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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Pleural Effusion
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Accession:DOID:9005883 term browser browse the term
Definition:Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.
Synonyms:exact_synonym: Pleural Effusions
 primary_id: MESH:D010996;   RDO:0006358
 xref: EFO:0009637


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Pleural Effusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 ISO associated with tuberculosis;protein:decreased activity:pleural fluid (human) RGD PMID:23091417 RGD:40818411 NCBI chrNW_004955519:2,591,229...2,643,705
Ensembl chrNW_004955519:2,591,248...2,633,495
JBrowse link
G Ada adenosine deaminase treatment ISO RGD PMID:25547995 RGD:152995274 NCBI chrNW_004955445:12,696,096...12,717,488
Ensembl chrNW_004955445:12,696,096...12,717,488
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit ISO ClinVar Annotator: match by term: Pleural effusion ClinVar PMID:25741868 PMID:28492532 PMID:30177536 PMID:31680349 PMID:36634413 NCBI chrNW_004955449:661,310...683,873
Ensembl chrNW_004955449:661,304...683,873
JBrowse link
G Il15 interleukin 15 ISO RGD PMID:15072171 RGD:4990458 NCBI chrNW_004955471:1,496,352...1,583,919
Ensembl chrNW_004955471:1,497,483...1,511,469
JBrowse link
G Lox lysyl oxidase ISO ClinVar Annotator: match by term: Pleural effusion ClinVar PMID:25741868 PMID:28492532 NCBI chrNW_004955521:178,290...193,926
Ensembl chrNW_004955521:185,792...193,926
JBrowse link
G Srfbp1 serum response factor binding protein 1 ISO ClinVar Annotator: match by term: Pleural effusion ClinVar PMID:25741868 PMID:28492532 NCBI chrNW_004955521:105,565...160,906
Ensembl chrNW_004955521:104,918...159,724
JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: therapeutic CTD PMID:2518282 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
JBrowse link
Malignant Pleural Effusions term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase disease_progression ISO protein:decreased expression:serum:
protein:increased activity:serum:
RGD PMID:1689629 PMID:1818842 PMID:27300446 RGD:152995272 RGD:152995292 RGD:152998934 NCBI chrNW_004955445:12,696,096...12,717,488
Ensembl chrNW_004955445:12,696,096...12,717,488
JBrowse link
G Il10 interleukin 10 ISO RGD PMID:30695099 RGD:14975123 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO associated with pleurisy; protein:decreased activity:pleura RGD PMID:17611666 RGD:5130711 NCBI chrNW_004955433:13,024,844...13,050,041
Ensembl chrNW_004955433:13,024,418...13,052,775
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO associated with pleurisy; protein:decreased activity:pleura RGD PMID:17611666 RGD:5130711 NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16063
    disease of anatomical entity 13809
      respiratory system disease 3077
        lower respiratory tract disease 1976
          pleural disease 96
            Pleural Effusion 10
              Malignant Pleural Effusions 4
paths to the root