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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Tongue Neoplasms
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Accession:DOID:9005873 term browser browse the term
Definition:Tumors or cancer of the TONGUE.
Synonyms:exact_synonym: tongue neoplasm;   tongue neoplasms
 primary_id: MESH:D014062
 alt_id: DOID:8649
 xref: EFO:0003871
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
Tongue Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor treatment ISO RGD PMID:17374970 RGD:1625338 NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322 		JBrowse link
G AQP3 aquaporin 3 (Gill blood group) EXP CTD Direct Evidence: marker/mechanism CTD PMID:21401805 NCBI chr 9:33,441,160...33,447,593
Ensembl chr 9:33,441,156...33,447,596 		JBrowse link
G BCL2 BCL2 apoptosis regulator ISO protein:increased expression:tongue: RGD PMID:12167434 RGD:8547871 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A disease_progression IEP RGD PMID:11488071 RGD:8662423 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A severity ISO DNA:point mutations, missense mutation:exon
DNA:loss of heterozygosity
protein:decreased expression:tongue		 RGD PMID:17091472 PMID:16527513 PMID:18804414 RGD:1600814, RGD:1578522, RGD:11252155 NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301 		JBrowse link
G CDKN2B cyclin dependent kinase inhibitor 2B ISO DNA:loss of heterozygosity RGD PMID:16527513 RGD:1578522 NCBI chr 9:22,002,903...22,009,313
Ensembl chr 9:22,002,903...22,009,305 		JBrowse link
G CRYAB crystallin alpha B EXP CTD Direct Evidence: marker/mechanism CTD PMID:19840781 NCBI chr11:111,908,564...111,923,740
Ensembl chr11:111,908,564...111,923,722 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:tongue epithelium RGD PMID:14674993 RGD:2293780 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G HRAS HRas proto-oncogene, GTPase susceptibility IMP
EXP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20043093 PMID:20043093 RGD:12738401 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321 		JBrowse link
G HSPB1 heat shock protein family B (small) member 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19840781 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295 		JBrowse link
G IGF1 insulin like growth factor 1 IEP protein:decreased expression:blood: RGD PMID:8493451 RGD:8548876 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:tongue epithelium RGD PMID:14674993 RGD:2293780 NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315 		JBrowse link
G KRT14 keratin 14 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16543248 NCBI chr17:41,582,279...41,586,895
Ensembl chr17:41,582,279...41,586,895 		JBrowse link
G MIR222 microRNA 222 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19487542 NCBI chr  X:45,747,015...45,747,124
Ensembl chr  X:45,747,015...45,747,124 		JBrowse link
G MT1X metallothionein 1X ISO CTD Direct Evidence: marker/mechanism CTD PMID:16543248 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196 		JBrowse link
G OGG1 8-oxoguanine DNA glycosylase IEP protein:decreased expression:saliva RGD PMID:19789535 RGD:8657148 NCBI chr 3:9,749,952...9,783,108
Ensembl chr 3:9,749,944...9,788,219 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16543248 PMID:22561872 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G SOD2 superoxide dismutase 2 IEP
EXP		 mRNA,protein:increased expression:tongue:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:20618948 PMID:20618948 RGD:8547519 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 disease_progression IDA
IEP		 RGD PMID:17169602 PMID:22302289 RGD:8694287, RGD:8694311 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,540 		JBrowse link
G TERC telomerase RNA component EXP CTD Direct Evidence: therapeutic CTD PMID:16051514 NCBI chr 3:169,764,610...169,765,060
Ensembl chr 3:169,764,610...169,765,047
Ensembl chr 3:169,764,610...169,765,047 		JBrowse link
G TLR5 toll like receptor 5 IEP protein:increased expression:tongue: RGD PMID:23287987 RGD:7814374 NCBI chr 1:223,109,404...223,143,248
Ensembl chr 1:223,109,404...223,143,248 		JBrowse link
G TNF tumor necrosis factor ISO
IEP		 mRNA,protein:increased expression:tongue:
protein:increased expression:saliva		 RGD PMID:14747060 PMID:21397550 RGD:7401243, RGD:7401244 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 IDA
ISO		 DNA:mutations:cds:
protein:increased expression:tongue:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16543248 PMID:21903770 PMID:12167434 PMID:9485768 RGD:8547850, RGD:8547871, RGD:8547872 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TYMS thymidylate synthetase EXP CTD Direct Evidence: marker/mechanism CTD PMID:16280240 NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578 		JBrowse link
G VEGFA vascular endothelial growth factor A disease_progression IEP RGD PMID:15289890 RGD:7488946 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G VEGFC vascular endothelial growth factor C disease_progression IEP RGD PMID:15289890 RGD:7488946 NCBI chr 4:176,683,538...176,792,922
Ensembl chr 4:176,683,538...176,792,922 		JBrowse link
congenital heart defects, hamartomas of tongue, and polysyndactyly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WDPCP WD repeat containing planar cell polarity effector IAGP ClinVar Annotator: match by term: Orstavik Lindemann Solberg syndrome
ClinVar Annotator: match by term: Heart defect - tongue hamartoma - polysyndactyly syndrome
ClinVar Annotator: match by term: Congenital heart defects, hamartomas of tongue, and polysyndactyly		 ClinVar
OMIM		 PMID:9536098 PMID:17576681 PMID:20671153 PMID:25326635 PMID:25427950 More... NCBI chr 2:63,119,559...63,840,826
Ensembl chr 2:63,119,559...63,827,843 		JBrowse link
tongue cancer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDX3X DEAD-box helicase 3 X-linked ameliorates ISO RGD PMID:25918862 RGD:151356506 NCBI chr  X:41,333,308...41,364,472
Ensembl chr  X:41,333,348...41,364,472 		JBrowse link
G FGFR3 fibroblast growth factor receptor 3 severity IEP associated with human papillomavirus;protein:decreased expression:tumor cells RGD PMID:30061236 RGD:36947883 NCBI chr 4:1,793,293...1,808,867
Ensembl chr 4:1,793,293...1,808,872 		JBrowse link
G MIR155 microRNA 155 IEP miRNA:decreased expression:tongue RGD PMID:30617160 RGD:21081517 NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044 		JBrowse link
G MIR491 microRNA 491 disease_progression IEP mRNA:decreased expression:tongue (human) RGD PMID:25749387 RGD:152995520 NCBI chr 9:20,716,105...20,716,188
Ensembl chr 9:20,716,105...20,716,188 		JBrowse link
G RICTOR RPTOR independent companion of MTOR complex 2 disease_progression IEP protein:increased expression:tongue (human) RGD PMID:25749387 RGD:152995520 NCBI chr 5:38,937,920...39,074,399
Ensembl chr 5:38,937,920...39,074,399 		JBrowse link
tongue carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BUB1B BUB1 mitotic checkpoint serine/threonine kinase B IEP associated with oral squamous cell carcinoma; protein:increased expression: oral mucosa squamous cell, cervical lymph node (human) RGD PMID:20204288 RGD:27372889 NCBI chr15:40,161,069...40,221,123
Ensembl chr15:40,161,023...40,221,123 		JBrowse link
tongue squamous cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase IEP protein:increased activity:saliva: RGD PMID:20379753 RGD:152995262 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,584,896...44,652,252 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing disease_progression IEP protein:decreased expression:serum RGD PMID:23181352 RGD:8694469 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G BCL2 BCL2 apoptosis regulator IEP protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 exacerbates IEP protein:increased expression:tongue (human) RGD PMID:18621506 RGD:153323319 NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670 		JBrowse link
G BRINP3 BMP/retinoic acid inducible neural specific 3 IEP mRNA:decreased expression:tongue: RGD PMID:19787213 RGD:14398487 NCBI chr 1:190,097,658...190,477,864
Ensembl chr 1:190,097,658...190,478,404 		JBrowse link
G CAV2 caveolin 2 IEP protein:increased expression:mucosa of tongue RGD PMID:20558341 RGD:8661771 NCBI chr 7:116,499,738...116,508,541
Ensembl chr 7:116,287,380...116,508,541 		JBrowse link
G CCND1 cyclin D1 IEP protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A disease_progression IEP RGD PMID:12162767 RGD:8662376 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 HEP mRNA:increased expression:head, neck (human) RGD PMID:31452775 RGD:150520018 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G EGFR epidermal growth factor receptor treatment ISO RGD PMID:19380367 RGD:8551769 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 disease_progression IEP RGD PMID:19691460 RGD:126781771 NCBI chr12:56,080,108...56,103,505
Ensembl chr12:56,076,799...56,103,505 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 severity IEP RGD PMID:19691460 RGD:126781771 NCBI chr 2:211,375,717...212,538,802
Ensembl chr 2:211,375,717...212,538,841 		JBrowse link
G FANCB FA complementation group B IEP RGD PMID:17409780 RGD:11049143 NCBI chr  X:14,689,524...14,873,069
Ensembl chr  X:14,690,388...14,873,255 		JBrowse link
G FANCC FA complementation group C IEP RGD PMID:17409780 RGD:11049143 NCBI chr 9:95,099,054...95,317,709
Ensembl chr 9:95,099,054...95,426,796 		JBrowse link
G FANCF FA complementation group F IEP mRNA:decreased expression:tongue: RGD PMID:17409780 RGD:11049143 NCBI chr11:22,622,533...22,625,823
Ensembl chr11:22,622,533...22,625,823 		JBrowse link
G FANCG FA complementation group G IEP RGD PMID:17409780 RGD:11049143 NCBI chr 9:35,073,839...35,079,942
Ensembl chr 9:35,073,835...35,080,004 		JBrowse link
G FANCI FA complementation group I IEP RGD PMID:17409780 RGD:11049143 NCBI chr15:89,243,979...89,317,259
Ensembl chr15:89,243,945...89,317,261 		JBrowse link
G FANCL FA complementation group L IEP RGD PMID:17409780 RGD:11049143 NCBI chr 2:58,159,243...58,241,380
Ensembl chr 2:58,159,243...58,241,410 		JBrowse link
G FANCM FA complementation group M IEP RGD PMID:17409780 RGD:11049143 NCBI chr14:45,135,930...45,200,890
Ensembl chr14:45,135,930...45,200,890 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit IEP mRNA,protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit IEP protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179 		JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit IEP protein:decreased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573 		JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit IEP mRNA,protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 2:28,392,858...28,417,317
Ensembl chr 2:28,392,448...28,417,317 		JBrowse link
G FUBP1 far upstream element binding protein 1 exacerbates IEP mRNA, protein:increased expression:tongue (human) RGD PMID:32339054 RGD:151361191 NCBI chr 1:77,944,055...77,979,501
Ensembl chr 1:77,944,055...77,979,110 		JBrowse link
G GJA1 gap junction protein alpha 1 ISO protein:decreased expression:epithelium RGD PMID:23568744 RGD:8662380 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G HGF hepatocyte growth factor IEP protein:increased expression:tongue: RGD PMID:20848408 RGD:8548612 NCBI chr 7:81,699,010...81,770,047
Ensembl chr 7:81,699,010...81,770,438 		JBrowse link
G IFNG interferon gamma disease_progression ISO protein:decreased expression:serum: RGD PMID:17338814 RGD:8662972 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL10 interleukin 10 disease_progression ISO protein:increased expression:serum: RGD PMID:17338814 RGD:8662972 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL1RL1 interleukin 1 receptor like 1 disease_progression IEP RGD PMID:25193287 RGD:39938972 NCBI chr 2:102,311,563...102,352,356
Ensembl chr 2:102,311,502...102,352,037 		JBrowse link
G IL2 interleukin 2 ISO protein:decreased expression:serum: RGD PMID:17338814 RGD:8662972 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL33 interleukin 33 disease_progression IEP RGD PMID:25193287 RGD:39938972 NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,786...6,257,983 		JBrowse link
G JAK3 Janus kinase 3 disease_progression ISO RGD PMID:26860129 RGD:11531126 NCBI chr19:17,824,782...17,847,982
Ensembl chr19:17,824,780...17,848,071 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit IEP mRNA,protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit IEP protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315 		JBrowse link
G JUND JunD proto-oncogene, AP-1 transcription factor subunit IEP protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr19:18,279,694...18,281,622
Ensembl chr19:18,279,694...18,281,622 		JBrowse link
G KDR kinase insert domain receptor treatment ISO RGD PMID:19380367 RGD:8551769 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595 		JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 IEP mRNA:increased expression:tongue squamous epithelium (human) RGD PMID:28319306 RGD:150429750 NCBI chr17:12,020,877...12,143,828
Ensembl chr17:12,020,829...12,143,830 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase IEP protein:increased expression:tongue: RGD PMID:20848408 RGD:8548612 NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377 		JBrowse link
G MMP9 matrix metallopeptidase 9 IEP protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MTUS1 microtubule associated scaffold protein 1 disease_progression IEP RGD PMID:22153618 RGD:25330347 NCBI chr 8:17,643,802...17,801,521
Ensembl chr 8:17,643,795...17,801,094 		JBrowse link
G SLC1A5 solute carrier family 1 member 5 disease_progression IEP RGD PMID:24762957 RGD:151361157 NCBI chr19:46,774,883...46,788,594
Ensembl chr19:46,774,883...46,788,594 		JBrowse link
G SLC3A2 solute carrier family 3 member 2 disease_progression IEP RGD PMID:24762957 RGD:151361157 NCBI chr11:62,856,109...62,888,860
Ensembl chr11:62,856,004...62,888,880 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 severity IEP RGD PMID:24762957 RGD:151361157 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349 		JBrowse link
G SLC7A5 solute carrier family 7 member 5 disease_progression IEP RGD PMID:24762957 RGD:151361157 NCBI chr16:87,830,023...87,869,507
Ensembl chr16:87,830,023...87,869,507 		JBrowse link
G SOX2 SRY-box transcription factor 2 disease_progression IEP RGD PMID:21689966 RGD:8661665 NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436 		JBrowse link
G TP53 tumor protein p53 ISO protein:increased expression:tongue: RGD PMID:20385474 RGD:8547851 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 26240
    sensory system disease 8034
      mouth disease 947
        tongue disease 82
          Tongue Neoplasms 74
            congenital heart defects, hamartomas of tongue, and polysyndactyly 1
            tongue cancer + 52
Path 2
Term Annotations click to browse term
  disease 26240
    disease of anatomical entity 21584
      nervous system disease 17673
        Neurologic Manifestations 11862
          sensory system disease 8034
            mouth disease 947
              tongue disease 82
                Tongue Neoplasms 74
                  congenital heart defects, hamartomas of tongue, and polysyndactyly 1
                  tongue cancer + 52
paths to the root