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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Tongue Neoplasms
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Accession:DOID:9005873 term browser browse the term
Definition:Tumors or cancer of the TONGUE.
Synonyms:exact_synonym: tongue neoplasm;   tongue neoplasms
 primary_id: MESH:D014062
 alt_id: DOID:8649
 xref: EFO:0003871
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
Tongue Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor treatment ISO RGD PMID:17374970 RGD:1625338 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641 		JBrowse link
G AQP3 aquaporin 3 (Gill blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:21401805 NCBI chr 9:33,221,989...33,228,469
Ensembl chr 9:34,032,983...34,039,438 		JBrowse link
G BCL2 BCL2 apoptosis regulator ISO protein:increased expression:tongue: RGD PMID:12167434 RGD:8547871 NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A disease_progression ISO RGD PMID:11488071 RGD:8662423 NCBI chr 6:36,241,405...36,250,032
Ensembl chr 6:37,436,990...37,445,599 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A severity ISO protein:decreased expression:tongue
DNA:point mutations, missense mutation:exon
DNA:loss of heterozygosity		 RGD PMID:16527513 PMID:17091472 PMID:18804414 RGD:11252155 RGD:1578522 RGD:1600814 NCBI chr 9:21,803,862...21,831,322 JBrowse link
G CDKN2B cyclin dependent kinase inhibitor 2B ISO DNA:loss of heterozygosity RGD PMID:16527513 RGD:1578522 NCBI chr 9:21,838,902...21,845,355
Ensembl chr 9:22,455,662...22,462,156 		JBrowse link
G CRYAB crystallin alpha B ISO CTD Direct Evidence: marker/mechanism CTD PMID:19840781 NCBI chr11:106,795,406...106,800,019
Ensembl chr11:110,639,442...110,644,272 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:tongue epithelium RGD PMID:14674993 RGD:2293780 NCBI chr14:55,832,570...55,835,984
Ensembl chr14:74,676,316...74,679,766 		JBrowse link
G HRAS HRas proto-oncogene, GTPase susceptibility ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:20043093 RGD:12738401 NCBI chr11:537,488...540,810
Ensembl chr11:568,305...571,078 		JBrowse link
G HSPB1 heat shock protein family B (small) member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19840781 NCBI chr 7:67,716,021...67,717,762
Ensembl chr 7:82,751,523...82,752,984 		JBrowse link
G IGF1 insulin like growth factor 1 ISO protein:decreased expression:blood: RGD PMID:8493451 RGD:8548876 NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177 		JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:tongue epithelium RGD PMID:14674993 RGD:2293780 NCBI chr19:12,353,760...12,355,598
Ensembl chr19:13,097,931...13,098,974 		JBrowse link
G LOC100975309 keratin, type I cytoskeletal 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16543248 NCBI chr17:15,730,066...15,734,665
Ensembl chr17:15,948,596...15,953,191 		JBrowse link
G OGG1 8-oxoguanine DNA glycosylase ISO protein:decreased expression:saliva RGD PMID:19789535 RGD:8657148 NCBI chr 3:9,702,311...9,742,283
Ensembl chr 3:9,940,955...9,947,335 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16543248 PMID:22561872 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519 		JBrowse link
G SOD2 superoxide dismutase 2 ISO mRNA,protein:increased expression:tongue:
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:20618948 RGD:8547519 NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 disease_progression ISO RGD PMID:17169602 PMID:22302289 RGD:8694287 RGD:8694311 NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067 		JBrowse link
G TLR5 toll like receptor 5 ISO protein:increased expression:tongue: RGD PMID:23287987 RGD:7814374 NCBI chr 1:198,787,046...198,819,537
Ensembl chr 1:203,798,767...203,801,343 		JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:saliva
mRNA,protein:increased expression:tongue:		 RGD PMID:14747060 PMID:21397550 RGD:7401243 RGD:7401244 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TP53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism
DNA:mutations:cds:
protein:increased expression:tongue:		 CTD
RGD		 PMID:9485768 PMID:12167434 PMID:16543248 PMID:21903770 RGD:8547850 RGD:8547871 RGD:8547872 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120 		JBrowse link
G TYMS thymidylate synthetase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16280240 NCBI chr18:13,653,085...13,668,478
Ensembl chr18:17,295,182...17,310,320 		JBrowse link
G VEGFA vascular endothelial growth factor A disease_progression ISO RGD PMID:15289890 RGD:7488946 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353 		JBrowse link
G VEGFC vascular endothelial growth factor C disease_progression ISO RGD PMID:15289890 RGD:7488946 NCBI chr 4:168,870,941...168,999,160
Ensembl chr 4:181,104,737...181,236,030 		JBrowse link
congenital heart defects, hamartomas of tongue, and polysyndactyly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WDPCP WD repeat containing planar cell polarity effector ISO ClinVar Annotator: match by term: Heart defect - tongue hamartoma - polysyndactyly syndrome OMIM
ClinVar		 PMID:9536098 PMID:17576681 PMID:20671153 PMID:25326635 PMID:25427950 More... NCBI chr2A:63,180,279...63,658,804
Ensembl chr2A:64,325,379...64,785,256 		JBrowse link
tongue cancer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDX3X DEAD-box helicase 3 X-linked ameliorates ISO RGD PMID:25918862 RGD:151356506 NCBI chr  X:33,780,381...33,796,829
Ensembl chr  X:41,475,116...41,505,837 		JBrowse link
G FGFR3 fibroblast growth factor receptor 3 severity ISO associated with human papillomavirus;protein:decreased expression:tumor cells RGD PMID:30061236 RGD:36947883 NCBI chr 4:1,933,172...1,948,742
Ensembl chr 4:1,843,774...1,861,692 		JBrowse link
G RICTOR RPTOR independent companion of MTOR complex 2 disease_progression ISO protein:increased expression:tongue (human) RGD PMID:25749387 RGD:152995520 NCBI chr 5:71,299,215...71,435,290
Ensembl chr 5:76,389,130...76,469,830 		JBrowse link
tongue carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BUB1B BUB1 mitotic checkpoint serine/threonine kinase B ISO associated with oral squamous cell carcinoma; protein:increased expression: oral mucosa squamous cell, cervical lymph node (human) RGD PMID:20204288 RGD:27372889 NCBI chr15:19,095,383...19,155,557
Ensembl chr15:37,350,826...37,410,648 		JBrowse link
tongue squamous cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase ISO protein:increased activity:saliva: RGD PMID:20379753 RGD:152995262 NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing disease_progression ISO protein:decreased expression:serum RGD PMID:23181352 RGD:8694469 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885 		JBrowse link
G BCL2 BCL2 apoptosis regulator ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100 		JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 exacerbates ISO protein:increased expression:tongue (human) RGD PMID:18621506 RGD:153323319 NCBI chr11:97,298,736...97,324,966
Ensembl chr11:100,793,036...100,822,421 		JBrowse link
G BRINP3 BMP/retinoic acid inducible neural specific 3 ISO mRNA:decreased expression:tongue: RGD PMID:19787213 RGD:14398487 NCBI chr 1:165,586,510...165,972,173
Ensembl chr 1:169,873,541...170,258,015 		JBrowse link
G CAV2 caveolin 2 ISO protein:increased expression:mucosa of tongue RGD PMID:20558341 RGD:8661771 NCBI chr 7:108,254,074...108,480,716
Ensembl chr 7:121,168,579...121,177,415 		JBrowse link
G CCND1 cyclin D1 ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr11:64,737,006...64,750,353 JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A disease_progression ISO RGD PMID:12162767 RGD:8662376 NCBI chr 6:36,241,405...36,250,032
Ensembl chr 6:37,436,990...37,445,599 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO mRNA:increased expression:head, neck (human) RGD PMID:31452775 RGD:150520018 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083 		JBrowse link
G EGFR epidermal growth factor receptor treatment ISO RGD PMID:19380367 RGD:8551769 NCBI chr 7:55,614,042...55,807,285
Ensembl chr 7:56,046,296...56,111,615 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 disease_progression ISO RGD PMID:19691460 RGD:126781771 NCBI chr12:32,811,533...32,834,958
Ensembl chr12:33,063,434...33,084,994 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 severity ISO RGD PMID:19691460 RGD:126781771 NCBI chr2B:98,625,630...99,795,371
Ensembl chr2B:217,069,644...218,272,006 		JBrowse link
G FANCB FA complementation group B ISO RGD PMID:17409780 RGD:11049143 NCBI chr  X:7,470,574...7,500,958
Ensembl chr  X:14,752,934...14,781,817 		JBrowse link
G FANCC FA complementation group C ISO RGD PMID:17409780 RGD:11049143 NCBI chr 9:66,201,581...66,418,229
Ensembl chr 9:94,329,971...94,477,198 		JBrowse link
G FANCF FA complementation group F ISO mRNA:decreased expression:tongue: RGD PMID:17409780 RGD:11049143 NCBI chr11:22,634,301...22,637,885
Ensembl chr11:22,544,052...22,545,176 		JBrowse link
G FANCG FA complementation group G ISO RGD PMID:17409780 RGD:11049143 NCBI chr 9:34,924,399...34,931,077
Ensembl chr 9:35,730,176...35,736,648 		JBrowse link
G FANCI FA complementation group I ISO RGD PMID:17409780 RGD:11049143 NCBI chr15:67,935,882...68,009,033
Ensembl chr15:87,142,871...87,215,271 		JBrowse link
G FANCL FA complementation group L ISO RGD PMID:17409780 RGD:11049143 NCBI chr2A:58,270,620...58,353,001
Ensembl chr2A:59,418,265...59,499,496 		JBrowse link
G FANCM FA complementation group M ISO RGD PMID:17409780 RGD:11049143 NCBI chr14:25,752,295...25,817,001
Ensembl chr14:44,080,146...44,143,958 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO mRNA,protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr14:55,832,570...55,835,984
Ensembl chr14:74,676,316...74,679,766 		JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr19:42,416,781...42,424,003
Ensembl chr19:51,013,350...51,020,570 		JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit ISO protein:decreased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr11:61,252,513...61,261,032
Ensembl chr11:64,581,841...64,589,304 		JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit ISO mRNA,protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr2A:28,392,328...28,416,838
Ensembl chr2A:28,485,613...28,498,397 		JBrowse link
G FUBP1 far upstream element binding protein 1 exacerbates ISO mRNA, protein:increased expression:tongue (human) RGD PMID:32339054 RGD:151361191 NCBI chr 1:77,162,675...77,198,486 JBrowse link
G GJA1 gap junction protein alpha 1 ISO protein:decreased expression:epithelium RGD PMID:23568744 RGD:8662380 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G HGF hepatocyte growth factor ISO protein:increased expression:tongue: RGD PMID:20848408 RGD:8548612 NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811 		JBrowse link
G IFNG interferon gamma disease_progression ISO protein:decreased expression:serum: RGD PMID:17338814 RGD:8662972 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IL10 interleukin 10 disease_progression ISO protein:increased expression:serum: RGD PMID:17338814 RGD:8662972 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL2 interleukin 2 ISO protein:decreased expression:serum: RGD PMID:17338814 RGD:8662972 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
G IL33 interleukin 33 disease_progression ISO RGD PMID:25193287 RGD:39938972 NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624 		JBrowse link
G JAK3 Janus kinase 3 disease_progression ISO RGD PMID:26860129 RGD:11531126 NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit ISO mRNA,protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 1:58,042,794...58,045,536 JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr19:12,353,760...12,355,598
Ensembl chr19:13,097,931...13,098,974 		JBrowse link
G JUND JunD proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr19:17,755,331...17,757,164 JBrowse link
G KDR kinase insert domain receptor treatment ISO RGD PMID:19380367 RGD:8551769 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109 		JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 ISO mRNA:increased expression:tongue squamous epithelium (human) RGD PMID:28319306 RGD:150429750 NCBI chr17:39,497,105...39,622,331
Ensembl chr17:44,248,857...44,359,909 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO protein:increased expression:tongue: RGD PMID:20848408 RGD:8548612 NCBI chr 7:108,646,278...108,772,238
Ensembl chr 7:121,365,438...121,468,159 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129 		JBrowse link
G MTUS1 microtubule associated scaffold protein 1 disease_progression ISO RGD PMID:22153618 RGD:25330347 NCBI chr 8:16,863,307...17,020,684 JBrowse link
G SLC1A5 solute carrier family 1 member 5 disease_progression ISO RGD PMID:24762957 RGD:151361157 NCBI chr19:43,765,001...43,778,981
Ensembl chr19:52,294,655...52,307,529 		JBrowse link
G SLC3A2 solute carrier family 3 member 2 disease_progression ISO RGD PMID:24762957 RGD:151361157 NCBI chr11:58,212,395...58,241,686
Ensembl chr11:61,565,680...61,594,579 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 severity ISO RGD PMID:24762957 RGD:151361157 NCBI chr 4:130,529,677...130,601,396
Ensembl chr 4:141,849,343...141,959,849 		JBrowse link
G SLC7A5 solute carrier family 7 member 5 disease_progression ISO RGD PMID:24762957 RGD:151361157 NCBI chr16:68,512,407...68,552,763 JBrowse link
G SOX2 SRY-box transcription factor 2 disease_progression ISO RGD PMID:21689966 RGD:8661665 NCBI chr 3:178,744,881...178,747,392
Ensembl chr 3:186,922,705...186,923,662 		JBrowse link
G TP53 tumor protein p53 ISO protein:increased expression:tongue: RGD PMID:20385474 RGD:8547851 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17632
    sensory system disease 6729
      mouth disease 869
        tongue disease 76
          Tongue Neoplasms 68
            congenital heart defects, hamartomas of tongue, and polysyndactyly 1
            tongue cancer + 49
Path 2
Term Annotations click to browse term
  disease 17632
    disease of anatomical entity 15049
      nervous system disease 13178
        Neurologic Manifestations 9597
          sensory system disease 6729
            mouth disease 869
              tongue disease 76
                Tongue Neoplasms 68
                  congenital heart defects, hamartomas of tongue, and polysyndactyly 1
                  tongue cancer + 49
paths to the root