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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Carcinoid Heart Disease
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Accession:DOID:9005906 term browser browse the term
Definition:Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation.
Synonyms:exact_synonym: Carcinoid Heart Diseases
 primary_id: MESH:D002275;   RDO:0005111
 xref: EFO:1001769

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Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16063
    syndrome 9329
      Malignant Carcinoid Syndrome 0
        Carcinoid Heart Disease 0
Path 2
Term Annotations click to browse term
  disease 16063
    disease of cellular proliferation 6683
      cancer 4843
        organ system cancer 4626
          nervous system cancer 849
            neuroectodermal tumor 399
              neuroendocrine tumor 194
                Carcinoid Tumor 10
                  Malignant Carcinoid Syndrome 0
                    Carcinoid Heart Disease 0
paths to the root