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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Periodontal Atrophy
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Accession:DOID:9005858 term browser browse the term
Definition:Degradation or wasting of the PERIODONTIUM tissues that may involve the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, or the PERIODONTAL LIGAMENT.
Synonyms:exact_synonym: Atrophy of Periodontium;   Gingivo Osseous Atrophy;   Gingivo-Osseous Atrophies;   Periodontal Atrophies;   Periodontium Atrophies;   Periodontium Atrophy
 primary_id: MESH:D055093


show annotations for term's descendants           Sort by:
Periodontal Atrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VEGFA vascular endothelial growth factor A ISO protein:decreased expression:maxilla: RGD PMID:22716278 RGD:7421608 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
Alveolar Bone Loss term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE2 angiotensin converting enzyme 2 treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236 		JBrowse link
G ACP5 acid phosphatase 5, tartrate resistant treatment ISO associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr19:11,574,660...11,578,975
Ensembl chr19:11,574,653...11,579,993 		JBrowse link
G AGTR1 angiotensin II receptor type 1 treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G AGTR2 angiotensin II receptor type 2 treatment ISO associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974 		JBrowse link
G ALPL alkaline phosphatase, biomineralization associated treatment EXP
ISO		 CTD Direct Evidence: marker/mechanism
associated with hypertension, periodontal disease		 CTD
RGD		 PMID:20630305 PMID:33364953 RGD:329956421 NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO associated with Periodontitis; RGD PMID:21241302 RGD:8661687 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940 		JBrowse link
G CTSK cathepsin K treatment ISO associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 1:150,796,208...150,808,260
Ensembl chr 1:150,794,880...150,809,577 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 treatment ISO associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G IL10 interleukin 10 treatment ISO associated with Diabetes Mellitus, Experimental
associated with periodontal disease		 RGD PMID:26270535 PMID:33364953 RGD:11049527, RGD:329956421 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL1B interleukin 1 beta treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G ITGAV integrin subunit alpha V treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 2:186,590,056...186,680,901
Ensembl chr 2:186,590,010...186,680,901 		JBrowse link
G MAS1 MAS1 proto-oncogene, G protein-coupled receptor treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 6:159,888,787...159,917,447
Ensembl chr 6:159,890,988...159,917,447 		JBrowse link
G MMP2 matrix metallopeptidase 2 treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G OSCAR osteoclast associated Ig-like receptor treatment ISO associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr19:54,094,668...54,100,803
Ensembl chr19:54,094,668...54,102,692 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 ISO RGD PMID:14630900 RGD:10413909 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma treatment ISO associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G TNF tumor necrosis factor treatment ISO associated with Diabetes Mellitus, Experimental
associated with periodontal disease		 RGD PMID:26270535 PMID:33364953 RGD:11049527, RGD:329956421 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF11A TNF receptor superfamily member 11a treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr18:62,325,310...62,391,288
Ensembl chr18:62,325,287...62,391,288 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885 		JBrowse link
G TNFSF11 TNF superfamily member 11 treatment EXP
ISO		 CTD Direct Evidence: marker/mechanism
associated with periodontal disease		 CTD
RGD		 PMID:19249596 PMID:33364953 RGD:329956421 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013 		JBrowse link
G VTN vitronectin treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr17:28,367,284...28,370,307
Ensembl chr17:28,367,284...28,373,091 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 41189
    Stomatognathic Diseases 1769
      tooth disease 772
        periodontal disease 143
          Periodontal Atrophy 24
            Alveolar Bone Loss 23
            Periodontal Attachment Loss 0
            gingival recession 0
Path 2
Term Annotations click to browse term
  disease 41189
    disease of anatomical entity 32344
      nervous system disease 26233
        Neurologic Manifestations 15387
          sensory system disease 9730
            mouth disease 1369
              tooth disease 772
                periodontal disease 143
                  Periodontal Atrophy 24
                    Alveolar Bone Loss 23
                    Periodontal Attachment Loss 0
                    gingival recession 0
paths to the root