13801040 NCBI chrNW_004955448:6,193,113...6,311,666
Ensembl chrNW_004955448:6,226,059...6,314,949 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming ISO RGD PMID:19099858 RGD:7349370 NCBI chrNW_004955476:11,108,826...11,135,697
Ensembl chrNW_004955476:11,108,826...11,135,697 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 treatment ISO RGD PMID:26646455 RGD:42722616 NCBI chrNW_004955403:19,510,122...19,536,428
Ensembl chrNW_004955403:19,532,103...19,535,944 		JBrowse link
G Nfkbia NFKB inhibitor alpha exacerbates
treatment		 ISO RGD PMID:10229101 PMID:19098124 RGD:126908017 RGD:126928139 NCBI chrNW_004955409:25,691,673...25,695,151
Ensembl chrNW_004955409:25,691,534...25,697,520 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:intestine		 CTD
RGD		 PMID:12620498 PMID:16787348 PMID:20519137 RGD:4891470 RGD:5147779 NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961 		JBrowse link
G Nos3 nitric oxide synthase 3 ISO protein:increased expression:aorta (rat) RGD PMID:10462376 RGD:7794732 NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814 		JBrowse link
G Npy neuropeptide Y treatment ISO RGD PMID:15342191 RGD:1580787 NCBI chrNW_004955410:26,348,388...26,355,232
Ensembl chrNW_004955410:26,348,504...26,355,297 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3 group C member 1 ISO RGD PMID:15640646 RGD:4892561 NCBI chrNW_004955415:10,494,704...10,585,778
Ensembl chrNW_004955415:10,494,640...10,586,221 		JBrowse link
G Otc ornithine transcarbamylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chrNW_004955601:481,524...543,176
Ensembl chrNW_004955601:481,480...543,176 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 ISO RGD PMID:12217886 PMID:19268478 RGD:10427879 RGD:625688 NCBI chrNW_004955445:1,909,012...1,914,032
Ensembl chrNW_004955445:1,908,946...1,915,002 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2, mitochondrial ISO mRNA,protein:decreased expression,decreased activity:liver: RGD PMID:19268478 RGD:10427879 NCBI chrNW_004955409:36,288,402...36,296,761
Ensembl chrNW_004955409:36,288,568...36,296,828 		JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 ISO RGD PMID:16337011 RGD:6483567 NCBI chrNW_004955418:16,181,809...16,224,274
Ensembl chrNW_004955418:16,181,771...16,224,603 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 ISO RGD PMID:16337011 RGD:6483567 NCBI chrNW_004955415:26,266,513...26,496,905
Ensembl chrNW_004955415:26,266,484...26,497,001 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:22119535 RGD:6771174 NCBI chrNW_004955478:7,448,584...7,531,860
Ensembl chrNW_004955478:7,478,492...7,531,188 		JBrowse link
G Pgf placental growth factor ISO protein:increased expression:multiple RGD PMID:16702604 RGD:6483601 NCBI chrNW_004955523:616,196...627,055
Ensembl chrNW_004955523:616,154...627,713 		JBrowse link
G Pla2g7 phospholipase A2 group VII ISO protein:increased expression: : RGD PMID:10748027 RGD:7248791 NCBI chrNW_004955437:11,534,251...11,577,942
Ensembl chrNW_004955437:11,534,173...11,555,996 		JBrowse link
G Plat plasminogen activator, tissue type treatment ISO RGD PMID:9091588 RGD:11541073 NCBI chrNW_004955536:730,962...754,333
Ensembl chrNW_004955536:730,981...756,394 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO protein:increased expression:small intestine mucosa RGD PMID:21641970 RGD:5135029 NCBI chrNW_004955429:14,814,690...14,936,869
Ensembl chrNW_004955429:14,873,908...14,937,387 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 ISO mRNA:decreased expression:epididymal fat pad RGD PMID:20421294 RGD:6484543 NCBI chrNW_004955426:25,079,718...25,102,090
Ensembl chrNW_004955426:25,079,718...25,102,090 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO protein:increased expression:liver, mitochondrion (mouse) RGD PMID:28615325 RGD:13432559 NCBI chrNW_004955439:18,664,230...19,953,358
Ensembl chrNW_004955439:18,664,379...19,951,152 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:18205901 PMID:23170801 RGD:11100030 RGD:11100034 NCBI chrNW_004955459:3,097,229...3,105,566
Ensembl chrNW_004955459:3,094,120...3,104,135 		JBrowse link
G Ptafr platelet activating factor receptor treatment ISO RGD PMID:2178565 RGD:10041063 NCBI chrNW_004955452:7,309,854...7,345,579
Ensembl chrNW_004955452:7,311,901...7,312,929 		JBrowse link
G Ptger4 prostaglandin E receptor 4 ISO protein:increased expression:paraventricular hypothalamic nucleus parvicellular division (rat) RGD PMID:11058222 RGD:10043329 NCBI chrNW_004955426:24,997,811...25,010,822
Ensembl chrNW_004955426:24,997,811...25,010,822 		JBrowse link
G Ptgis prostaglandin I2 synthase treatment ISO RGD PMID:11076704 RGD:401960076 NCBI chrNW_004955445:8,624,228...8,663,385
Ensembl chrNW_004955445:8,623,430...8,677,658 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:21641970 RGD:5135029 NCBI chrNW_004955406:25,077,988...25,086,259
Ensembl chrNW_004955406:25,079,945...25,086,171 		JBrowse link
G Ren renin ISO protein:increased activity:blood plasma (rat)
protein:increased activity:blood plasma (mouse)		 RGD PMID:16512638 PMID:30027346 RGD:125097481 RGD:125097499 NCBI chrNW_004955406:40,016,624...40,026,286
Ensembl chrNW_004955406:40,016,630...40,026,286 		JBrowse link
G Serpinc1 serpin family C member 1 treatment ISO RGD PMID:15995859 PMID:16457847 PMID:20519137 PMID:21396682 RGD:1599326 RGD:1599332 RGD:5147765 RGD:5147779 NCBI chrNW_004955406:14,024,183...14,036,206
Ensembl chrNW_004955406:14,024,313...14,035,948 		JBrowse link
G Serpine1 serpin family E member 1 treatment ISO RGD PMID:21396682 PMID:25396762 RGD:10449434 RGD:5147765 NCBI chrNW_004955456:16,147,523...16,157,040
Ensembl chrNW_004955456:16,145,944...16,157,142 		JBrowse link
G Serpinf1 serpin family F member 1 ISO protein:increased expression:plasma (human) RGD PMID:12386642 RGD:36174005 NCBI chrNW_004955481:1,414,930...1,426,436
Ensembl chrNW_004955481:1,414,930...1,426,241 		JBrowse link
G Serping1 serpin family G member 1 treatment ISO RGD PMID:18652771 RGD:8661643 NCBI chrNW_004955511:2,545,337...2,557,850
Ensembl chrNW_004955511:2,545,285...2,557,982 		JBrowse link
G Slc18a3 solute carrier family 18 member A3 ISO protein:decreased expression:parietal cortex RGD PMID:17306796 RGD:5686693 NCBI chrNW_004955556:696,779...698,869
Ensembl chrNW_004955556:696,974...698,566 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 treatment ISO RGD PMID:18313662 RGD:7243881 NCBI chrNW_004955439:20,567,241...20,608,281
Ensembl chrNW_004955439:20,567,212...20,609,105 		JBrowse link
G Slc38a3 solute carrier family 38 member 3 ISO RGD PMID:20036385 RGD:9999227 NCBI chrNW_004955532:2,023,694...2,046,556
Ensembl chrNW_004955532:2,023,694...2,050,708 		JBrowse link
G Slc38a5 solute carrier family 38 member 5 ISO RGD PMID:20036385 RGD:9999227 NCBI chrNW_004955543:15,968...24,644
Ensembl chrNW_004955543:16,089...24,668 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 ISO RGD PMID:26337286 RGD:151361133 NCBI chrNW_004955541:2,103,437...2,129,668
Ensembl chrNW_004955541:2,103,384...2,130,310 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO mRNA:increased expression:liver, skeletal muscle RGD PMID:15169905 RGD:2298923 NCBI chrNW_004955442:7,321,337...7,323,109
Ensembl chrNW_004955442:7,321,337...7,323,109 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO mRNA:increased expression:liver, skeletal muscle RGD PMID:12217886 PMID:15169905 RGD:2298923 RGD:625688 NCBI chrNW_004955506:4,222,455...4,225,563
Ensembl chrNW_004955506:4,222,455...4,225,563 		JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163 		JBrowse link
G Sparc secreted protein acidic and cysteine rich ISO mRNA, protein:decreased expression:kidney RGD PMID:10703670 RGD:2300026 NCBI chrNW_004955408:6,100,123...6,122,460
Ensembl chrNW_004955408:6,099,003...6,122,459 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B ISO protein:decreased tyrosine phosphorylation:liver RGD PMID:17327369 RGD:1601383 NCBI chrNW_004955451:16,253,645...16,295,337 JBrowse link
G Tbxa2r thromboxane A2 receptor ISO RGD PMID:2580129 PMID:15647606 RGD:11059531 RGD:1601450 NCBI chrNW_004955495:5,539,382...5,557,441
Ensembl chrNW_004955495:5,539,889...5,557,441 		JBrowse link
G Tbxas1 thromboxane A synthase 1 ISO RGD PMID:15647606 RGD:1601450 NCBI chrNW_004955494:3,161,032...3,321,974
Ensembl chrNW_004955494:3,160,653...3,334,411 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase severity ISO RGD PMID:24930766 RGD:39939032 NCBI chrNW_004955471:11,229,795...11,245,255
Ensembl chrNW_004955471:11,229,273...11,245,375 		JBrowse link
G Tfpi tissue factor pathway inhibitor treatment ISO RGD PMID:17537762 RGD:11062086 NCBI chrNW_004955403:10,925,155...11,004,229
Ensembl chrNW_004955403:10,924,893...11,004,284 		JBrowse link
G Thbd thrombomodulin ISO mRNA:decreased expression:endothelial cell RGD PMID:12611420 PMID:19487933 PMID:20348393 RGD:1601652 RGD:5684988 RGD:5685037 NCBI chrNW_004955415:30,222,830...30,226,406 JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 ISO RGD PMID:17083784 RGD:2290426 NCBI chrNW_004955405:41,613,976...41,655,813
Ensembl chrNW_004955405:41,613,966...41,655,813 		JBrowse link
G Tlr2 toll like receptor 2 treatment ISO RGD PMID:22172266 RGD:7241094 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258 		JBrowse link
G Tlr4 toll like receptor 4 treatment
disease_progression		 ISO mRNA:increased expression:liver: RGD PMID:22172266 PMID:23977376 RGD:14697731 RGD:7241094 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
G Tnf tumor necrosis factor treatment ISO XCO:0000822 JTE-607
associated with liver cirrhosis
protein:increased expression:plasma (rat)		 RGD PMID:8283134 PMID:10493164 PMID:12813371 PMID:15242491 PMID:17324147 More... RGD:14995427 RGD:14995443 RGD:15023464 RGD:38501090 RGD:40903016 RGD:4891465 RGD:5147765 RGD:5147779 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO mRNA:increased expression:brain: RGD PMID:20061033 RGD:7240511 NCBI chrNW_004955435:5,390,745...5,410,025
Ensembl chrNW_004955435:5,390,751...5,411,691 		JBrowse link
G Vwf von Willebrand factor ISO protein:increased expression:endothelial cell: RGD PMID:2650559 RGD:11079230 NCBI chrNW_004955413:3,672,470...3,825,588
Ensembl chrNW_004955413:3,672,470...3,819,571 		JBrowse link
endotoxin shock term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gch1 GTP cyclohydrolase 1 treatment ISO RGD PMID:8602831 RGD:329961578 NCBI chrNW_004955409:8,624,225...8,670,436
Ensembl chrNW_004955409:8,624,468...8,668,614 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A treatment ISO RGD PMID:19318092 RGD:401901206 NCBI chrNW_004955431:583,165...646,991
Ensembl chrNW_004955431:580,713...647,345 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16063
    disease by infectious agent 1919
      Bacterial Infections and Mycoses 925
        Toxemia 137
          Endotoxemia 137
            endotoxin shock 2
Path 2
Term Annotations click to browse term
  disease 16063
    disease of anatomical entity 13820
      Immune & Inflammatory Diseases 4634
        Inflammation 2225
          Systemic Inflammatory Response Syndrome 332
            Sepsis 330
              bacterial sepsis 149
                Bacteremia 149
                  Endotoxemia 137
                    endotoxin shock 2
paths to the root