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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Carcinoid Heart Disease
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Accession:DOID:9005906 term browser browse the term
Definition:Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation.
Synonyms:exact_synonym: Carcinoid Heart Diseases
 primary_id: MESH:D002275;   RDO:0005111
 xref: EFO:1001769


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Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    syndrome 10833
      Malignant Carcinoid Syndrome 0
        Carcinoid Heart Disease 0
Path 2
Term Annotations click to browse term
  disease 21128
    disease of cellular proliferation 7667
      cancer 5483
        organ system cancer 5237
          nervous system cancer 959
            neuroectodermal tumor 448
              neuroendocrine tumor 231
                Carcinoid Tumor 28
                  Malignant Carcinoid Syndrome 0
                    Carcinoid Heart Disease 0
paths to the root