Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Tongue Neoplasms
go back to main search page
Accession:DOID:9005873 term browser browse the term
Definition:Tumors or cancer of the TONGUE.
Synonyms:exact_synonym: tongue neoplasm;   tongue neoplasms
 primary_id: MESH:D014062
 alt_id: DOID:8649
 xref: EFO:0003871
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
Tongue Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor treatment ISO RGD PMID:17374970 RGD:1625338 NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,120...24,221,162 		JBrowse link
G AQP3 aquaporin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21401805 NCBI chr10:33,045,374...33,050,285
Ensembl chr10:33,045,245...33,051,082 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A disease_progression ISO RGD PMID:11488071 RGD:8662423 NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,359,455...32,363,761 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A severity ISO DNA:loss of heterozygosity
protein:decreased expression:tongue
DNA:point mutations, missense mutation:exon		 RGD PMID:16527513 PMID:17091472 PMID:18804414 RGD:11252155 RGD:1578522 RGD:1600814 NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,792,469...200,798,854 		JBrowse link
G CDKN2B cyclin dependent kinase inhibitor 2B ISO DNA:loss of heterozygosity RGD PMID:16527513 RGD:1578522 NCBI chr 1:200,666,250...200,770,880
Ensembl chr 1:200,761,004...200,766,056 		JBrowse link
G CRYAB crystallin alpha B ISO CTD Direct Evidence: marker/mechanism CTD PMID:19840781 NCBI chr 9:39,638,505...39,643,530
Ensembl chr 9:39,638,506...39,643,530 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:tongue epithelium RGD PMID:14674993 RGD:2293780 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554 		JBrowse link
G HRAS HRas proto-oncogene, GTPase susceptibility ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:20043093 RGD:12738401 NCBI chr 2:299,662...302,539
Ensembl chr 2:299,660...302,501 		JBrowse link
G HSPB1 heat shock protein family B (small) member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19840781 NCBI chr 3:10,038,074...10,039,441
Ensembl chr 3:10,037,949...10,039,704 		JBrowse link
G IGF1 insulin like growth factor 1 ISO protein:decreased expression:blood: RGD PMID:8493451 RGD:8548876 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033 		JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:tongue epithelium RGD PMID:14674993 RGD:2293780 NCBI chr 2:66,214,086...66,219,435
Ensembl chr 2:66,214,138...66,217,002 		JBrowse link
G KDSR 3-ketodihydrosphingosine reductase ISO protein:increased expression:tongue: RGD PMID:12167434 RGD:8547871 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879 		JBrowse link
G LOC110255312 keratin, type I cytoskeletal 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16543248 NCBI chr12:21,074,965...21,079,393
Ensembl chr12:21,024,314...21,119,396 		JBrowse link
G MIR222 microRNA mir-222 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19487542 NCBI chr  X:40,571,808...40,571,887
Ensembl chr  X:40,571,808...40,571,887 		JBrowse link
G OGG1 8-oxoguanine DNA glycosylase ISO protein:decreased expression:saliva RGD PMID:19789535 RGD:8657148 NCBI chr13:66,038,669...66,045,478 JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16543248 PMID:22561872 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
G SOD2 superoxide dismutase 2 ISO mRNA,protein:increased expression:tongue:
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:20618948 RGD:8547519 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 disease_progression ISO RGD PMID:17169602 PMID:22302289 RGD:8694287 RGD:8694311 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992 		JBrowse link
G TLR5 toll like receptor 5 ISO protein:increased expression:tongue: RGD PMID:23287987 RGD:7814374 NCBI chr10:19,387,666...19,410,024
Ensembl chr10:19,387,666...19,410,024 		JBrowse link
G TNF tumor necrosis factor ISO mRNA,protein:increased expression:tongue:
protein:increased expression:saliva		 RGD PMID:14747060 PMID:21397550 RGD:7401243 RGD:7401244 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
G TP53 tumor protein p53 ISO protein:increased expression:tongue:
CTD Direct Evidence: marker/mechanism
DNA:mutations:cds:		 RGD
CTD		 PMID:9485768 PMID:12167434 PMID:16543248 PMID:21903770 RGD:8547850 RGD:8547871 RGD:8547872 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
G TYMS thymidylate synthetase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16280240 NCBI chr 6:105,642,730...105,660,279
Ensembl chr 6:105,642,381...105,660,578 		JBrowse link
G VEGFA vascular endothelial growth factor A disease_progression ISO RGD PMID:15289890 RGD:7488946 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366 		JBrowse link
G VEGFC vascular endothelial growth factor C disease_progression ISO RGD PMID:15289890 RGD:7488946 NCBI chr15:39,037,764...39,136,234
Ensembl chr15:39,039,311...39,132,936 		JBrowse link
congenital heart defects, hamartomas of tongue, and polysyndactyly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WDPCP WD repeat containing planar cell polarity effector ISO ClinVar Annotator: match by term: Heart defect - tongue hamartoma - polysyndactyly syndrome OMIM
ClinVar		 PMID:9536098 PMID:17576681 PMID:20671153 PMID:25326635 PMID:25427950 More... NCBI chr 3:78,435,154...78,726,313
Ensembl chr 3:78,268,922...78,856,893 		JBrowse link
tongue cancer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDX3X DEAD-box helicase 3 X-linked ameliorates ISO RGD PMID:25918862 RGD:151356506 NCBI chr  X:36,988,031...37,005,496
Ensembl chr  X:36,988,031...37,018,202 		JBrowse link
G FGFR3 fibroblast growth factor receptor 3 severity ISO associated with human papillomavirus;protein:decreased expression:tumor cells RGD PMID:30061236 RGD:36947883 NCBI chr 8:879,151...894,968
Ensembl chr 8:879,159...894,964 		JBrowse link
G MIR155 microRNA mir-155 ISO miRNA:decreased expression:tongue RGD PMID:30617160 RGD:21081517 NCBI chr13:189,138,822...189,138,902
Ensembl chr13:189,138,822...189,138,902 		JBrowse link
G MIR491 microRNA mir-491 disease_progression ISO mRNA:decreased expression:tongue (human) RGD PMID:25749387 RGD:152995520 NCBI chr 1:202,227,251...202,227,326
Ensembl chr 1:202,227,236...202,227,336 		JBrowse link
G RICTOR RPTOR independent companion of MTOR complex 2 disease_progression ISO protein:increased expression:tongue (human) RGD PMID:25749387 RGD:152995520 NCBI chr16:24,109,934...24,250,019
Ensembl chr16:24,109,939...24,311,132 		JBrowse link
tongue carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BUB1B BUB1 mitotic checkpoint serine/threonine kinase B ISO associated with oral squamous cell carcinoma; protein:increased expression: oral mucosa squamous cell, cervical lymph node (human) RGD PMID:20204288 RGD:27372889 NCBI chr 1:131,093,026...131,143,840
Ensembl chr 1:131,092,958...131,143,794 		JBrowse link
tongue squamous cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase ISO protein:increased activity:saliva: RGD PMID:20379753 RGD:152995262 NCBI chr17:47,044,492...47,072,232
Ensembl chr17:47,044,497...47,072,245 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing disease_progression ISO protein:decreased expression:serum RGD PMID:23181352 RGD:8694469 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646 		JBrowse link
G BRINP3 BMP/retinoic acid inducible neural specific 3 ISO mRNA:decreased expression:tongue: RGD PMID:19787213 RGD:14398487 NCBI chr10:2,963,237...3,367,629
Ensembl chr10:2,963,527...3,367,623 		JBrowse link
G CAV2 caveolin 2 ISO protein:increased expression:mucosa of tongue RGD PMID:20558341 RGD:8661771 NCBI chr18:29,699,012...29,707,277
Ensembl chr18:29,699,020...29,707,277 		JBrowse link
G CCND1 cyclin D1 ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A disease_progression ISO RGD PMID:12162767 RGD:8662376 NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,359,455...32,363,761 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO mRNA:increased expression:head, neck (human) RGD PMID:31452775 RGD:150520018 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G EGFR epidermal growth factor receptor treatment ISO RGD PMID:19380367 RGD:8551769 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 disease_progression ISO RGD PMID:19691460 RGD:126781771 NCBI chr 5:21,474,218...21,495,040
Ensembl chr 5:21,474,475...21,495,038 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 severity ISO RGD PMID:19691460 RGD:126781771 NCBI chr15:113,966,573...115,096,984
Ensembl chr15:113,974,437...115,096,565 		JBrowse link
G FANCB FA complementation group B ISO RGD PMID:17409780 RGD:11049143 NCBI chr  X:11,386,360...11,408,958
Ensembl chr  X:11,384,912...11,409,057 		JBrowse link
G FANCC FA complementation group C ISO RGD PMID:17409780 RGD:11049143 NCBI chr10:26,796,546...27,055,271
Ensembl chr10:26,796,572...27,061,801 		JBrowse link
G FANCF FA complementation group F ISO mRNA:decreased expression:tongue: RGD PMID:17409780 RGD:11049143 NCBI chr 2:36,884,701...36,886,661
Ensembl chr 2:36,884,777...36,885,856 		JBrowse link
G FANCG FA complementation group G ISO RGD PMID:17409780 RGD:11049143 NCBI chr 1:235,871,073...235,879,604
Ensembl chr 1:235,871,075...235,877,974 		JBrowse link
G FANCI FA complementation group I ISO RGD PMID:17409780 RGD:11049143 NCBI chr 7:54,811,024...54,889,992
Ensembl chr 7:54,811,027...54,889,998 		JBrowse link
G FANCL FA complementation group L ISO RGD PMID:17409780 RGD:11049143 NCBI chr 3:83,136,355...83,436,948
Ensembl chr 3:83,337,253...83,436,942 		JBrowse link
G FANCM FA complementation group M ISO RGD PMID:17409780 RGD:11049143 NCBI chr 1:175,333,965...175,402,065
Ensembl chr 1:175,334,141...175,400,685 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO mRNA,protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554 		JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 6:51,836,780...51,844,531
Ensembl chr 6:51,837,719...51,844,529 		JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit ISO protein:decreased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 2:6,430,158...6,436,173
Ensembl chr 2:6,430,153...6,436,173 		JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit ISO mRNA,protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 3:110,820,403...110,842,903
Ensembl chr 3:110,823,666...110,843,068 		JBrowse link
G FUBP1 far upstream element binding protein 1 exacerbates ISO mRNA, protein:increased expression:tongue (human) RGD PMID:32339054 RGD:151361191 NCBI chr 6:135,281,474...135,319,055
Ensembl chr 6:135,281,521...135,318,714 		JBrowse link
G GJA1 gap junction protein alpha 1 ISO protein:decreased expression:epithelium RGD PMID:23568744 RGD:8662380 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156 		JBrowse link
G HGF hepatocyte growth factor ISO protein:increased expression:tongue: RGD PMID:20848408 RGD:8548612 NCBI chr 9:98,437,771...98,513,573
Ensembl chr 9:98,438,143...98,513,564 		JBrowse link
G IFNG interferon gamma disease_progression ISO protein:decreased expression:serum: RGD PMID:17338814 RGD:8662972 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IL10 interleukin 10 disease_progression ISO protein:increased expression:serum: RGD PMID:17338814 RGD:8662972 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378 		JBrowse link
G IL1RL1 interleukin 1 receptor like 1 disease_progression ISO RGD PMID:25193287 RGD:39938972 NCBI chr 3:51,868,549...51,902,454
Ensembl chr 3:51,846,792...51,951,383 		JBrowse link
G IL2 interleukin 2 ISO protein:decreased expression:serum: RGD PMID:17338814 RGD:8662972 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609 		JBrowse link
G IL33 interleukin 33 disease_progression ISO RGD PMID:25193287 RGD:39938972 NCBI chr 1:215,899,830...215,941,944
Ensembl chr 1:215,899,436...215,941,840 		JBrowse link
G JAK3 Janus kinase 3 disease_progression ISO RGD PMID:26860129 RGD:11531126 NCBI chr 2:59,905,901...59,926,504
Ensembl chr 2:59,905,919...59,926,495 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit ISO mRNA,protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 6:153,686,425...153,687,635
Ensembl chr 6:153,685,682...153,687,636 		JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 2:66,214,086...66,219,435
Ensembl chr 2:66,214,138...66,217,002 		JBrowse link
G JUND JunD proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 2:59,530,991...59,532,846 JBrowse link
G KDR kinase insert domain receptor treatment ISO RGD PMID:19380367 RGD:8551769 NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,122...41,856,336 		JBrowse link
G KDSR 3-ketodihydrosphingosine reductase ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879 		JBrowse link
G LOC100622859 baculoviral IAP repeat-containing protein 2 exacerbates ISO protein:increased expression:tongue (human) RGD PMID:18621506 RGD:153323319 NCBI chr 9:33,041,592...33,062,865
Ensembl chr 9:33,041,663...33,062,854 		JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 ISO mRNA:increased expression:tongue squamous epithelium (human) RGD PMID:28319306 RGD:150429750 NCBI chr12:56,402,029...56,516,217
Ensembl chr12:56,402,075...56,516,238 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO protein:increased expression:tongue: RGD PMID:20848408 RGD:8548612 NCBI chr18:29,426,044...29,541,526
Ensembl chr18:29,426,048...29,541,512 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788 		JBrowse link
G MTUS1 microtubule associated scaffold protein 1 disease_progression ISO RGD PMID:22153618 RGD:25330347 NCBI chr17:5,331,668...5,507,212
Ensembl chr17:5,329,750...5,507,119 		JBrowse link
G SLC1A5 solute carrier family 1 member 5 disease_progression ISO RGD PMID:24762957 RGD:151361157 NCBI chr 6:52,647,432...52,661,464
Ensembl chr 6:52,647,438...52,661,459 		JBrowse link
G SLC3A2 solute carrier family 3 member 2 disease_progression ISO RGD PMID:24762957 RGD:151361157 NCBI chr 2:8,892,071...8,919,070
Ensembl chr 2:8,892,089...8,919,072 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 severity ISO RGD PMID:24762957 RGD:151361157 NCBI chr 8:88,608,083...88,690,589
Ensembl chr 8:88,608,174...88,687,250 		JBrowse link
G SLC7A5 solute carrier family 7 member 5 disease_progression ISO RGD PMID:24762957 RGD:151361157 NCBI chr 6:1,545,940...1,574,298
Ensembl chr 6:1,545,944...1,574,285 		JBrowse link
G SOX2 SRY-box transcription factor 2 disease_progression ISO RGD PMID:21689966 RGD:8661665 NCBI chr13:119,668,476...119,669,435
Ensembl chr13:119,668,476...119,669,435 		JBrowse link
G TP53 tumor protein p53 ISO protein:increased expression:tongue: RGD PMID:20385474 RGD:8547851 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17287
    sensory system disease 6667
      mouth disease 880
        tongue disease 80
          Tongue Neoplasms 72
            congenital heart defects, hamartomas of tongue, and polysyndactyly 1
            tongue cancer + 52
Path 2
Term Annotations click to browse term
  disease 17287
    disease of anatomical entity 14854
      nervous system disease 12995
        Neurologic Manifestations 9461
          sensory system disease 6667
            mouth disease 880
              tongue disease 80
                Tongue Neoplasms 72
                  congenital heart defects, hamartomas of tongue, and polysyndactyly 1
                  tongue cancer + 52
paths to the root