RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Endotoxemia
Accession: DOID:9005930
browse the term
Definition: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
Synonyms: exact_synonym: Endotoxemias
primary_id: MESH:D019446
GViewer not supported for the selected species.
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Abcb1
ATP binding cassette subfamily B member 1
ISO
mRNA:decreased expression:liver (rat)
RGD
PMID:26977098
RGD:11041000
NCBI chrNW_004955432:4,911,774...5,085,349
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Abcb11
ATP binding cassette subfamily B member 11
ISO
RGD
PMID:9828229
RGD:1598596
NCBI chrNW_004955449:5,412,958...5,511,629
Ensembl chrNW_004955449:5,412,876...5,512,701
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Abcc2
ATP binding cassette subfamily C member 2
ISO
RGD
PMID:16572733
RGD:1598611
NCBI chrNW_004955507:5,724,788...5,791,281
Ensembl chrNW_004955507:5,724,762...5,790,812
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Abcc8
ATP binding cassette subfamily C member 8
ISO
RGD
PMID:17285300
RGD:2301914
NCBI chrNW_004955414:32,216,243...32,289,028
Ensembl chrNW_004955414:32,216,196...32,289,053
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Ache
acetylcholinesterase (Cartwright blood group)
ISO
RGD
PMID:17657467
RGD:5688055
NCBI chrNW_004955573:79,606...85,799
Ensembl chrNW_004955573:80,298...85,799
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Actc1
actin alpha cardiac muscle 1
ISO
RGD
PMID:11680626
RGD:1598729
NCBI chrNW_004955416:2,139,541...2,144,678
Ensembl chrNW_004955416:2,137,101...2,145,416
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Adamts1
ADAM metallopeptidase with thrombospondin type 1 motif 1
ISO
protein:increased expression:plasma, spleen
RGD
PMID:23025351
RGD:9681752
NCBI chrNW_004955407:26,524,487...26,533,038
Ensembl chrNW_004955407:26,524,130...26,533,038
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Adipoq
adiponectin, C1Q and collagen domain containing
ISO
associated with Obesity
RGD
PMID:23838384
RGD:8695926
NCBI chrNW_004955420:20,911,181...20,922,992
Ensembl chrNW_004955420:20,912,348...20,914,402
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Adipor2
adiponectin receptor 2
severity
ISO
associated with obesity;mRNA:decreased expression:liver (rat)
RGD
PMID:23838384
RGD:8695926
NCBI chrNW_004955454:4,243,898...4,327,255
Ensembl chrNW_004955454:4,243,898...4,327,308
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Adra2a
adrenoceptor alpha 2A
onset
ISO
mRNA:increased expression:spleen
RGD
PMID:20302880
RGD:6480487
NCBI chrNW_004955485:384,405...387,332
Ensembl chrNW_004955485:385,800...387,240
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Agtr2
angiotensin II receptor type 2
ISO
protein:decreased expression:kidney
RGD
PMID:16725227
RGD:6903849
NCBI chrNW_004955534:3,653,112...3,654,248
Ensembl chrNW_004955534:3,653,157...3,654,248
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Ahr
aryl hydrocarbon receptor
severity
ISO
RGD
PMID:24930766
RGD:39939032
NCBI chrNW_004955410:20,428,531...20,459,482
Ensembl chrNW_004955410:20,428,546...20,456,836
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Akt1
AKT serine/threonine kinase 1
ISO
RGD
PMID:22824368
RGD:38676479
NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904
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Alox5
arachidonate 5-lipoxygenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15328337
NCBI chrNW_004955546:2,495,226...2,550,909
Ensembl chrNW_004955546:2,494,819...2,550,909
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Apoa1
apolipoprotein A1
treatment
ISO
RGD
PMID:18593575 PMID:23227448
RGD:7241573 RGD:7241868
NCBI chrNW_004955412:18,170,331...18,172,298
Ensembl chrNW_004955412:18,170,331...18,172,298
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Apob
apolipoprotein B
ISO
RGD
PMID:16719989
RGD:1599165
NCBI chrNW_004955469:3,437,422...3,478,408
Ensembl chrNW_004955469:3,436,450...3,478,424
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Apoe
apolipoprotein E
ISO
rat model treated with human protein
RGD
PMID:9153287
RGD:6904216
NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
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Asl
argininosuccinate lyase
ISO
RGD
PMID:10652239
RGD:1599265
NCBI chrNW_004955456:8,409,767...8,419,915
Ensembl chrNW_004955456:8,411,220...8,416,992
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Ass1
argininosuccinate synthase 1
ISO
RGD
PMID:10652239
RGD:1599265
NCBI chrNW_004955513:443,372...485,190
Ensembl chrNW_004955513:445,462...485,190
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Atf2
activating transcription factor 2
treatment
ISO
protein:increased expression, increased activity:small intestine mucosa
RGD
PMID:21641970 PMID:24312512
RGD:10047418 RGD:5135029
NCBI chrNW_004955449:332,563...411,218
Ensembl chrNW_004955449:338,193...411,218
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Atp5f1a
ATP synthase F1 subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16741687
NCBI chrNW_004955402:31,652,226...31,662,114
Ensembl chrNW_004955402:31,651,960...31,662,762
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Bax
BCL2 associated X, apoptosis regulator
ISO
mRNA:increased expression:diaphragm
RGD
PMID:23940949
RGD:10054120
NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244
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Bche
butyrylcholinesterase
ISO
RGD
PMID:17657467
RGD:5688055
NCBI chrNW_004955448:15,327,374...15,396,827
Ensembl chrNW_004955448:15,329,273...15,396,970
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Bcl2
BCL2 apoptosis regulator
ISO
mRNA:decreased expression:diaphragm
RGD
PMID:23940949
RGD:10054120
NCBI chrNW_004955402:46,911,125...47,084,214
Ensembl chrNW_004955402:46,916,266...47,084,485
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C5ar1
complement C5a receptor 1
ISO
mRNA:increased expression:lung
RGD
PMID:9272704
RGD:70679
NCBI chrNW_004955574:1,221,942...1,229,634
Ensembl chrNW_004955574:1,221,187...1,231,655
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Casp3
caspase 3
ISO
mRNA:increased expression:diaphragm
RGD
PMID:23940949
RGD:10054120
NCBI chrNW_004955403:24,315,712...24,326,271
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Casp7
caspase 7
ISO
RGD
PMID:19168786
RGD:5684539
NCBI chrNW_004955431:18,685,408...18,723,221
Ensembl chrNW_004955431:18,686,190...18,723,524
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Casp9
caspase 9
treatment
ISO
RGD
PMID:23214195
RGD:10400903
NCBI chrNW_004955527:2,613,691...2,630,217
Ensembl chrNW_004955527:2,613,683...2,629,738
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Cbs
cystathionine beta-synthase
severity
ISO
mRNA:increased expression:liver (rat) Protein:increased expression:spleen, lung (mouse)
RGD
PMID:16100527 PMID:24702258 PMID:27748832
RGD:40903019 RGD:40903035 RGD:40903049
NCBI chrNW_004955407:38,924,355...38,939,790
Ensembl chrNW_004955407:38,924,321...38,939,790
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Ccl5
C-C motif chemokine ligand 5
ISO
protein:increased expression:plasma
RGD
PMID:16215387
RGD:2307171
NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143
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Cd14
CD14 molecule
ISO
protein:increased expression:liver, endothelial cell of sinusoid
RGD
PMID:12046090
RGD:724637
NCBI chrNW_004955418:73,736...75,345
Ensembl chrNW_004955418:73,897...75,224
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Cd40
CD40 molecule
ISO
protein:decreased nitrosylation:macrophage
RGD
PMID:20473113
RGD:5490974
NCBI chrNW_004955445:11,191,817...11,202,156
Ensembl chrNW_004955445:11,190,603...11,202,093
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Cebpb
CCAAT enhancer binding protein beta
treatment
ISO
RGD
PMID:14659593 PMID:15192048
RGD:1625687 RGD:40903034
NCBI chrNW_004955445:8,060,432...8,061,289
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Cps1
carbamoyl-phosphate synthase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16741687
NCBI chrNW_004955457:4,848,116...4,961,384
Ensembl chrNW_004955457:4,844,152...4,961,246
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Cs
citrate synthase
ISO
protein:increased expression:gastrocnemius
RGD
PMID:25674200
RGD:329337350
NCBI chrNW_004955458:3,881,798...3,913,044
Ensembl chrNW_004955458:3,881,798...3,893,401
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Csf3
colony stimulating factor 3
treatment
ISO
RGD
PMID:9514298
RGD:11039535
NCBI chrNW_004955451:14,688,181...14,690,126
Ensembl chrNW_004955451:14,688,181...14,690,126
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Cx3cl1
C-X3-C motif chemokine ligand 1
ISO
protein:increased expression:atrium endocardium
RGD
PMID:19282612
RGD:4891965
NCBI chrNW_004955433:15,023,272...15,034,650
Ensembl chrNW_004955433:15,023,050...15,034,711
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Edn1
endothelin 1
ISO
mRNA, protein:increased expression:liver (rat)
RGD
PMID:11206318
RGD:8662297
NCBI chrNW_004955465:2,287,906...2,314,945
Ensembl chrNW_004955465:2,287,798...2,314,753
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Ep300
E1A binding protein p300
ISO
associated with Kidney Reperfusion Injury; protein:altered localization:kidney (rat)
RGD
PMID:23936185
RGD:7257563
NCBI chrNW_004955413:26,647,553...26,727,875
Ensembl chrNW_004955413:26,648,339...26,727,933
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Ephx2
epoxide hydrolase 2
ISO
RGD
PMID:19154430
RGD:5688360
NCBI chrNW_004955403:49,999,563...50,038,800
Ensembl chrNW_004955403:49,999,563...50,041,572
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Epo
erythropoietin
treatment
ISO
RGD
PMID:23214195
RGD:10400903
NCBI chrNW_004955573:203,875...206,078
Ensembl chrNW_004955573:203,441...206,355
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F12
coagulation factor XII
ISO
RGD
PMID:11092686
RGD:7394782
NCBI chrNW_004955408:29,644,279...29,665,161
Ensembl chrNW_004955408:29,642,096...29,650,950
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F2
coagulation factor II, thrombin
severity treatment
ISO
associated with liver cirrhosis;protein:increased expression:plasma (human) associated with liver cirrhosis;protein:increased expression:blood plasma (human)
RGD
PMID:7615203 PMID:9863491 PMID:10604885 PMID:10887118 PMID:20519137 PMID:21396682 PMID:22227956 PMID:25396762 More...
RGD:10449434 RGD:14401592 RGD:14974253 RGD:40818427 RGD:40818436 RGD:5147765 RGD:5147779 RGD:6893482
NCBI chrNW_004955422:1,356,675...1,367,788
Ensembl chrNW_004955422:1,356,769...1,367,517
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F3
coagulation factor III, tissue factor
treatment
ISO
associated with Protein C Deficiency
RGD
PMID:8956768 PMID:20858853 PMID:21396682
RGD:11340208 RGD:11341685 RGD:5147765
NCBI chrNW_004955423:254,060...264,448
Ensembl chrNW_004955423:254,189...264,159
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F5
coagulation factor V
ISO
RGD
PMID:11092686
RGD:7394782
NCBI chrNW_004955462:7,695,004...7,757,832
Ensembl chrNW_004955462:7,694,939...7,757,463
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F7
coagulation factor VII
treatment
ISO
RGD
PMID:11092686 PMID:16378835
RGD:11041650 RGD:7394782
NCBI chrNW_004955404:685,170...692,797
Ensembl chrNW_004955404:680,594...693,665
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F8
coagulation factor VIII
ISO
RGD
PMID:11092686
RGD:7394782
NCBI chrNW_004955594:658,686...800,101
Ensembl chrNW_004955594:658,523...802,865
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Fas
Fas cell surface death receptor
ISO
mRNA, protein:increased expression:spleen (rat)
RGD
PMID:20428798
RGD:8662930
NCBI chrNW_004955425:3,961,671...3,987,513
Ensembl chrNW_004955425:3,961,013...3,987,455
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Fga
fibrinogen alpha chain
treatment
ISO
RGD
PMID:19295478
RGD:11040925
NCBI chrNW_004955471:8,806,964...8,814,671
Ensembl chrNW_004955471:8,806,650...8,816,791
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Foxp3
forkhead box P3
ISO
protein:increased expression:intestinal mucosa
RGD
PMID:19998507
RGD:38455980
NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606
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Gch1
GTP cyclohydrolase 1
treatment
ISO
mRNA:increased expression:lung associated with liver cirrhosis
RGD
PMID:9388472 PMID:14647062 PMID:16845913
RGD:329961576 RGD:401700399 RGD:401793756
NCBI chrNW_004955409:8,624,225...8,670,436
Ensembl chrNW_004955409:8,624,468...8,668,614
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Gfer
growth factor, augmenter of liver regeneration
ISO
RGD
PMID:23073658
RGD:9685733
NCBI chrNW_004955442:15,280,753...15,283,405
Ensembl chrNW_004955442:15,281,419...15,283,266
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Ghr
growth hormone receptor
ISO
mRNA:decreased expression:liver
RGD
PMID:12217886 PMID:12654216
RGD:2307380 RGD:625688
NCBI chrNW_004955426:26,553,509...26,873,619
Ensembl chrNW_004955426:26,689,581...26,871,684
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Gpt
glutamic--pyruvic transaminase
treatment
ISO
RGD
PMID:25514429
RGD:401717525
NCBI chrNW_004955454:3,127,997...3,132,459
Ensembl chrNW_004955454:3,127,997...3,132,459
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Gsr
glutathione-disulfide reductase
treatment
ISO
RGD
PMID:25469663
RGD:10401928
NCBI chrNW_004955463:7,130,459...7,153,631
Ensembl chrNW_004955463:7,131,364...7,153,583
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Hmgb1
high mobility group box 1
ISO
protein:increased expression:heart, serum
RGD
PMID:18503231
RGD:10402065
NCBI chrNW_004955431:15,373,207...15,377,339
Ensembl chrNW_004955431:15,373,207...15,377,339
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Hmox1
heme oxygenase 1
treatment
ISO
RGD
PMID:21396999
RGD:10755715
NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979
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Hsf1
heat shock transcription factor 1
treatment
ISO
RGD
PMID:25571843
RGD:10402404
NCBI chrNW_004955454:2,907,265...2,932,352
Ensembl chrNW_004955454:2,907,265...2,932,351
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Hspa9
heat shock protein family A (Hsp70) member 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16741687
NCBI chrNW_004955418:1,915,985...1,931,017
Ensembl chrNW_004955418:1,915,985...1,931,017
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Hspd1
heat shock protein family D (Hsp60) member 1
ISO
mRNA, protein:increased expression:medulla oblongata CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:16675490 PMID:16741687
RGD:1624232
NCBI chrNW_004955403:3,062,724...3,073,419
Ensembl chrNW_004955403:3,063,133...3,073,419
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Icam1
intercellular adhesion molecule 1
ISO
protein:increased expression:lung (rat)
RGD
PMID:19776691
RGD:4145502
NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
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Ido1
indoleamine 2,3-dioxygenase 1
ISO
RGD
PMID:24930766 PMID:28077574
RGD:39939032 RGD:39939117
NCBI chrNW_004955536:2,944,770...2,955,829
Ensembl chrNW_004955536:2,943,611...2,955,829
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Ido2
indoleamine 2,3-dioxygenase 2
ISO
RGD
PMID:24930766
RGD:39939032
NCBI chrNW_004955536:2,894,410...2,938,862
Ensembl chrNW_004955536:2,894,308...2,939,016
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Ifng
interferon gamma
ISO
protein:increased expression:serum:
RGD
PMID:9195172
RGD:10755747
NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
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Igf1
insulin like growth factor 1
ISO
mRNA, protein:decreased expression:liver, serum
RGD
PMID:12217886 PMID:18492809
RGD:10402757 RGD:625688
NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152
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Igfals
insulin like growth factor binding protein acid labile subunit
ISO
RGD
PMID:12217886
RGD:625688
NCBI chrNW_004955442:15,469,602...15,482,115
Ensembl chrNW_004955442:15,478,202...15,482,115
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Igfbp1
insulin like growth factor binding protein 1
ISO
RGD
PMID:12217886
RGD:625688
NCBI chrNW_004955456:6,810,461...6,814,944
Ensembl chrNW_004955456:6,810,056...6,815,685
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Igfbp3
insulin like growth factor binding protein 3
ISO
mRNA, protein:decreased expression:liver, serum
RGD
PMID:18492809
RGD:10402757
NCBI chrNW_004955456:6,795,560...6,802,147
Ensembl chrNW_004955456:6,795,604...6,800,845
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Igfbp5
insulin like growth factor binding protein 5
ISO
RGD
PMID:12217886
RGD:625688
NCBI chrNW_004955453:16,530,110...16,550,733
Ensembl chrNW_004955453:16,530,110...16,550,733
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Il10
interleukin 10
treatment
ISO
protein:increased expression:plasma
RGD
PMID:19302852 PMID:27943364 PMID:28664613
RGD:14975137 RGD:14975170 RGD:2311055
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
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Il13
interleukin 13
treatment
ISO
RGD
PMID:10674721
RGD:8549626
NCBI chrNW_004955408:4,046,406...4,049,795
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Il1a
interleukin 1 alpha
ISO
protein:increased expression:plasma
RGD
PMID:9636192 PMID:22426124
RGD:6907109 RGD:7794786
NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466
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Il1b
interleukin 1 beta
ISO
protein:increased expression:plasma
RGD
PMID:17201737
RGD:1626625
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il1rn
interleukin 1 receptor antagonist
treatment
ISO
mRNA:increased expression:lung, spleen, liver (rat)
RGD
PMID:1385928 PMID:8855299
RGD:11522760 RGD:8551846
NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471
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Il6
interleukin 6
ISO
associated with Diabetes Mellitus, Experimental; Protein:increased expression:extracellular space (rat) protein:increased expression:serum (rat)
RGD
PMID:19449282 PMID:21396682 PMID:22227956
RGD:2307179 RGD:5147765 RGD:6893482
NCBI chrNW_004955410:25,079,835...25,084,390
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Irak3
interleukin 1 receptor associated kinase 3
ISO
mRNA, protein:increased expression:blood (human)
RGD
PMID:17982103
RGD:36049802
NCBI chrNW_004955458:12,839,995...12,880,285
Ensembl chrNW_004955458:12,846,237...12,879,316
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Irs1
insulin receptor substrate 1
ISO
protein:increased tyrosine nitration, decreased tyrosine phosphorylation:skeletal muscle
RGD
PMID:21206533
RGD:6483008
NCBI chrNW_004955453:7,685,715...7,742,262
Ensembl chrNW_004955453:7,685,715...7,742,262
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Itga2b
integrin subunit alpha 2b
ISO
RGD
PMID:15280099
RGD:2316360
NCBI chrNW_004955451:17,381,323...17,392,122
Ensembl chrNW_004955451:17,382,779...17,391,859
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Itgb3
integrin subunit beta 3
ISO
RGD
PMID:15280099
RGD:2316360
NCBI chrNW_004955478:9,788,192...9,830,254
Ensembl chrNW_004955478:9,788,149...9,823,746
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Keap1
kelch like ECH associated protein 1
ISO
RGD
PMID:22609006
RGD:6892951
NCBI chrNW_004955495:1,704,695...1,711,339
Ensembl chrNW_004955495:1,704,695...1,711,290
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Map2
microtubule associated protein 2
ISO
mRNA, protein:decreased expression:neuron
RGD
PMID:21421895
RGD:6483086
NCBI chrNW_004955457:5,678,826...5,816,114
Ensembl chrNW_004955457:5,678,436...5,875,024
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Mapk14
mitogen-activated protein kinase 14
treatment
ISO
protein:increased activity:small intestine mucosa
RGD
PMID:21641970 PMID:24312512
RGD:10047418 RGD:5135029
NCBI chrNW_004955437:3,836,331...3,884,083
Ensembl chrNW_004955437:3,838,232...3,884,083
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Mapk8
mitogen-activated protein kinase 8
ISO
protein:increased phophorylation:hippocampus (rat)
RGD
PMID:12207162
RGD:150340687
NCBI chrNW_004955556:1,593,552...1,705,543
Ensembl chrNW_004955556:1,593,494...1,665,784
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Mc4r
melanocortin 4 receptor
ISO
mRNA:increased expression:paraventricular nucleus (rat)
RGD
PMID:21343543
RGD:6484214
NCBI chrNW_004955402:44,453,973...44,456,689
Ensembl chrNW_004955402:44,455,294...44,456,292
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Mif
macrophage migration inhibitory factor
ISO
protein:increased expression:plasma
RGD
PMID:16601957
RGD:1641983
NCBI chrNW_004955455:8,367,566...8,368,460
Ensembl chrNW_004955455:8,367,566...8,368,460
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Mme
membrane metalloendopeptidase
severity
ISO
RGD
PMID:11078421
RGD:13801040
NCBI chrNW_004955448:6,193,113...6,311,666
Ensembl chrNW_004955448:6,226,059...6,314,949
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Muc2
mucin 2, oligomeric mucus/gel-forming
ISO
RGD
PMID:19099858
RGD:7349370
NCBI chrNW_004955476:11,108,826...11,135,697
Ensembl chrNW_004955476:11,108,826...11,135,697
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Nfe2l2
NFE2 like bZIP transcription factor 2
treatment
ISO
RGD
PMID:26646455
RGD:42722616
NCBI chrNW_004955403:19,510,122...19,536,428
Ensembl chrNW_004955403:19,532,103...19,535,944
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Nfkbia
NFKB inhibitor alpha
exacerbates treatment
ISO
RGD
PMID:10229101 PMID:19098124
RGD:126908017 RGD:126928139
NCBI chrNW_004955409:25,691,673...25,695,151
Ensembl chrNW_004955409:25,691,534...25,697,520
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Nos2
nitric oxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism mRNA, protein:increased expression:intestine
CTD RGD
PMID:12620498 PMID:16787348 PMID:20519137
RGD:4891470 RGD:5147779
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
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Nos3
nitric oxide synthase 3
ISO
protein:increased expression:aorta (rat)
RGD
PMID:10462376
RGD:7794732
NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814
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Npy
neuropeptide Y
treatment
ISO
RGD
PMID:15342191
RGD:1580787
NCBI chrNW_004955410:26,348,388...26,355,232
Ensembl chrNW_004955410:26,348,504...26,355,297
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Nr3c1
nuclear receptor subfamily 3 group C member 1
ISO
RGD
PMID:15640646
RGD:4892561
NCBI chrNW_004955415:10,494,704...10,585,778
Ensembl chrNW_004955415:10,494,640...10,586,221
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Otc
ornithine transcarbamylase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16741687
NCBI chrNW_004955601:481,524...543,176
Ensembl chrNW_004955601:481,480...543,176
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Pck1
phosphoenolpyruvate carboxykinase 1
ISO
RGD
PMID:12217886 PMID:19268478
RGD:10427879 RGD:625688
NCBI chrNW_004955445:1,909,012...1,914,032
Ensembl chrNW_004955445:1,908,946...1,915,002
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Pck2
phosphoenolpyruvate carboxykinase 2, mitochondrial
ISO
mRNA,protein:decreased expression,decreased activity:liver:
RGD
PMID:19268478
RGD:10427879
NCBI chrNW_004955409:36,288,402...36,296,761
Ensembl chrNW_004955409:36,288,568...36,296,828
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Pcsk1
proprotein convertase subtilisin/kexin type 1
ISO
RGD
PMID:16337011
RGD:6483567
NCBI chrNW_004955418:16,181,809...16,224,274
Ensembl chrNW_004955418:16,181,771...16,224,603
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Pcsk2
proprotein convertase subtilisin/kexin type 2
ISO
RGD
PMID:16337011
RGD:6483567
NCBI chrNW_004955415:26,266,513...26,496,905
Ensembl chrNW_004955415:26,266,484...26,497,001
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Pecam1
platelet and endothelial cell adhesion molecule 1
ISO
RGD
PMID:22119535
RGD:6771174
NCBI chrNW_004955478:7,448,584...7,531,860
Ensembl chrNW_004955478:7,478,492...7,531,188
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Pgf
placental growth factor
ISO
protein:increased expression:multiple
RGD
PMID:16702604
RGD:6483601
NCBI chrNW_004955523:616,196...627,055
Ensembl chrNW_004955523:616,154...627,713
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Pla2g7
phospholipase A2 group VII
ISO
protein:increased expression: :
RGD
PMID:10748027
RGD:7248791
NCBI chrNW_004955437:11,534,251...11,577,942
Ensembl chrNW_004955437:11,534,173...11,555,996
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Plat
plasminogen activator, tissue type
treatment
ISO
RGD
PMID:9091588
RGD:11541073
NCBI chrNW_004955536:730,962...754,333
Ensembl chrNW_004955536:730,981...756,394
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Pparg
peroxisome proliferator activated receptor gamma
ISO
protein:increased expression:small intestine mucosa
RGD
PMID:21641970
RGD:5135029
NCBI chrNW_004955429:14,814,690...14,936,869
Ensembl chrNW_004955429:14,873,908...14,937,387
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Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
ISO
mRNA:decreased expression:epididymal fat pad
RGD
PMID:20421294
RGD:6484543
NCBI chrNW_004955426:25,079,718...25,102,090
Ensembl chrNW_004955426:25,079,718...25,102,090
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Prkn
parkin RBR E3 ubiquitin protein ligase
ISO
protein:increased expression:liver, mitochondrion (mouse)
RGD
PMID:28615325
RGD:13432559
NCBI chrNW_004955439:18,664,230...19,953,358
Ensembl chrNW_004955439:18,664,379...19,951,152
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Proc
protein C, inactivator of coagulation factors Va and VIIIa
treatment
ISO
RGD
PMID:18205901 PMID:23170801
RGD:11100030 RGD:11100034
NCBI chrNW_004955459:3,097,229...3,105,566
Ensembl chrNW_004955459:3,094,120...3,104,135
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Ptafr
platelet activating factor receptor
treatment
ISO
RGD
PMID:2178565
RGD:10041063
NCBI chrNW_004955452:7,309,854...7,345,579
Ensembl chrNW_004955452:7,311,901...7,312,929
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Ptger4
prostaglandin E receptor 4
ISO
protein:increased expression:paraventricular hypothalamic nucleus parvicellular division (rat)
RGD
PMID:11058222
RGD:10043329
NCBI chrNW_004955426:24,997,811...25,010,822
Ensembl chrNW_004955426:24,997,811...25,010,822
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Ptgis
prostaglandin I2 synthase
treatment
ISO
RGD
PMID:11076704
RGD:401960076
NCBI chrNW_004955445:8,624,228...8,663,385
Ensembl chrNW_004955445:8,623,430...8,677,658
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
RGD
PMID:21641970
RGD:5135029
NCBI chrNW_004955406:25,077,988...25,086,259
Ensembl chrNW_004955406:25,079,945...25,086,171
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Ren
renin
ISO
protein:increased activity:blood plasma (rat) protein:increased activity:blood plasma (mouse)
RGD
PMID:16512638 PMID:30027346
RGD:125097481 RGD:125097499
NCBI chrNW_004955406:40,016,624...40,026,286
Ensembl chrNW_004955406:40,016,630...40,026,286
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Serpinc1
serpin family C member 1
treatment
ISO
RGD
PMID:15995859 PMID:16457847 PMID:20519137 PMID:21396682
RGD:1599326 RGD:1599332 RGD:5147765 RGD:5147779
NCBI chrNW_004955406:14,024,183...14,036,206
Ensembl chrNW_004955406:14,024,313...14,035,948
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Serpine1
serpin family E member 1
treatment
ISO
RGD
PMID:21396682 PMID:25396762
RGD:10449434 RGD:5147765
NCBI chrNW_004955456:16,147,523...16,157,040
Ensembl chrNW_004955456:16,145,944...16,157,142
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Serpinf1
serpin family F member 1
ISO
protein:increased expression:plasma (human)
RGD
PMID:12386642
RGD:36174005
NCBI chrNW_004955481:1,414,930...1,426,436
Ensembl chrNW_004955481:1,414,930...1,426,241
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Serping1
serpin family G member 1
treatment
ISO
RGD
PMID:18652771
RGD:8661643
NCBI chrNW_004955511:2,545,337...2,557,850
Ensembl chrNW_004955511:2,545,285...2,557,982
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Slc18a3
solute carrier family 18 member A3
ISO
protein:decreased expression:parietal cortex
RGD
PMID:17306796
RGD:5686693
NCBI chrNW_004955556:696,779...698,869
Ensembl chrNW_004955556:696,974...698,566
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Slc22a2
solute carrier family 22 member 2
treatment
ISO
RGD
PMID:18313662
RGD:7243881
NCBI chrNW_004955439:20,567,241...20,608,281
Ensembl chrNW_004955439:20,567,212...20,609,105
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Slc38a3
solute carrier family 38 member 3
ISO
RGD
PMID:20036385
RGD:9999227
NCBI chrNW_004955532:2,023,694...2,046,556
Ensembl chrNW_004955532:2,023,694...2,050,708
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Slc38a5
solute carrier family 38 member 5
ISO
RGD
PMID:20036385
RGD:9999227
NCBI chrNW_004955543:15,968...24,644
Ensembl chrNW_004955543:16,089...24,668
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Slc7a5
solute carrier family 7 member 5
ISO
RGD
PMID:26337286
RGD:151361133
NCBI chrNW_004955541:2,103,437...2,129,668
Ensembl chrNW_004955541:2,103,384...2,130,310
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Socs1
suppressor of cytokine signaling 1
ISO
mRNA:increased expression:liver, skeletal muscle
RGD
PMID:15169905
RGD:2298923
NCBI chrNW_004955442:7,321,337...7,323,109
Ensembl chrNW_004955442:7,321,337...7,323,109
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Socs3
suppressor of cytokine signaling 3
ISO
mRNA:increased expression:liver, skeletal muscle
RGD
PMID:12217886 PMID:15169905
RGD:2298923 RGD:625688
NCBI chrNW_004955506:4,222,455...4,225,563
Ensembl chrNW_004955506:4,222,455...4,225,563
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Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16741687
NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163
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Sparc
secreted protein acidic and cysteine rich
ISO
mRNA, protein:decreased expression:kidney
RGD
PMID:10703670
RGD:2300026
NCBI chrNW_004955408:6,100,123...6,122,460
Ensembl chrNW_004955408:6,099,003...6,122,459
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Stat5b
signal transducer and activator of transcription 5B
ISO
protein:decreased tyrosine phosphorylation:liver
RGD
PMID:17327369
RGD:1601383
NCBI chrNW_004955451:16,253,645...16,295,337
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Tbxa2r
thromboxane A2 receptor
ISO
RGD
PMID:2580129 PMID:15647606
RGD:11059531 RGD:1601450
NCBI chrNW_004955495:5,539,382...5,557,441
Ensembl chrNW_004955495:5,539,889...5,557,441
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Tbxas1
thromboxane A synthase 1
ISO
RGD
PMID:15647606
RGD:1601450
NCBI chrNW_004955494:3,161,032...3,321,974
Ensembl chrNW_004955494:3,160,653...3,334,411
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Tdo2
tryptophan 2,3-dioxygenase
severity
ISO
RGD
PMID:24930766
RGD:39939032
NCBI chrNW_004955471:11,229,795...11,245,255
Ensembl chrNW_004955471:11,229,273...11,245,375
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Tfpi
tissue factor pathway inhibitor
treatment
ISO
RGD
PMID:17537762
RGD:11062086
NCBI chrNW_004955403:10,925,155...11,004,229
Ensembl chrNW_004955403:10,924,893...11,004,284
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Thbd
thrombomodulin
ISO
mRNA:decreased expression:endothelial cell
RGD
PMID:12611420 PMID:19487933 PMID:20348393
RGD:1601652 RGD:5684988 RGD:5685037
NCBI chrNW_004955415:30,222,830...30,226,406
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Timp3
TIMP metallopeptidase inhibitor 3
ISO
RGD
PMID:17083784
RGD:2290426
NCBI chrNW_004955405:41,613,976...41,655,813
Ensembl chrNW_004955405:41,613,966...41,655,813
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Tlr2
toll like receptor 2
treatment
ISO
RGD
PMID:22172266
RGD:7241094
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
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Tlr4
toll like receptor 4
treatment disease_progression
ISO
mRNA:increased expression:liver:
RGD
PMID:22172266 PMID:23977376
RGD:14697731 RGD:7241094
NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
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Tnf
tumor necrosis factor
treatment
ISO
XCO:0000822 JTE-607 associated with liver cirrhosis protein:increased expression:plasma (rat)
RGD
PMID:8283134 PMID:10493164 PMID:12813371 PMID:15242491 PMID:17324147 PMID:18078960 PMID:20519137 PMID:21396682 More...
RGD:14995427 RGD:14995443 RGD:15023464 RGD:38501090 RGD:40903016 RGD:4891465 RGD:5147765 RGD:5147779
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Vcam1
vascular cell adhesion molecule 1
ISO
mRNA:increased expression:brain:
RGD
PMID:20061033
RGD:7240511
NCBI chrNW_004955435:5,390,745...5,410,025
Ensembl chrNW_004955435:5,390,751...5,411,691
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Vwf
von Willebrand factor
ISO
protein:increased expression:endothelial cell:
RGD
PMID:2650559
RGD:11079230
NCBI chrNW_004955413:3,672,470...3,825,588
Ensembl chrNW_004955413:3,672,470...3,819,571
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Gch1
GTP cyclohydrolase 1
treatment
ISO
RGD
PMID:8602831
RGD:329961578
NCBI chrNW_004955409:8,624,225...8,670,436
Ensembl chrNW_004955409:8,624,468...8,668,614
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Htr2a
5-hydroxytryptamine receptor 2A
treatment
ISO
RGD
PMID:19318092
RGD:401901206
NCBI chrNW_004955431:583,165...646,991
Ensembl chrNW_004955431:580,713...647,345
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