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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Vulvar Neoplasms
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Accession:DOID:9005804 term browser browse the term
Definition:Tumors or cancer of the VULVA.
Synonyms:exact_synonym: neoplasm of vulva;   vulva neoplasm;   vulva neoplasms;   vulval neoplasm;   vulvar neoplasm;   vulvar tumor
 primary_id: MESH:D014846
 xref: NCI:C3443
For additional species annotation, visit the Alliance of Genome Resources.


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Vulvar Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDKN2A cyclin dependent kinase inhibitor 2A IEP protein:increased expression:vulva
associated with Papillomavirus Infections;protein:increased expression:vulva
RGD PMID:16998595 PMID:18192968 RGD:2289682, RGD:2289673 NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301
JBrowse link
G CHEK2 checkpoint kinase 2 IAGP DNA:polymorphism:cds:252A>G RGD PMID:11875739 RGD:2298483 NCBI chr22:28,687,743...28,741,866
Ensembl chr22:28,687,743...28,742,422
JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase disease_progression IEP protein:decreased expression:vulva, squamous epithelial cell RGD PMID:16608079 RGD:2301231 NCBI chr 3:59,747,277...61,251,452
Ensembl chr 3:59,747,277...61,251,459
JBrowse link
G MLH1 mutL homolog 1 IEP protein:increased expression:vulva RGD PMID:15870899 RGD:2293514 NCBI chr 3:36,993,487...37,050,846
Ensembl chr 3:36,993,350...37,050,846
JBrowse link
G MSH2 mutS homolog 2 IEP protein:increased expression:vulva RGD PMID:15870899 RGD:2293514 NCBI chr 2:47,403,067...47,634,501
Ensembl chr 2:47,403,067...47,663,146
JBrowse link
G TP53 tumor protein p53 IEP
ISO
protein:increased expression:vulva RGD PMID:16033093 PMID:30514679 RGD:2290537, RGD:14995938 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TP73 tumor protein p73 IEP mRNA, protein:splice variant, increased expression:vulva RGD PMID:11720444 RGD:2290590 NCBI chr 1:3,652,516...3,736,201
Ensembl chr 1:3,652,516...3,736,201
JBrowse link
vulva cancer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 severity IEP associated with Papillomavirus Infections RGD PMID:22685591 RGD:38676500 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G HLA-A major histocompatibility complex, class I, A susceptibility IAGP associated with Papillomavirus Infections;DNA:polymorphism: :HLA-A2 RGD PMID:12543794 RGD:2314696 NCBI chr 6:29,942,532...29,945,870
Ensembl chr 6:29,941,260...29,945,884
JBrowse link
G HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 susceptibility IAGP associated with Papillomavirus Infections;DNA:polymorphisms: :HLA-DQB1*03032,DQB1*5(human) RGD PMID:12543794 RGD:2314696 NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383
JBrowse link
G HLA-DRB1 major histocompatibility complex, class II, DR beta 1 susceptibility IAGP associated with Papillomavirus Infections;DNA:polymorphisms: :HLA-DRB1*11,DRB1*01,DRB1*13(human) RGD PMID:12543794 RGD:2314696 NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,578,769...32,589,848
JBrowse link
G MMP13 matrix metallopeptidase 13 IEP vulvar squamous cell carcinoma (SCC); mRNA:increased expression:tumor:expressed in 9/12 tumors but not in normal vulvar epithelium, cervical SCCs, or endometrial or ovarian adenocarcinomas RGD PMID:10027405 RGD:2293612 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G NOS3 nitric oxide synthase 3 disease_progression IAGP DNA:repeat:intron RGD PMID:15196865 RGD:2292078 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
vulva squamous cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC25A cell division cycle 25A IEP protein:increased expression:vulva RGD PMID:20500813 RGD:2729590 NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417
JBrowse link
G CDC25B cell division cycle 25B disease_progression IEP protein:increased expression:vulva RGD PMID:20500813 RGD:2729590 NCBI chr20:3,786,951...3,806,118
Ensembl chr20:3,786,772...3,806,121
JBrowse link
G CDC25C cell division cycle 25C disease_progression IEP protein:increased expression:vulva RGD PMID:20500813 RGD:2729590 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355
JBrowse link
G SFN stratifin IDA DNA, mRNA:hypermethylation, decreased expression:vulva RGD PMID:11896620 RGD:2299936 NCBI chr 1:26,863,149...26,864,456
Ensembl chr 1:26,863,149...26,864,456
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 20257
    disease of anatomical entity 18858
      reproductive system disease 3394
        female reproductive system disease 1885
          vulvar disease 24
            Vulvar Neoplasms 17
              vulva cancer + 10
              vulvar benign neoplasm + 0
Path 2
Term Annotations click to browse term
  disease 20257
    disease of anatomical entity 18858
      Urogenital Diseases 4839
        Female Urogenital Diseases and Pregnancy Complications 2210
          Female Urogenital Diseases 1889
            female reproductive system disease 1885
              vulvar disease 24
                Vulvar Neoplasms 17
                  vulva cancer + 10
                  vulvar benign neoplasm + 0
paths to the root