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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Fungal Lung Diseases
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Accession:DOID:9005724 term browser browse the term
Definition:Pulmonary diseases caused by fungal infections, usually through hematogenous spread.
Synonyms:exact_synonym: Fungal Lung Disease;   Pulmonary Fungal Disease;   Pulmonary Fungal Diseases;   Pulmonary Fungal Infection;   Pulmonary Fungal Infections
 primary_id: MESH:D008172
 alt_id: RDO:0000483
For additional species annotation, visit the Alliance of Genome Resources.


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Fungal Lung Diseases term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C5 complement C5 ISO RGD PMID:2612053 RGD:5130160 NCBI chrNW_004936487:9,391,774...9,474,168 JBrowse link
G Gata2 GATA binding protein 2 ISO associated with Pneumocystis Infections RGD PMID:16774119 RGD:9587813 NCBI chrNW_004936798:406,258...414,785 JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:lung RGD PMID:16544260 PMID:19752036 RGD:4145474 RGD:4145506 NCBI chrNW_004936647:2,529,933...2,532,503 JBrowse link
G Il33 interleukin 33 ISO protein:increased expression:lung RGD PMID:25746970 RGD:39938968 NCBI chrNW_004936539:763,755...791,461 JBrowse link
G Nos2 nitric oxide synthase 2 ISO protein:decreased expression:lung RGD PMID:10639453 RGD:4891455 NCBI chrNW_004936538:4,052,277...4,097,051 JBrowse link
G Sftpd surfactant protein D susceptibility ISO RGD PMID:20413160 RGD:4143489 NCBI chrNW_004936716:60,754...73,010 JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:lung RGD PMID:16544260 RGD:4145506 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
allergic bronchopulmonary aspergillosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl17 C-C motif chemokine ligand 17 ISO associated with Cystic Fibrosis RGD PMID:17898016 RGD:4145612 NCBI chrNW_004936475:9,475,013...9,476,326 JBrowse link
G Cftr CF transmembrane conductance regulator ISO DNA:mutations: : RGD PMID:11243954 RGD:4140482 NCBI chrNW_004936589:1,565,933...1,719,208 JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO RGD PMID:7743671 RGD:8547590 NCBI chrNW_004936659:616,570...627,172 JBrowse link
G Il1a interleukin 1 alpha ISO RGD PMID:8699818 RGD:7794730 NCBI chrNW_004936783:1,210,715...1,218,315 JBrowse link
G LOC101964209 C-C chemokine receptor type 1 ISO RGD PMID:15951834 RGD:5688155 NCBI chrNW_004936596:177,774...183,186 JBrowse link
G Tnf tumor necrosis factor ISO RGD PMID:8699818 RGD:7794730 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A susceptibility ISO DNA:snps:5' utr, exon:g.-609G>T rs4149570, g.36A>G rs767455 (human) RGD PMID:20646338 RGD:5131174 NCBI chrNW_004936709:1,407,327...1,421,448 JBrowse link
aspergillosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end-product specific receptor ISO DNA:SNP:promoter:-374T>A (human) RGD PMID:22114731 RGD:8695981 NCBI chrNW_004936727:1,418,342...1,422,005 JBrowse link
G Ccl19 C-C motif chemokine ligand 19 ISO associated with Neutropenia;mRNA:increased expression:lung RGD PMID:19783686 RGD:5130908 NCBI chrNW_004936524:2,765,271...2,767,259 JBrowse link
G Ccr7 C-C motif chemokine receptor 7 ISO associated with Neutropenia RGD PMID:19783686 RGD:5130908 NCBI chrNW_004936490:15,575,764...15,579,766 JBrowse link
G Cftr CF transmembrane conductance regulator severity ISO RGD PMID:22135344 RGD:35673332 NCBI chrNW_004936589:1,565,933...1,719,208 JBrowse link
G Clec1a C-type lectin domain family 1 member A susceptibility ISO ClinVar Annotator: match by term: Aspergillosis, susceptibility to
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:29489751 NCBI chrNW_004936902:458,097...480,606 JBrowse link
G Clec7a C-type lectin domain containing 7A susceptibility ISO ClinVar Annotator: match by term: Aspergillosis, susceptibility to
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:19864674 PMID:20807886 PMID:24033266 NCBI chrNW_004936902:436,224...446,435 JBrowse link
G Il15 interleukin 15 ISO DNA:polymorphism (human) RGD PMID:16893395 RGD:4981337 NCBI chrNW_004936535:6,344,348...6,358,803 JBrowse link
G LOC101969640 C-reactive protein treatment ISO RGD PMID:20879853 RGD:9495929 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Tlr1 toll like receptor 1 susceptibility ISO DNA:SNPs: :p.R80T, p.N248S (human) RGD PMID:16461792 RGD:4889535 NCBI chrNW_004936482:6,582,430...6,591,128 JBrowse link
G Tlr2 toll like receptor 2 ISO mRNA:increased expression:lung RGD PMID:19781388 RGD:4145322 NCBI chrNW_004936576:522,234...531,660 JBrowse link
G Tlr6 toll like receptor 6 susceptibility ISO DNA:SNP: :p.S249P (human) RGD PMID:16461792 RGD:4889535 NCBI chrNW_004936482:6,607,723...6,610,161 JBrowse link
invasive aspergillosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end-product specific receptor ISO RGD PMID:21423669 RGD:5508765 NCBI chrNW_004936727:1,418,342...1,422,005 JBrowse link
G Ccl20 C-C motif chemokine ligand 20 ISO protein:increased expression:lung RGD PMID:20926800 RGD:7483599 NCBI chrNW_004936525:8,238,128...8,240,974 JBrowse link
G Ccr6 C-C motif chemokine receptor 6 disease_progression ISO RGD PMID:17379855 RGD:7483617 NCBI chrNW_004936489:16,669,297...16,689,451 JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:17298426 RGD:5135501 NCBI chrNW_004936762:66,636...69,694 JBrowse link
G Il17a interleukin 17A severity ISO RGD PMID:21807912 RGD:8698654 NCBI chrNW_004936476:8,621,860...8,625,008 JBrowse link
G LOC101966992 cytochrome b-245 heavy chain ISO RGD PMID:24054721 RGD:10450528 NCBI chrNW_004936502:4,631,750...4,676,686 JBrowse link
G Ptx3 pentraxin 3 severity ISO DNA:SNPs, missense mutation:intron, cds:rs2305619, rs1840680, rs3816527
protein:increased expression:bronchoalveolar lavage fluid (human)
RGD PMID:28487045 PMID:30275011 RGD:38501097 RGD:38508892 NCBI chrNW_004936519:4,303,549...4,309,143 JBrowse link
G Tlr2 toll like receptor 2 ISO RGD PMID:16113258 RGD:8553022 NCBI chrNW_004936576:522,234...531,660 JBrowse link
G Tlr4 toll like receptor 4 susceptibility ISO DNA:polymorphism:exon:p.D299G(human) RGD PMID:18275280 RGD:5130863 NCBI chrNW_004936487:6,519,140...6,532,018 JBrowse link
Invasive Pulmonary Aspergillosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1a interleukin 1 alpha ISO DNA:polymorphism, haplotype:promoter:-889C>T (human) RGD PMID:18484169 RGD:4142867 NCBI chrNW_004936783:1,210,715...1,218,315 JBrowse link
G Il1b interleukin 1 beta ISO DNA:polymorphism, haplotype: :-511C>T (human) RGD PMID:18484169 RGD:4142867 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 ISO protein:increased expression:respiratory system fluid/secretion, serum RGD PMID:24360996 RGD:40903005 NCBI chrNW_004936473:3,573,282...3,589,345 JBrowse link
G Ptx3 pentraxin 3 no_association
susceptibility
ISO protein:increased expression:plasma
DNA:SNP, missense mutation:intron, cds:rs2305619, rs3816527
protein:increased expression:bronchoalveolar lavage fluid, plasma (human)
DNA:SNP:intron:rs1840680 (human)
RGD PMID:29020397 PMID:29964232 RGD:38501098 RGD:38508894 NCBI chrNW_004936519:4,303,549...4,309,143 JBrowse link
G Vegfa vascular endothelial growth factor A treatment ISO RGD PMID:23303813 RGD:8655596 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
pneumocystosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Azin1 antizyme inhibitor 1 ISO mRNA:increased expression:alveolar macrophage RGD PMID:19158080 RGD:14700806 NCBI chrNW_004936470:40,801,943...40,832,543 JBrowse link
G C3 complement C3 ISO RGD PMID:17169032 RGD:5129525 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Cd40 CD40 molecule treatment ISO RGD PMID:10968950 RGD:8547797 NCBI chrNW_004936514:6,936,915...6,947,246 JBrowse link
G Csf2 colony stimulating factor 2 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:19487471 RGD:5131475 NCBI chrNW_004936647:3,081,896...3,083,864 JBrowse link
G Il23a interleukin 23 subunit alpha ISO RGD PMID:17403873 RGD:39458043 NCBI chrNW_004936646:743,630...745,998 JBrowse link
G Il33 interleukin 33 treatment ISO RGD PMID:21220696 RGD:40400892 NCBI chrNW_004936539:763,755...791,461 JBrowse link
G Muc1 mucin 1, cell surface associated ISO protein:increased expression:serum RGD PMID:9617869 RGD:5131424 NCBI chrNW_004936580:4,691,870...4,694,092 JBrowse link
G Nos2 nitric oxide synthase 2 ISO protein:decreased dimerization:alveolar macrophage
mRNA:increased expression:alveolar macrophage
RGD PMID:20377877 PMID:20558778 RGD:4144112 RGD:4891486 NCBI chrNW_004936538:4,052,277...4,097,051 JBrowse link
G Sftpb surfactant protein B ISO protein:decreased expression:lung RGD PMID:11385364 RGD:4143431 NCBI chrNW_004936712:1,614,979...1,621,207 JBrowse link
G Sftpc surfactant protein C ISO protein:decreased expression:lung RGD PMID:11385364 RGD:4143431 NCBI chrNW_004936555:5,966,610...5,982,083 JBrowse link
G Sftpd surfactant protein D ISO protein:increased expression:lung RGD PMID:11385364 RGD:4143431 NCBI chrNW_004936716:60,754...73,010 JBrowse link
G Tlr2 toll like receptor 2 ISO RGD PMID:18400546 RGD:4145341 NCBI chrNW_004936576:522,234...531,660 JBrowse link
pulmonary aspergilloma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptx3 pentraxin 3 ISO protein:increased expression:bronchoalveolar lavage fluid, plasma (human) RGD PMID:29964232 RGD:38508894 NCBI chrNW_004936519:4,303,549...4,309,143 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12837
    disease by infectious agent 1647
      Bacterial Infections and Mycoses 632
        fungal infectious disease 81
          Fungal Lung Diseases 41
            Aspergillus Niger Infection 0
            adiaspiromycosis 0
            aspergillosis + 27
            blastomycosis 0
            invasive aspergillosis + 19
            pneumocystosis 12
Path 2
Term Annotations click to browse term
  disease 12837
    disease of anatomical entity 12515
      respiratory system disease 2478
        lower respiratory tract disease 1534
          lung disease 1499
            Fungal Lung Diseases 41
              Aspergillus Niger Infection 0
              adiaspiromycosis 0
              aspergillosis + 27
              blastomycosis 0
              invasive aspergillosis + 19
              pneumocystosis 12
paths to the root