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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Carcinoid Heart Disease
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Accession:DOID:9005906 term browser browse the term
Definition:Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation.
Synonyms:exact_synonym: Carcinoid Heart Diseases
 primary_id: MESH:D002275;   RDO:0005111
For additional species annotation, visit the Alliance of Genome Resources.

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Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16035
    syndrome 7010
      Malignant Carcinoid Syndrome 0
        Carcinoid Heart Disease 0
Path 2
Term Annotations click to browse term
  disease 16035
    disease of cellular proliferation 5921
      cancer 4243
        organ system cancer 4068
          nervous system cancer 1605
            neuroectodermal tumor 638
              neuroendocrine tumor 470
                Carcinoid Tumor 24
                  Malignant Carcinoid Syndrome 0
                    Carcinoid Heart Disease 0
paths to the root