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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Neoplasms, Second Primary
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Accession:DOID:9005715 term browser browse the term
Definition:Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Synonyms:exact_synonym: Metachronous Neoplasm;   Metachronous Neoplasms;   Metachronous Second Primary Neoplasms;   Second Cancer;   Second Cancers;   Second Malignancies;   Second Malignancy;   Second Neoplasm;   Second Neoplasms;   Second Primary Cancer;   Second Primary Cancers;   Second Primary Neoplasm;   Therapy Associated Cancer;   Therapy Associated Neoplasms;   Therapy Related Cancer;   Therapy Related Neoplasms;   Therapy-Associated Cancers;   Therapy-Associated Neoplasm;   Therapy-Related Cancers;   Therapy-Related Neoplasm;   Treatment Associated Cancer;   Treatment Associated Neoplasms;   Treatment Related Cancer;   Treatment Related Neoplasms;   Treatment-Associated Cancers;   Treatment-Associated Neoplasm;   Treatment-Related Cancers;   Treatment-Related Neoplasm
 primary_id: MESH:D016609;   RDO:0006982


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Neoplasms, Second Primary term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSF3 colony stimulating factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20026017 NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729 		JBrowse link
G DAPK1 death associated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19874806 NCBI chr 9:58,628,872...58,836,205
Ensembl chr 9:86,681,953...86,887,958 		JBrowse link
G GMPS guanine monophosphate synthase ISO treatment-related acute type M4 myeloid leukemia; chromosomal translocation resulted in a fusion of MLL and GMPS genes RGD PMID:11110714 RGD:1598998 NCBI chr 3:152,925,905...152,999,180
Ensembl chr 3:160,977,222...161,045,214 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16703596 Ensembl chr 1:127,979,238...128,010,411 JBrowse link
G PML PML nuclear body scaffold ISO CTD Direct Evidence: marker/mechanism CTD PMID:19884644 NCBI chr15:52,903,874...52,955,151
Ensembl chr15:71,658,884...71,710,883 		JBrowse link
G RAD9A RAD9 checkpoint clamp component A ISO CTD Direct Evidence: marker/mechanism CTD PMID:21991345 NCBI chr11:62,675,480...62,756,886
Ensembl chr11:66,061,208...66,068,214 		JBrowse link
G RARA retinoic acid receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:19884644 NCBI chr17:16,932,485...16,980,958 JBrowse link
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  disease 17996
    disease of cellular proliferation 7240
      Neoplasms, Second Primary 7
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