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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Vulvar Neoplasms
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Accession:DOID:9005804 term browser browse the term
Definition:Tumors or cancer of the VULVA.
Synonyms:exact_synonym: neoplasm of vulva;   vulva neoplasm;   vulva neoplasms;   vulval neoplasm;   vulvar neoplasm;   vulvar tumor
 primary_id: MESH:D014846
 xref: NCI:C3443


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Vulvar Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDKN2A cyclin dependent kinase inhibitor 2A ISO associated with Papillomavirus Infections;protein:increased expression:vulva RGD PMID:16998595 PMID:18192968 RGD:2289673 RGD:2289682 NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379 		JBrowse link
G CHEK2 checkpoint kinase 2 ISO DNA:polymorphism:cds:252A>G RGD PMID:11875739 RGD:2298483 NCBI chr26:22,052,256...22,145,675
Ensembl chr26:21,427,961...22,240,624 		JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase disease_progression ISO protein:decreased expression:vulva, squamous epithelial cell RGD PMID:16608079 RGD:2301231 NCBI chr20:29,735,380...31,113,859
Ensembl chr20:30,356,572...31,113,859 		JBrowse link
G MLH1 mutL homolog 1 ISO protein:increased expression:vulva RGD PMID:15870899 RGD:2293514 NCBI chr23:6,889,108...6,938,117
Ensembl chr23:6,889,135...6,938,116 		JBrowse link
G MSH2 mutS homolog 2 ISO protein:increased expression:vulva RGD PMID:15870899 RGD:2293514 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210 		JBrowse link
G TP53 tumor protein p53 ISO protein:increased expression:vulva RGD PMID:16033093 PMID:30514679 RGD:14995938 RGD:2290537 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109 		JBrowse link
G TP73 tumor protein p73 ISO mRNA, protein:splice variant, increased expression:vulva RGD PMID:11720444 RGD:2290590 NCBI chr 5:58,194,385...58,241,159
Ensembl chr 5:58,187,826...58,240,839 		JBrowse link
vulva cancer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 severity ISO associated with Papillomavirus Infections RGD PMID:22685591 RGD:38676500 NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193 		JBrowse link
G DLA-DQB1 major histocompatibility complex, class II, DQ beta 1 susceptibility ISO associated with Papillomavirus Infections;DNA:polymorphisms: :HLA-DQB1*03032,DQB1*5(human) RGD PMID:12543794 RGD:2314696 NCBI chr12:2,305,307...2,307,711 JBrowse link
G HLA-DRB1 MHC class II DLA DRB1 beta chain susceptibility ISO associated with Papillomavirus Infections;DNA:polymorphisms: :HLA-DRB1*11,DRB1*01,DRB1*13(human) RGD PMID:12543794 RGD:2314696 NCBI chr12:2,151,409...2,164,564 JBrowse link
G MMP13 matrix metallopeptidase 13 ISO vulvar squamous cell carcinoma (SCC); mRNA:increased expression:tumor:expressed in 9/12 tumors but not in normal vulvar epithelium, cervical SCCs, or endometrial or ovarian adenocarcinomas RGD PMID:10027405 RGD:2293612 NCBI chr 5:28,793,568...28,864,832
Ensembl chr 5:28,850,522...28,864,121 		JBrowse link
G NOS3 nitric oxide synthase 3 disease_progression ISO DNA:repeat:intron RGD PMID:15196865 RGD:2292078 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277 		JBrowse link
vulva squamous cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC25A cell division cycle 25A ISO protein:increased expression:vulva RGD PMID:20500813 RGD:2729590 NCBI chr20:40,823,683...40,849,113
Ensembl chr20:40,823,459...40,847,608 		JBrowse link
G CDC25B cell division cycle 25B disease_progression ISO protein:increased expression:vulva RGD PMID:20500813 RGD:2729590 NCBI chr24:17,552,206...17,561,791
Ensembl chr24:17,553,316...17,561,759 		JBrowse link
G CDC25C cell division cycle 25C disease_progression ISO protein:increased expression:vulva RGD PMID:20500813 RGD:2729590 NCBI chr11:25,904,152...25,940,754
Ensembl chr11:25,904,144...25,935,744 		JBrowse link
G SFN stratifin ISO DNA, mRNA:hypermethylation, decreased expression:vulva RGD PMID:11896620 RGD:2299936 NCBI chr 2:73,268,289...73,269,663
Ensembl chr 2:73,268,791...73,269,537 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17774
    disease of anatomical entity 15146
      reproductive system disease 2897
        female reproductive system disease 1912
          vulvar disease 26
            Vulvar Neoplasms 16
              vulva cancer + 9
              vulvar benign neoplasm + 0
              vulvar intraepithelial neoplasia 0
Path 2
Term Annotations click to browse term
  disease 17774
    disease of anatomical entity 15146
      Urogenital Diseases 4732
        Female Urogenital Diseases and Pregnancy Complications 2355
          Female Urogenital Diseases 1915
            female reproductive system disease 1912
              vulvar disease 26
                Vulvar Neoplasms 16
                  vulva cancer + 9
                  vulvar benign neoplasm + 0
                  vulvar intraepithelial neoplasia 0
paths to the root